The network for 'amino acid activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

amino acid activation

The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.

NameDescriptionProbabilityFunc Analog Organism
Garsglycyl-tRNA synthetase0.984
Narsasparaginyl-tRNA synthetase0.978
Larsleucyl-tRNA synthetase0.934
Aarsalanyl-tRNA synthetase0.816
Yarstyrosyl-tRNA synthetase0.707
Eif3deukaryotic translation initiation factor 3, subunit D0.623
Eif3ceukaryotic translation initiation factor 3, subunit C0.611
Iarsisoleucine-tRNA synthetase0.578
Tarsthreonyl-tRNA synthetase0.500
Marsmethionine-tRNA synthetase0.449
Rarsarginyl-tRNA synthetase0.306
Eprsglutamyl-prolyl-tRNA synthetase0.286
Sarsseryl-aminoacyl-tRNA synthetase0.257
Asnsasparagine synthetase0.218
Farsbphenylalanyl-tRNA synthetase, beta subunit0.143
Nop56NOP56 ribonucleoprotein homolog (yeast)0.130
Wdr74WD repeat domain 740.102
Nsun2NOL1/NOP2/Sun domain family member 20.094
Eif3geukaryotic translation initiation factor 3, subunit G0.087
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.083
Mthfd2methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase0.051
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.051
Srp68signal recognition particle 680.049
Elac2elaC homolog 2 (E. coli)0.036
Mrps18bmitochondrial ribosomal protein S18B0.034
Lrrc59leucine rich repeat containing 590.034
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.033
Lsg1large subunit GTPase 1 homolog (S. cerevisiae)0.033
Atf4activating transcription factor 40.031
Carscysteinyl-tRNA synthetase0.030
Eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.029
Pus1pseudouridine synthase 10.029
Ddx56DEAD (Asp-Glu-Ala-Asp) box polypeptide 560.028
Lonp1lon peptidase 1, mitochondrial0.026
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.026
Aatfapoptosis antagonizing transcription factor0.025
Gtf2f1general transcription factor IIF, polypeptide 10.025
Abcf1ATP-binding cassette, sub-family F (GCN20), member 10.022
Vcpvalosin containing protein0.022
Ncbp1nuclear cap binding protein subunit 10.021
Wdr36WD repeat domain 360.020
Xpotexportin, tRNA (nuclear export receptor for tRNAs)0.019
Ftsj3FtsJ homolog 3 (E. coli)0.019
Psat1phosphoserine aminotransferase 10.018
Drg2developmentally regulated GTP binding protein 20.018
Larp1La ribonucleoprotein domain family, member 10.017
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.017
Mybbp1aMYB binding protein (P160) 1a0.017
Nop14NOP14 nucleolar protein homolog (yeast)0.017
Fam98afamily with sequence similarity 98, member A0.014
Eif2b3eukaryotic translation initiation factor 2B, subunit 30.014
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.014
Las1lLAS1-like (S. cerevisiae)0.014
Eif3beukaryotic translation initiation factor 3, subunit B0.014
Fam192afamily with sequence similarity 192, member A0.013
Hspa9heat shock protein 90.013
Trmt5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)0.013
Dohhdeoxyhypusine hydroxylase/monooxygenase0.012
Bms1BMS1 homolog, ribosome assembly protein (yeast)0.011
ClpbClpB caseinolytic peptidase B homolog (E. coli)0.011
Psphphosphoserine phosphatase0.010
Nolc1nucleolar and coiled-body phosphoprotein 10.010
Lrpprcleucine-rich PPR-motif containing0.010
Ttc4tetratricopeptide repeat domain 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Aats-leuLeucyl-tRNA synthetase0.637
Aats-thrThreonyl-tRNA synthetase0.576
Aats-asnAsparaginyl-tRNA synthetase0.466
Aats-tyrTyrosyl-tRNA synthetase0.323
Srp68CG5064 gene product from transcript CG5064-RA0.271
Aats-aspAspartyl-tRNA synthetase0.264
CG1703CG1703 gene product from transcript CG1703-RA0.178
CG17259CG17259 gene product from transcript CG17259-RA0.129
Hsc70-5Heat shock protein cognate 50.068
Srp54kSignal recognition particle protein 54k0.054
Aats-metMethionyl-tRNA synthetase0.038
Aats-trpTryptophanyl-tRNA synthetase0.034
Drp1Dynamin related protein 10.034
CG33123CG33123 gene product from transcript CG33123-RA0.027
Xbp1X box binding protein-10.027
CG12264CG12264 gene product from transcript CG12264-RA0.025
Aats-gluproGlutamyl-prolyl-tRNA synthetase0.025
Aats-glyGlycyl-tRNA synthetase0.023
Aats-proProlyl-tRNA synthetase0.023
Aats-alaAlanyl-tRNA synthetase0.022
l(2)k01209lethal (2) k012090.020
beta'Copbeta'-coatomer protein0.018
CG11771CG11771 gene product from transcript CG11771-RA0.018
Aats-hisHistidyl-tRNA synthetase0.017
ATP7CG1886 gene product from transcript CG1886-RB0.014
Aats-valValyl-tRNA synthetase0.014
l(2)37Cclethal (2) 37Cc0.014
Trxr-1Thioredoxin reductase-10.014
CG15100CG15100 gene product from transcript CG15100-RA0.013
eIF2B-epsilonCG3806 gene product from transcript CG3806-RB0.013
Gcn2CG1609 gene product from transcript CG1609-RA0.013
CG42630CG42630 gene product from transcript CG42630-RA0.013
JhI-1Juvenile hormone-inducible protein 10.012
CG8417CG8417 gene product from transcript CG8417-RA0.011
eIF3-S8CG4954 gene product from transcript CG4954-RA0.011
Aats-cysCysteinyl-tRNA synthetase0.011
SrpRbetaSignal recognition particle receptor beta0.011
CG4679CG4679 gene product from transcript CG4679-RA0.011
droshaCG8730 gene product from transcript CG8730-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GARSglycyl-tRNA synthetase1.000
IARSisoleucyl-tRNA synthetase1.000
EPRSglutamyl-prolyl-tRNA synthetase1.000
AARSalanyl-tRNA synthetase1.000
MARSmethionyl-tRNA synthetase1.000
ASNSasparagine synthetase (glutamine-hydrolyzing)0.999
CARScysteinyl-tRNA synthetase0.998
YARStyrosyl-tRNA synthetase0.998
AIMP2aminoacyl tRNA synthetase complex-interacting multifunctional protein 20.992
NARSasparaginyl-tRNA synthetase0.992
LARSleucyl-tRNA synthetase0.833
RARSarginyl-tRNA synthetase0.829
SARSseryl-tRNA synthetase0.766
TARSthreonyl-tRNA synthetase0.756
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.657
KARSlysyl-tRNA synthetase0.592
AIMP1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.326
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.269
ECSITECSIT homolog (Drosophila)0.239
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.193
MRPS27mitochondrial ribosomal protein S270.187
LONP1lon peptidase 1, mitochondrial0.085
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.084
DARSaspartyl-tRNA synthetase0.080
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.069
PSAT1phosphoserine aminotransferase 10.066
KRT8keratin 80.061
CNOcappuccino homolog (mouse)0.057
MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.052
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.044
MRRFmitochondrial ribosome recycling factor0.037
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.037
LARS2leucyl-tRNA synthetase 2, mitochondrial0.035
IARS2isoleucyl-tRNA synthetase 2, mitochondrial0.032
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.032
EIF3CLeukaryotic translation initiation factor 3, subunit C-like0.031
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.031
ATP13A1ATPase type 13A10.029
C12orf44chromosome 12 open reading frame 440.025
MINAMYC induced nuclear antigen0.025
OTUD5OTU domain containing 50.025
EIF2B2eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa0.023
RPTORregulatory associated protein of MTOR, complex 10.022
DPH5DPH5 homolog (S. cerevisiae)0.020
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.020
TARS2threonyl-tRNA synthetase 2, mitochondrial (putative)0.018
TRAP1TNF receptor-associated protein 10.018
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.018
ARMC6armadillo repeat containing 60.017
HMBShydroxymethylbilane synthase0.017
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.016
PHGDHphosphoglycerate dehydrogenase0.016
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.016
BCS1LBCS1-like (S. cerevisiae)0.016
PFASphosphoribosylformylglycinamidine synthase0.015
GCDHglutaryl-CoA dehydrogenase0.015
TRIB3tribbles homolog 3 (Drosophila)0.015
LIG3ligase III, DNA, ATP-dependent0.014
XPO5exportin 50.014
DLATdihydrolipoamide S-acetyltransferase0.014
THG1LtRNA-histidine guanylyltransferase 1-like (S. cerevisiae)0.013
WARStryptophanyl-tRNA synthetase0.013
GPS1G protein pathway suppressor 10.013
FARS2phenylalanyl-tRNA synthetase 2, mitochondrial0.013
LIASlipoic acid synthetase0.013
BMS1BMS1 homolog, ribosome assembly protein (yeast)0.013
DNAJC11DnaJ (Hsp40) homolog, subfamily C, member 110.013
TH1LTH1-like (Drosophila)0.012
HOXB7homeobox B70.012
TSFMTs translation elongation factor, mitochondrial0.012
GUF1GUF1 GTPase homolog (S. cerevisiae)0.012
TRMT1TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)0.011
RTN4IP1reticulon 4 interacting protein 10.011
MRPL1mitochondrial ribosomal protein L10.011
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.011
METTL8methyltransferase like 80.011
SCFD2sec1 family domain containing 20.011
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.010
POLRMTpolymerase (RNA) mitochondrial (DNA directed)0.010
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.010
EIF2Deukaryotic translation initiation factor 2D0.010
GMDSGDP-mannose 4,6-dehydratase0.010
WDR46WD repeat domain 460.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Yarstyrosyl-tRNA synthetase0.922
Marsmethionine-tRNA synthetase0.484
Eif3ceukaryotic translation initiation factor 3, subunit C0.387
Aarsalanyl-tRNA synthetase0.373
Sarsseryl-tRNA synthetase0.344
Garsglycyl-tRNA synthetase0.235
Eif3deukaryotic translation initiation factor 3, subunit D0.222
Tarsthreonyl-tRNA synthetase0.222
Eif3beukaryotic translation initiation factor 3, subunit B0.130
Pno1partner of NOB1 homolog (S. cerevisiae)0.128
Carscysteinyl-tRNA synthetase0.093
Nsfl1cNSFL1 (p97) cofactor (p47)0.050
Eif2deukaryotic translation initiation factor 2D0.038
Aatfapoptosis antagonizing transcription factor0.032
LOC100360406rCG34104-like0.031
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.030
Dymdymeclin0.030
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.030
Cpsf3cleavage and polyadenylation specificity factor 30.029
Nmt1N-myristoyltransferase 10.027
Eprsglutamyl-prolyl-tRNA synthetase0.025
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.024
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.022
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.022
Eef1deukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)0.022
Hax1HCLS1 associated protein X-10.019
Cirh1acirrhosis, autosomal recessive 1A (cirhin)0.017
Warstryptophanyl-tRNA synthetase0.014
Dmap1DNA methyltransferase 1-associated protein 10.014
Rpl19ribosomal protein L190.014
Ciao1cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)0.014
Tcp1t-complex 10.013
Ppp2r2dprotein phosphatase 2, regulatory subunit B, delta isoform0.013
Prmt1protein arginine methyltransferase 10.013
Uba5ubiquitin-like modifier activating enzyme 50.012
Farsbphenylalanyl-tRNA synthetase, beta subunit0.012
Abcf1ATP-binding cassette, subfamily F (GCN20), member 10.012
Rpl3ribosomal protein L30.011
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.011
Anapc5anaphase-promoting complex subunit 50.011
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ILS1Ils1p0.994
VAS1Vas1p0.980
CDC60Cdc60p0.978
SES1Ses1p0.975
GUS1Gus1p0.953
SLM5Slm5p0.942
DYS1Dys1p0.908
DED81Ded81p0.898
PET112Pet112p0.871
KRS1Krs1p0.827
GRS1Grs1p0.804
THS1Ths1p0.751
FRS2Frs2p0.750
IFM1Ifm1p0.749
YHR020Whypothetical protein0.588
GLN4Gln4p0.557
KAP104Kap104p0.479
MSF1Msf1p0.457
MSE1Mse1p0.446
TYS1Tys1p0.404
MES1Mes1p0.403
GCN20Gcn20p0.402
SUP35Sup35p0.375
ALA1Ala1p0.356
YNL247Whypothetical protein0.340
HTS1Hts1p0.339
YDR341Chypothetical protein0.337
FRS1Frs1p0.295
ASN2Asn2p0.289
AIM10Aim10p0.284
YFH7Yfh7p0.270
KEL3Kel3p0.270
SUB2Sub2p0.215
RRF1Rrf1p0.199
MSY1Msy1p0.196
ISM1Ism1p0.170
MRF1Mrf1p0.170
TCM62Tcm62p0.142
CTM1Ctm1p0.135
GYL1Gyl1p0.131
CYM1Cym1p0.131
GUA1Gua1p0.128
MEF2Mef2p0.118
COQ1Coq1p0.114
MSD1Msd1p0.097
RPS20Rps20p0.087
MRP20Mrp20p0.078
YHB1Yhb1p0.076
OCT1Oct1p0.072
PRO2Pro2p0.071
ART10Art10p0.060
MST1Mst1p0.058
ADE6Ade6p0.057
PET494Pet494p0.055
ILV3Ilv3p0.054
YLR264C-Ahypothetical protein0.052
CCM1Ccm1p0.052
AEP3Aep3p0.051
RSM23Rsm23p0.051
SRD1Srd1p0.051
URA4Ura4p0.051
MAP2Map2p0.050
MDN1Mdn1p0.046
ARC1Arc1p0.046
EFT1Eft1p0.045
ARP10Arp10p0.044
ASN1Asn1p0.044
GUF1Guf1p0.043
YOL038C-Ahypothetical protein0.042
ISA2Isa2p0.042
YLR162Whypothetical protein0.042
IBA57Iba57p0.042
URA2Ura2p0.041
AAP1Aap1p0.040
CYS4Cys4p0.038
MER1Mer1p0.037
IMD2Imd2p0.037
EFR3Efr3p0.037
SHM1Shm1p0.037
NAM2Nam2p0.037
RSM19Rsm19p0.036
RPS5Rps5p0.036
LEU2Leu2p0.036
MKC7Mkc7p0.035
EMC1Emc1p0.034
ATP6Atp6p0.034
CUP1-1Cup1-1p0.034
AIM33Aim33p0.034
LYS21Lys21p0.034
CPD1Cpd1p0.032
YPR157Whypothetical protein0.032
PRS2Prs2p0.031
URA3Ura3p0.031
AGC1Agc1p0.031
ZPS1Zps1p0.030
YAR068Whypothetical protein0.030
OPT2Opt2p0.030
CCT2Cct2p0.030
YRB1Yrb1p0.029
HXT3Hxt3p0.029