The network for 'cardiac muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell differentiation

The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgf8fibroblast growth factor 81.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Pitx2paired-like homeodomain transcription factor 21.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Foxc2forkhead box C21.000
Tbx1T-box 10.999
Isl1ISL1 transcription factor, LIM/homeodomain0.999
Pax3paired box gene 30.999
Pax2paired box gene 20.999
Foxc1forkhead box C10.997
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.996
Nos3nitric oxide synthase 3, endothelial cell0.996
Bmp4bone morphogenetic protein 40.996
Eya1eyes absent 1 homolog (Drosophila)0.995
Chd7chromodomain helicase DNA binding protein 70.994
Otx2orthodenticle homolog 2 (Drosophila)0.994
Jag1jagged 10.993
Fgfr2fibroblast growth factor receptor 20.991
Efnb2ephrin B20.991
Gli3GLI-Kruppel family member GLI30.991
Gata4GATA binding protein 40.990
Tbx3T-box 30.989
Fgfr1fibroblast growth factor receptor 10.988
Sox9SRY-box containing gene 90.985
Rxraretinoid X receptor alpha0.985
Tcfap2atranscription factor AP-2, alpha0.983
Apcadenomatosis polyposis coli0.982
Hoxa1homeobox A10.977
Ptpn11protein tyrosine phosphatase, non-receptor type 110.974
Hand1heart and neural crest derivatives expressed transcript 10.968
Lhx1LIM homeobox protein 10.966
Ntf3neurotrophin 30.966
Meox2mesenchyme homeobox 20.962
Prrx1paired related homeobox 10.957
Ctnnb1catenin (cadherin associated protein), beta 10.956
Gbx2gastrulation brain homeobox 20.947
Notch1Notch gene homolog 1 (Drosophila)0.947
Tgfb2transforming growth factor, beta 20.943
Mesp1mesoderm posterior 10.939
Rargretinoic acid receptor, gamma0.936
Nf1neurofibromatosis 10.935
Sox2SRY-box containing gene 20.923
Vegfavascular endothelial growth factor A0.911
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.910
Tgfbr2transforming growth factor, beta receptor II0.895
Hey2hairy/enhancer-of-split related with YRPW motif 20.888
Pax8paired box gene 80.885
Bmp7bone morphogenetic protein 70.884
Ror2receptor tyrosine kinase-like orphan receptor 20.872
Dlx5distal-less homeobox 50.838
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.822
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.816
Actc1actin, alpha, cardiac muscle 10.815
Rarbretinoic acid receptor, beta0.808
Fgf10fibroblast growth factor 100.807
Gli2GLI-Kruppel family member GLI20.800
Vangl2vang-like 2 (van gogh, Drosophila)0.799
Gscgoosecoid homeobox0.788
Smad6MAD homolog 6 (Drosophila)0.786
Foxg1forkhead box G10.780
Msx1homeobox, msh-like 10.774
Notch2Notch gene homolog 2 (Drosophila)0.769
Tnnt3troponin T3, skeletal, fast0.749
Acvr1activin A receptor, type 10.730
Ednraendothelin receptor type A0.728
Cnn1calponin 10.702
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.695
Tbx15T-box 150.691
Ldb3LIM domain binding 30.679
Wt1Wilms tumor 1 homolog0.676
Hoxa3homeobox A30.672
Ece1endothelin converting enzyme 10.663
Hoxa13homeobox A130.656
Emx2empty spiracles homolog 2 (Drosophila)0.647
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.641
Myl3myosin, light polypeptide 30.638
Actn2actinin alpha 20.627
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.626
Pitx1paired-like homeodomain transcription factor 10.617
Hoxa2homeobox A20.608
Gata3GATA binding protein 30.592
Tbx2T-box 20.585
Wnt11wingless-related MMTV integration site 110.585
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.583
Myl9myosin, light polypeptide 9, regulatory0.581
Wnt3awingless-related MMTV integration site 3A0.556
Dkk1dickkopf homolog 1 (Xenopus laevis)0.552
Cdx2caudal type homeobox 20.552
Retret proto-oncogene0.550
Gata5GATA binding protein 50.548
Wnt4wingless-related MMTV integration site 40.545
Zic3zinc finger protein of the cerebellum 30.538
Hrchistidine rich calcium binding protein0.511
Lmx1aLIM homeobox transcription factor 1 alpha0.502
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.999
nkx2.5NK2 transcription factor related 50.999
bmp4bone morphogenetic protein 40.997
ttnatitin a0.993
aldh1a2aldehyde dehydrogenase 1 family, member A20.985
vmhcventricular myosin heavy chain0.981
smyd1bSET and MYND domain containing 1b0.966
tnnc1btroponin C type 1b (slow)0.963
myf5myogenic factor 50.940
myl7myosin, light polypeptide 7, regulatory0.938
pcdh8protocadherin 80.936
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.928
pdlim7PDZ and LIM domain 70.924
wt1awilms tumor 1a0.890
kdrlkinase insert domain receptor like0.888
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.881
unc45bunc-45 homolog B (C. elegans)0.878
bmp2bbone morphogenetic protein 2b0.860
mylz2myosin, light polypeptide 2, skeletal muscle0.852
smyhc1slow myosin heavy chain 10.838
tbx5aT-box 5a0.798
myl1myosin, light chain 1, alkali; skeletal, fast0.786
mef2cbmyocyte enhancer factor 2cb0.775
hey2hairy/enhancer-of-split related with YRPW motif 20.747
tnni2a.4troponin I, skeletal, fast 2a.40.685
tnni1btroponin I, skeletal, slow b0.668
osr1odd-skipped related 1 (Drosophila)0.668
wnt11rwingless-type MMTV integration site family, member 11, related0.663
crabp2acellular retinoic acid binding protein 2, a0.662
tbx2aT-box gene 2a0.657
itgb1b.2integrin, beta 1b.20.649
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.646
actc1bactin, alpha, cardiac muscle 1b0.642
tbx1T-box 10.636
tbx18T-box 180.601
smyhc2slow myosin heavy chain 20.578
pax2apaired box gene 2a0.569
actn3bactinin alpha 3b0.553
tbx20T-box 200.517
desmadesmin a0.516
tbx5bT-box 5b0.504
ttnbtitin b0.468
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.460
wnt11wingless-type MMTV integration site family, member 110.444
hoxa9ahomeo box A9a0.443
mef2camyocyte enhancer factor 2ca0.438
tnnt3btroponin T3b, skeletal, fast0.438
hsp90a.1heat shock protein 90-alpha 10.426
hand2heart and neural crest derivatives expressed transcript 20.396
shhasonic hedgehog a0.385
mespamesoderm posterior a0.383
scn12absodium channel, voltage gated, type XII, alpha b0.371
synpo2lbsynaptopodin 2-like b0.353
myf6myogenic factor 60.327
tnni1altroponin I, skeletal, slow like0.324
rx3retinal homeobox gene 30.318
dmrt2adoublesex and mab-3 related transcription factor 2a0.311
xirp1xin actin-binding repeat containing 10.311
myhz2myosin, heavy polypeptide 2, fast muscle specific0.301
fezf2FEZ family zinc finger 20.301
fgf8afibroblast growth factor 8 a0.301
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.279
her3hairy-related 30.274
pitx2paired-like homeodomain transcription factor 20.272
gja3gap junction protein, alpha 30.270
prickle1aprickle-like 1 (Drosophila) a0.264
gapdhglyceraldehyde-3-phosphate dehydrogenase0.259
tnnc1atroponin C type 1a (slow)0.229
gro1groucho 10.218
tnnc2troponin C type 2 (fast)0.213
znf503zinc finger protein 5030.211
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.210
txlnbataxilin beta a0.207
aplnrbapelin receptor b0.207
fgf3fibroblast growth factor 30.197
neurog1neurogenin 10.195
wt1bwilms tumor 1b0.195
popdc2popeye domain containing 20.190
rx2retinal homeobox gene 20.188
hspb1heat shock protein, alpha-crystallin-related, 10.186
adrb2aadrenergic receptor, beta 2a0.178
dhrs3adehydrogenase/reductase (SDR family) member 3a0.166
actc1aactin, alpha, cardiac muscle 1a0.164
lhx5LIM homeobox 50.162
rarabretinoic acid receptor, alpha b0.161
raraaretinoic acid receptor, alpha a0.160
lhx1aLIM homeobox 1a0.156
tnnt2atroponin T2a, cardiac0.152
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.150
eng2aengrailed 2a0.150
wnt5bwingless-type MMTV integration site family, member 5b0.148
her1hairy-related 10.147
ndr2nodal-related 20.146
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
LanB2Laminin B20.017
wupAwings up A0.016
HLH54FCG5005 gene product from transcript CG5005-RA0.015
MhcMyosin heavy chain0.014
numbCG3779 gene product from transcript CG3779-RB0.014
Actnalpha actinin0.014
cicubitus interruptus0.014
Zasp52Z band alternatively spliced PDZ-motif protein 520.014
CG12558CG12558 gene product from transcript CG12558-RA0.014
mewmultiple edematous wings0.013
howheld out wings0.013
Mlc2Myosin light chain 20.013
Act88FActin 88F0.013
rolsrolling pebbles0.013
Mlc1Myosin alkali light chain 10.012
Zasp66Z band alternatively spliced PDZ-motif protein 660.012
CG13627CG13627 gene product from transcript CG13627-RA0.012
Trxr-1Thioredoxin reductase-10.012
LanALaminin A0.012
grhgrainy head0.012
Orct2Organic cation transporter 20.012
CG31226CG31226 gene product from transcript CG31226-RB0.012
pashapartner of drosha0.012
LanB1CG7123 gene product from transcript CG7123-RA0.011
CG14061CG14061 gene product from transcript CG14061-RA0.011
HandCG18144 gene product from transcript CG18144-RA0.011
l(3)82FdCG32464 gene product from transcript CG32464-RR0.011
CG17658CG17658 gene product from transcript CG17658-RA0.011
wbwing blister0.011
pigspickled eggs0.011
Lim1CG11354 gene product from transcript CG11354-RA0.011
PvrPDGF- and VEGF-receptor related0.011
CG9705CG9705 gene product from transcript CG9705-RA0.011
CG15365CG15365 gene product from transcript CG15365-RA0.011
Fas2Fasciclin 20.011
Su(z)2Suppressor of zeste 20.011
Pabp2CG2163 gene product from transcript CG2163-RA0.011
CG2950CG2950 gene product from transcript CG2950-RD0.011
kibrakibra ortholog0.011
Dhc64CDynein heavy chain 64C0.010
EgfrEpidermal growth factor receptor0.010
ThiolaseCG4581 gene product from transcript CG4581-RA0.010
Rya-r44FRyanodine receptor 44F0.010
CG5376CG5376 gene product from transcript CG5376-RA0.010
Act5CActin 5C0.010
CG11912CG11912 gene product from transcript CG11912-RA0.010
PdiProtein disulfide isomerase0.010
CG15631CG15631 gene product from transcript CG15631-RA0.010
Su(z)12CG8013 gene product from transcript CG8013-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRFserum response factor (c-fos serum response element-binding transcription factor)0.998
RARAretinoic acid receptor, alpha0.965
TRIM63tripartite motif containing 630.895
RXRAretinoid X receptor, alpha0.887
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.830
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.651
NOTCH1notch 10.644
BMPR1Abone morphogenetic protein receptor, type IA0.610
NRP1neuropilin 10.608
TBX5T-box 50.561
FKBP1AFK506 binding protein 1A, 12kDa0.556
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.533
NCOA1nuclear receptor coactivator 10.475
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.464
HDAC4histone deacetylase 40.417
COL4A2collagen, type IV, alpha 20.395
BMP2bone morphogenetic protein 20.335
MED25mediator complex subunit 250.309
YAP1Yes-associated protein 10.306
FSTL1follistatin-like 10.259
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.259
COL4A1collagen, type IV, alpha 10.230
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.218
LRP6low density lipoprotein receptor-related protein 60.215
FLNAfilamin A, alpha0.210
JAG1jagged 10.205
CDK2cyclin-dependent kinase 20.202
SMAD7SMAD family member 70.194
TGFB1transforming growth factor, beta 10.190
ACTN1actinin, alpha 10.166
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.162
MYOD1myogenic differentiation 10.152
SPOPspeckle-type POZ protein0.121
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.120
PDGFAplatelet-derived growth factor alpha polypeptide0.117
TGFB3transforming growth factor, beta 30.108
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.107
SPENspen homolog, transcriptional regulator (Drosophila)0.106
TSC2tuberous sclerosis 20.103
NCOR2nuclear receptor corepressor 20.090
ESR1estrogen receptor 10.088
MYOZ1myozenin 10.086
COL4A6collagen, type IV, alpha 60.076
HNF4Ahepatocyte nuclear factor 4, alpha0.072
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.063
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.062
IFITM2interferon induced transmembrane protein 2 (1-8D)0.059
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.057
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.057
ACTN2actinin, alpha 20.053
MYH9myosin, heavy chain 9, non-muscle0.049
GDF5growth differentiation factor 50.047
MYOGmyogenin (myogenic factor 4)0.044
CREBBPCREB binding protein0.044
PDGFCplatelet derived growth factor C0.043
NCOR1nuclear receptor corepressor 10.040
COL4A5collagen, type IV, alpha 50.037
ITGA7integrin, alpha 70.036
FZD1frizzled homolog 1 (Drosophila)0.034
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.034
MYL9myosin, light chain 9, regulatory0.034
PRKD2protein kinase D20.033
GATA4GATA binding protein 40.033
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.033
GATAD2BGATA zinc finger domain containing 2B0.032
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.032
ACVR1activin A receptor, type I0.031
THBS1thrombospondin 10.030
MKL1megakaryoblastic leukemia (translocation) 10.029
PRKG1protein kinase, cGMP-dependent, type I0.029
TNRC6Atrinucleotide repeat containing 6A0.029
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.028
AGLamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase0.028
CAPN3calpain 3, (p94)0.028
ND1NADH dehydrogenase, subunit 1 (complex I)0.027
CDK1cyclin-dependent kinase 10.026
NCK2NCK adaptor protein 20.026
NOTCH3notch 30.026
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.026
WDFY3WD repeat and FYVE domain containing 30.025
ARandrogen receptor0.025
FLNBfilamin B, beta0.025
CCNB2cyclin B20.025
ACTA2actin, alpha 2, smooth muscle, aorta0.025
LAMB1laminin, beta 10.024
TCAPtitin-cap (telethonin)0.024
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.022
CCNA2cyclin A20.022
CAV1caveolin 1, caveolae protein, 22kDa0.021
COL5A2collagen, type V, alpha 20.020
TPM4tropomyosin 40.020
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.019
VASPvasodilator-stimulated phosphoprotein0.019
TGFBR1transforming growth factor, beta receptor 10.018
CNN2calponin 20.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism