The network for 'mitochondrial genome maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitochondrial genome maintenance

The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.

NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.903
Trp53transformation related protein 530.327
Hdac4histone deacetylase 40.280
Mef2cmyocyte enhancer factor 2C0.141
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.124
Mef2dmyocyte enhancer factor 2D0.070
Rb1retinoblastoma 10.059
Hdac5histone deacetylase 50.057
Ulk1Unc-51 like kinase 1 (C. elegans)0.055
Esr1estrogen receptor 1 (alpha)0.051
Apcadenomatosis polyposis coli0.040
Terf1telomeric repeat binding factor 10.039
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.039
Sqstm1sequestosome 10.038
Qkquaking0.037
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.034
Ncoa3nuclear receptor coactivator 30.034
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.033
Txndc16thioredoxin domain containing 160.030
Hmgb2high mobility group box 20.028
Mdm2transformed mouse 3T3 cell double minute 20.028
Fnip1folliculin interacting protein 10.026
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.026
Ubl3ubiquitin-like 30.025
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.024
Dhx16DEAH (Asp-Glu-Ala-His) box polypeptide 160.023
Xpr1xenotropic and polytropic retrovirus receptor 10.023
Spnb2spectrin beta 20.023
Mdm4transformed mouse 3T3 cell double minute 40.023
Smn1survival motor neuron 10.022
Hmbshydroxymethylbilane synthase0.022
Skp2S-phase kinase-associated protein 2 (p45)0.021
Brca1breast cancer 10.020
Hellshelicase, lymphoid specific0.020
Pwp2PWP2 periodic tryptophan protein homolog (yeast)0.020
Klhl24kelch-like 24 (Drosophila)0.020
Zmynd11zinc finger, MYND domain containing 110.020
Wdr55WD repeat domain 550.020
Bcl2B-cell leukemia/lymphoma 20.019
Ppanpeter pan homolog (Drosophila)0.019
Zeb2zinc finger E-box binding homeobox 20.018
Kif1bkinesin family member 1B0.017
Emx1empty spiracles homolog 1 (Drosophila)0.017
Parlpresenilin associated, rhomboid-like0.017
Sesn1sestrin 10.016
Xpcxeroderma pigmentosum, complementation group C0.016
Trpc2transient receptor potential cation channel, subfamily C, member 20.016
Htatip2HIV-1 tat interactive protein 2, homolog (human)0.015
Ppargperoxisome proliferator activated receptor gamma0.015
Nr1d2nuclear receptor subfamily 1, group D, member 20.015
Pitpnc1phosphatidylinositol transfer protein, cytoplasmic 10.015
Brca2breast cancer 20.014
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.014
A930001N09RikRIKEN cDNA A930001N09 gene0.014
Sos2son of sevenless homolog 2 (Drosophila)0.014
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.014
Mef2amyocyte enhancer factor 2A0.014
Mrps2mitochondrial ribosomal protein S20.013
Ikbkginhibitor of kappaB kinase gamma0.013
Cdx2caudal type homeobox 20.013
Rtn4ip1reticulon 4 interacting protein 10.013
Myo5amyosin VA0.013
Hdac9histone deacetylase 90.013
Ulk2Unc-51 like kinase 2 (C. elegans)0.013
Irf6interferon regulatory factor 60.013
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.013
Npc1Niemann Pick type C10.013
Cdca7cell division cycle associated 70.013
Hspa9heat shock protein 90.012
Klf7Kruppel-like factor 7 (ubiquitous)0.012
Iqcb1IQ calmodulin-binding motif containing 10.012
Ate1arginyltransferase 10.012
Inpp5kinositol polyphosphate 5-phosphatase K0.012
Pptc7PTC7 protein phosphatase homolog (S. cerevisiae)0.012
Hhathedgehog acyltransferase0.012
Mecp2methyl CpG binding protein 20.012
Fam134bfamily with sequence similarity 134, member B0.012
Ccdc137coiled-coil domain containing 1370.012
Lims1LIM and senescent cell antigen-like domains 10.012
Rbl1retinoblastoma-like 1 (p107)0.012
Fbxo31F-box protein 310.012
Huwe1HECT, UBA and WWE domain containing 10.011
Ncoa1nuclear receptor coactivator 10.011
Aktipthymoma viral proto-oncogene 1 interacting protein0.011
Dtldenticleless homolog (Drosophila)0.011
Cpeb2cytoplasmic polyadenylation element binding protein 20.011
Zfp187zinc finger protein 1870.011
Gucy1a3guanylate cyclase 1, soluble, alpha 30.011
Mycmyelocytomatosis oncogene0.011
Sfnstratifin0.011
Uqccubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog (yeast)0.011
Hivep2human immunodeficiency virus type I enhancer binding protein 20.011
Mbnl1muscleblind-like 1 (Drosophila)0.011
Tars2threonyl-tRNA synthetase 2, mitochondrial (putative)0.010
BrafBraf transforming gene0.010
Setdb1SET domain, bifurcated 10.010
Rnmtl1RNA methyltransferase like 10.010
Dcp1aDCP1 decapping enzyme homolog A (S. cerevisiae)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
guk-1Protein GUK-10.018
dna-2Protein DNA-20.017
ruvb-2Protein RUVB-20.014
ent-5Protein ENT-50.013
cee-1Protein CEE-10.012
C56G2.7Protein C56G2.70.010
mrp-4Protein MRP-40.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PSMB6proteasome (prosome, macropain) subunit, beta type, 60.019
KIF23kinesin family member 230.014
USP1ubiquitin specific peptidase 10.014
MCM4minichromosome maintenance complex component 40.013
CENPFcentromere protein F, 350/400kDa (mitosin)0.012
MELKmaternal embryonic leucine zipper kinase0.012
HMMRhyaluronan-mediated motility receptor (RHAMM)0.011
FBLfibrillarin0.011
ADRM1adhesion regulating molecule 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TIM23Tim23p0.328
GEP3Gep3p0.300
DNM1Dnm1p0.246
TIM44Tim44p0.245
YTA12Yta12p0.223
FCJ1Fcj1p0.217
HMI1Hmi1p0.181
RRG8Rrg8p0.174
MRPL20Mrpl20p0.168
RRG1Rrg1p0.162
FIS1Fis1p0.157
MRS2Mrs2p0.128
PIF1Pif1p0.125
CCM1Ccm1p0.114
LEU2Leu2p0.113
NUM1Num1p0.112
AIM34Aim34p0.111
MDJ1Mdj1p0.106
ERG10Erg10p0.105
IRC19Irc19p0.097
ACH1Ach1p0.096
RNR3Rnr3p0.095
AFG3Afg3p0.089
UBC13Ubc13p0.088
GDH1Gdh1p0.082
MDM38Mdm38p0.077
MSH1Msh1p0.077
IMG1Img1p0.076
OCT1Oct1p0.073
IDP1Idp1p0.071
MGM1Mgm1p0.070
IFM1Ifm1p0.069
MDM32Mdm32p0.065
APN1Apn1p0.063
PET309Pet309p0.062
SLS1Sls1p0.061
MEF2Mef2p0.060
MTG2Mtg2p0.059
AIM22Aim22p0.059
MRS3Mrs3p0.057
KDX1Kdx1p0.057
YME1Yme1p0.053
TOS4Tos4p0.053
CNB1Cnb1p0.052
MDH1Mdh1p0.052
SKG6Skg6p0.051
AHA1Aha1p0.051
CYC3Cyc3p0.051
GLG2Glg2p0.050
MDM10Mdm10p0.050
MRPL16Mrpl16p0.049
RAD14Rad14p0.049
UPS2Ups2p0.048
MIP1Mip1p0.047
YHR080Chypothetical protein0.046
OLI1F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP20.046
SUV3Suv3p0.045
GUT2Gut2p0.044
OAC1Oac1p0.043
MGM101Mgm101p0.041
AEP1Aep1p0.040
ADH2Adh2p0.040
COQ1Coq1p0.040
MSS116Mss116p0.040
PMP2Pmp2p0.040
MRC1Mrc1p0.039
FZO1Fzo1p0.039
RPL2BRpl2bp0.039
KCS1Kcs1p0.038
PST1Pst1p0.038
ARP10Arp10p0.038
MSG5Msg5p0.038
SWI1Swi1p0.037
AIM38Aim38p0.037
ICS2Ics2p0.037
UPS3Ups3p0.037
CCW14Ccw14p0.036
UGO1Ugo1p0.036
YLR419Whypothetical protein0.036
APN2Apn2p0.036
LYS9Lys9p0.036
RSM22Rsm22p0.035
NST1Nst1p0.035
FMP30Fmp30p0.035
ASN1Asn1p0.035
GEP5Gep5p0.034
YLR264C-Ahypothetical protein0.034
VPS9Vps9p0.034
MSR1Msr1p0.034
YER121Whypothetical protein0.034
TOM5Tom5p0.033
SRD1Srd1p0.033
YGR205Whypothetical protein0.033
CEM1Cem1p0.033
ALG11Alg11p0.033
YNL234Whypothetical protein0.033
YER039C-Ahypothetical protein0.033
YLR253Whypothetical protein0.033
ILV3Ilv3p0.032
HSP150Hsp150p0.032