The network for 'regulation of inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of inflammatory response

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Lyz2lysozyme 20.998
FasFas (TNF receptor superfamily member 6)0.998
Il6interleukin 60.996
Tlr4toll-like receptor 40.991
Casp4caspase 4, apoptosis-related cysteine peptidase0.989
Il10interleukin 100.988
Stat3signal transducer and activator of transcription 30.985
Ccl2chemokine (C-C motif) ligand 20.983
Ptgs2prostaglandin-endoperoxide synthase 20.983
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.981
Leprleptin receptor0.975
Il1r1interleukin 1 receptor, type I0.972
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.968
Il1binterleukin 1 beta0.967
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.967
Ccr1chemokine (C-C motif) receptor 10.966
Cd44CD44 antigen0.966
Cd40CD40 antigen0.965
Il1rninterleukin 1 receptor antagonist0.939
Cfhcomplement component factor h0.937
AxlAXL receptor tyrosine kinase0.934
Il4interleukin 40.934
Cd28CD28 antigen0.931
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.929
Ccl4chemokine (C-C motif) ligand 40.927
Apoeapolipoprotein E0.927
Nos2nitric oxide synthase 2, inducible0.922
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.922
Fcgr2bFc receptor, IgG, low affinity IIb0.922
MefvMediterranean fever0.918
Cxcr2chemokine (C-X-C motif) receptor 20.912
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.912
Prdm1PR domain containing 1, with ZNF domain0.910
Cd4CD4 antigen0.904
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.900
Cxcl13chemokine (C-X-C motif) ligand 130.892
C1qccomplement component 1, q subcomponent, C chain0.881
C3ar1complement component 3a receptor 10.879
Il4rainterleukin 4 receptor, alpha0.875
TyrobpTYRO protein tyrosine kinase binding protein0.871
Pdcd1programmed cell death 10.856
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.846
C3complement component 30.845
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.840
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.834
Map3k14mitogen-activated protein kinase kinase kinase 140.833
Ptgirprostaglandin I receptor (IP)0.829
Il1ainterleukin 1 alpha0.827
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.816
Ptprcprotein tyrosine phosphatase, receptor type, C0.807
Ccl3chemokine (C-C motif) ligand 30.804
Emx2empty spiracles homolog 2 (Drosophila)0.800
Stat6signal transducer and activator of transcription 60.790
Ccl17chemokine (C-C motif) ligand 170.789
Nos1nitric oxide synthase 1, neuronal0.784
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.782
Msr1macrophage scavenger receptor 10.781
Clec4dC-type lectin domain family 4, member d0.775
Ccr2chemokine (C-C motif) receptor 20.767
Ifnginterferon gamma0.767
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.767
Selpselectin, platelet0.764
AF251705cDNA sequence AF2517050.758
Foxn1forkhead box N10.749
Ccr3chemokine (C-C motif) receptor 30.749
Nlrp3NLR family, pyrin domain containing 30.748
Krt6akeratin 6A0.745
Osmroncostatin M receptor0.744
Batf2basic leucine zipper transcription factor, ATF-like 20.738
Ctla2bcytotoxic T lymphocyte-associated protein 2 beta0.735
Lhx3LIM homeobox protein 30.730
Folr2folate receptor 2 (fetal)0.728
Clec4nC-type lectin domain family 4, member n0.726
Cd19CD19 antigen0.725
Icosinducible T-cell co-stimulator0.724
Il10rainterleukin 10 receptor, alpha0.723
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.719
Csf1colony stimulating factor 1 (macrophage)0.716
TcraT-cell receptor alpha chain0.702
Cd14CD14 antigen0.699
Mrc1mannose receptor, C type 10.694
S100a9S100 calcium binding protein A9 (calgranulin B)0.691
Il6stinterleukin 6 signal transducer0.690
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.682
Thrbthyroid hormone receptor beta0.665
Socs3suppressor of cytokine signaling 30.660
Relreticuloendotheliosis oncogene0.656
JunbJun-B oncogene0.655
C1qbcomplement component 1, q subcomponent, beta polypeptide0.652
Tlr2toll-like receptor 20.649
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.646
Ccl12chemokine (C-C motif) ligand 120.646
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.640
Birc3baculoviral IAP repeat-containing 30.617
Ubdubiquitin D0.614
Myd88myeloid differentiation primary response gene 880.613
Trem3triggering receptor expressed on myeloid cells 30.609
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.608
Il2rbinterleukin 2 receptor, beta chain0.605
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.388
rhagRhesus blood group-associated glycoprotein0.314
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.282
tgm2btransglutaminase 2b0.251
foxi3aforkhead box I3a0.231
ripk2receptor-interacting serine-threonine kinase 20.216
tnfatumor necrosis factor a (TNF superfamily, member 2)0.206
il1binterleukin 1, beta and interleukin 1, beta0.201
ptrfbpolymerase I and transcript release factor b0.199
nod1nucleotide-binding oligomerization domain containing 10.175
cry1acryptochrome 1a0.173
pglyrp5peptidoglycan recognition protein 50.170
LOC557072caspase recruitment domain-containing protein 11-like0.169
tp63tumor protein p630.160
il8interleukin 80.157
cry3cryptochrome 30.155
epas1bendothelial PAS domain protein 1b0.153
anxa1aannexin A1a0.151
mcoln1mucolipin 10.150
atf3activating transcription factor 30.149
LOC100332193growth hormone secretagogue receptor type 1-like0.137
junbjun B proto-oncogene0.131
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.126
LOC100003330melanocortin-2 receptor accessory protein 2-like0.125
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.120
igfbp1ainsulin-like growth factor binding protein 1a0.120
cd63Cd63 antigen0.120
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.119
gcm2glial cells missing homolog 2 (Drosophila)0.116
ighzimmunoglobulin heavy constant zeta0.112
socs3asuppressor of cytokine signaling 3a0.112
tagln2transgelin 20.109
myh11amyosin, heavy polypeptide 11, smooth muscle a0.108
alpalkaline phosphatase0.108
guca1cguanylate cyclase activator 1C0.106
bmp2abone morphogenetic protein 2a0.102
castcalpastatin0.099
mmp13amatrix metalloproteinase 13a0.098
igfbp1binsulin-like growth factor binding protein 1b0.095
ca15acarbonic anhydrase XV a0.094
si:dkey-76b14.4si:dkey-76b14.40.092
ighz2immunoglobulin heavy constant zeta20.090
grk7aG-protein-coupled receptor kinase 7a0.089
mmp9matrix metalloproteinase 90.087
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.086
socs1suppressor of cytokine signaling 10.086
si:ch211-9d9.3si:ch211-9d9.30.085
alkanaplastic lymphoma kinase (Ki-1)0.085
wu:fb80a07wu:fb80a070.084
pufaPUF (Pumilio/FBF) domain-containing A0.084
ctsl1acathepsin L, 1 a0.082
pglyrp6peptidoglycan recognition protein 60.080
adipor1badiponectin receptor 1b0.080
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.080
igf1rainsulin-like growth factor 1a receptor0.079
znf703zinc finger protein 7030.078
zgc:123282zgc:1232820.078
sema3fbsemaphorin 3fb0.077
irf8interferon regulatory factor 80.077
sgpl1sphingosine-1-phosphate lyase 10.076
ccr6achemokine (C-C motif) receptor 6a0.076
LOC100000934hypothetical protein LOC1000009340.076
sgk1serum/glucocorticoid regulated kinase 10.075
junbljun B proto-oncogene, like0.075
mstnamyostatin a0.075
cpn1carboxypeptidase N, polypeptide 10.074
sgpp1sphingosine-1-phosphate phosphatase 10.073
slc2a1bsolute carrier family 2 (facilitated glucose transporter), member 1b0.073
trpv6transient receptor potential cation channel, subfamily V, member 60.073
gc3guanylyl cyclase 30.072
gpibglucose phosphate isomerase b0.072
tfatransferrin-a0.072
tmprss4atransmembrane protease, serine 4a0.072
cldniclaudin i0.071
frylfurry homolog-like (Drosophila)0.071
adrb1adrenergic receptor, beta 10.071
tlr9toll-like receptor 90.071
ctsbacathepsin B, a0.071
prom1bprominin 1 b0.070
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.070
aldobaldolase b, fructose-bisphosphate0.069
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.068
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.068
pdcd2programmed cell death 20.068
rrm2bribonucleotide reductase M2 b0.067
ptger2aprostaglandin E receptor 2a (subtype EP2)0.067
klf4aKruppel-like transcription factor 4a0.067
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.067
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.066
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.066
nr1d1nuclear receptor subfamily 1, group d, member 10.066
ldb1aLIM-domain binding factor 1a0.065
coro1acoronin, actin binding protein, 1A0.064
rcv1recoverin0.064
dhrs9dehydrogenase/reductase (SDR family) member 90.064
inhbbinhibin, beta B0.064
arnt2aryl hydrocarbon receptor nuclear translocator 20.063
drd1dopamine receptor D10.063
rhcgbRhesus blood group, C glycoprotein b0.062
hspb6heat shock protein, alpha-crystallin-related, b60.061
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ICAM1intercellular adhesion molecule 10.984
S100BS100 calcium binding protein B0.966
PTPN1protein tyrosine phosphatase, non-receptor type 10.925
IL8interleukin 80.914
CASP8caspase 8, apoptosis-related cysteine peptidase0.883
IL1Binterleukin 1, beta0.876
SOCS3suppressor of cytokine signaling 30.724
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.720
PLAURplasminogen activator, urokinase receptor0.697
GHRgrowth hormone receptor0.632
S100A8S100 calcium binding protein A80.613
BCL3B-cell CLL/lymphoma 30.613
CXCL2chemokine (C-X-C motif) ligand 20.590
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.585
TNFtumor necrosis factor0.578
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.566
TAL1T-cell acute lymphocytic leukemia 10.547
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.528
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.482
CCL2chemokine (C-C motif) ligand 20.459
TNFAIP3tumor necrosis factor, alpha-induced protein 30.451
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.446
CCL4chemokine (C-C motif) ligand 40.433
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.433
ALBalbumin0.427
S100A9S100 calcium binding protein A90.424
CFLARCASP8 and FADD-like apoptosis regulator0.410
PLAUplasminogen activator, urokinase0.402
FASFas (TNF receptor superfamily, member 6)0.394
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.390
ANXA2annexin A20.388
PYCARDPYD and CARD domain containing0.387
FADDFas (TNFRSF6)-associated via death domain0.372
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.352
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.323
CCR5chemokine (C-C motif) receptor 50.312
TLR2toll-like receptor 20.296
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.293
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.267
HPhaptoglobin0.251
CXCL3chemokine (C-X-C motif) ligand 30.251
CASP10caspase 10, apoptosis-related cysteine peptidase0.250
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.250
S100A6S100 calcium binding protein A60.234
ZNF496zinc finger protein 4960.233
NLRC4NLR family, CARD domain containing 40.233
TRAF1TNF receptor-associated factor 10.215
CXCL9chemokine (C-X-C motif) ligand 90.214
C1Scomplement component 1, s subcomponent0.212
PELP1proline, glutamate and leucine rich protein 10.203
NR0B1nuclear receptor subfamily 0, group B, member 10.200
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.199
IL1RNinterleukin 1 receptor antagonist0.189
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.178
S100A1S100 calcium binding protein A10.170
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.161
IL6interleukin 6 (interferon, beta 2)0.157
TTRtransthyretin0.155
C1Rcomplement component 1, r subcomponent0.147
IL10interleukin 100.145
S100A14S100 calcium binding protein A140.144
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.142
SOD2superoxide dismutase 2, mitochondrial0.136
SRGNserglycin0.131
MYD88myeloid differentiation primary response gene (88)0.123
CCL8chemokine (C-C motif) ligand 80.122
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.117
PLATplasminogen activator, tissue0.107
APOC3apolipoprotein C-III0.106
IL4Rinterleukin 4 receptor0.105
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.105
NAMPTnicotinamide phosphoribosyltransferase0.104
AREGamphiregulin0.104
ENGendoglin0.103
S100A11S100 calcium binding protein A110.103
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.100
CCL22chemokine (C-C motif) ligand 220.100
S100A4S100 calcium binding protein A40.100
CCR1chemokine (C-C motif) receptor 10.099
TIMP1TIMP metallopeptidase inhibitor 10.098
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.094
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.093
ZBTB16zinc finger and BTB domain containing 160.092
APOC1apolipoprotein C-I0.090
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.089
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.089
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.087
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.086
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.086
APOC2apolipoprotein C-II0.085
FN1fibronectin 10.085
PPM1Fprotein phosphatase, Mg2+/Mn2+ dependent, 1F0.085
CCL19chemokine (C-C motif) ligand 190.082
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.081
RIPK2receptor-interacting serine-threonine kinase 20.081
TNFAIP6tumor necrosis factor, alpha-induced protein 60.080
IL18RAPinterleukin 18 receptor accessory protein0.079
MASP2mannan-binding lectin serine peptidase 20.078
CCR7chemokine (C-C motif) receptor 70.076
IL6Rinterleukin 6 receptor0.076
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd14CD14 molecule0.361
Il1ainterleukin 1 alpha0.238
Iappislet amyloid polypeptide0.236
Il6interleukin 60.208
S100a9S100 calcium binding protein A90.193
S100a8S100 calcium binding protein A80.173
Cxcr5chemokine (C-X-C motif) receptor 50.168
Cd44Cd44 molecule0.167
Il1binterleukin 1 beta0.162
Ccl2chemokine (C-C motif) ligand 20.159
Ptafrplatelet-activating factor receptor0.141
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.129
Cxcl2chemokine (C-X-C motif) ligand 20.122
Gzmkgranzyme K0.118
Tnftumor necrosis factor (TNF superfamily, member 2)0.116
Pzppregnancy-zone protein0.113
Cd38CD38 molecule0.110
S1pr2sphingosine-1-phosphate receptor 20.107
Slco2b1solute carrier organic anion transporter family, member 2b10.106
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.103
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.102
Il1rninterleukin 1 receptor antagonist0.102
Dusp4dual specificity phosphatase 40.097
Plaurplasminogen activator, urokinase receptor0.097
Socs3suppressor of cytokine signaling 30.091
Il1r1interleukin 1 receptor, type I0.086
Apoa5apolipoprotein A-V0.082
Lst1leukocyte specific transcript 10.082
C5ar1complement component 5a receptor 10.079
Vcanversican0.078
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.077
Crhbpcorticotropin releasing hormone binding protein0.074
Ccr1chemokine (C-C motif) receptor 10.074
Tcf21transcription factor 210.071
Plauplasminogen activator, urokinase0.071
Olr1496olfactory receptor 14960.069
Olr1078olfactory receptor 10780.069
Adora1adenosine A1 receptor0.065
Olr1082olfactory receptor 10820.065
Hspb1heat shock protein 10.062
Cd5Cd5 molecule0.062
Psg19pregnancy specific glycoprotein 190.061
Alpialkaline phosphatase, intestinal0.060
Edn1endothelin 10.059
Neurog3neurogenin 30.059
Ltalymphotoxin alpha (TNF superfamily, member 1)0.058
Grprgastrin releasing peptide receptor0.058
Hes2hairy and enhancer of split 2 (Drosophila)0.058
Hpgdshematopoietic prostaglandin D synthase0.057
Tlr4toll-like receptor 40.056
Gucy2eguanylate cyclase 2E0.055
Cd302CD302 molecule0.054
Cd8aCD8a molecule0.054
Agtr1aangiotensin II receptor, type 1a0.051
Trhr2thyrotropin releasing hormone receptor 20.051
Cfdcomplement factor D (adipsin)0.051
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.051
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.051
Ppyr1pancreatic polypeptide receptor 10.050
Cgm4carcinoembryonic antigen gene family 40.050
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.050
Btcbetacellulin0.050
Rhorhodopsin0.050
Omdosteomodulin0.048
Hrh2histamine receptor H 20.048
Tmem163transmembrane protein 1630.048
Dab2disabled homolog 2 (Drosophila)0.047
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.047
Ccl7chemokine (C-C motif) ligand 70.047
Scn11asodium channel, voltage-gated, type XI, alpha0.047
Gcgroup specific component0.046
Stat3signal transducer and activator of transcription 30.046
Cmklr1chemokine-like receptor 10.046
Fam38bfamily with sequence similarity 38, member B0.046
Ucnurocortin0.045
Fgf7fibroblast growth factor 70.044
Sellselectin L0.043
Insrrinsulin receptor-related receptor0.043
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.043
Tas2r126taste receptor, type 2, member 1260.043
Tcf4transcription factor 40.043
Il1r2interleukin 1 receptor, type II0.043
Ccr5chemokine (C-C motif) receptor 50.042
Cpb2carboxypeptidase B2 (plasma)0.042
Pecam1platelet/endothelial cell adhesion molecule 10.042
Ccl3chemokine (C-C motif) ligand 30.042
Cd4Cd4 molecule0.042
Gzmbgranzyme B0.042
Ubdubiquitin D0.042
Fosl1fos-like antigen 10.041
Ncr1natural cytotoxicity triggering receptor 10.041
Cideacell death-inducing DFFA-like effector a0.041
Ripk3receptor-interacting serine-threonine kinase 30.041
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.041
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.040
Tacr1tachykinin receptor 10.039
Nmur2neuromedin U receptor 20.039
Pax6paired box 60.039
Vom2r27vomeronasal 2 receptor, 270.038
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.038
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism