The network for 'central nervous system neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

central nervous system neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Pax6paired box gene 61.000
Msx1homeobox, msh-like 11.000
Dlx5distal-less homeobox 51.000
Gli2GLI-Kruppel family member GLI20.999
Pitx2paired-like homeodomain transcription factor 20.999
Pax2paired box gene 20.999
Tbx1T-box 10.999
Isl1ISL1 transcription factor, LIM/homeodomain0.999
Fgfr2fibroblast growth factor receptor 20.999
Sox2SRY-box containing gene 20.998
Msx2homeobox, msh-like 20.998
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.998
Fgfr1fibroblast growth factor receptor 10.997
Hand1heart and neural crest derivatives expressed transcript 10.997
Pax3paired box gene 30.996
Foxg1forkhead box G10.996
Emx1empty spiracles homolog 1 (Drosophila)0.996
Tbx3T-box 30.996
Eya1eyes absent 1 homolog (Drosophila)0.995
Foxc1forkhead box C10.995
Lhx3LIM homeobox protein 30.994
Ascl1achaete-scute complex homolog 1 (Drosophila)0.994
Hoxa2homeobox A20.992
Fgf10fibroblast growth factor 100.992
Fgf8fibroblast growth factor 80.991
Neurod1neurogenic differentiation 10.989
Pax8paired box gene 80.988
Dlx6distal-less homeobox 60.987
Hoxa1homeobox A10.987
UncxUNC homeobox0.987
Hoxb1homeobox B10.986
Sox9SRY-box containing gene 90.985
Notch1Notch gene homolog 1 (Drosophila)0.985
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.983
Hes1hairy and enhancer of split 1 (Drosophila)0.983
Nr2e1nuclear receptor subfamily 2, group E, member 10.983
Ctnnb1catenin (cadherin associated protein), beta 10.982
Bmp7bone morphogenetic protein 70.980
En1engrailed 10.979
Rargretinoic acid receptor, gamma0.979
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.976
Fgf15fibroblast growth factor 150.976
Hoxa10homeobox A100.975
Robo1roundabout homolog 1 (Drosophila)0.973
Pitx1paired-like homeodomain transcription factor 10.972
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.972
Fgf3fibroblast growth factor 30.972
Lmx1aLIM homeobox transcription factor 1 alpha0.971
Wnt1wingless-related MMTV integration site 10.970
Hand2heart and neural crest derivatives expressed transcript 20.968
Lhx1LIM homeobox protein 10.968
Cbln1cerebellin 1 precursor protein0.965
Smosmoothened homolog (Drosophila)0.964
Bmp4bone morphogenetic protein 40.964
Gbx2gastrulation brain homeobox 20.964
Hoxd9homeobox D90.962
Phox2bpaired-like homeobox 2b0.961
Pbx1pre B-cell leukemia transcription factor 10.960
Mab21l2mab-21-like 2 (C. elegans)0.958
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.956
Ptenphosphatase and tensin homolog0.952
Ephb2Eph receptor B20.951
Tcfap2atranscription factor AP-2, alpha0.949
Hoxa13homeobox A130.948
Nkx2-1NK2 homeobox 10.947
Onecut1one cut domain, family member 10.943
Hoxd3homeobox D30.941
Tlx3T-cell leukemia, homeobox 30.940
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.934
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.934
Neurog2neurogenin 20.930
Pax9paired box gene 90.922
Emx2empty spiracles homolog 2 (Drosophila)0.920
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.917
Runx2runt related transcription factor 20.914
Otx1orthodenticle homolog 1 (Drosophila)0.912
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.911
Gscgoosecoid homeobox0.907
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.903
Dlx2distal-less homeobox 20.899
En2engrailed 20.894
Nrxn1neurexin I0.893
Gata4GATA binding protein 40.892
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.891
Ebf3early B-cell factor 30.885
Ptch1patched homolog 10.882
Bdnfbrain derived neurotrophic factor0.878
Wnt6wingless-related MMTV integration site 60.876
Sall4sal-like 4 (Drosophila)0.865
Foxd2forkhead box D20.864
Prrx1paired related homeobox 10.862
Ptf1apancreas specific transcription factor, 1a0.862
Zeb1zinc finger E-box binding homeobox 10.861
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.855
Dlx1distal-less homeobox 10.854
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli1GLI-Kruppel family member 10.998
tbx1T-box 10.994
robo3roundabout homolog 30.991
pitx3paired-like homeodomain transcription factor 30.990
gli2aGLI-Kruppel family member GLI2a0.984
lhx2bLIM homeobox 2b0.980
pax6apaired box gene 6a0.958
phox2apaired-like homeobox 2a0.951
sox10SRY-box containing gene 100.937
six3bsine oculis homeobox homolog 3b0.909
tbx2bT-box 2b0.903
lhx5LIM homeobox 50.898
irx1airoquois homeobox protein 1, a0.896
shhbsonic hedgehog b0.888
gata2aGATA-binding protein 2a0.854
nrp2bneuropilin 2b0.853
dbx1adeveloping brain homeobox 1a0.844
gata3GATA-binding protein 30.840
shhasonic hedgehog a0.829
barhl2BarH-like 20.819
her15.1hairy and enhancer of split-related 15.10.800
arxaristaless related homeobox0.784
otx2orthodenticle homolog 20.736
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.709
wnt8bwingless-type MMTV integration site family, member 8b0.709
foxa1forkhead box A10.696
efnb2aephrin B2a0.673
gli2bGLI-Kruppel family member GLI2b0.663
fezf2FEZ family zinc finger 20.647
nkx2.2aNK2 transcription factor related 2a0.646
fzd7afrizzled homolog 7a0.645
lhx1aLIM homeobox 1a0.638
pou3f1POU class 3 homeobox 10.627
foxp2forkhead box P20.610
olig2oligodendrocyte lineage transcription factor 20.598
wnt4awingless-type MMTV integration site family, member 4a0.597
meis3myeloid ecotropic viral integration site 30.595
hoxd4ahomeo box D4a0.585
dlx1adistal-less homeobox gene 1a0.566
olig4oligodendrocyte transcription factor 40.564
pcdh10bprotocadherin 10b0.557
eomesaeomesodermin homolog a0.547
tal2T-cell acute lymphocytic leukemia 20.545
wnt3wingless-type MMTV integration site family, member 30.542
nkx2.1aNK2 homeobox 1a0.539
efnb1ephrin B10.535
apcadenomatosis polyposis coli0.534
pax7apaired box gene 7a0.524
vsx1visual system homeobox 1 homolog, chx10-like0.521
eng2bengrailed 2b0.519
sim1asingle-minded homolog 1a (Drosophila)0.515
robo2roundabout homolog 20.513
jag2jagged 20.509
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.508
evx1even-skipped homeobox 10.506
dlx6adistal-less homeobox gene 6a0.492
foxa2forkhead box A20.490
scn8aasodium channel, voltage-gated, type VIII, alpha a0.485
hnf1baHNF1 homeobox Ba0.468
nrp2aneuropilin 2a0.462
tbx20T-box 200.446
wnt5bwingless-type MMTV integration site family, member 5b0.445
her5hairy-related 50.444
ptf1apancreas specific transcription factor, 1a0.431
notch1anotch homolog 1a0.431
ghrlghrelin/obestatin preprohormone0.428
pax8paired box gene 80.427
neurodneurogenic differentiation0.423
prox1prospero-related homeobox gene 10.419
spry2sprouty homolog 20.416
olfm2olfactomedin 20.412
fzd5frizzled homolog 50.406
sox1aSRY-box containing gene 1a0.403
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.400
prdm14PR domain containing 140.399
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.396
rx3retinal homeobox gene 30.394
six4bsine oculis homeobox homolog 4b0.388
gbx2gastrulation brain homeo box 20.378
chrna6cholinergic receptor, nicotinic, alpha 60.376
cdh2cadherin 2, neuronal0.375
irx4airoquois homeobox protein 4a0.375
hmx3homeo box (H6 family) 30.371
foxg1aforkhead box G1a0.366
csf1racolony stimulating factor 1 receptor, a0.365
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.364
wnt3awingless-type MMTV integration site family, member 3A0.364
tal1T-cell acute lymphocytic leukemia 10.363
eng2aengrailed 2a0.362
sox21bSRY-box containing gene 21 b0.359
gata4GATA-binding protein 40.358
cntn2contactin 20.349
lhx1bLIM homeobox 1b0.346
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.629
HLHmbetaE(spl) region transcript mbeta0.310
HLHm7E(spl) region transcript m70.274
HGTXCG13475 gene product from transcript CG13475-RB0.195
HLHmgammaE(spl) region transcript mgamma0.142
gcmglial cells missing0.131
CtBPC-terminal Binding Protein0.129
lblladybird late0.119
rapretina aberrant in pattern0.116
slp1sloppy paired 10.111
ctpcut up0.080
elavembryonic lethal abnormal vision0.079
vvlventral veins lacking0.070
robo3CG5423 gene product from transcript CG5423-RA0.068
cicubitus interruptus0.064
Sema-1aCG18405 gene product from transcript CG18405-RD0.052
slp2sloppy paired 20.052
InRInsulin-like receptor0.049
Trim9CG31721 gene product from transcript CG31721-RB0.047
EphEph receptor tyrosine kinase0.044
PoxnPox neuro0.043
ash2absent, small, or homeotic discs 20.039
snssticks and stones0.038
CkIalphaCasein kinase Ialpha0.037
fasfaint sausage0.034
ph-ppolyhomeotic proximal0.034
CycACyclin A0.033
HLHm3E(spl) region transcript m30.033
amosabsent MD neurons and olfactory sensilla0.032
nkdnaked cuticle0.031
jingCG9397 gene product from transcript CG9397-RI0.031
Ptp69DProtein tyrosine phosphatase 69D0.030
unc-5CG8166 gene product from transcript CG8166-RA0.030
pdm2POU domain protein 20.028
Wnt2Wnt oncogene analog 20.026
HLHm5E(spl) region transcript m50.026
Rab5Rab-protein 50.024
salmspalt major0.024
EphrinCG1862 gene product from transcript CG1862-RA0.024
Syx1ASyntaxin 1A0.024
reporeversed polarity0.022
CG12424CG12424 gene product from transcript CG12424-RC0.022
l(2)k16918lethal (2) k169180.022
snostrawberry notch0.021
Ca-alpha1DCa[2+]-channel protein alpha[[1]] subunit D0.021
Taf1TBP-associated factor 10.021
fz2frizzled 20.021
Wnt5Wnt oncogene analog 50.020
Galpha49BG protein alpha49B0.018
dlg1discs large 10.018
Ras85DRas oncogene at 85D0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.501
TAL1T-cell acute lymphocytic leukemia 10.309
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.288
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.206
NOTCH3notch 30.156
POU3F2POU class 3 homeobox 20.152
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.107
PDX1pancreatic and duodenal homeobox 10.093
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.093
NR0B1nuclear receptor subfamily 0, group B, member 10.071
ATN1atrophin 10.065
LBX1ladybird homeobox 10.059
FGF3fibroblast growth factor 30.058
TP73tumor protein p730.054
SUFUsuppressor of fused homolog (Drosophila)0.053
HOXD12homeobox D120.050
ADAM19ADAM metallopeptidase domain 190.050
VEGFAvascular endothelial growth factor A0.047
SOX1SRY (sex determining region Y)-box 10.044
NOTCH1notch 10.039
SOX11SRY (sex determining region Y)-box 110.038
EP300E1A binding protein p3000.038
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.038
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.036
RUNX1runt-related transcription factor 10.035
APCadenomatous polyposis coli0.035
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.035
FGF1fibroblast growth factor 1 (acidic)0.035
RAXretina and anterior neural fold homeobox0.034
MAPK1mitogen-activated protein kinase 10.034
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.033
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.032
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.031
PEX14peroxisomal biogenesis factor 140.030
TRIP6thyroid hormone receptor interactor 60.030
TCF4transcription factor 40.028
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.028
SOX10SRY (sex determining region Y)-box 100.028
PCGF2polycomb group ring finger 20.027
OTPorthopedia homeobox0.026
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.026
SIX3SIX homeobox 30.026
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.026
CALCAcalcitonin-related polypeptide alpha0.025
NEDD4neural precursor cell expressed, developmentally down-regulated 40.025
PAX8paired box 80.025
SIX6SIX homeobox 60.025
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.024
PDZD11PDZ domain containing 110.024
NEUROG3neurogenin 30.024
FUSfused in sarcoma0.023
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.023
MEOX2mesenchyme homeobox 20.023
PRMT1protein arginine methyltransferase 10.022
MYOD1myogenic differentiation 10.022
PAX6paired box 60.021
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.020
GFI1Bgrowth factor independent 1B transcription repressor0.020
NKX6-1NK6 homeobox 10.020
POU4F3POU class 4 homeobox 30.019
GAB1GRB2-associated binding protein 10.019
LHX5LIM homeobox 50.019
BHLHE23basic helix-loop-helix family, member e230.019
HIPK2homeodomain interacting protein kinase 20.019
PAX2paired box 20.019
FOXD3forkhead box D30.019
CCT8chaperonin containing TCP1, subunit 8 (theta)0.019
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.018
ACTL6Bactin-like 6B0.018
SOX2SRY (sex determining region Y)-box 20.018
TLX2T-cell leukemia homeobox 20.018
SOS1son of sevenless homolog 1 (Drosophila)0.018
FOXA2forkhead box A20.018
WNT10Awingless-type MMTV integration site family, member 10A0.017
SKIv-ski sarcoma viral oncogene homolog (avian)0.017
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.017
INSRinsulin receptor0.017
HNF4Ahepatocyte nuclear factor 4, alpha0.017
JAG1jagged 10.016
CBX4chromobox homolog 40.016
ALX3ALX homeobox 30.016
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.016
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.016
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.016
HOXC8homeobox C80.016
NCKAP1NCK-associated protein 10.015
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.015
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.015
NPAS1neuronal PAS domain protein 10.015
SCMH1sex comb on midleg homolog 1 (Drosophila)0.015
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.015
NEUROD1neurogenic differentiation 10.015
NKX2-2NK2 homeobox 20.015
DISC1disrupted in schizophrenia 10.015
STK36serine/threonine kinase 360.014
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.014
NKX2-1NK2 homeobox 10.014
GRB7growth factor receptor-bound protein 70.014
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.014
EIF2C1eukaryotic translation initiation factor 2C, 10.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.200
Gria4glutamate receptor, ionotrophic, AMPA 40.109
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.074
Nrcamneuronal cell adhesion molecule0.069
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.046
Unc13cunc-13 homolog C (C. elegans)0.043
St18suppression of tumorigenicity 180.040
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.033
Drd1adopamine receptor D1A0.032
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.032
Robo2roundabout homolog 2 (Drosophila)0.031
Giprgastric inhibitory polypeptide receptor0.029
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.028
Gad1glutamate decarboxylase 10.026
Pgcprogastricsin (pepsinogen C)0.026
Mogmyelin oligodendrocyte glycoprotein0.026
Grm7glutamate receptor, metabotropic 70.026
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.024
Nfianuclear factor I/A0.024
Camk1gcalcium/calmodulin-dependent protein kinase IG0.024
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.024
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.023
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.023
Hoxc4homeo box C40.022
Stox2storkhead box 20.022
Htr75-hydroxytryptamine (serotonin) receptor 70.022
Lrrc7leucine rich repeat containing 70.021
Nr4a2nuclear receptor subfamily 4, group A, member 20.021
Svs5seminal vesicle secretory protein 50.021
Nxph1neurexophilin 10.021
Pcdha13protocadherin alpha 130.020
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.020
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.020
Olr287olfactory receptor 2870.020
Crybb3crystallin, beta B30.020
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.019
Mobpmyelin-associated oligodendrocyte basic protein0.019
Adrb1adrenergic, beta-1-, receptor0.019
Esr2estrogen receptor 2 (ER beta)0.019
Unc5aunc-5 homolog A (C. elegans)0.018
Robo1roundabout homolog 1 (Drosophila)0.018
Gdf11growth differentiation factor 110.018
Nr4a3nuclear receptor subfamily 4, group A, member 30.018
Drp2dystrophin related protein 20.018
Myt1lmyelin transcription factor 1-like0.018
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.018
Gria2glutamate receptor, ionotropic, AMPA 20.017
Grm1glutamate receptor, metabotropic 10.017
Grm5glutamate receptor, metabotropic 50.017
Tmod2tropomodulin 20.017
Galr3galanin receptor 30.017
Hpcal4hippocalcin-like 40.017
Il13interleukin 130.017
Tulp1tubby like protein 10.017
Ncam1neural cell adhesion molecule 10.017
Gabrg2gamma-aminobutyric acid (GABA) A receptor, gamma 20.017
Shc2SHC (Src homology 2 domain containing) transforming protein 20.017
Cdkl3cyclin-dependent kinase-like 30.016
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.016
Hoxb7homeo box B70.016
Cdh6cadherin 60.016
NrarpNotch-regulated ankyrin repeat protein0.016
Itpr2inositol 1,4,5-triphosphate receptor, type 20.016
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.016
Grik1glutamate receptor, ionotropic, kainate 10.015
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.015
Cntfrciliary neurotrophic factor receptor0.015
Dlg4discs, large homolog 4 (Drosophila)0.015
Klf2Kruppel-like factor 2 (lung)0.015
Myl7myosin, light chain 7, regulatory0.015
Cnksr2connector enhancer of kinase suppressor of Ras 20.015
Rph3arabphilin 3A0.015
Kcnn2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 20.015
Racgap1Rac GTPase-activating protein 10.015
Atxn1ataxin 10.015
Gng7guanine nucleotide binding protein (G protein), gamma 70.014
Mfrpmembrane frizzled-related protein0.014
Epha7Eph receptor A70.014
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.014
Sox17SRY (sex determining region Y)-box 170.014
Mycsmyc-like oncogene, s-myc protein0.014
Akap5A kinase (PRKA) anchor protein 50.014
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.014
Hes3hairy and enhancer of split 3 (Drosophila)0.014
Nr2f2nuclear receptor subfamily 2, group F, member 20.013
Nrxn3neurexin 30.013
Clcn4-2chloride channel 4-20.013
Mipmajor intrinsic protein of lens fiber0.013
Olr1361olfactory receptor 13610.013
Syn1synapsin I0.013
Ecel1endothelin converting enzyme-like 10.013
GperG protein-coupled estrogen receptor 10.013
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.013
Prph2peripherin 20.013
Rhoaras homolog gene family, member A0.013
Trpc4transient receptor potential cation channel, subfamily C, member 40.013
Pax8paired box 80.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism