The network for 'epithelial tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial tube formation

The developmental process pertaining to the initial formation of an epithelial tube.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Pax3paired box gene 31.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Gli2GLI-Kruppel family member GLI20.999
Hand1heart and neural crest derivatives expressed transcript 10.998
Tcfap2atranscription factor AP-2, alpha0.998
Bmp4bone morphogenetic protein 40.998
Foxc1forkhead box C10.997
Pax6paired box gene 60.995
Lhx1LIM homeobox protein 10.994
Pitx2paired-like homeodomain transcription factor 20.994
Sox2SRY-box containing gene 20.989
Hes1hairy and enhancer of split 1 (Drosophila)0.987
Emx2empty spiracles homolog 2 (Drosophila)0.986
Pax2paired box gene 20.983
Pbx1pre B-cell leukemia transcription factor 10.982
Msx1homeobox, msh-like 10.982
Smosmoothened homolog (Drosophila)0.981
Fgf8fibroblast growth factor 80.981
Gata4GATA binding protein 40.977
Tbx1T-box 10.977
Eya1eyes absent 1 homolog (Drosophila)0.976
Hoxa1homeobox A10.973
Bmp7bone morphogenetic protein 70.966
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.965
Fgfr1fibroblast growth factor receptor 10.965
Ascl1achaete-scute complex homolog 1 (Drosophila)0.961
Sfrp2secreted frizzled-related protein 20.957
Hoxa13homeobox A130.949
Tbx3T-box 30.948
Rargretinoic acid receptor, gamma0.944
Foxc2forkhead box C20.936
Fzd8frizzled homolog 8 (Drosophila)0.934
Vegfavascular endothelial growth factor A0.934
Mks1Meckel syndrome, type 10.927
Wnt3awingless-related MMTV integration site 3A0.926
Emx1empty spiracles homolog 1 (Drosophila)0.920
Ptch1patched homolog 10.920
Dlx5distal-less homeobox 50.907
Chd7chromodomain helicase DNA binding protein 70.904
Hoxa11homeobox A110.898
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.892
Zic3zinc finger protein of the cerebellum 30.890
Msx2homeobox, msh-like 20.889
Smad6MAD homolog 6 (Drosophila)0.887
Tcfap2ctranscription factor AP-2, gamma0.886
Hoxd13homeobox D130.878
Alx4aristaless-like homeobox 40.875
Dvl3dishevelled 3, dsh homolog (Drosophila)0.874
Pax8paired box gene 80.869
Foxg1forkhead box G10.869
Prrx1paired related homeobox 10.867
Isl1ISL1 transcription factor, LIM/homeodomain0.861
Ptenphosphatase and tensin homolog0.859
Neurog2neurogenin 20.857
Hand2heart and neural crest derivatives expressed transcript 20.854
Hoxa2homeobox A20.852
Dvl2dishevelled 2, dsh homolog (Drosophila)0.851
Foxh1forkhead box H10.849
Jag1jagged 10.848
Hes5hairy and enhancer of split 5 (Drosophila)0.835
Megf8multiple EGF-like-domains 80.834
Arid1aAT rich interactive domain 1A (SWI-like)0.832
Snai1snail homolog 1 (Drosophila)0.826
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.809
Apcadenomatosis polyposis coli0.809
Retret proto-oncogene0.806
Wnt4wingless-related MMTV integration site 40.800
Hoxd9homeobox D90.798
Smad1MAD homolog 1 (Drosophila)0.780
Ctnnb1catenin (cadherin associated protein), beta 10.777
Apaf1apoptotic peptidase activating factor 10.774
Tlx3T-cell leukemia, homeobox 30.763
Hoxa5homeobox A50.761
Ror2receptor tyrosine kinase-like orphan receptor 20.759
Acvr2bactivin receptor IIB0.758
Sall4sal-like 4 (Drosophila)0.756
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.751
Yap1yes-associated protein 10.749
Fgf3fibroblast growth factor 30.748
Pou3f3POU domain, class 3, transcription factor 30.746
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.738
Rarbretinoic acid receptor, beta0.738
Hoxd11homeobox D110.734
Hoxb6homeobox B60.732
Ptk7PTK7 protein tyrosine kinase 70.731
Efna2ephrin A20.728
Hoxb4homeobox B40.726
Rararetinoic acid receptor, alpha0.724
Gata6GATA binding protein 60.709
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.703
Pou5f1POU domain, class 5, transcription factor 10.693
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pax2apaired box gene 2a0.978
epb41l5erythrocyte membrane protein band 4.1 like 50.793
gyltl1bglycosyltransferase-like 1b0.721
col2a1acollagen type II, alpha-1a0.697
wnt5bwingless-type MMTV integration site family, member 5b0.688
cdh2cadherin 2, neuronal0.652
atoh1batonal homolog 1b0.562
mecomMDS1 and EVI1 complex locus0.555
egr2bearly growth response 2b0.518
foxd3forkhead box D30.429
guca1cguanylate cyclase activator 1C0.428
shhasonic hedgehog a0.399
sox3SRY-box containing gene 30.394
ptf1apancreas specific transcription factor, 1a0.392
notch1anotch homolog 1a0.373
pou3f3bPOU class 3 homeobox 3b0.371
pcdh8protocadherin 80.324
prkciprotein kinase C, iota0.323
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.305
jag2jagged 20.292
zic1zic family member 1 (odd-paired homolog, Drosophila)0.289
fgf8afibroblast growth factor 8 a0.285
gli2aGLI-Kruppel family member GLI2a0.285
hmx3homeo box (H6 family) 30.281
cdoncell adhesion molecule-related/down-regulated by oncogenes0.273
foxg1aforkhead box G1a0.269
sox1aSRY-box containing gene 1a0.256
crabp2acellular retinoic acid binding protein 2, a0.254
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.248
kdrlkinase insert domain receptor like0.233
bmp2bbone morphogenetic protein 2b0.233
sema3aasemaphorin 3aa0.224
six3asine oculis homeobox homolog 3a0.221
traf4atnf receptor-associated factor 4a0.212
gli1GLI-Kruppel family member 10.208
atoh1aatonal homolog 1a0.204
smad5MAD homolog 5 (Drosophila)0.202
wnt11wingless-type MMTV integration site family, member 110.194
bocbrother of CDO0.190
gdf6agrowth differentiation factor 6a0.190
osr2odd-skipped related 2 (Drosophila)0.182
mdkamidkine-related growth factor0.180
otpborthopedia homolog b0.179
wnt4awingless-type MMTV integration site family, member 4a0.178
meis2.1myeloid ecotropic viral integration site 2.10.177
tbx1T-box 10.173
raraaretinoic acid receptor, alpha a0.170
sox10SRY-box containing gene 100.170
gbx2gastrulation brain homeo box 20.169
meis3myeloid ecotropic viral integration site 30.168
mibmind bomb0.165
pkd2polycystic kidney disease 20.160
irx3airoquois homeobox protein 3a0.152
sp5lSp5 transcription factor-like0.146
s1pr2sphingosine-1-phosphate receptor 20.146
hoxb1bhomeo box B1b0.141
eya1eyes absent homolog 10.135
sox2SRY-box containing gene 20.133
cc2d2acoiled-coil and C2 domain containing 2A0.132
etv5bets variant 5b0.129
pax6bpaired box gene 6b0.128
skianuclear oncoprotein skia0.123
neurodneurogenic differentiation0.122
bmpr1aabone morphogenetic protein receptor, type 1aa0.121
robo1roundabout homolog 10.118
fgf8bfibroblast growth factor 8 b0.118
foxi1forkhead box I10.115
zic5zic family member 5 (odd-paired homolog, Drosophila)0.112
dctn1adynactin 1a0.111
wnt3wingless-type MMTV integration site family, member 30.111
gpr98G protein-coupled receptor 980.107
otx2orthodenticle homolog 20.106
znfl2azinc finger-like gene 2a0.103
pitx3paired-like homeodomain transcription factor 30.103
snai1asnail homolog 1a (Drosophila)0.102
odz4odd Oz/ten-m homolog 40.102
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.100
efnb1ephrin B10.099
foxj1aforkhead box J1a0.096
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.095
six1asine oculis homeobox homolog 1a0.092
eng1aengrailed 1a0.087
fn1fibronectin 10.085
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.083
epha4aeph receptor A4a0.083
sox19aSRY-box containing gene 19a0.083
crabp2bcellular retinoic acid binding protein 2, b0.082
ext1aexostoses (multiple) 1a0.080
grem1agremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)0.074
ift88intraflagellar transport 88 homolog0.073
zeb2azinc finger E-box binding homeobox 2a0.073
zic4zic family member 40.073
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.072
vangl2vang-like 2 (van gogh, Drosophila)0.071
tbx16T-box gene 160.069
six2asine oculis-related homeobox 2a0.069
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.981
HLHmdeltaE(spl) region transcript mdelta0.943
HLHm7E(spl) region transcript m70.752
HLHmgammaE(spl) region transcript mgamma0.588
TomTwin of m40.345
kkvkrotzkopf verkehrt0.339
E(spl)Enhancer of split0.318
HLHm3E(spl) region transcript m30.183
m2E(spl) region transcript m20.160
malphaE(spl) region transcript malpha0.127
Abd-BAbdominal B0.105
oddodd skipped0.102
HLHmbetaE(spl) region transcript mbeta0.067
opaodd paired0.056
HLHm5E(spl) region transcript m50.046
taptarget of Poxn0.041
m4E(spl) region transcript m40.030
grhgrainy head0.024
eyaeyes absent0.022
HmgcrHMG Coenzyme A reductase0.022
sogshort gastrulation0.020
spn-FCG12114 gene product from transcript CG12114-RA0.017
emsempty spiracles0.013
fasfaint sausage0.012
gcmglial cells missing0.011
nrv2nervana 20.011
CG9867CG9867 gene product from transcript CG9867-RA0.011
Stat92ESignal-transducer and activator of transcription protein at 92E0.010
Wnt6CG4969 gene product from transcript CG4969-RB0.010
orboo18 RNA-binding protein0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
APCadenomatous polyposis coli0.590
SMAD3SMAD family member 30.212
DVL3dishevelled, dsh homolog 3 (Drosophila)0.143
PRKCZprotein kinase C, zeta0.112
TSC2tuberous sclerosis 20.111
LRRK2leucine-rich repeat kinase 20.095
ANKRD28ankyrin repeat domain 280.084
STRN3striatin, calmodulin binding protein 30.081
GSK3Bglycogen synthase kinase 3 beta0.048
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.046
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.041
PCM1pericentriolar material 10.040
AXIN1axin 10.038
SLMAPsarcolemma associated protein0.035
BMPR1Abone morphogenetic protein receptor, type IA0.033
CNKSR2connector enhancer of kinase suppressor of Ras 20.032
C9orf89chromosome 9 open reading frame 890.030
CREBBPCREB binding protein0.029
YAP1Yes-associated protein 10.026
INADLInaD-like (Drosophila)0.026
SEC23ASec23 homolog A (S. cerevisiae)0.025
ZFYVE9zinc finger, FYVE domain containing 90.021
ZRANB1zinc finger, RAN-binding domain containing 10.019
RXRAretinoid X receptor, alpha0.019
STK4serine/threonine kinase 40.018
SMAD2SMAD family member 20.017
STK3serine/threonine kinase 30.016
BCORBCL6 corepressor0.016
PKP4plakophilin 40.016
MEOX2mesenchyme homeobox 20.015
CSNK1Ecasein kinase 1, epsilon0.015
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.015
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.014
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.014
RASA1RAS p21 protein activator (GTPase activating protein) 10.013
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.012
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.012
USP9Xubiquitin specific peptidase 9, X-linked0.012
ACTG1actin, gamma 10.012
MED25mediator complex subunit 250.012
SEC24DSEC24 family, member D (S. cerevisiae)0.012
DVL1dishevelled, dsh homolog 1 (Drosophila)0.012
ACTBactin, beta0.011
SORBS3sorbin and SH3 domain containing 30.011
AKAP11A kinase (PRKA) anchor protein 110.011
SETD8SET domain containing (lysine methyltransferase) 80.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.030
Ptov1prostate tumor overexpressed 10.028
Dctn1dynactin 10.022
Atp6v0a1ATPase, H+ transporting, lysosomal V0 subunit A10.020
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.019
Tuba1ctubulin, alpha 1C0.018
Fgfr2fibroblast growth factor receptor 20.018
Scaf1SR-related CTD-associated factor 10.017
Ireb2iron responsive element binding protein 20.017
Ccna1cyclin A10.016
Cyfip1cytoplasmic FMR1 interacting protein 10.016
Loxl1lysyl oxidase-like 10.016
Cxxc4CXXC finger 40.016
Actbactin, beta0.016
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.015
Nek9NIMA (never in mitosis gene a)- related kinase 90.015
Sox17SRY (sex determining region Y)-box 170.015
Man2c1mannosidase, alpha, class 2C, member 10.015
Sox10SRY (sex determining region Y)-box 100.014
Gpr176G protein-coupled receptor 1760.014
Ascl1achaete-scute complex homolog 1 (Drosophila)0.014
Ltbp3latent transforming growth factor beta binding protein 30.014
Crygbcrystallin, gamma B0.014
Dlgap3discs, large (Drosophila) homolog-associated protein 30.014
RT1-DOaRT1 class II, locus DOa0.014
Fmr1fragile X mental retardation 10.013
Dcakddephospho-CoA kinase domain containing0.013
Mlf2myeloid leukemia factor 20.013
Pfn1profilin 10.013
Garnl1GTPase activating Rap/RanGAP domain-like 10.013
Arpc4actin related protein 2/3 complex, subunit 40.013
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.013
Pgm2phosphoglucomutase 20.013
Apoa2apolipoprotein A-II0.013
Wdr6WD repeat domain 60.012
Bglapbone gamma-carboxyglutamate (gla) protein0.012
Pik3r3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.012
Fzd2frizzled homolog 2 (Drosophila)0.012
Foxe3forkhead box E30.012
Mink1misshapen-like kinase 1 (zebrafish)0.012
Vegfavascular endothelial growth factor A0.012
G3bp2GTPase activating protein (SH3 domain) binding protein 20.012
Unc5bunc-5 homolog B (C. elegans)0.011
Foxs1forkhead box S10.011
Lig3ligase III, DNA, ATP-dependent0.011
Atxn7l4ataxin 7-like 40.011
Zfp260zinc finger protein 2600.011
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.011
Megf6multiple EGF-like-domains 60.011
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.011
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.011
Ect2epithelial cell transforming sequence 2 oncogene0.011
Dact1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)0.011
Slc25a23solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 230.011
Tff3trefoil factor 3, intestinal0.010
Celcarboxyl ester lipase0.010
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.010
Dbn1drebrin 10.010
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.010
Fat1FAT tumor suppressor homolog 1 (Drosophila)0.010
Cyb5r1cytochrome b5 reductase 10.010
Ptk7PTK7 protein tyrosine kinase 70.010
Olr1701olfactory receptor 17010.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism