The network for 'inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.999
Tnftumor necrosis factor0.995
Lyz2lysozyme 20.994
Tlr4toll-like receptor 40.994
Ptgs2prostaglandin-endoperoxide synthase 20.988
Selpselectin, platelet0.987
Leprleptin receptor0.979
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.976
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.975
Il1binterleukin 1 beta0.971
Ccl2chemokine (C-C motif) ligand 20.970
Cd19CD19 antigen0.963
Pax5paired box gene 50.954
Cd40CD40 antigen0.943
Csf1colony stimulating factor 1 (macrophage)0.939
Ccr1chemokine (C-C motif) receptor 10.939
Il10interleukin 100.924
Smad4MAD homolog 4 (Drosophila)0.916
Nos3nitric oxide synthase 3, endothelial cell0.916
Stat3signal transducer and activator of transcription 30.912
Cxcl13chemokine (C-X-C motif) ligand 130.906
Acvrl1activin A receptor, type II-like 10.897
Ccl4chemokine (C-C motif) ligand 40.891
Smad3MAD homolog 3 (Drosophila)0.891
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.889
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.887
Birc3baculoviral IAP repeat-containing 30.884
Cd5CD5 antigen0.884
Cxcl2chemokine (C-X-C motif) ligand 20.883
Cxcr5chemokine (C-X-C motif) receptor 50.866
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.859
Osmroncostatin M receptor0.850
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.849
Cd4CD4 antigen0.849
Tgfbr2transforming growth factor, beta receptor II0.844
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.833
Asprv1aspartic peptidase, retroviral-like 10.830
Tnfaip3tumor necrosis factor, alpha-induced protein 30.829
Pdcd1programmed cell death 10.829
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.823
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.816
Htra3HtrA serine peptidase 30.809
Il1rninterleukin 1 receptor antagonist0.809
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.798
Vegfavascular endothelial growth factor A0.796
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.792
C1qbcomplement component 1, q subcomponent, beta polypeptide0.787
Nlrp3NLR family, pyrin domain containing 30.785
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.779
Egfrepidermal growth factor receptor0.779
Ighimmunoglobulin heavy chain complex0.774
Ccr3chemokine (C-C motif) receptor 30.773
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.771
Cd14CD14 antigen0.770
Fcgr2bFc receptor, IgG, low affinity IIb0.769
Apcadenomatosis polyposis coli0.768
Ifngr1interferon gamma receptor 10.764
Cd28CD28 antigen0.762
Robo1roundabout homolog 1 (Drosophila)0.759
Il27rainterleukin 27 receptor, alpha0.757
Il10rainterleukin 10 receptor, alpha0.755
Clec4dC-type lectin domain family 4, member d0.753
Klk1b26kallikrein 1-related petidase b260.752
Slamf8SLAM family member 80.750
Ubdubiquitin D0.749
Prdm1PR domain containing 1, with ZNF domain0.749
C3ar1complement component 3a receptor 10.746
Il2rbinterleukin 2 receptor, beta chain0.746
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.744
Map3k14mitogen-activated protein kinase kinase kinase 140.743
Vhlvon Hippel-Lindau tumor suppressor0.741
Cd33CD33 antigen0.739
Batfbasic leucine zipper transcription factor, ATF-like0.739
Eya1eyes absent 1 homolog (Drosophila)0.738
Ccr2chemokine (C-C motif) receptor 20.737
Casp1caspase 10.736
Rspo2R-spondin 2 homolog (Xenopus laevis)0.735
Ror2receptor tyrosine kinase-like orphan receptor 20.731
Ins2insulin II0.731
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.730
Cd6CD6 antigen0.723
Fgfr2fibroblast growth factor receptor 20.716
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.714
Cxcr2chemokine (C-X-C motif) receptor 20.711
Smad1MAD homolog 1 (Drosophila)0.708
AxlAXL receptor tyrosine kinase0.708
Il4interleukin 40.704
Il6interleukin 60.701
Ptenphosphatase and tensin homolog0.696
Stat5asignal transducer and activator of transcription 5A0.693
C5ar1complement component 5a receptor 10.690
Cmahcytidine monophospho-N-acetylneuraminic acid hydroxylase0.689
Chi3l1chitinase 3-like 10.683
MefvMediterranean fever0.682
C1qacomplement component 1, q subcomponent, alpha polypeptide0.679
Ccl8chemokine (C-C motif) ligand 80.679
Pax2paired box gene 20.677
Pzppregnancy zone protein0.675
Cry2cryptochrome 2 (photolyase-like)0.675
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.673
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.728
ppargperoxisome proliferator activated receptor gamma0.548
mmp13amatrix metalloproteinase 13a0.421
mmp9matrix metalloproteinase 90.330
mcoln1mucolipin 10.247
bmp2bbone morphogenetic protein 2b0.224
tbx1T-box 10.178
mpxmyeloid-specific peroxidase0.170
foxi3aforkhead box I3a0.170
fabp11afatty acid binding protein 11a0.153
lcp1lymphocyte cytosolic plastin 10.121
adam8aa disintegrin and metalloproteinase domain 8a0.101
thtyrosine hydroxylase0.095
nod1nucleotide-binding oligomerization domain containing 10.087
fabp2fatty acid binding protein 2, intestinal0.073
dnmt4DNA (cytosine-5-)-methyltransferase 40.071
apoebapolipoprotein Eb0.069
gcm2glial cells missing homolog 2 (Drosophila)0.063
cav1caveolin 10.062
alpalkaline phosphatase0.061
ighzimmunoglobulin heavy constant zeta0.060
aldobaldolase b, fructose-bisphosphate0.059
terttelomerase reverse transcriptase0.058
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.052
grk7aG-protein-coupled receptor kinase 7a0.051
coro1acoronin, actin binding protein, 1A0.050
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.047
dab1adisabled homolog 1a (Drosophila)0.044
tgm2btransglutaminase 2b0.044
myh11amyosin, heavy polypeptide 11, smooth muscle a0.042
rtn1breticulon 1b0.041
cry1acryptochrome 1a0.039
ca8carbonic anhydrase VIII0.038
rargaretinoic acid receptor gamma a0.038
slc16a1solute carrier family 16 (monocarboxylic acid transporters), member 10.037
lrrc15leucine rich repeat containing 150.037
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.036
il8interleukin 80.034
bmp2abone morphogenetic protein 2a0.033
sgpl1sphingosine-1-phosphate lyase 10.032
bmp4bone morphogenetic protein 40.031
cpa5carboxypeptidase A50.031
mpzmyelin protein zero0.031
lama4laminin, alpha 40.031
prdm5PR domain containing 50.030
rhagRhesus blood group-associated glycoprotein0.030
guca1cguanylate cyclase activator 1C0.029
LOC100332193growth hormone secretagogue receptor type 1-like0.028
ctssb.2cathepsin S, b.20.027
ca15acarbonic anhydrase XV a0.027
arnt2aryl hydrocarbon receptor nuclear translocator 20.027
ascl1aachaete-scute complex-like 1a (Drosophila)0.027
junbjun B proto-oncogene0.027
epas1bendothelial PAS domain protein 1b0.026
stc1lstanniocalcin 1, like0.025
tshbthyroid stimulating hormone, beta subunit0.024
rag1recombination activating gene 10.024
apobapolipoprotein B0.024
sgk1serum/glucocorticoid regulated kinase 10.024
fn1bfibronectin 1b0.024
il1binterleukin 1, beta and interleukin 1, beta0.024
pcsk1proprotein convertase subtilisin/kexin type 10.023
anxa1aannexin A1a0.023
slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.023
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.023
ripk2receptor-interacting serine-threonine kinase 20.023
sox11aSRY-box containing gene 11a0.022
entpd1ectonucleoside triphosphate diphosphohydrolase 10.022
ncf1neutrophil cytosolic factor 10.022
olig2oligodendrocyte lineage transcription factor 20.021
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.021
LOC557072caspase recruitment domain-containing protein 11-like0.021
rnasel1ribonuclease like 10.021
tagln2transgelin 20.021
prkczprotein kinase C, zeta0.020
sox7SRY-box containing gene 70.020
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.020
tbx2aT-box gene 2a0.020
tmem88atransmembrane protein 88 a0.020
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.019
valopavertebrate ancient long opsin a0.019
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.019
tnfatumor necrosis factor a (TNF superfamily, member 2)0.018
foxi3bforkhead box I3b0.018
s1pr3sphingosine-1-phosphate receptor 30.018
tp63tumor protein p630.017
hoxa11ahomeo box A11a0.017
pglyrp5peptidoglycan recognition protein 50.016
ptrfbpolymerase I and transcript release factor b0.016
dhrs9dehydrogenase/reductase (SDR family) member 90.016
cirbpcold inducible RNA binding protein0.016
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.016
ctssb.1cathepsin S, b.10.016
gc3guanylyl cyclase 30.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.994
IL8interleukin 80.936
PLAURplasminogen activator, urokinase receptor0.933
ICAM1intercellular adhesion molecule 10.916
IL1Binterleukin 1, beta0.911
CXCL2chemokine (C-X-C motif) ligand 20.867
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.831
PYCARDPYD and CARD domain containing0.818
MDM2Mdm2 p53 binding protein homolog (mouse)0.800
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.752
S100A6S100 calcium binding protein A60.744
C3complement component 30.739
CCL2chemokine (C-C motif) ligand 20.716
S100A9S100 calcium binding protein A90.707
NCF4neutrophil cytosolic factor 4, 40kDa0.697
NCF2neutrophil cytosolic factor 20.694
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.661
BCL3B-cell CLL/lymphoma 30.657
NCF1neutrophil cytosolic factor 10.647
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.644
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.615
BLNKB-cell linker0.600
CCL22chemokine (C-C motif) ligand 220.585
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.558
NCOR2nuclear receptor corepressor 20.555
C1Rcomplement component 1, r subcomponent0.554
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.549
IL6interleukin 6 (interferon, beta 2)0.531
FADDFas (TNFRSF6)-associated via death domain0.522
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.513
CXCL9chemokine (C-X-C motif) ligand 90.511
SOCS3suppressor of cytokine signaling 30.491
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.485
C1Scomplement component 1, s subcomponent0.469
CCL5chemokine (C-C motif) ligand 50.451
RUNX1runt-related transcription factor 10.448
TNFAIP2tumor necrosis factor, alpha-induced protein 20.419
HSF1heat shock transcription factor 10.409
CCR5chemokine (C-C motif) receptor 50.400
S100A8S100 calcium binding protein A80.395
FN1fibronectin 10.391
APOEapolipoprotein E0.389
GHRgrowth hormone receptor0.386
TBXA2Rthromboxane A2 receptor0.379
TNFAIP3tumor necrosis factor, alpha-induced protein 30.371
CCL4chemokine (C-C motif) ligand 40.367
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.363
ANXA2annexin A20.358
TNFRSF9tumor necrosis factor receptor superfamily, member 90.348
CCR7chemokine (C-C motif) receptor 70.346
CXCL3chemokine (C-X-C motif) ligand 30.326
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.326
POMPproteasome maturation protein0.318
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.313
ESR1estrogen receptor 10.290
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.288
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.288
TRAF1TNF receptor-associated factor 10.287
CCL19chemokine (C-C motif) ligand 190.284
MYD88myeloid differentiation primary response gene (88)0.282
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.279
PLAUplasminogen activator, urokinase0.277
MAP3K8mitogen-activated protein kinase kinase kinase 80.276
CCR1chemokine (C-C motif) receptor 10.271
S100A14S100 calcium binding protein A140.271
TGFB1transforming growth factor, beta 10.266
TNFtumor necrosis factor0.265
IL10interleukin 100.261
TLR2toll-like receptor 20.257
JAG1jagged 10.253
CSF1colony stimulating factor 1 (macrophage)0.252
CCR2chemokine (C-C motif) receptor 20.251
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.249
NR0B1nuclear receptor subfamily 0, group B, member 10.247
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.242
ARRB1arrestin, beta 10.235
IL2RBinterleukin 2 receptor, beta0.235
CD80CD80 molecule0.231
ALOX5arachidonate 5-lipoxygenase0.229
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.228
CCL20chemokine (C-C motif) ligand 200.223
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.222
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.222
S100A12S100 calcium binding protein A120.216
NLRC4NLR family, CARD domain containing 40.215
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.212
HMGB1high mobility group box 10.210
IL10RAinterleukin 10 receptor, alpha0.206
SYKspleen tyrosine kinase0.204
TAL1T-cell acute lymphocytic leukemia 10.202
FCN1ficolin (collagen/fibrinogen domain containing) 10.201
CCL7chemokine (C-C motif) ligand 70.200
CCL13chemokine (C-C motif) ligand 130.195
IL4Rinterleukin 4 receptor0.195
CD14CD14 molecule0.189
SOD2superoxide dismutase 2, mitochondrial0.187
S100BS100 calcium binding protein B0.184
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.973
Cd14CD14 molecule0.899
Ccr5chemokine (C-C motif) receptor 50.749
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.748
Slco2a1solute carrier organic anion transporter family, member 2a10.739
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.720
Fn1fibronectin 10.661
Tnftumor necrosis factor (TNF superfamily, member 2)0.655
Apoa5apolipoprotein A-V0.632
Ccr2chemokine (C-C motif) receptor 20.630
Il1rninterleukin 1 receptor antagonist0.596
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.591
Sellselectin L0.587
Lst1leukocyte specific transcript 10.560
Timp1TIMP metallopeptidase inhibitor 10.532
Cxcr5chemokine (C-X-C motif) receptor 50.522
Ccl2chemokine (C-C motif) ligand 20.522
Cxcl2chemokine (C-X-C motif) ligand 20.507
Il1r1interleukin 1 receptor, type I0.505
Ccl3chemokine (C-C motif) ligand 30.504
Mmp9matrix metallopeptidase 90.504
S100a8S100 calcium binding protein A80.490
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.479
Ptafrplatelet-activating factor receptor0.470
LOC293989cytochrome P450-like0.463
Cfdcomplement factor D (adipsin)0.456
Itgamintegrin, alpha M0.455
Cd4Cd4 molecule0.454
Igsf6immunoglobulin superfamily, member 60.434
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.433
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.432
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.429
Cd44Cd44 molecule0.424
Anxa2annexin A20.417
Flt1FMS-related tyrosine kinase 10.412
Itgadintegrin, alpha D0.408
Agtr1aangiotensin II receptor, type 1a0.402
Socs3suppressor of cytokine signaling 30.397
Casp1caspase 10.390
Mpeg1macrophage expressed 10.388
Stat3signal transducer and activator of transcription 30.379
Metmet proto-oncogene0.366
Cpb2carboxypeptidase B2 (plasma)0.365
Gzmkgranzyme K0.364
Vom2r27vomeronasal 2 receptor, 270.362
Crhbpcorticotropin releasing hormone binding protein0.360
Folh1folate hydrolase 10.358
Cd2Cd2 molecule0.356
Pon1paraoxonase 10.355
FaslgFas ligand (TNF superfamily, member 6)0.350
Leprleptin receptor0.345
Hes2hairy and enhancer of split 2 (Drosophila)0.345
Adora2aadenosine A2a receptor0.340
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.337
Sisucrase-isomaltase (alpha-glucosidase)0.336
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.331
Mas1MAS1 oncogene0.325
Mbl1mannose-binding lectin (protein A) 10.324
Pcsk1proprotein convertase subtilisin/kexin type 10.320
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.310
Cficomplement factor I0.303
S1pr2sphingosine-1-phosphate receptor 20.295
RT1-BaRT1 class II, locus Ba0.294
Cfbcomplement factor B0.291
Ccl20chemokine (C-C motif) ligand 200.291
Fgafibrinogen alpha chain0.289
Spink1serine peptidase inhibitor, Kazal type 10.289
S100a9S100 calcium binding protein A90.289
Aqp8aquaporin 80.282
Adam17ADAM metallopeptidase domain 170.281
Gcgroup specific component0.280
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.276
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.273
Il1r2interleukin 1 receptor, type II0.265
Gfapglial fibrillary acidic protein0.264
Neurl3neuralized homolog 3 (Drosophila)0.262
Ifi204interferon activated gene 2040.259
Trim47tripartite motif-containing 470.258
Cckarcholecystokinin A receptor0.255
Ccl4chemokine (C-C motif) ligand 40.252
Fcnbficolin B0.245
Icam1intercellular adhesion molecule 10.242
Jak1Janus kinase 10.241
Kng1kininogen 10.240
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.240
Iappislet amyloid polypeptide0.238
Tfectranscription factor EC0.237
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.234
Procprotein C0.234
Il7rinterleukin 7 receptor0.233
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.232
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.229
Il6interleukin 60.228
Anxa1annexin A10.224
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism