The network for 'regulation of cytokine biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cytokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex1.000
Tnftumor necrosis factor0.999
Myd88myeloid differentiation primary response gene 880.999
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.998
Cd40CD40 antigen0.993
Lyz2lysozyme 20.990
Ikzf1IKAROS family zinc finger 10.984
Cd19CD19 antigen0.982
Tlr4toll-like receptor 40.978
Icosinducible T-cell co-stimulator0.978
Stat3signal transducer and activator of transcription 30.972
Il4interleukin 40.972
Ifnginterferon gamma0.972
FasFas (TNF receptor superfamily member 6)0.963
Foxp3forkhead box P30.960
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.956
Cd28CD28 antigen0.947
Il1r1interleukin 1 receptor, type I0.947
Ccr7chemokine (C-C motif) receptor 70.940
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.938
Irf4interferon regulatory factor 40.914
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.907
Ccr2chemokine (C-C motif) receptor 20.891
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.888
Il2rbinterleukin 2 receptor, beta chain0.874
Il10interleukin 100.867
Sfpi1SFFV proviral integration 10.859
Birc3baculoviral IAP repeat-containing 30.843
BtkBruton agammaglobulinemia tyrosine kinase0.826
Pdcd1programmed cell death 10.822
Map3k14mitogen-activated protein kinase kinase kinase 140.812
FaslFas ligand (TNF superfamily, member 6)0.808
Il4rainterleukin 4 receptor, alpha0.805
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.788
Stat5bsignal transducer and activator of transcription 5B0.781
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.778
Ccl2chemokine (C-C motif) ligand 20.752
Tnfaip3tumor necrosis factor, alpha-induced protein 30.747
Ltalymphotoxin A0.736
Clec4dC-type lectin domain family 4, member d0.726
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.720
Cd86CD86 antigen0.699
Il27rainterleukin 27 receptor, alpha0.688
Card11caspase recruitment domain family, member 110.683
Irf9interferon regulatory factor 90.661
Clec4eC-type lectin domain family 4, member e0.635
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.619
Ikbkbinhibitor of kappaB kinase beta0.607
Cd5CD5 antigen0.574
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.566
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.551
Map3k7mitogen-activated protein kinase kinase kinase 70.549
Cd44CD44 antigen0.547
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.545
Irf1interferon regulatory factor 10.544
Runx1runt related transcription factor 10.539
Batfbasic leucine zipper transcription factor, ATF-like0.535
Ccr5chemokine (C-C motif) receptor 50.532
Ikbkginhibitor of kappaB kinase gamma0.528
Inhbainhibin beta-A0.520
Il1binterleukin 1 beta0.496
Ccr6chemokine (C-C motif) receptor 60.489
Tnip1TNFAIP3 interacting protein 10.469
Socs1suppressor of cytokine signaling 10.444
Il2interleukin 20.441
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.437
Cd7CD7 antigen0.436
Ccl4chemokine (C-C motif) ligand 40.417
Itgalintegrin alpha L0.412
Cxcr2chemokine (C-X-C motif) receptor 20.411
Traf6TNF receptor-associated factor 60.402
Ticam1toll-like receptor adaptor molecule 10.397
Rag1recombination activating gene 10.389
Traf3ip2TRAF3 interacting protein 20.385
Stat1signal transducer and activator of transcription 10.374
Vav1vav 1 oncogene0.355
Klrk1killer cell lectin-like receptor subfamily K, member 10.352
Flt3FMS-like tyrosine kinase 30.350
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.349
Ccr1chemokine (C-C motif) receptor 10.343
Slamf1signaling lymphocytic activation molecule family member 10.343
Prf1perforin 1 (pore forming protein)0.340
Xcr1chemokine (C motif) receptor 10.333
Klrd1killer cell lectin-like receptor, subfamily D, member 10.332
Il6interleukin 60.330
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.313
Sykbspleen tyrosine kinase0.306
Ccr9chemokine (C-C motif) receptor 90.292
Klrg1killer cell lectin-like receptor subfamily G, member 10.291
Cxcl13chemokine (C-X-C motif) ligand 130.289
Apoeapolipoprotein E0.285
Cd80CD80 antigen0.284
Cd4CD4 antigen0.284
Mx1myxovirus (influenza virus) resistance 10.280
Bcl3B-cell leukemia/lymphoma 30.280
Fcgr2bFc receptor, IgG, low affinity IIb0.273
Msr1macrophage scavenger receptor 10.272
Chukconserved helix-loop-helix ubiquitous kinase0.270
Sellselectin, lymphocyte0.260
C3ar1complement component 3a receptor 10.258
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
eporerythropoietin receptor0.147
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.075
osr1odd-skipped related 1 (Drosophila)0.054
cpoxcoproporphyrinogen oxidase0.046
tnfatumor necrosis factor a (TNF superfamily, member 2)0.045
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.045
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.042
LOC100332193growth hormone secretagogue receptor type 1-like0.035
irak4interleukin-1 receptor-associated kinase 40.032
bmp2bbone morphogenetic protein 2b0.032
csf3rcolony stimulating factor 3 receptor (granulocyte)0.031
hcrthypocretin (orexin) neuropeptide precursor0.031
optcopticin0.031
pdcd2programmed cell death 20.030
mmp9matrix metalloproteinase 90.029
tlr2toll-like receptor 20.028
limk1LIM domain kinase 10.028
nos2anitric oxide synthase 2a, inducible0.028
LOC100151531zinc finger protein Gfi-1b-like0.027
per3period homolog 3 (Drosophila)0.027
nod1nucleotide-binding oligomerization domain containing 10.026
c1qccomplement component 1, q subcomponent, C chain0.026
sp2sp2 transcription factor0.026
LOC100534776toll-like receptor 7-like0.025
fn1fibronectin 10.024
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.024
zgc:63721zgc:637210.023
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.023
il6rinterleukin 6 receptor0.022
tlr20atoll-like receptor 20a0.022
creb3l3lcAMP responsive element binding protein 3-like 3 like0.022
LOC100003514protein kinase C alpha type-like0.022
myd88myeloid differentiation primary response gene (88)0.022
tlr20ftoll-like receptor 20f0.021
kal1bKallmann syndrome 1b sequence0.021
ntd5ntl-dependent gene 50.020
amotl2aangiomotin like 2a0.020
btkBruton agammaglobulinemia tyrosine kinase0.020
kpna3karyopherin (importin) alpha 30.020
hnf1bbHNF1 homeobox Bb0.020
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.020
bhlhe41basic helix-loop-helix family, member e410.019
ifng1-2interferon, gamma 1-20.019
vcanbversican b0.019
il6stinterleukin 6 signal transducer0.019
ppardbperoxisome proliferator-activated receptor delta b0.019
traf6TNF receptor-associated factor 60.018
tgm2btransglutaminase 2b0.018
si:dkey-145p14.5si:dkey-145p14.50.018
crfb7cytokine receptor family member b70.018
tlr3toll-like receptor 30.018
sqstm1sequestosome 10.017
aplnapelin0.017
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.017
wnt11wingless-type MMTV integration site family, member 110.017
tal2T-cell acute lymphocytic leukemia 20.017
col5a1procollagen, type V, alpha 10.017
clic2chloride intracellular channel 20.017
elovl1aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1a0.017
matn4matrilin 40.017
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.017
mmp13amatrix metalloproteinase 13a0.017
prkczprotein kinase C, zeta0.016
ticam1toll-like receptor adaptor molecule 10.016
vps37avacuolar protein sorting 37A0.016
stc1lstanniocalcin 1, like0.016
igf2ainsulin-like growth factor 2a0.016
wnt3wingless-type MMTV integration site family, member 30.016
igf2binsulin-like growth factor 2b0.016
csadcysteine sulfinic acid decarboxylase0.016
ucp2uncoupling protein 20.016
dnm2dynamin 20.016
drldraculin0.016
LOC566708FL cytokine receptor-like0.016
cdkl1cyclin-dependent kinase-like 1 (CDC2-related kinase)0.015
igfbp1ainsulin-like growth factor binding protein 1a0.015
pxnpaxillin0.015
tlr1toll-like receptor 10.015
tmprss4atransmembrane protease, serine 4a0.015
robo1roundabout homolog 10.015
sec31asec31 homolog A (S. cerevisiae)0.015
elnaelastin a0.015
prok2prokineticin 20.015
largelike-glycosyltransferase0.015
stat1bsignal transducer and activator of transcription 1b0.015
mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.015
alkanaplastic lymphoma kinase (Ki-1)0.015
dag1dystroglycan 10.015
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.015
tbx5bT-box 5b0.014
ddr2bdiscoidin domain receptor family, member 2b0.014
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.014
stxbp2syntaxin binding protein 20.014
hif1aahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a0.014
zgc:153148zgc:1531480.014
cd247lCD247 antigen like0.014
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.014
hbaa1hemoglobin alpha adult-10.014
prkcbbprotein kinase C, beta b0.014
fktnfukutin0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.993
PTPN6protein tyrosine phosphatase, non-receptor type 60.985
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.966
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.963
CD80CD80 molecule0.943
BCL3B-cell CLL/lymphoma 30.936
SYKspleen tyrosine kinase0.933
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.854
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.853
BTN3A1butyrophilin, subfamily 3, member A10.837
DDIT3DNA-damage-inducible transcript 30.806
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.806
BTN3A3butyrophilin, subfamily 3, member A30.805
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.779
TNFAIP3tumor necrosis factor, alpha-induced protein 30.761
IL4Rinterleukin 4 receptor0.759
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.755
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.738
BTN3A2butyrophilin, subfamily 3, member A20.717
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.640
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.628
CTLA4cytotoxic T-lymphocyte-associated protein 40.613
CD86CD86 molecule0.569
IL1R1interleukin 1 receptor, type I0.525
BIRC3baculoviral IAP repeat containing 30.471
TRAF1TNF receptor-associated factor 10.447
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.407
PILRApaired immunoglobin-like type 2 receptor alpha0.342
TLR4toll-like receptor 40.338
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.338
IL10RAinterleukin 10 receptor, alpha0.335
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.309
TRAF5TNF receptor-associated factor 50.294
TRAF3TNF receptor-associated factor 30.230
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.219
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.204
TICAM2toll-like receptor adaptor molecule 20.204
PTAFRplatelet-activating factor receptor0.204
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.190
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.178
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.174
IRAK1interleukin-1 receptor-associated kinase 10.174
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.164
RIPK2receptor-interacting serine-threonine kinase 20.153
IRAK2interleukin-1 receptor-associated kinase 20.149
CD28CD28 molecule0.146
TNIP2TNFAIP3 interacting protein 20.144
TNFAIP2tumor necrosis factor, alpha-induced protein 20.143
MYD88myeloid differentiation primary response gene (88)0.136
ITGAMintegrin, alpha M (complement component 3 receptor 3 subunit)0.135
CCR1chemokine (C-C motif) receptor 10.132
IL1RNinterleukin 1 receptor antagonist0.131
IL6Rinterleukin 6 receptor0.131
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.127
SIGLEC7sialic acid binding Ig-like lectin 70.126
TRAF2TNF receptor-associated factor 20.123
TNIP1TNFAIP3 interacting protein 10.120
C9orf89chromosome 9 open reading frame 890.120
JUNjun proto-oncogene0.118
TRAF6TNF receptor-associated factor 60.113
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.108
IL1Binterleukin 1, beta0.107
CREBBPCREB binding protein0.102
IL2RBinterleukin 2 receptor, beta0.098
EPORerythropoietin receptor0.093
BTN2A2butyrophilin, subfamily 2, member A20.093
INSRinsulin receptor0.092
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.088
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.088
KAT2BK(lysine) acetyltransferase 2B0.080
CD40CD40 molecule, TNF receptor superfamily member 50.079
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.079
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.077
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.077
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.076
LATlinker for activation of T cells0.075
PDPK13-phosphoinositide dependent protein kinase-10.075
DUSP1dual specificity phosphatase 10.073
BAG3BCL2-associated athanogene 30.072
SLAMF1signaling lymphocytic activation molecule family member 10.072
MAP3K3mitogen-activated protein kinase kinase kinase 30.069
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.069
SIRPB1signal-regulatory protein beta 10.068
IER2immediate early response 20.067
CDHR2cadherin-related family member 20.067
TYMPthymidine phosphorylase0.064
UBASH3Bubiquitin associated and SH3 domain containing B0.061
CHUKconserved helix-loop-helix ubiquitous kinase0.060
SP1Sp1 transcription factor0.060
IL1RAPinterleukin 1 receptor accessory protein0.060
TLR2toll-like receptor 20.060
CD247CD247 molecule0.060
TNFRSF9tumor necrosis factor receptor superfamily, member 90.059
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.059
HK3hexokinase 3 (white cell)0.058
IRF1interferon regulatory factor 10.057
IL8interleukin 80.053
PTPN1protein tyrosine phosphatase, non-receptor type 10.053
PIAS4protein inhibitor of activated STAT, 40.052
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl3chemokine (C-C motif) ligand 30.459
Igsf6immunoglobulin superfamily, member 60.355
Ccl4chemokine (C-C motif) ligand 40.353
Il1binterleukin 1 beta0.198
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.167
Cxcl2chemokine (C-X-C motif) ligand 20.162
Il6interleukin 60.121
Tlr2toll-like receptor 20.102
Gzmbgranzyme B0.102
Ccl2chemokine (C-C motif) ligand 20.097
C5ar1complement component 5a receptor 10.096
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.094
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.075
Errfi1ERBB receptor feedback inhibitor 10.075
Nraddneurotrophin receptor associated death domain0.074
Zfp36zinc finger protein 360.069
Ccl20chemokine (C-C motif) ligand 200.067
Il1ainterleukin 1 alpha0.062
Map3k8mitogen-activated protein kinase kinase kinase 80.059
Cxcl3chemokine (C-X-C motif) ligand 30.058
Nkg7natural killer cell group 7 sequence0.058
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.056
Prdm1PR domain containing 1, with ZNF domain0.055
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.053
Plscr1phospholipid scramblase 10.053
Folr2folate receptor 2 (fetal)0.052
Rhobras homolog gene family, member B0.052
Klrd1killer cell lectin-like receptor, subfamily D, member 10.051
Stk40serine/threonine kinase 400.051
Gzmkgranzyme K0.049
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.048
Tlr4toll-like receptor 40.048
Mmp12matrix metallopeptidase 120.048
Il2rbinterleukin 2 receptor, beta0.047
Cd46CD46 molecule, complement regulatory protein0.046
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.045
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.044
Cd247Cd247 molecule0.043
Atf3activating transcription factor 30.043
Il2rginterleukin 2 receptor, gamma0.042
Rgs1regulator of G-protein signaling 10.042
Cd14CD14 molecule0.041
Duox2dual oxidase 20.041
Dnase1l3deoxyribonuclease 1-like 30.040
Stx11syntaxin 110.039
Il8rbinterleukin 8 receptor, beta0.039
Fcn1ficolin (collagen/fibrinogen domain containing) 10.038
Prf1perforin 1 (pore forming protein)0.038
Reg3bregenerating islet-derived 3 beta0.037
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.036
Ccl7chemokine (C-C motif) ligand 70.036
Selpselectin P0.035
Tnftumor necrosis factor (TNF superfamily, member 2)0.035
Ch25hcholesterol 25-hydroxylase0.034
Dock8dedicator of cytokinesis 80.034
Cfpcomplement factor properdin0.034
Cxcl10chemokine (C-X-C motif) ligand 100.033
Fcer1aFc fragment of IgE, high affinity I, receptor for; alpha polypeptide0.032
Slc9a2solute carrier family 9 (sodium/hydrogen exchanger), member 20.032
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.032
Fosl1fos-like antigen 10.031
Vom2r27vomeronasal 2 receptor, 270.031
Slasrc-like adaptor0.031
Il1r2interleukin 1 receptor, type II0.031
Ccr2chemokine (C-C motif) receptor 20.030
Nox4NADPH oxidase 40.029
Il1rl1interleukin 1 receptor-like 10.029
Cnr2cannabinoid receptor 2 (macrophage)0.029
Neurl3neuralized homolog 3 (Drosophila)0.029
Cd8aCD8a molecule0.029
Cst7cystatin F (leukocystatin)0.028
Hspa1aheat shock 70kD protein 1A0.027
Kapkidney androgen regulated protein0.027
Xcl1chemokine (C motif) ligand 10.026
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.026
Rassf5Ras association (RalGDS/AF-6) domain family member 50.026
Gimap4GTPase, IMAP family member 40.026
Plekpleckstrin0.026
Dusp1dual specificity phosphatase 10.026
Ncr1natural cytotoxicity triggering receptor 10.025
Klf10Kruppel-like factor 100.025
Muskmuscle, skeletal, receptor tyrosine kinase0.025
Rp9retinitis pigmentosa 9 (human)0.025
Rab20RAB20, member RAS oncogene family0.025
Arl11ADP-ribosylation factor-like 110.025
Myocmyocilin0.025
Pank2pantothenate kinase 2 (Hallervorden-Spatz syndrome)0.025
Zcwpw1zinc finger, CW-type with PWWP domain 10.025
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.024
Slpisecretory leukocyte peptidase inhibitor0.024
Clrn3clarin 30.024
Cd2Cd2 molecule0.024
Smad1SMAD family member 10.024
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.024
Stat3signal transducer and activator of transcription 30.024
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.024
Il13ra2interleukin 13 receptor, alpha 20.024
LOC304903similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)0.024
Tipintimeless interacting protein0.024
Tectec protein tyrosine kinase0.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism