IMP
Process View
The network for 'negative regulation of purine nucleotide catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of purine nucleotide catabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.965 | |
| Spry4 | sprouty homolog 4 (Drosophila) | 0.895 | |
| Lsm2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.843 | |
| Thoc4 | THO complex 4 | 0.541 | |
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.523 | |
| Ppp4c | protein phosphatase 4, catalytic subunit | 0.490 | |
| Neurl1a | neuralized homolog 1A (Drosophila) | 0.417 | |
| Refbp2 | RNA and export factor binding protein 2 | 0.385 | |
| Banf1 | barrier to autointegration factor 1 | 0.338 | |
| Spry2 | sprouty homolog 2 (Drosophila) | 0.333 | |
| Tubb5 | tubulin, beta 5 | 0.242 | |
| Prmt1 | protein arginine N-methyltransferase 1 | 0.241 | |
| Fbl | fibrillarin | 0.189 | |
| Ywhah | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.184 | |
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.183 | |
| Spry1 | sprouty homolog 1 (Drosophila) | 0.182 | |
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.163 | |
| Ptma | prothymosin alpha | 0.151 | |
| Vegfa | vascular endothelial growth factor A | 0.130 | |
| Eif4a1 | eukaryotic translation initiation factor 4A1 | 0.128 | |
| Tomm40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | 0.120 | |
| Hnrnpab | heterogeneous nuclear ribonucleoprotein A/B | 0.105 | |
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.094 | |
| Uhrf1 | ubiquitin-like, containing PHD and RING finger domains, 1 | 0.092 | |
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.090 | |
| Pfn1 | profilin 1 | 0.082 | |
| Hnrnpm | heterogeneous nuclear ribonucleoprotein M | 0.081 | |
| Epas1 | endothelial PAS domain protein 1 | 0.077 | |
| Siah2 | seven in absentia 2 | 0.075 | |
| Rcc2 | regulator of chromosome condensation 2 | 0.074 | |
| Adcy9 | adenylate cyclase 9 | 0.073 | |
| Rab5a | RAB5A, member RAS oncogene family | 0.068 | |
| Kif1b | kinesin family member 1B | 0.061 | |
| Cpeb2 | cytoplasmic polyadenylation element binding protein 2 | 0.060 | |
| Ranbp1 | RAN binding protein 1 | 0.059 | |
| Arhgef7 | Rho guanine nucleotide exchange factor (GEF7) | 0.058 | |
| Cpeb4 | cytoplasmic polyadenylation element binding protein 4 | 0.057 | |
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.056 | |
| Gipc1 | GIPC PDZ domain containing family, member 1 | 0.056 | |
| Ppm1g | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform | 0.055 | |
| Stim2 | stromal interaction molecule 2 | 0.054 | |
| Ywhag | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.053 | |
| Pcbp1 | poly(rC) binding protein 1 | 0.052 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.050 | |
| Dlg1 | discs, large homolog 1 (Drosophila) | 0.050 | |
| Rfc5 | replication factor C (activator 1) 5 | 0.047 | |
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 0.045 | |
| P4htm | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 0.044 | |
| Nr2f1 | nuclear receptor subfamily 2, group F, member 1 | 0.044 | |
| U2af1 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 | 0.043 | |
| Ptprn | protein tyrosine phosphatase, receptor type, N | 0.043 | |
| Txn2 | thioredoxin 2 | 0.039 | |
| Yap1 | yes-associated protein 1 | 0.038 | |
| Rsl24d1 | ribosomal L24 domain containing 1 | 0.036 | |
| Dab1 | disabled homolog 1 (Drosophila) | 0.036 | |
| Ppil1 | peptidylprolyl isomerase (cyclophilin)-like 1 | 0.036 | |
| Sult4a1 | sulfotransferase family 4A, member 1 | 0.036 | |
| Cdk4 | cyclin-dependent kinase 4 | 0.035 | |
| Rb1cc1 | RB1-inducible coiled-coil 1 | 0.034 | |
| Srm | spermidine synthase | 0.034 | |
| Ubtf | upstream binding transcription factor, RNA polymerase I | 0.033 | |
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.033 | |
| Tsc22d2 | TSC22 domain family, member 2 | 0.033 | |
| Ppm1a | protein phosphatase 1A, magnesium dependent, alpha isoform | 0.031 | |
| Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.031 | |
| Dnajb9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.031 | |
| Ppp3ca | protein phosphatase 3, catalytic subunit, alpha isoform | 0.031 | |
| Rnf11 | ring finger protein 11 | 0.030 | |
| H2afx | H2A histone family, member X | 0.028 | |
| Tuba1b | tubulin, alpha 1B | 0.028 | |
| Mbd3 | methyl-CpG binding domain protein 3 | 0.027 | |
| Vars | valyl-tRNA synthetase | 0.027 | |
| Cab39 | calcium binding protein 39 | 0.026 | |
| Lmo7 | LIM domain only 7 | 0.026 | |
| Gar1 | GAR1 ribonucleoprotein homolog (yeast) | 0.025 | |
| Cdc34 | cell division cycle 34 homolog (S. cerevisiae) | 0.025 | |
| Gsr | glutathione reductase | 0.024 | |
| Timeless | timeless homolog (Drosophila) | 0.024 | |
| Snrk | SNF related kinase | 0.023 | |
| 1110008P14Rik | RIKEN cDNA 1110008P14 gene | 0.023 | |
| Josd2 | Josephin domain containing 2 | 0.022 | |
| Sos2 | son of sevenless homolog 2 (Drosophila) | 0.022 | |
| Cpeb3 | cytoplasmic polyadenylation element binding protein 3 | 0.022 | |
| Pfdn2 | prefoldin 2 | 0.022 | |
| Prkaa2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.022 | |
| Dag1 | dystroglycan 1 | 0.021 | |
| Hivep1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.020 | |
| Eea1 | early endosome antigen 1 | 0.020 | |
| Cks1b | CDC28 protein kinase 1b | 0.020 | |
| Psat1 | phosphoserine aminotransferase 1 | 0.020 | |
| Trak1 | trafficking protein, kinesin binding 1 | 0.020 | |
| Yrdc | yrdC domain containing (E.coli) | 0.019 | |
| Gm16517 | predicted gene, Gm16517 | 0.019 | |
| Dohh | deoxyhypusine hydroxylase/monooxygenase | 0.019 | |
| Tnnc1 | troponin C, cardiac/slow skeletal | 0.018 | |
| Tob1 | transducer of ErbB-2.1 | 0.018 | |
| Kif21a | kinesin family member 21A | 0.018 | |
| Mef2a | myocyte enhancer factor 2A | 0.018 | |
| Arhgef11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.018 | |
| Rb1 | retinoblastoma 1 | 0.018 |
Loading network...
Drosophila melanogaster| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ras85D | Ras oncogene at 85D | 0.093 | |
| Rpb11 | CG6840 gene product from transcript CG6840-RA | 0.083 | |
| CG6540 | CG6540 gene product from transcript CG6540-RA | 0.073 | |
| CG9797 | CG9797 gene product from transcript CG9797-RA | 0.062 | |
| Set | CG4299 gene product from transcript CG4299-RA | 0.059 | |
| lwr | lesswright | 0.048 | |
| LSm7 | CG13277 gene product from transcript CG13277-RA | 0.048 | |
| CG4646 | CG4646 gene product from transcript CG4646-RA | 0.040 | |
| SC35 | CG5442 gene product from transcript CG5442-RC | 0.037 | |
| CG16903 | CG16903 gene product from transcript CG16903-RA | 0.037 | |
| CG2091 | CG2091 gene product from transcript CG2091-RA | 0.032 | |
| esc | extra sexcombs | 0.029 | |
| polo | CG12306 gene product from transcript CG12306-RA | 0.028 | |
| exd | extradenticle | 0.028 | |
| Rpb5 | CG11979 gene product from transcript CG11979-RA | 0.027 | |
| CG11267 | CG11267 gene product from transcript CG11267-RA | 0.027 | |
| Prosbeta2 | Proteasome beta2 subunit | 0.026 | |
| thoc7 | CG17143 gene product from transcript CG17143-RB | 0.026 | |
| Prx5 | Peroxiredoxin 5 | 0.024 | |
| RpII140 | RNA polymerase II 140kD subunit | 0.024 | |
| dup | double parked | 0.022 | |
| CG4866 | CG4866 gene product from transcript CG4866-RB | 0.021 | |
| RanGap | Ran GTPase activating protein | 0.021 | |
| ncd | non-claret disjunctional | 0.019 | |
| Srp19 | Signal recognition particle protein 19 | 0.019 | |
| Mcm2 | Minichromosome maintenance 2 | 0.019 | |
| CG1307 | CG1307 gene product from transcript CG1307-RB | 0.019 | |
| CG13364 | CG13364 gene product from transcript CG13364-RA | 0.018 | |
| mRpL17 | mitochondrial ribosomal protein L17 | 0.018 | |
| CG17266 | CG17266 gene product from transcript CG17266-RA | 0.018 | |
| NHP2 | CG5258 gene product from transcript CG5258-RA | 0.017 | |
| dpa | disc proliferation abnormal | 0.017 | |
| Fas2 | Fasciclin 2 | 0.016 | |
| CG32708 | CG32708 gene product from transcript CG32708-RA | 0.016 | |
| sty | sprouty | 0.015 | |
| Oscp | Oligomycin sensitivity-conferring protein | 0.015 | |
| RpLP0-like | Ribosomal protein LP0-like | 0.015 | |
| Bka | Bekka | 0.014 | |
| CG2021 | CG2021 gene product from transcript CG2021-RA | 0.013 | |
| dgt2 | dim gamma-tubulin 2 | 0.013 | |
| Bgb | Big brother | 0.013 | |
| Hop | Hsp70/Hsp90 organizing protein homolog | 0.013 | |
| aur | aurora | 0.013 | |
| mars | CG17064 gene product from transcript CG17064-RB | 0.013 | |
| CG15735 | CG15735 gene product from transcript CG15735-RA | 0.013 | |
| D1 | D1 chromosomal protein | 0.013 | |
| U4-U6-60K | U4-U6 small nuclear riboprotein factor 60K | 0.013 | |
| shot | short stop | 0.012 | |
| CG4769 | CG4769 gene product from transcript CG4769-RA | 0.012 | |
| CG3436 | CG3436 gene product from transcript CG3436-RA | 0.012 | |
| Rrp42 | CG8395 gene product from transcript CG8395-RA | 0.012 | |
| mor | moira | 0.012 | |
| CG17282 | CG17282 gene product from transcript CG17282-RA | 0.012 | |
| Bap60 | Brahma associated protein 60kD | 0.012 | |
| CG7950 | CG7950 gene product from transcript CG7950-RB | 0.012 | |
| Su(var)205 | Suppressor of variegation 205 | 0.011 | |
| CG8108 | CG8108 gene product from transcript CG8108-RA | 0.011 | |
| Rho1 | CG8416 gene product from transcript CG8416-RB | 0.011 | |
| crn | crooked neck | 0.010 | |
| Caf1 | Chromatin assembly factor 1 subunit | 0.010 |
Loading network...
Homo sapiens| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| TNNC1 | troponin C type 1 (slow) | 0.177 | |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.067 | |
| SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 0.051 | |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.050 | |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.033 | |
| HAP1 | huntingtin-associated protein 1 | 0.029 | |
| RALBP1 | ralA binding protein 1 | 0.028 | |
| LMAN1 | lectin, mannose-binding, 1 | 0.028 | |
| YAP1 | Yes-associated protein 1 | 0.027 | |
| RND1 | Rho family GTPase 1 | 0.027 | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.027 | |
| HMOX2 | heme oxygenase (decycling) 2 | 0.023 | |
| ARRB1 | arrestin, beta 1 | 0.023 | |
| TBCD | tubulin folding cofactor D | 0.022 | |
| TRIM63 | tripartite motif containing 63 | 0.019 | |
| AMOTL1 | angiomotin like 1 | 0.017 | |
| THOC5 | THO complex 5 | 0.015 | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.014 | |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.013 | |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.013 | |
| RALGDS | ral guanine nucleotide dissociation stimulator | 0.013 | |
| MCM3 | minichromosome maintenance complex component 3 | 0.011 | |
| MST1R | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 0.011 | |
| TFRC | transferrin receptor (p90, CD71) | 0.011 | |
| EPAS1 | endothelial PAS domain protein 1 | 0.011 | |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.011 | |
| GMPR2 | guanosine monophosphate reductase 2 | 0.011 |