The network for 'adaptive immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex1.000
Cd19CD19 antigen1.000
Tnftumor necrosis factor1.000
Lyz2lysozyme 21.000
Cd40CD40 antigen1.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.999
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.998
H2-Ab1histocompatibility 2, class II antigen A, beta 10.995
Stat3signal transducer and activator of transcription 30.995
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.993
Ifnginterferon gamma0.990
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.989
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.989
FaslFas ligand (TNF superfamily, member 6)0.988
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.986
Il4interleukin 40.986
Socs1suppressor of cytokine signaling 10.984
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.982
Casp4caspase 4, apoptosis-related cysteine peptidase0.982
Prf1perforin 1 (pore forming protein)0.978
Icosinducible T-cell co-stimulator0.977
H2-Eb1histocompatibility 2, class II antigen E beta0.976
H2-Aahistocompatibility 2, class II antigen A, alpha0.975
Ptprcprotein tyrosine phosphatase, receptor type, C0.972
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.971
Ccr1chemokine (C-C motif) receptor 10.970
Ikzf1IKAROS family zinc finger 10.968
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.967
FasFas (TNF receptor superfamily member 6)0.959
Ptenphosphatase and tensin homolog0.959
Ccl2chemokine (C-C motif) ligand 20.954
Cd44CD44 antigen0.954
Il2interleukin 20.952
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.951
B2mbeta-2 microglobulin0.950
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.944
Irf8interferon regulatory factor 80.938
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.938
Il1binterleukin 1 beta0.938
BtkBruton agammaglobulinemia tyrosine kinase0.934
Pax5paired box gene 50.933
Il2rbinterleukin 2 receptor, beta chain0.930
Cd22CD22 antigen0.927
Stat6signal transducer and activator of transcription 60.923
Prdm1PR domain containing 1, with ZNF domain0.922
Ccr7chemokine (C-C motif) receptor 70.921
Foxp3forkhead box P30.917
Tlr4toll-like receptor 40.915
Myd88myeloid differentiation primary response gene 880.911
Irf4interferon regulatory factor 40.909
C1qacomplement component 1, q subcomponent, alpha polypeptide0.909
Bcl6B-cell leukemia/lymphoma 60.909
Ccl22chemokine (C-C motif) ligand 220.898
Il6interleukin 60.891
Il2rginterleukin 2 receptor, gamma chain0.886
Zeb1zinc finger E-box binding homeobox 10.877
Batfbasic leucine zipper transcription factor, ATF-like0.871
Rab27aRAB27A, member RAS oncogene family0.870
Sh2d2aSH2 domain protein 2A0.867
Cd4CD4 antigen0.864
TapbpTAP binding protein0.863
Klrg1killer cell lectin-like receptor subfamily G, member 10.860
Map3k14mitogen-activated protein kinase kinase kinase 140.855
Efnb2ephrin B20.854
Birc3baculoviral IAP repeat-containing 30.854
Gzmagranzyme A0.853
Cyldcylindromatosis (turban tumor syndrome)0.852
Il10interleukin 100.851
H2-K1histocompatibility 2, K1, K region0.849
Klrd1killer cell lectin-like receptor, subfamily D, member 10.841
Il1r1interleukin 1 receptor, type I0.835
Foxn1forkhead box N10.829
Gpr132G protein-coupled receptor 1320.825
Igkimmunoglobulin kappa chain complex0.824
Sfpi1SFFV proviral integration 10.823
Cishcytokine inducible SH2-containing protein0.822
Ifngr1interferon gamma receptor 10.822
Traf2TNF receptor-associated factor 20.816
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.805
Klrk1killer cell lectin-like receptor subfamily K, member 10.802
Ccr6chemokine (C-C motif) receptor 60.798
Ptpn11protein tyrosine phosphatase, non-receptor type 110.795
FynFyn proto-oncogene0.793
Ctswcathepsin W0.792
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.788
Atmataxia telangiectasia mutated homolog (human)0.783
Gdf3growth differentiation factor 30.782
Ciitaclass II transactivator0.782
Casp1caspase 10.777
FcrlaFc receptor-like A0.777
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.775
Ccr2chemokine (C-C motif) receptor 20.771
Cst7cystatin F (leukocystatin)0.769
Il6stinterleukin 6 signal transducer0.769
Clec4dC-type lectin domain family 4, member d0.765
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.764
TyrobpTYRO protein tyrosine kinase binding protein0.764
Cxcl13chemokine (C-X-C motif) ligand 130.761
Cd180CD180 antigen0.760
H2-D1histocompatibility 2, D region locus 10.751
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
grnagranulin a0.534
csf1racolony stimulating factor 1 receptor, a0.408
zgc:64115zgc:641150.240
c1qccomplement component 1, q subcomponent, C chain0.115
dnmt4DNA (cytosine-5-)-methyltransferase 40.098
LOC557072caspase recruitment domain-containing protein 11-like0.085
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.074
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.070
mef2amyocyte enhancer factor 2a0.070
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.068
irak4interleukin-1 receptor-associated kinase 40.066
lndc1ly6/neurotoxin domain containing 10.062
stat1bsignal transducer and activator of transcription 1b0.053
cd247lCD247 antigen like0.053
ctssb.2cathepsin S, b.20.052
tlr3toll-like receptor 30.044
dlg2discs, large (Drosophila) homolog 20.041
irf11interferon regulatory factor 110.035
zgc:64051zgc:640510.035
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.033
illr1immune-related, lectin-like receptor 10.032
adipoqladiponectin, C1Q and collagen domain containing, like0.032
nod1nucleotide-binding oligomerization domain containing 10.031
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.031
LOC100000934hypothetical protein LOC1000009340.030
msh2mutS homolog 2 (E. coli)0.024
cxcr3.2chemokine (C-X-C motif) receptor 3.20.023
tlr9toll-like receptor 90.023
tyrobpTYRO protein tyrosine kinase binding protein0.022
ctsbacathepsin B, a0.021
adipoql2adiponectin, C1Q and collagen domain containing, like 20.021
il7rinterleukin 7 receptor0.021
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.020
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.020
jag1bjagged 1b0.019
grn1granulin 10.019
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.018
jam2ajunctional adhesion molecule 2a0.017
c1qacomplement component 1, q subcomponent, A chain0.017
adipor2adiponectin receptor 20.017
terttelomerase reverse transcriptase0.017
cd40lgCD40 ligand0.017
il4rinterleukin 4 receptor0.016
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.016
coro1acoronin, actin binding protein, 1A0.015
tbx21T-box 210.015
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.015
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.015
tnfatumor necrosis factor a (TNF superfamily, member 2)0.014
calcrcalcitonin receptor0.014
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.014
pth1aparathyroid hormone 1a0.013
foxp3aforkhead box P3a0.013
lrrc33leucine rich repeat containing 330.013
c1qbcomplement component 1, q subcomponent, B chain0.013
il12bbinterleukin 12B, b0.013
LOC100534776toll-like receptor 7-like0.013
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.012
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.012
adrb2aadrenergic receptor, beta 2a0.012
ighzimmunoglobulin heavy constant zeta0.012
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.012
wt1bwilms tumor 1b0.011
psapprosaposin0.011
si:dkeyp-22b2.3si:dkeyp-22b2.30.011
pdgfaaplatelet-derived growth factor alpha a0.011
si:ch211-195h23.3si:ch211-195h23.30.011
dnttdeoxynucleotidyltransferase, terminal0.010
angptl1angiopoietin-like 10.010
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TRAF1TNF receptor-associated factor 10.999
BIRC3baculoviral IAP repeat containing 30.998
B2Mbeta-2-microglobulin0.992
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.979
HLA-Amajor histocompatibility complex, class I, A0.979
PTPN6protein tyrosine phosphatase, non-receptor type 60.977
HLA-Cmajor histocompatibility complex, class I, C0.969
TRAF2TNF receptor-associated factor 20.968
CD40CD40 molecule, TNF receptor superfamily member 50.955
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.943
TNFAIP3tumor necrosis factor, alpha-induced protein 30.908
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.892
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.887
IL2RGinterleukin 2 receptor, gamma0.881
IL4Rinterleukin 4 receptor0.870
LCKlymphocyte-specific protein tyrosine kinase0.868
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.842
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.838
BRCA1breast cancer 1, early onset0.831
CD80CD80 molecule0.819
CCL4chemokine (C-C motif) ligand 40.801
TRAF3TNF receptor-associated factor 30.796
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.779
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.765
TRAF6TNF receptor-associated factor 60.736
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.708
TNFtumor necrosis factor0.699
TRADDTNFRSF1A-associated via death domain0.670
CASP8caspase 8, apoptosis-related cysteine peptidase0.661
LTAlymphotoxin alpha (TNF superfamily, member 1)0.659
TAPBPTAP binding protein (tapasin)0.614
IRF1interferon regulatory factor 10.607
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.597
STAT2signal transducer and activator of transcription 2, 113kDa0.581
SMURF2SMAD specific E3 ubiquitin protein ligase 20.580
HLA-DMBmajor histocompatibility complex, class II, DM beta0.578
HLA-Bmajor histocompatibility complex, class I, B0.575
TANKTRAF family member-associated NFKB activator0.551
CXCL9chemokine (C-X-C motif) ligand 90.528
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.517
CD86CD86 molecule0.509
NOTCH1notch 10.498
ICAM1intercellular adhesion molecule 10.481
SNAP23synaptosomal-associated protein, 23kDa0.472
SYKspleen tyrosine kinase0.467
HLA-Gmajor histocompatibility complex, class I, G0.456
SMAD3SMAD family member 30.443
CCR7chemokine (C-C motif) receptor 70.421
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.415
GRAP2GRB2-related adaptor protein 20.412
CCL5chemokine (C-C motif) ligand 50.406
CXCL10chemokine (C-X-C motif) ligand 100.381
CD2CD2 molecule0.378
HLA-Emajor histocompatibility complex, class I, E0.375
RNF11ring finger protein 110.369
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.367
CCR5chemokine (C-C motif) receptor 50.359
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.350
C1QAcomplement component 1, q subcomponent, A chain0.349
CASP10caspase 10, apoptosis-related cysteine peptidase0.347
THOC5THO complex 50.346
TNFRSF9tumor necrosis factor receptor superfamily, member 90.343
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.337
MDC1mediator of DNA-damage checkpoint 10.329
BCL3B-cell CLL/lymphoma 30.326
BIRC2baculoviral IAP repeat containing 20.311
CCL2chemokine (C-C motif) ligand 20.302
CARD11caspase recruitment domain family, member 110.280
CTLA4cytotoxic T-lymphocyte-associated protein 40.276
HLA-Fmajor histocompatibility complex, class I, F0.272
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.271
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.265
TRAF5TNF receptor-associated factor 50.255
NRP1neuropilin 10.253
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.243
PMLpromyelocytic leukemia0.238
CCL22chemokine (C-C motif) ligand 220.218
DLG1discs, large homolog 1 (Drosophila)0.217
TRIM38tripartite motif containing 380.217
C1QCcomplement component 1, q subcomponent, C chain0.216
SLAMF1signaling lymphocytic activation molecule family member 10.215
LAIR1leukocyte-associated immunoglobulin-like receptor 10.209
TLR2toll-like receptor 20.206
NOTCH3notch 30.205
IL2RBinterleukin 2 receptor, beta0.204
CCR1chemokine (C-C motif) receptor 10.203
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.203
KAT2BK(lysine) acetyltransferase 2B0.198
IRF4interferon regulatory factor 40.195
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.195
IL23Ainterleukin 23, alpha subunit p190.181
CD163CD163 molecule0.178
SIGLEC7sialic acid binding Ig-like lectin 70.171
CD22CD22 molecule0.165
IRF2interferon regulatory factor 20.161
SRGNserglycin0.159
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.156
BTN2A2butyrophilin, subfamily 2, member A20.156
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.156
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.156
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.227
RT1-BaRT1 class II, locus Ba0.096
Cd37CD37 molecule0.074
RT1-DaRT1 class II, locus Da0.061
Gbp2guanylate binding protein 20.056
RT1-S3RT1 class Ib, locus S30.051
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.045
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.039
Cxcl10chemokine (C-X-C motif) ligand 100.036
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.034
Apol3apolipoprotein L, 30.032
Slfn2schlafen 20.032
Hckhemopoietic cell kinase0.031
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.028
Hsph1heat shock 105/110 protein 10.027
Casp1caspase 10.027
Cpceruloplasmin0.025
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.023
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.019
Irf1interferon regulatory factor 10.019
Plcg2phospholipase C, gamma 20.018
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.017
Aif1allograft inflammatory factor 10.016
Ccl5chemokine (C-C motif) ligand 50.016
Ciitaclass II, major histocompatibility complex, transactivator0.015
B2mbeta-2 microglobulin0.014
Cd3gCD3 molecule, gamma0.014
Epha2Eph receptor A20.013
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.013
Icosinducible T-cell co-stimulator0.013
Ctsscathepsin S0.013
Bdkrb2bradykinin receptor B20.013
Arhgap4Rho GTPase activating protein 40.013
Mpeg1macrophage expressed 10.013
Il2rbinterleukin 2 receptor, beta0.012
Rab20RAB20, member RAS oncogene family0.012
Cd5Cd5 molecule0.012
Tmem176btransmembrane protein 176B0.012
Cd8aCD8a molecule0.011
Rsad2radical S-adenosyl methionine domain containing 20.011
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.011
Gja5gap junction protein, alpha 50.011
C1qbcomplement component 1, q subcomponent, B chain0.011
Nrg2neuregulin 20.011
Chek2CHK2 checkpoint homolog (S. pombe)0.010
Il1binterleukin 1 beta0.010
Inpp5dinositol polyphosphate-5-phosphatase D0.010
Nkg7natural killer cell group 7 sequence0.010
Cd53Cd53 molecule0.010
Cd4Cd4 molecule0.010
Itih4inter alpha-trypsin inhibitor, heavy chain 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism