The network for 'positive regulation of lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte activation

Any process that activates or increases the frequency, rate or extent of lymphocyte activation.

NameDescriptionProbabilityFunc Analog Organism
Cd40CD40 antigen0.999
Tnftumor necrosis factor0.999
Leprleptin receptor0.996
Ikzf1IKAROS family zinc finger 10.993
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.988
Pdcd1programmed cell death 10.969
Lcklymphocyte protein tyrosine kinase0.956
Ptprcprotein tyrosine phosphatase, receptor type, C0.953
FynFyn proto-oncogene0.946
Pax2paired box gene 20.929
Jak2Janus kinase 20.913
FasFas (TNF receptor superfamily member 6)0.905
RybpRING1 and YY1 binding protein0.896
Ltalymphotoxin A0.894
Il2rbinterleukin 2 receptor, beta chain0.875
Myd88myeloid differentiation primary response gene 880.872
Efnb2ephrin B20.866
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.865
Socs1suppressor of cytokine signaling 10.864
Cd247CD247 antigen0.858
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.849
Cd28CD28 antigen0.847
Ccr2chemokine (C-C motif) receptor 20.840
Map3k14mitogen-activated protein kinase kinase kinase 140.837
Cd5CD5 antigen0.817
Tnfaip3tumor necrosis factor, alpha-induced protein 30.813
Cd6CD6 antigen0.774
Icosinducible T-cell co-stimulator0.770
Latlinker for activation of T cells0.757
Gli2GLI-Kruppel family member GLI20.756
Tgfbr1transforming growth factor, beta receptor I0.742
FaslFas ligand (TNF superfamily, member 6)0.741
FosFBJ osteosarcoma oncogene0.732
Itgalintegrin alpha L0.717
Ifnginterferon gamma0.707
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.707
Stat5bsignal transducer and activator of transcription 5B0.706
Casp4caspase 4, apoptosis-related cysteine peptidase0.705
Zap70zeta-chain (TCR) associated protein kinase0.704
Il2rginterleukin 2 receptor, gamma chain0.703
Ptgs2prostaglandin-endoperoxide synthase 20.702
Cd80CD80 antigen0.697
Stat3signal transducer and activator of transcription 30.693
Arandrogen receptor0.692
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.690
Cd44CD44 antigen0.676
H2-Ab1histocompatibility 2, class II antigen A, beta 10.671
Snai1snail homolog 1 (Drosophila)0.661
Il2interleukin 20.658
Cd86CD86 antigen0.657
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.656
Il4interleukin 40.651
Tbx21T-box 210.647
Trp63transformation related protein 630.644
Sh2d2aSH2 domain protein 2A0.635
Map3k8mitogen-activated protein kinase kinase kinase 80.634
Csf1colony stimulating factor 1 (macrophage)0.632
Runx1runt related transcription factor 10.628
Casp1caspase 10.623
Klrd1killer cell lectin-like receptor, subfamily D, member 10.621
Batfbasic leucine zipper transcription factor, ATF-like0.620
Klrk1killer cell lectin-like receptor subfamily K, member 10.620
Gli3GLI-Kruppel family member GLI30.617
Tbx3T-box 30.610
ItkIL2-inducible T-cell kinase0.609
Rargretinoic acid receptor, gamma0.607
Gpr132G protein-coupled receptor 1320.605
Ppargperoxisome proliferator activated receptor gamma0.603
Il6interleukin 60.599
Ccl4chemokine (C-C motif) ligand 40.596
Lag3lymphocyte-activation gene 30.595
Traf1TNF receptor-associated factor 10.595
Ccl2chemokine (C-C motif) ligand 20.593
Klrg1killer cell lectin-like receptor subfamily G, member 10.592
Dok2docking protein 20.591
Cd96CD96 antigen0.590
Foxn1forkhead box N10.584
Psapprosaposin0.574
Cd14CD14 antigen0.574
Gata6GATA binding protein 60.561
Lyz2lysozyme 20.556
Ccr6chemokine (C-C motif) receptor 60.532
Prdm1PR domain containing 1, with ZNF domain0.528
Ptpn11protein tyrosine phosphatase, non-receptor type 110.528
Ccr9chemokine (C-C motif) receptor 90.528
Gdf3growth differentiation factor 30.527
Pitx3paired-like homeodomain transcription factor 30.526
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.522
Rhohras homolog gene family, member H0.516
Gzmkgranzyme K0.513
Tlr4toll-like receptor 40.511
Ccr7chemokine (C-C motif) receptor 70.511
Traf2TNF receptor-associated factor 20.507
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.504
Irf8interferon regulatory factor 80.503
Ltblymphotoxin B0.485
Il12binterleukin 12b0.480
anonagouti0.480
Ccr5chemokine (C-C motif) receptor 50.479
Ifnar1interferon (alpha and beta) receptor 10.473
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
LCKlymphocyte-specific protein tyrosine kinase0.997
IL4Rinterleukin 4 receptor0.958
PTPN6protein tyrosine phosphatase, non-receptor type 60.957
FGFR2fibroblast growth factor receptor 20.907
SYKspleen tyrosine kinase0.896
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.885
CD80CD80 molecule0.880
TNFAIP3tumor necrosis factor, alpha-induced protein 30.878
GRB2growth factor receptor-bound protein 20.854
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.831
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.807
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.791
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.789
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.771
BCL2B-cell CLL/lymphoma 20.770
SH3KBP1SH3-domain kinase binding protein 10.730
CD86CD86 molecule0.687
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.666
CXCL9chemokine (C-X-C motif) ligand 90.662
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.653
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.642
SOCS3suppressor of cytokine signaling 30.629
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.626
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.622
CCR7chemokine (C-C motif) receptor 70.621
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.621
B2Mbeta-2-microglobulin0.618
CCL5chemokine (C-C motif) ligand 50.618
HLA-Bmajor histocompatibility complex, class I, B0.616
HLA-Fmajor histocompatibility complex, class I, F0.612
PTPN1protein tyrosine phosphatase, non-receptor type 10.610
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.605
TICAM2toll-like receptor adaptor molecule 20.602
CAV1caveolin 1, caveolae protein, 22kDa0.599
IL1Binterleukin 1, beta0.592
BTN3A3butyrophilin, subfamily 3, member A30.581
ICAM1intercellular adhesion molecule 10.576
IL2RGinterleukin 2 receptor, gamma0.575
BTN3A1butyrophilin, subfamily 3, member A10.556
BTN3A2butyrophilin, subfamily 3, member A20.533
CTLA4cytotoxic T-lymphocyte-associated protein 40.516
SLAMF1signaling lymphocytic activation molecule family member 10.501
SH2D1ASH2 domain containing 1A0.480
CCL22chemokine (C-C motif) ligand 220.467
CCR5chemokine (C-C motif) receptor 50.437
LATlinker for activation of T cells0.435
IL1R1interleukin 1 receptor, type I0.424
IL2RBinterleukin 2 receptor, beta0.410
CCL4chemokine (C-C motif) ligand 40.398
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.388
ITKIL2-inducible T-cell kinase0.384
HLA-DMBmajor histocompatibility complex, class II, DM beta0.375
IRAK1interleukin-1 receptor-associated kinase 10.363
NCOR2nuclear receptor corepressor 20.359
HLA-DRB5major histocompatibility complex, class II, DR beta 50.359
SIGLEC7sialic acid binding Ig-like lectin 70.351
IL10RAinterleukin 10 receptor, alpha0.343
TLR2toll-like receptor 20.340
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.335
CD247CD247 molecule0.329
IRF4interferon regulatory factor 40.328
INSRinsulin receptor0.315
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.304
CXCL10chemokine (C-X-C motif) ligand 100.284
STAT4signal transducer and activator of transcription 40.276
TNFRSF9tumor necrosis factor receptor superfamily, member 90.272
NLRC4NLR family, CARD domain containing 40.259
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.255
JAK1Janus kinase 10.251
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.236
TGIF1TGFB-induced factor homeobox 10.233
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.231
HLA-DPB1major histocompatibility complex, class II, DP beta 10.231
AXLAXL receptor tyrosine kinase0.229
BCL2L1BCL2-like 10.229
TRAF1TNF receptor-associated factor 10.223
CCL8chemokine (C-C motif) ligand 80.223
CD40CD40 molecule, TNF receptor superfamily member 50.222
CD6CD6 molecule0.221
SIN3ASIN3 homolog A, transcription regulator (yeast)0.220
IL6Rinterleukin 6 receptor0.210
IRAK2interleukin-1 receptor-associated kinase 20.197
HLA-Emajor histocompatibility complex, class I, E0.197
GAS6growth arrest-specific 60.195
BIRC3baculoviral IAP repeat containing 30.187
CD28CD28 molecule0.183
TRAF6TNF receptor-associated factor 60.175
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.174
IFNGinterferon, gamma0.170
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.169
IL2RAinterleukin 2 receptor, alpha0.169
EPORerythropoietin receptor0.167
LIN9lin-9 homolog (C. elegans)0.165
NR4A1nuclear receptor subfamily 4, group A, member 10.160
TNFtumor necrosis factor0.158
HLA-DRB4major histocompatibility complex, class II, DR beta 40.157
FASFas (TNF receptor superfamily, member 6)0.155
GAS7growth arrest-specific 70.154
PILRApaired immunoglobin-like type 2 receptor alpha0.153
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.658
RT1-BaRT1 class II, locus Ba0.436
Cd37CD37 molecule0.416
Cd247Cd247 molecule0.311
RT1-BbRT1 class II, locus Bb0.302
RT1-Db1RT1 class II, locus Db10.270
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.248
Itgb7integrin, beta 70.189
Cd5Cd5 molecule0.140
Ptprcprotein tyrosine phosphatase, receptor type, C0.102
Cd2Cd2 molecule0.086
Il2rbinterleukin 2 receptor, beta0.081
Calcrcalcitonin receptor0.075
Il2rginterleukin 2 receptor, gamma0.070
RT1-DMbRT1 class II, locus DMb0.061
Ptger4prostaglandin E receptor 4 (subtype EP4)0.057
Ciitaclass II, major histocompatibility complex, transactivator0.057
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.055
Reg3gregenerating islet-derived 3 gamma0.055
Il10interleukin 100.055
Rassf5Ras association (RalGDS/AF-6) domain family member 50.049
Calcrlcalcitonin receptor-like0.045
Kcnv1potassium channel, subfamily V, member 10.045
Ccr5chemokine (C-C motif) receptor 50.045
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.043
Map4k1mitogen activated protein kinase kinase kinase kinase 10.043
Zbp1Z-DNA binding protein 10.043
Cxcr3chemokine (C-X-C motif) receptor 30.041
Scn11asodium channel, voltage-gated, type XI, alpha0.039
TcrbT-cell receptor beta chain0.039
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.039
Fmnl1formin-like 10.038
Il1binterleukin 1 beta0.038
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.037
Ptafrplatelet-activating factor receptor0.036
Cd38CD38 molecule0.036
Nkg7natural killer cell group 7 sequence0.035
Gzmkgranzyme K0.035
Cd53Cd53 molecule0.034
Alox5arachidonate 5-lipoxygenase0.034
Napsanapsin A aspartic peptidase0.033
Vipvasoactive intestinal peptide0.032
Socs3suppressor of cytokine signaling 30.030
Add2adducin 2 (beta)0.030
Casp1caspase 10.030
Icosinducible T-cell co-stimulator0.029
Cd3gCD3 molecule, gamma0.029
Arhgap4Rho GTPase activating protein 40.029
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.029
Prl8a9prolactin family 8, subfamily a, member 90.029
Cd22CD22 molecule0.029
Flt1FMS-related tyrosine kinase 10.028
Dnase1l3deoxyribonuclease 1-like 30.028
Il6interleukin 60.028
Arrb2arrestin, beta 20.027
Mmp10matrix metallopeptidase 100.027
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.027
Gja4gap junction protein, alpha 40.027
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.026
Csn1s1casein alpha s10.026
Il17rainterleukin 17 receptor A0.025
Metmet proto-oncogene0.025
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.025
Itgadintegrin, alpha D0.024
Il9rinterleukin 9 receptor0.024
Cd4Cd4 molecule0.024
Cfpcomplement factor properdin0.024
Csf1colony stimulating factor 1 (macrophage)0.024
Il6stinterleukin 6 signal transducer0.023
KlKlotho0.023
Spnsialophorin0.023
Gdnfglial cell derived neurotrophic factor0.022
Il1r1interleukin 1 receptor, type I0.022
Rin1Ras and Rab interactor 10.022
Aif1allograft inflammatory factor 10.022
Dock8dedicator of cytokinesis 80.021
Npy5rneuropeptide Y receptor Y50.021
Pspparotid secretory protein0.020
Syt8synaptotagmin VIII0.020
Ccl5chemokine (C-C motif) ligand 50.020
Prkcqprotein kinase C, theta0.020
Slfn2schlafen 20.020
Olr1500olfactory receptor 15000.020
Inpp5dinositol polyphosphate-5-phosphatase D0.020
Il2rainterleukin 2 receptor, alpha0.019
Hmha1histocompatibility (minor) HA-10.019
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.019
Psd4pleckstrin and Sec7 domain containing 40.019
Apol3apolipoprotein L, 30.019
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.019
Sellselectin L0.019
Hcsthematopoietic cell signal transducer0.019
Eregepiregulin0.019
Ido1indoleamine 2,3-dioxygenase 10.019
Ly6g6clymphocyte antigen 6 complex, locus G6C0.018
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.018
Nek9NIMA (never in mitosis gene a)- related kinase 90.018
FaslgFas ligand (TNF superfamily, member 6)0.018
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.018
Il7rinterleukin 7 receptor0.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism