The network for 'regulation of natural killer cell mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of natural killer cell mediated immunity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.

NameDescriptionProbabilityFunc Analog Organism
H2-D1histocompatibility 2, D region locus 10.997
B2mbeta-2 microglobulin0.997
H2-K1histocompatibility 2, K1, K region0.995
TapbpTAP binding protein0.992
Klra9killer cell lectin-like receptor subfamily A, member 90.981
Klrc1killer cell lectin-like receptor subfamily C, member 10.967
H2-Q7histocompatibility 2, Q region locus 70.941
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.941
Stat5bsignal transducer and activator of transcription 5B0.892
Klrk1killer cell lectin-like receptor subfamily K, member 10.885
FaslFas ligand (TNF superfamily, member 6)0.866
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.858
Gzmagranzyme A0.802
Gzmkgranzyme K0.798
Klrd1killer cell lectin-like receptor, subfamily D, member 10.797
Xcl1chemokine (C motif) ligand 10.763
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.738
Stat5asignal transducer and activator of transcription 5A0.627
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.602
Irf9interferon regulatory factor 90.554
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.544
Il18rapinterleukin 18 receptor accessory protein0.532
Gzmbgranzyme B0.531
Stat3signal transducer and activator of transcription 30.524
Ncr1natural cytotoxicity triggering receptor 10.410
Klra7killer cell lectin-like receptor, subfamily A, member 70.364
H2-Q6histocompatibility 2, Q region locus 60.358
Cd7CD7 antigen0.354
Icosinducible T-cell co-stimulator0.339
Slamf1signaling lymphocytic activation molecule family member 10.313
ItkIL2-inducible T-cell kinase0.304
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.283
H2-Q8histocompatibility 2, Q region locus 80.268
Ctswcathepsin W0.247
Arrb1arrestin, beta 10.239
Klra3killer cell lectin-like receptor, subfamily A, member 30.231
Cd244CD244 natural killer cell receptor 2B40.204
Il10interleukin 100.192
Slamf7SLAM family member 70.179
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.174
Klrg1killer cell lectin-like receptor subfamily G, member 10.174
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.133
Cd96CD96 antigen0.131
Klre1killer cell lectin-like receptor family E member 10.119
Il7rinterleukin 7 receptor0.113
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.112
H2-Eb1histocompatibility 2, class II antigen E beta0.109
Klrb1fkiller cell lectin-like receptor subfamily B member 1F0.105
Nkg7natural killer cell group 7 sequence0.104
Cd180CD180 antigen0.100
Il18r1interleukin 18 receptor 10.098
Spna1spectrin alpha 10.096
Tbx21T-box 210.093
Emr4EGF-like module containing, mucin-like, hormone receptor-like sequence 40.092
H2-Q5histocompatibility 2, Q region locus 50.088
Il6interleukin 60.087
Klra8killer cell lectin-like receptor, subfamily A, member 80.085
Itgaxintegrin alpha X0.076
H2-T18histocompatibility 2, T region locus 180.076
Cd3gCD3 antigen, gamma polypeptide0.074
Pyhin1pyrin and HIN domain family, member 10.074
Lgals8lectin, galactose binding, soluble 80.072
Sh2d2aSH2 domain protein 2A0.071
Aoahacyloxyacyl hydrolase0.071
BC147527cDNA sequence BC1475270.070
Ccl5chemokine (C-C motif) ligand 50.066
Trim21tripartite motif-containing 210.061
Stat4signal transducer and activator of transcription 40.060
Cxcr6chemokine (C-X-C motif) receptor 60.060
Cd28CD28 antigen0.060
Lair1leukocyte-associated Ig-like receptor 10.058
Il2rbinterleukin 2 receptor, beta chain0.056
Tgtp2T-cell specific GTPase 20.054
Cd3dCD3 antigen, delta polypeptide0.052
TxkTXK tyrosine kinase0.051
Sh2d1b1SH2 domain protein 1B10.049
Il2rainterleukin 2 receptor, alpha chain0.047
Gcet2germinal center expressed transcript 20.047
Gpr33G protein-coupled receptor 330.046
Xcr1chemokine (C motif) receptor 10.046
Ifnar2interferon (alpha and beta) receptor 20.043
Tlr4toll-like receptor 40.043
Il6stinterleukin 6 signal transducer0.043
Clec2iC-type lectin domain family 2, member i0.043
Cxcr3chemokine (C-X-C motif) receptor 30.040
Nckap1lNCK associated protein 1 like0.039
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.039
Il2interleukin 20.038
Cd160CD160 antigen0.038
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.037
Tcn2transcobalamin 20.037
Ccr3chemokine (C-C motif) receptor 30.037
Zfp36zinc finger protein 360.036
Parp14poly (ADP-ribose) polymerase family, member 140.036
Ctsbcathepsin B0.035
Klra2killer cell lectin-like receptor, subfamily A, member 20.035
Ccl3chemokine (C-C motif) ligand 30.034
Leprleptin receptor0.034
Klra6killer cell lectin-like receptor, subfamily A, member 60.033
Gbp1guanylate binding protein 10.033
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
im:7141132im:71411320.273
styk1serine/threonine/tyrosine kinase 10.227
zgc:101598zgc:1015980.169
defbl3defensin, beta-like 30.149
fxr2fragile X mental retardation, autosomal homolog 20.122
zgc:172101zgc:1721010.086
itln3intelectin 30.084
nitr13novel immune-type receptor 130.074
kpna3karyopherin (importin) alpha 30.060
tlr22toll-like receptor 220.057
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.048
gsk3bglycogen synthase kinase 3 beta0.048
tlr4bbtoll-like receptor 4b, duplicate b0.046
dmrt1doublesex and mab-3 related transcription factor 10.043
pcsk9proprotein convertase subtilisin/kexin type 90.043
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.042
nitr8novel immune-type receptor 80.041
cul1bcullin 1b0.039
illr3immune-related, lectin-like receptor 30.037
atp2b4ATPase, Ca++ transporting, plasma membrane 40.036
fbln4fibulin 40.036
plauaplasminogen activator, urokinase a0.036
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.034
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.033
ptk6aPTK6 protein tyrosine kinase 6a0.032
zgc:66100zgc:661000.031
wu:fb80e01wu:fb80e010.031
nos2anitric oxide synthase 2a, inducible0.029
nitr4anovel immune-type receptor 4a0.029
wacaWW domain containing adaptor with coiled-coil a0.028
znf148zinc finger protein 1480.027
yth2YTH domain family 20.027
im:7135980im:71359800.026
illr1immune-related, lectin-like receptor 10.026
sb:cb429sb:cb4290.026
rap1bRAS related protein 1b0.026
illr4immune-related, lectin-like receptor 40.025
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.024
nitr12novel immune-type receptor 120.024
slc4a2bsolute carrier family 4, anion exchanger, member 2b0.024
zgc:112992zgc:1129920.024
fcho2FCH domain only 20.024
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.024
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.024
si:ch73-9j13.1si:ch73-9j13.10.023
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.023
c3ccomplement component c3c0.022
arl4aaADP-ribosylation factor-like 4aa0.022
ddr2bdiscoidin domain receptor family, member 2b0.022
etnk1ethanolamine kinase 10.022
arhgef1rho guanine nucleotide exchange factor (GEF) 10.022
fzd2frizzled homolog 20.021
cry1acryptochrome 1a0.020
slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.020
c1qbcomplement component 1, q subcomponent, B chain0.020
irak4interleukin-1 receptor-associated kinase 40.020
lrrc15leucine rich repeat containing 150.019
LOC555739serine/threonine-protein kinase LMTK1-like0.019
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.019
ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.019
LOC100000934hypothetical protein LOC1000009340.019
rbbp6retinoblastoma binding protein 60.019
wu:fi40d09wu:fi40d090.019
tlr9toll-like receptor 90.018
defbl1defensin, beta-like 10.018
tnfrsf18tumor necrosis factor receptor superfamily, member 180.018
im:7152557im:71525570.018
si:dkey-76b14.4si:dkey-76b14.40.018
LOC794786interferon-induced protein with tetratricopeptide repeats 1-like0.017
lrrfip1aleucine rich repeat (in FLII) interacting protein 1a0.017
tectec protein tyrosine kinase0.017
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.017
tyrobpTYRO protein tyrosine kinase binding protein0.017
zgc:103710zgc:1037100.017
cd40lgCD40 ligand0.017
phrf1PHD and ring finger domains 10.016
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.016
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.016
arpc1bactin related protein 2/3 complex, subunit 1B0.016
capza1bcapping protein (actin filament) muscle Z-line, alpha 1b0.015
stat6signal transducer and activator of transcription 6, interleukin-4 induced0.015
slc12a10.1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.10.015
angptl3angiopoietin-like 30.015
il10interleukin 100.015
pcsk7proprotein convertase subtilisin/kexin type 70.015
si:ch211-140f21.1si:ch211-140f21.10.015
atp2b1bATPase, Ca++ transporting, plasma membrane 1b0.015
crfb13cytokine receptor family member b130.015
naa15bN(alpha)-acetyltransferase 15, NatA auxiliary subunit b0.014
si:ch211-284e13.2si:ch211-284e13.20.014
abi1aabl-interactor 1a0.014
snx8sorting nexin 80.014
hmgb3ahigh-mobility group box 3a0.014
LOC100538108tissue-type plasminogen activator-like0.014
ucp3uncoupling protein 30.014
slc4a11solute carrier family 4, sodium borate transporter, member 110.014
lmo7aLIM domain only 7a0.014
tbx21T-box 210.014
si:dkey-151c10.1si:dkey-151c10.10.014
ncor2nuclear receptor co-repressor 20.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Cmajor histocompatibility complex, class I, C1.000
HLA-Gmajor histocompatibility complex, class I, G0.999
B2Mbeta-2-microglobulin0.997
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.991
HLA-Amajor histocompatibility complex, class I, A0.975
CD84CD84 molecule0.945
TAPBPTAP binding protein (tapasin)0.872
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.871
HLA-Bmajor histocompatibility complex, class I, B0.825
HLA-Emajor histocompatibility complex, class I, E0.747
HLA-Fmajor histocompatibility complex, class I, F0.563
PILRApaired immunoglobin-like type 2 receptor alpha0.493
KLRD1killer cell lectin-like receptor subfamily D, member 10.447
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.353
PTPN6protein tyrosine phosphatase, non-receptor type 60.220
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.216
IL2RBinterleukin 2 receptor, beta0.177
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.130
GBAglucosidase, beta, acid0.111
PVRL4poliovirus receptor-related 40.103
SIGLEC7sialic acid binding Ig-like lectin 70.101
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.087
SLAMF1signaling lymphocytic activation molecule family member 10.086
PTAFRplatelet-activating factor receptor0.076
IL23Ainterleukin 23, alpha subunit p190.075
HK3hexokinase 3 (white cell)0.069
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.064
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.061
FYBFYN binding protein0.057
KLRC2killer cell lectin-like receptor subfamily C, member 20.051
GRNgranulin0.050
KLRK1killer cell lectin-like receptor subfamily K, member 10.050
PSAPprosaposin0.048
GZMKgranzyme K (granzyme 3; tryptase II)0.044
KLRC3killer cell lectin-like receptor subfamily C, member 30.044
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.043
INSRinsulin receptor0.043
IFNGinterferon, gamma0.042
ITM2Bintegral membrane protein 2B0.042
TPP1tripeptidyl peptidase I0.038
NCSTNnicastrin0.033
ARRB2arrestin, beta 20.033
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.032
STAP2signal transducing adaptor family member 20.031
NPC2Niemann-Pick disease, type C20.030
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.030
IL18RAPinterleukin 18 receptor accessory protein0.025
GNSglucosamine (N-acetyl)-6-sulfatase0.024
NLRP3NLR family, pyrin domain containing 30.023
EPORerythropoietin receptor0.022
GNLYgranulysin0.021
AOAHacyloxyacyl hydrolase (neutrophil)0.020
PVRL3poliovirus receptor-related 30.020
CD33CD33 molecule0.020
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.018
PTPN1protein tyrosine phosphatase, non-receptor type 10.018
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.018
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.018
CTSAcathepsin A0.018
PRF1perforin 1 (pore forming protein)0.018
MAPK10mitogen-activated protein kinase 100.017
CD3GCD3g molecule, gamma (CD3-TCR complex)0.017
CCR1chemokine (C-C motif) receptor 10.016
IFITM2interferon induced transmembrane protein 2 (1-8D)0.016
SIRPB1signal-regulatory protein beta 10.015
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.015
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.014
CD226CD226 molecule0.014
RAB14RAB14, member RAS oncogene family0.014
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.014
TAPBPLTAP binding protein-like0.014
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.013
CCL5chemokine (C-C motif) ligand 50.013
BTN3A1butyrophilin, subfamily 3, member A10.013
CXCR6chemokine (C-X-C motif) receptor 60.012
FPR1formyl peptide receptor 10.012
XCL2chemokine (C motif) ligand 20.012
CD86CD86 molecule0.011
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.011
CMKLR1chemokine-like receptor 10.011
HCSThematopoietic cell signal transducer0.011
SIGLEC9sialic acid binding Ig-like lectin 90.011
TREM1triggering receptor expressed on myeloid cells 10.011
MAP3K5mitogen-activated protein kinase kinase kinase 50.011
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.011
LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 40.011
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.011
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.011
PGCPplasma glutamate carboxypeptidase0.010
KLRF1killer cell lectin-like receptor subfamily F, member 10.010
LAIR1leukocyte-associated immunoglobulin-like receptor 10.010
BCAR1breast cancer anti-estrogen resistance 10.010
KLRC1killer cell lectin-like receptor subfamily C, member 10.010
ASGR2asialoglycoprotein receptor 20.010
BIN2bridging integrator 20.010
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Klrd1killer cell lectin-like receptor, subfamily D, member 10.799
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.603
Mmp12matrix metallopeptidase 120.493
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.374
Gzmkgranzyme K0.207
RT1-EC2RT1 class Ib, locus EC20.186
Nkg7natural killer cell group 7 sequence0.174
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.146
Prf1perforin 1 (pore forming protein)0.140
Gzmbgranzyme B0.131
RT1-N3RT1 class Ib, locus N30.105
Ccl5chemokine (C-C motif) ligand 50.077
Irf7interferon regulatory factor 70.066
RT1-CE12RT1 class I, locus CE120.063
Cd8aCD8a molecule0.047
Spnsialophorin0.046
Klra5killer cell lectin-like receptor, subfamily A, member 50.046
Cxcl10chemokine (C-X-C motif) ligand 100.044
RT1-M3-1RT1 class Ib, locus M3, gene 10.034
Mcpt8mast cell protease 80.034
LOC100364485mCG1051031-like0.031
Cd247Cd247 molecule0.024
Oas1a2'-5' oligoadenylate synthetase 1A0.023
Il7rinterleukin 7 receptor0.021
Ccr2chemokine (C-C motif) receptor 20.021
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.021
Apol3apolipoprotein L, 30.018
Irf1interferon regulatory factor 10.017
Cd2Cd2 molecule0.016
FaslgFas ligand (TNF superfamily, member 6)0.016
Gimap4GTPase, IMAP family member 40.016
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.016
Sellselectin L0.016
Gzmmgranzyme M (lymphocyte met-ase 1)0.016
Il2rbinterleukin 2 receptor, beta0.016
RT1-S3RT1 class Ib, locus S30.015
Oas1i2 ' -5 ' oligoadenylate synthetase 1I0.015
TapbpTAP binding protein0.014
Xcl1chemokine (C motif) ligand 10.013
Cd69Cd69 molecule0.013
Hes2hairy and enhancer of split 2 (Drosophila)0.013
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.013
Epsti1epithelial stromal interaction 1 (breast)0.012
Ly6elymphocyte antigen 6 complex, locus E0.012
Cd5Cd5 molecule0.011
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.011
Fam26ffamily with sequence similarity 26, member F0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism