The network for 'regulation of protein activation cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein activation cascade

Any process that modulates the frequency, rate or extent of protein activation cascade.

NameDescriptionProbabilityFunc Analog Organism
Cd59aCD59a antigen0.680
Cpceruloplasmin0.657
F9coagulation factor IX0.492
C9complement component 90.407
C1racomplement component 1, r subcomponent A0.364
Cfhcomplement component factor h0.335
Akr1c6aldo-keto reductase family 1, member C60.289
Apcsserum amyloid P-component0.286
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.245
Otcornithine transcarbamylase0.204
Saa4serum amyloid A 40.186
Lyz2lysozyme 20.181
Itih4inter alpha-trypsin inhibitor, heavy chain 40.177
Cps1carbamoyl-phosphate synthetase 10.158
Mug1murinoglobulin 10.144
Mbl2mannose-binding lectin (protein C) 20.135
Mrpl3mitochondrial ribosomal protein L30.122
Apoeapolipoprotein E0.116
Gcgroup specific component0.095
CrpC-reactive protein, pentraxin-related0.093
Hrghistidine-rich glycoprotein0.093
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.093
1300017J02RikRIKEN cDNA 1300017J02 gene0.092
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.088
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.086
Mup3major urinary protein 30.077
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.074
Cfhr1complement factor H-related 10.069
Mug2murinoglobulin 20.065
Timd2T-cell immunoglobulin and mucin domain containing 20.064
Dcndecorin0.064
Kng1kininogen 10.060
Hchemolytic complement0.060
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.055
Aadacarylacetamide deacetylase (esterase)0.055
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.054
Cficomplement component factor i0.052
Cd59bCD59b antigen0.050
Albalbumin0.047
Itih3inter-alpha trypsin inhibitor, heavy chain 30.043
Plgplasminogen0.042
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.041
Afmafamin0.040
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.038
Rdh7retinol dehydrogenase 70.038
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.036
Lect2leukocyte cell-derived chemotaxin 20.036
Tdo2tryptophan 2,3-dioxygenase0.036
Aponapolipoprotein N0.035
Lipclipase, hepatic0.034
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.030
Fgbfibrinogen beta chain0.029
Slco1b2solute carrier organic anion transporter family, member 1b20.029
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.028
Apofapolipoprotein F0.028
Nr5a2nuclear receptor subfamily 5, group A, member 20.028
Rnase4ribonuclease, RNase A family 40.028
Ces1ccarboxylesterase 1C0.027
Hao1hydroxyacid oxidase 1, liver0.026
ND6NADH dehydrogenase subunit 60.025
Ces3acarboxylesterase 3A0.025
Cd55CD55 antigen0.024
Mbl1mannose-binding lectin (protein A) 10.023
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.022
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.022
Fgafibrinogen alpha chain0.022
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.021
G6pcglucose-6-phosphatase, catalytic0.021
B2mbeta-2 microglobulin0.021
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.021
C1scomplement component 1, s subcomponent0.020
Hgdhomogentisate 1, 2-dioxygenase0.020
Uoxurate oxidase0.020
Rp1retinitis pigmentosa 1 (human)0.019
Il1r1interleukin 1 receptor, type I0.019
Abcb11ATP-binding cassette, sub-family B (MDR/TAP), member 110.019
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.019
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.019
Orm2orosomucoid 20.018
Cml2camello-like 20.018
Slco1a1solute carrier organic anion transporter family, member 1a10.018
Itih1inter-alpha trypsin inhibitor, heavy chain 10.018
Fggfibrinogen gamma chain0.017
Slc17a3solute carrier family 17 (sodium phosphate), member 30.017
Cyp2c37cytochrome P450, family 2. subfamily c, polypeptide 370.017
Cfhr2complement factor H-related 20.017
Gm4788predicted gene 47880.016
C730048C13RikRIKEN cDNA C730048C13 gene0.016
Ahsgalpha-2-HS-glycoprotein0.015
Fcgr2bFc receptor, IgG, low affinity IIb0.015
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.015
Lumlumican0.014
F2coagulation factor II0.014
Ambpalpha 1 microglobulin/bikunin0.014
Creb3l3cAMP responsive element binding protein 3-like 30.014
Spna1spectrin alpha 10.014
Atad3aATPase family, AAA domain containing 3A0.014
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.013
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.013
Aadataminoadipate aminotransferase0.013
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
C1Scomplement component 1, s subcomponent1.000
C1Rcomplement component 1, r subcomponent0.999
C3complement component 30.952
SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 10.746
CFHcomplement factor H0.298
CFIcomplement factor I0.197
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.167
CFHR1complement factor H-related 10.092
APOEapolipoprotein E0.084
DCNdecorin0.041
NNMTnicotinamide N-methyltransferase0.038
FN1fibronectin 10.028
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.018
PLGplasminogen0.017
CFBcomplement factor B0.017
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.016
CPceruloplasmin (ferroxidase)0.015
RARRES1retinoic acid receptor responder (tazarotene induced) 10.015
CPDcarboxypeptidase D0.014
C7complement component 70.014
CAV1caveolin 1, caveolae protein, 22kDa0.013
RARRES2retinoic acid receptor responder (tazarotene induced) 20.013
YBX1Y box binding protein 10.012
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.011
CD164CD164 molecule, sialomucin0.011
CFHR2complement factor H-related 20.011
PLTPphospholipid transfer protein0.011
HPhaptoglobin0.011
IL1R1interleukin 1 receptor, type I0.011
SAA4serum amyloid A4, constitutive0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C1scomplement component 1, s subcomponent0.026
Cpceruloplasmin0.016
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism