The network for 'negative regulation of extrinsic apoptotic signaling pathway via death domain receptors' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

NameDescriptionProbabilityFunc Analog Organism
Psen1presenilin 10.991
Ptgs2prostaglandin-endoperoxide synthase 20.982
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.917
Notch1Notch gene homolog 1 (Drosophila)0.849
Itgb1integrin beta 1 (fibronectin receptor beta)0.841
Mmp9matrix metallopeptidase 90.837
Ccl2chemokine (C-C motif) ligand 20.723
Cd44CD44 antigen0.712
Sfrp2secreted frizzled-related protein 20.677
Sfrp1secreted frizzled-related protein 10.663
Notch2Notch gene homolog 2 (Drosophila)0.663
Egfrepidermal growth factor receptor0.648
Apcadenomatosis polyposis coli0.603
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.542
Trp53transformation related protein 530.539
Thbs1thrombospondin 10.521
Plgplasminogen0.486
Nos2nitric oxide synthase 2, inducible0.419
Psen2presenilin 20.359
Rb1retinoblastoma 10.322
Ncstnnicastrin0.294
Mdm2transformed mouse 3T3 cell double minute 20.287
Tnfrsf22tumor necrosis factor receptor superfamily, member 220.265
Ctnnb1catenin (cadherin associated protein), beta 10.260
Esr1estrogen receptor 1 (alpha)0.242
Stat3signal transducer and activator of transcription 30.239
Ptenphosphatase and tensin homolog0.212
FasFas (TNF receptor superfamily member 6)0.175
Lyz2lysozyme 20.159
Smad3MAD homolog 3 (Drosophila)0.151
Plauplasminogen activator, urokinase0.147
Nos1nitric oxide synthase 1, neuronal0.138
Fggfibrinogen gamma chain0.138
Cav1caveolin 1, caveolae protein0.127
BrafBraf transforming gene0.123
Runx1runt related transcription factor 10.116
Tnfrsf23tumor necrosis factor receptor superfamily, member 230.109
Csf1colony stimulating factor 1 (macrophage)0.096
Itchitchy, E3 ubiquitin protein ligase0.092
Fgfr1fibroblast growth factor receptor 10.091
Cdkn1bcyclin-dependent kinase inhibitor 1B0.090
Plaurplasminogen activator, urokinase receptor0.080
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.079
Appamyloid beta (A4) precursor protein0.074
Hif1ahypoxia inducible factor 1, alpha subunit0.074
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.074
Ptmaprothymosin alpha0.069
Il6interleukin 60.069
Trp73transformation related protein 730.068
Tlr4toll-like receptor 40.063
Il4rainterleukin 4 receptor, alpha0.060
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.060
Vhlvon Hippel-Lindau tumor suppressor0.059
Ambpalpha 1 microglobulin/bikunin0.057
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.056
Pvrpoliovirus receptor0.055
Kitkit oncogene0.053
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.052
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.051
Loxlysyl oxidase0.045
Vangl2vang-like 2 (van gogh, Drosophila)0.042
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.041
Itga5integrin alpha 5 (fibronectin receptor alpha)0.041
F2coagulation factor II0.040
Il6stinterleukin 6 signal transducer0.035
Slc12a4solute carrier family 12, member 40.035
St3gal1ST3 beta-galactoside alpha-2,3-sialyltransferase 10.035
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.034
Cficomplement component factor i0.034
Brca2breast cancer 20.034
Ikbkbinhibitor of kappaB kinase beta0.034
Tgfb1transforming growth factor, beta 10.033
Lifleukemia inhibitory factor0.030
Ptpn11protein tyrosine phosphatase, non-receptor type 110.029
Cxcl1chemokine (C-X-C motif) ligand 10.029
Traf6TNF receptor-associated factor 60.029
Erlin2ER lipid raft associated 20.029
Nf1neurofibromatosis 10.028
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.028
Cxcl2chemokine (C-X-C motif) ligand 20.028
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.028
Snai1snail homolog 1 (Drosophila)0.028
Myd88myeloid differentiation primary response gene 880.026
LitafLPS-induced TN factor0.026
Itgb3integrin beta 30.026
Timp1tissue inhibitor of metalloproteinase 10.026
Osmroncostatin M receptor0.026
Msh2mutS homolog 2 (E. coli)0.025
Apoa1apolipoprotein A-I0.025
Tgm2transglutaminase 2, C polypeptide0.025
Cyr61cysteine rich protein 610.024
Il10interleukin 100.024
Zfp36zinc finger protein 360.024
Admadrenomedullin0.023
Qsox1quiescin Q6 sulfhydryl oxidase 10.022
Nbnnibrin0.021
Tlr2toll-like receptor 20.021
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.020
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.020
Leprleptin receptor0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
h2afvlH2A histone family, member V, like0.287
hmgb2ahigh-mobility group box 2a0.243
hmgb3ahigh-mobility group box 3a0.090
gata6GATA-binding protein 60.077
zgc:158409zgc:1584090.047
LOC100002342carboxypeptidase A6-like0.026
btybloodthirsty0.023
pcdh18bprotocadherin 18b0.023
hmga1ahigh mobility group AT-hook 1a0.022
foxf1forkhead box F10.018
scrt1ascratch homolog 1, zinc finger protein a (Drosophila)0.018
fggfibrinogen, gamma polypeptide0.017
elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.017
foxp1bforkhead box P1b0.017
morf4l1mortality factor 4 like 10.016
zgc:77155zgc:771550.016
hgfbhepatocyte growth factor b0.016
fgbfibrinogen, B beta polypeptide0.015
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.014
cx32.3connexin 32.30.014
bhlhe41basic helix-loop-helix family, member e410.014
cfl2lcofilin 2, like0.014
notum3notum 30.014
h3f3aH3 histone, family 3A0.013
cox5abcytochrome c oxidase subunit Vab0.013
olig4oligodendrocyte transcription factor 40.013
zff9zinc finger protein 90.013
vat1vesicle amine transport protein 1 homolog (T californica)0.012
kitbkit receptor b0.012
zgc:110540zgc:1105400.011
wu:fb58e05wu:fb58e050.011
cpceruloplasmin0.011
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
TEKTEK tyrosine kinase, endothelial0.988
FGAfibrinogen alpha chain0.942
CASP10caspase 10, apoptosis-related cysteine peptidase0.933
FADDFas (TNFRSF6)-associated via death domain0.902
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.823
FASFas (TNF receptor superfamily, member 6)0.821
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.788
FGBfibrinogen beta chain0.733
PLAUplasminogen activator, urokinase0.619
MAPK1mitogen-activated protein kinase 10.609
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.583
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.475
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.458
MAP2K1mitogen-activated protein kinase kinase 10.343
FGGfibrinogen gamma chain0.267
FTLferritin, light polypeptide0.170
CRPC-reactive protein, pentraxin-related0.165
PLAURplasminogen activator, urokinase receptor0.161
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.138
TRAF6TNF receptor-associated factor 60.116
SQSTM1sequestosome 10.114
MDM4Mdm4 p53 binding protein homolog (mouse)0.089
METmet proto-oncogene (hepatocyte growth factor receptor)0.088
PLATplasminogen activator, tissue0.085
TRAF1TNF receptor-associated factor 10.081
CFLARCASP8 and FADD-like apoptosis regulator0.068
TNIP1TNFAIP3 interacting protein 10.062
FASLGFas ligand (TNF superfamily, member 6)0.057
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.056
FHL2four and a half LIM domains 20.055
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.050
ANGPT2angiopoietin 20.050
MDM2Mdm2 p53 binding protein homolog (mouse)0.050
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.048
IRAK2interleukin-1 receptor-associated kinase 20.044
SPHK1sphingosine kinase 10.043
KLF5Kruppel-like factor 5 (intestinal)0.040
MAPK3mitogen-activated protein kinase 30.039
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.036
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.036
DAXXdeath-domain associated protein0.034
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.033
CIB1calcium and integrin binding 1 (calmyrin)0.032
BIRC3baculoviral IAP repeat containing 30.031
DUSP3dual specificity phosphatase 30.030
TNIP2TNFAIP3 interacting protein 20.029
PSEN1presenilin 10.028
ANGPT1angiopoietin 10.026
OSMRoncostatin M receptor0.025
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.024
ORM1orosomucoid 10.023
LRP1low density lipoprotein receptor-related protein 10.023
IL8interleukin 80.022
PTPRJprotein tyrosine phosphatase, receptor type, J0.022
SOD1superoxide dismutase 1, soluble0.022
PEBP4phosphatidylethanolamine-binding protein 40.021
OAZ1ornithine decarboxylase antizyme 10.021
HMGB1high mobility group box 10.020
ATXN3ataxin 30.020
IFNGR2interferon gamma receptor 2 (interferon gamma transducer 1)0.019
XIAPX-linked inhibitor of apoptosis0.019
CD44CD44 molecule (Indian blood group)0.019
ICAM1intercellular adhesion molecule 10.019
IRF1interferon regulatory factor 10.019
ADMadrenomedullin0.019
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.017
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14A0.017
DUSP1dual specificity phosphatase 10.017
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.017
CASP8AP2caspase 8 associated protein 20.017
F2coagulation factor II (thrombin)0.016
OPTNoptineurin0.016
BADBCL2-associated agonist of cell death0.016
BCL2L11BCL2-like 11 (apoptosis facilitator)0.016
ARandrogen receptor0.016
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.015
RBBP8retinoblastoma binding protein 80.015
TNFtumor necrosis factor0.014
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.014
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.014
SH3KBP1SH3-domain kinase binding protein 10.013
FTH1ferritin, heavy polypeptide 10.013
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.013
BCL2L1BCL2-like 10.013
PEBP1phosphatidylethanolamine binding protein 10.012
BAG1BCL2-associated athanogene0.012
STC1stanniocalcin 10.012
TIMP1TIMP metallopeptidase inhibitor 10.011
HMGN2high mobility group nucleosomal binding domain 20.011
ITGA7integrin, alpha 70.011
ITGB5integrin, beta 50.011
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.011
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.011
SOD2superoxide dismutase 2, mitochondrial0.011
EMP3epithelial membrane protein 30.011
IL6interleukin 6 (interferon, beta 2)0.011
SRIsorcin0.010
TRAF3TNF receptor-associated factor 30.010
TRADDTNFRSF1A-associated via death domain0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism