The network for 'neuron remodeling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron remodeling

The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.

NameDescriptionProbabilityFunc Analog Organism
Pcgf2polycomb group ring finger 20.756
Ephb2Eph receptor B20.680
Ctnnb1catenin (cadherin associated protein), beta 10.428
Efnb2ephrin B20.413
Itgb1integrin beta 1 (fibronectin receptor beta)0.332
Gli3GLI-Kruppel family member GLI30.255
Trp53transformation related protein 530.232
Grb10growth factor receptor bound protein 100.169
Rnf2ring finger protein 20.159
Fgfr1fibroblast growth factor receptor 10.135
Appamyloid beta (A4) precursor protein0.119
Pax2paired box gene 20.098
Grip1glutamate receptor interacting protein 10.087
Ptenphosphatase and tensin homolog0.081
Prnpprion protein0.068
Gbp5guanylate binding protein 50.058
Hif1ahypoxia inducible factor 1, alpha subunit0.049
Rargretinoic acid receptor, gamma0.047
Thrathyroid hormone receptor alpha0.043
Igf2insulin-like growth factor 20.040
Fgfr2fibroblast growth factor receptor 20.039
Lama5laminin, alpha 50.037
Lzts2leucine zipper, putative tumor suppressor 20.036
Vangl2vang-like 2 (van gogh, Drosophila)0.033
Ephb3Eph receptor B30.032
Jag1jagged 10.032
Notch1Notch gene homolog 1 (Drosophila)0.029
Sox2SRY-box containing gene 20.028
Foxg1forkhead box G10.027
Shhsonic hedgehog0.026
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.021
RybpRING1 and YY1 binding protein0.020
Rac1RAS-related C3 botulinum substrate 10.020
Clstn1calsyntenin 10.020
Tcfap2atranscription factor AP-2, alpha0.019
Isl1ISL1 transcription factor, LIM/homeodomain0.019
Cplx2complexin 20.018
Nedd4neural precursor cell expressed, developmentally down-regulated 40.018
Epha4Eph receptor A40.017
Ncam1neural cell adhesion molecule 10.016
Gata5GATA binding protein 50.016
Tlr4toll-like receptor 40.016
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.016
Aplp2amyloid beta (A4) precursor-like protein 20.016
Dab1disabled homolog 1 (Drosophila)0.016
Efnb1ephrin B10.016
Smosmoothened homolog (Drosophila)0.015
Pax6paired box gene 60.015
Kdm2blysine (K)-specific demethylase 2B0.015
Cav1caveolin 1, caveolae protein0.014
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.014
Fbn2fibrillin 20.014
Vdrvitamin D receptor0.014
Lama1laminin, alpha 10.013
Retret proto-oncogene0.013
Igf1rinsulin-like growth factor I receptor0.013
Zeb1zinc finger E-box binding homeobox 10.013
Psen1presenilin 10.013
Emx2empty spiracles homolog 2 (Drosophila)0.013
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.013
Scaf11SR-related CTD-associated factor 110.013
Arhgef40Rho guanine nucleotide exchange factor (GEF) 400.013
Tnftumor necrosis factor0.012
Rb1retinoblastoma 10.012
Gli2GLI-Kruppel family member GLI20.012
Bcl6B-cell leukemia/lymphoma 60.012
Bdnfbrain derived neurotrophic factor0.012
Rararetinoic acid receptor, alpha0.012
Igf2rinsulin-like growth factor 2 receptor0.011
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.011
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.011
Tgfb1transforming growth factor, beta 10.011
Gata3GATA binding protein 30.011
Il18interleukin 180.011
NynrinNYN domain and retroviral integrase containing0.011
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.011
Ptk2PTK2 protein tyrosine kinase 20.010
Trim46tripartite motif-containing 460.010
Nfibnuclear factor I/B0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
igf1rbinsulin-like growth factor 1b receptor0.310
aplp2amyloid beta (A4) precursor-like protein 20.192
insrbinsulin receptor b0.189
h1mlinker histone H1M0.139
thrbthyroid hormone receptor beta0.105
vdravitamin D receptor a0.105
prnprs3prion protein, related sequence 30.095
robo1roundabout homolog 10.082
vedventrally expressed dharma/bozozok antagonist0.071
zeb2azinc finger E-box binding homeobox 2a0.064
sox11bSRY-box containing gene 11b0.059
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.058
otx5orthodenticle homolog 50.056
snap29synaptosomal-associated protein 290.054
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.043
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.041
fmr1fragile X mental retardation 10.041
arid4aAT rich interactive domain 4A (RBP1-like)0.039
lpin1lipin 10.038
kif5aakinesin family member 5A, a0.034
tcf7transcription factor 7 (T-cell specific, HMG-box)0.034
slit1aslit homolog 1a (Drosophila)0.033
klhl11kelch-like 11 (Drosophila)0.033
tbc1d23TBC1 domain family, member 230.032
fcho2FCH domain only 20.031
spred1sprouty-related, EVH1 domain containing 10.031
wnt10awingless-type MMTV integration site family, member 10a0.031
birc2baculoviral IAP repeat-containing 20.031
greb1growth regulation by estrogen in breast cancer 10.030
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.030
rspo3R-spondin 3 homolog (Xenopus laevis)0.029
piwil2piwi-like 2 (Drosophila)0.029
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.029
traf4atnf receptor-associated factor 4a0.028
insrainsulin receptor a0.027
ankrd12ankyrin repeat domain 120.027
dlg2discs, large (Drosophila) homolog 20.027
znf148zinc finger protein 1480.026
mapk3mitogen-activated protein kinase 30.026
cnot6CCR4-NOT transcription complex, subunit 60.026
kif5bbkinesin family member 5B, b0.026
stau1staufen, RNA binding protein, homolog 1 (Drosophila)0.026
runx1runt-related transcription factor 10.026
polbpolymerase (DNA directed), beta0.025
wnt7bawingless-type MMTV integration site family, member 7Ba0.025
tgfbitransforming growth factor, beta-induced0.025
tcf12transcription factor 120.025
kdm5clysine (K)-specific demethylase 5C0.024
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.024
lhx2bLIM homeobox 2b0.024
acsl1acyl-CoA synthetase long-chain family member 10.024
bfbcomplement component bfb0.024
crxcone-rod homeobox0.023
eno2enolase 20.023
tdrd1tudor domain containing 10.023
ulk2unc-51-like kinase 2 (C. elegans)0.023
ptk2.1protein tyrosine kinase 2a0.022
hmx1H6 homeo box 10.022
irf2bp2ainterferon regulatory factor 2 binding protein 2a0.022
casc3cancer susceptibility candidate 30.022
dirc2disrupted in renal carcinoma 20.022
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.022
igf1insulin-like growth factor 10.022
sec24cSEC24 family, member C (S. cerevisiae)0.022
celsr1bcadherin EGF LAG seven-pass G-type receptor 1b0.021
ndrg1lN-myc downstream regulated gene 1, like0.021
tubb5tubulin, beta 50.021
ankrd6ankyrin repeat domain 60.021
per3period homolog 3 (Drosophila)0.021
rps6kalribosomal protein S6 kinase, like0.020
spry1sprouty homolog 1 (Drosophila)0.020
ldb1aLIM-domain binding factor 1a0.020
ncoa2nuclear receptor coactivator 20.020
otx2orthodenticle homolog 20.020
itgb1b.2integrin, beta 1b.20.020
acvr1bactivin A receptor, type IB0.020
helbhelicase (DNA) B0.020
antxr1anthrax toxin receptor 10.020
foxo3bforkhead box O3b0.020
mapk4mitogen-activated protein kinase 40.020
robo2roundabout homolog 20.020
rlfrearranged L-myc fusion0.020
rab11fip4aRAB11 family interacting protein 4 (class II) a0.019
zbtb4zinc finger and BTB domain containing 40.018
ptenaphosphatase and tensin homolog A0.018
usp4ubiquitin specific protease 4 (proto-oncogene)0.018
gria3bglutamate receptor, ionotrophic, AMPA 3b0.018
frmd6FERM domain containing 60.018
spry2sprouty homolog 20.018
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
skpACG16983 gene product from transcript CG16983-RD0.719
sbrsmall bristles0.417
ik2IkappaB kinase-like 20.408
DscamDown syndrome cell adhesion molecule0.355
EphrinCG1862 gene product from transcript CG1862-RA0.330
gfAgiant fibre A0.316
G-ialpha65AG protein alphai subunit 65A0.275
bratbrain tumor0.271
myoglianinCG1838 gene product from transcript CG1838-RD0.260
Vps16AVacuolar protein sorting 16A0.227
Ptp69DProtein tyrosine phosphatase 69D0.220
Vrp1Verprolin 10.200
Sox14Sox box protein 140.179
mubmushroom-body expressed0.178
Rpn6Proteasome p44.5 subunit0.162
Hr51Hormone receptor 510.144
grimCG4345 gene product from transcript CG4345-RA0.139
plexAplexin A0.136
IceCG7788 gene product from transcript CG7788-RA0.134
NmnatNicotinamide mononucleotide adenylyltransferase0.126
AGO2Argonaute 20.123
CG6490CG6490 gene product from transcript CG6490-RB0.122
rapretina aberrant in pattern0.120
jebjelly belly0.118
imdimmune deficiency0.102
BG4CG12297 gene product from transcript CG12297-RA0.097
Hsc70-3Heat shock protein cognate 30.092
pashapartner of drosha0.092
ari-2ariadne 20.092
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.092
Rab5Rab-protein 50.089
CG13366CG13366 gene product from transcript CG13366-RA0.087
exbaextra bases0.080
Rac2CG8556 gene product from transcript CG8556-RA0.072
CG3305CG3305 gene product from transcript CG3305-RA0.069
tbcetubulin-specific chaperone E0.067
Dap160Dynamin associated protein 1600.064
CkIalphaCasein kinase Ialpha0.062
WASpCG1520 gene product from transcript CG1520-RA0.059
Mov34CG3416 gene product from transcript CG3416-RA0.058
DrefDNA replication-related element factor0.058
dvedefective proventriculus0.054
fasfaint sausage0.051
CapsCalcium activated protein for secretion0.050
MED31Mediator complex subunit 310.049
smt3CG4494 gene product from transcript CG4494-RA0.048
emsempty spiracles0.048
Su(z)12CG8013 gene product from transcript CG8013-RA0.046
ctpcut up0.046
zfh2Zn finger homeodomain 20.045
Mi-2CG8103 gene product from transcript CG8103-RA0.045
CG9316CG9316 gene product from transcript CG9316-RA0.043
SAKSak kinase0.043
alphaTub84Balpha-Tubulin at 84B0.042
Cap-GCG34438 gene product from transcript CG34438-RF0.038
Pabp2CG2163 gene product from transcript CG2163-RA0.038
CSN1bCOP9 complex homolog subunit 1 b0.035
ird5immune response deficient 50.033
abd-Aabdominal A0.033
CG14937CG14937 gene product from transcript CG14937-RA0.033
Pk17EProtein kinase-like 17E0.031
Pkd2Polycystic kidney disease gene-20.031
Su(H)Suppressor of Hairless0.031
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
USP11ubiquitin specific peptidase 110.978
BTRCbeta-transducin repeat containing0.950
CUL1cullin 10.946
SKP1S-phase kinase-associated protein 10.912
EGFRepidermal growth factor receptor0.869
FBXW11F-box and WD repeat domain containing 110.835
RING1ring finger protein 10.823
PLXNB1plexin B10.756
FBXW2F-box and WD repeat domain containing 20.531
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.523
PCGF2polycomb group ring finger 20.512
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.481
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.455
ZNF746zinc finger protein 7460.380
IRS1insulin receptor substrate 10.353
PCGF3polycomb group ring finger 30.334
NLRC4NLR family, CARD domain containing 40.256
PPARAperoxisome proliferator-activated receptor alpha0.239
IGF1Rinsulin-like growth factor 1 receptor0.227
ARRB1arrestin, beta 10.221
BMI1BMI1 polycomb ring finger oncogene0.196
COX17COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)0.172
ZFYVE9zinc finger, FYVE domain containing 90.157
FBXW7F-box and WD repeat domain containing 70.147
PHC2polyhomeotic homolog 2 (Drosophila)0.143
YAP1Yes-associated protein 10.140
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.133
FBXO33F-box protein 330.131
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.127
CDC34cell division cycle 34 homolog (S. cerevisiae)0.118
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.115
CTCFCCCTC-binding factor (zinc finger protein)0.097
LRDDleucine-rich repeats and death domain containing0.096
CDK9cyclin-dependent kinase 90.093
RNF2ring finger protein 20.091
CASP4caspase 4, apoptosis-related cysteine peptidase0.091
GRB10growth factor receptor-bound protein 100.084
SKP2S-phase kinase-associated protein 2 (p45)0.078
WEE1WEE1 homolog (S. pombe)0.073
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.067
TRAF2TNF receptor-associated factor 20.065
RBL1retinoblastoma-like 1 (p107)0.064
PSEN1presenilin 10.063
PCGF1polycomb group ring finger 10.061
HMGA2high mobility group AT-hook 20.061
PIAS3protein inhibitor of activated STAT, 30.059
KRTAP4-12keratin associated protein 4-120.059
PHC1polyhomeotic homolog 1 (Drosophila)0.057
NCOR1nuclear receptor corepressor 10.057
GAB1GRB2-associated binding protein 10.055
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.053
SOS1son of sevenless homolog 1 (Drosophila)0.053
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.052
FGFR1fibroblast growth factor receptor 10.051
INSRinsulin receptor0.047
MYH9myosin, heavy chain 9, non-muscle0.046
HDAC3histone deacetylase 30.045
LATlinker for activation of T cells0.044
IRS2insulin receptor substrate 20.042
IFNAR1interferon (alpha, beta and omega) receptor 10.042
LRP1low density lipoprotein receptor-related protein 10.041
GAB2GRB2-associated binding protein 20.041
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.040
VHLvon Hippel-Lindau tumor suppressor0.040
YBX1Y box binding protein 10.038
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.038
SHC1SHC (Src homology 2 domain containing) transforming protein 10.037
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.037
CBX6chromobox homolog 60.037
BACE1beta-site APP-cleaving enzyme 10.037
NCOR2nuclear receptor corepressor 20.036
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.036
TBK1TANK-binding kinase 10.036
RIPK2receptor-interacting serine-threonine kinase 20.035
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like0.034
PCGF6polycomb group ring finger 60.033
AZI25-azacytidine induced 20.033
RIN1Ras and Rab interactor 10.032
ELF4E74-like factor 4 (ets domain transcription factor)0.031
TRIM9tripartite motif containing 90.031
MARCKSL1MARCKS-like 10.031
IL18interleukin 18 (interferon-gamma-inducing factor)0.030
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.029
ALAS1aminolevulinate, delta-, synthase 10.029
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.028
ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)0.028
FBXO4F-box protein 40.028
NTRK1neurotrophic tyrosine kinase, receptor, type 10.028
TNFRSF21tumor necrosis factor receptor superfamily, member 210.028
SIN3ASIN3 homolog A, transcription regulator (yeast)0.028
CARD16caspase recruitment domain family, member 160.027
TBKBP1TBK1 binding protein 10.027
CUL2cullin 20.026
RAI1retinoic acid induced 10.026
PTPN4protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)0.026
GBP1guanylate binding protein 1, interferon-inducible0.026
RBX1ring-box 1, E3 ubiquitin protein ligase0.025
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.025
CBX7chromobox homolog 70.025
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism