The network for 'histone h3 k4 trimethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone h3 k4 trimethylation

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

NameDescriptionProbabilityFunc Analog Organism
Arid4bAT rich interactive domain 4B (RBP1-like)0.989
Arid1aAT rich interactive domain 1A (SWI-like)0.731
RictorRPTOR independent companion of MTOR, complex 20.636
Ccnt2cyclin T20.531
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.501
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.442
Sfrs18serine/arginine-rich splicing factor 180.383
Zmym2zinc finger, MYM-type 20.360
Fnbp4formin binding protein 40.226
Sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.221
Ptenphosphatase and tensin homolog0.198
Rbm5RNA binding motif protein 50.170
Zfp445zinc finger protein 4450.160
Clk1CDC-like kinase 10.156
Arid4aAT rich interactive domain 4A (RBP1-like)0.137
Fam48afamily with sequence similarity 48, member A0.132
NipblNipped-B homolog (Drosophila)0.110
Fam193bfamily with sequence similarity 193, member B0.110
CrebzfCREB/ATF bZIP transcription factor0.109
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.106
Chd2chromodomain helicase DNA binding protein 20.103
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.103
Ttc14tetratricopeptide repeat domain 140.102
Zmym5zinc finger, MYM-type 50.101
Usp9xubiquitin specific peptidase 9, X chromosome0.099
Ncbp2nuclear cap binding protein subunit 20.096
Rsf1remodeling and spacing factor 10.096
Msl1male-specific lethal 1 homolog (Drosophila)0.096
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.094
Ankrd16ankyrin repeat domain 160.081
Tet2tet oncogene family member 20.080
Zfc3h1zinc finger, C3H1-type containing0.079
Nktrnatural killer tumor recognition sequence0.076
Brwd1bromodomain and WD repeat domain containing 10.071
CrebbpCREB binding protein0.069
Clk4CDC like kinase 40.068
Mysm1myb-like, SWIRM and MPN domains 10.067
Tnrc6ctrinucleotide repeat containing 6C0.065
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.063
Rerearginine glutamic acid dipeptide (RE) repeats0.061
BrafBraf transforming gene0.056
A430102J17RikRIKEN cDNA A430102J17 gene0.055
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.053
4921513D23RikRIKEN cDNA 4921513D23 gene0.051
Macf1microtubule-actin crosslinking factor 10.050
BC018507cDNA sequence BC0185070.050
Smg1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)0.049
2810046L04RikRIKEN cDNA 2810046L04 gene0.049
Rapgef6Rap guanine nucleotide exchange factor (GEF) 60.049
Mbtd1mbt domain containing 10.049
Tia1cytotoxic granule-associated RNA binding protein 10.046
Phf21aPHD finger protein 21A0.044
Ep300E1A binding protein p3000.043
Tnrc6btrinucleotide repeat containing 6b0.043
1700081L11RikRIKEN cDNA 1700081L11 gene0.041
Ccnl2cyclin L20.039
Clk2CDC-like kinase 20.038
Fam76bfamily with sequence similarity 76, member B0.038
Ylpm1YLP motif containing 10.038
Ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.037
Rfx7regulatory factor X, 70.037
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.035
Rnf44ring finger protein 440.034
Dmtf1cyclin D binding myb-like transcription factor 10.034
Mapk8mitogen-activated protein kinase 80.031
SonSon DNA binding protein0.030
Zcchc11zinc finger, CCHC domain containing 110.029
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.028
Ythdf1YTH domain family 10.027
Atf2activating transcription factor 20.027
Akt3thymoma viral proto-oncogene 30.027
Leng8leukocyte receptor cluster (LRC) member 80.027
Tnrc6atrinucleotide repeat containing 6a0.026
SpenSPEN homolog, transcriptional regulator (Drosophila)0.026
Med13lmediator complex subunit 13-like0.025
Wbp7WW domain binding protein 70.025
Zfmlzinc finger, matrin-like0.024
Hdac2histone deacetylase 20.024
Brd8bromodomain containing 80.024
Med12mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)0.023
Top2btopoisomerase (DNA) II beta0.023
0610009D07RikRIKEN cDNA 0610009D07 gene0.023
Prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.022
Klhl24kelch-like 24 (Drosophila)0.022
Zfp740zinc finger protein 7400.022
Trim39tripartite motif-containing 390.022
Pik3c3phosphoinositide-3-kinase, class 30.022
Atmataxia telangiectasia mutated homolog (human)0.021
Sin3atranscriptional regulator, SIN3A (yeast)0.021
Zfp292zinc finger protein 2920.020
Phf12PHD finger protein 120.020
Casc3cancer susceptibility candidate 30.020
Ankrd12ankyrin repeat domain 120.020
Hcfc1host cell factor C10.020
Ubp1upstream binding protein 10.019
Zfp329zinc finger protein 3290.019
Fbxl3F-box and leucine-rich repeat protein 30.019
Senp7SUMO1/sentrin specific peptidase 70.019
Lime1Lck interacting transmembrane adaptor 10.018
Ccnt1cyclin T10.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cec-3Protein CEC-30.017
F41G3.6Protein F41G3.60.015
mom-2Protein MOM-20.013
rnr-2Protein RNR-20.013
patr-1Protein PATR-10.012
bath-42Protein BATH-420.011
C35D10.7Protein C35D10.70.011
CELE_C08F8.3Protein C08F8.30.010
F10E9.3Protein F10E9.30.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
WDR5WD repeat domain 50.991
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.876
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.400
RBBP5retinoblastoma binding protein 50.316
HCFC1host cell factor C1 (VP16-accessory protein)0.199
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.199
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.177
MEN1multiple endocrine neoplasia I0.142
CXXC1CXXC finger protein 10.042
MYST1MYST histone acetyltransferase 10.038
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.036
CHD8chromodomain helicase DNA binding protein 80.034
MLL2myeloid/lymphoid or mixed-lineage leukemia 20.021
SETD1ASET domain containing 1A0.016
AFF1AF4/FMR2 family, member 10.013
HCFC2host cell factor C20.013
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.012
AFF4AF4/FMR2 family, member 40.011
NCOA6nuclear receptor coactivator 60.011
HIST1H3Bhistone cluster 1, H3b0.011
MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SDC1Sdc1p0.765
SET1Set1p0.659
SWD3Swd3p0.566
SWD1Swd1p0.344
SHG1Shg1p0.171
BRE2Bre2p0.113
RTF1Rtf1p0.091
SPP1Spp1p0.079
SET2Set2p0.056
PTI1Pti1p0.048
CTR9Ctr9p0.042
SRD1Srd1p0.031
LEU2Leu2p0.029
YLR264C-Ahypothetical protein0.026
POB3Pob3p0.024
YLR162Whypothetical protein0.024
MER1Mer1p0.023
YOL038C-Ahypothetical protein0.023
ARP10Arp10p0.020
HXT3Hxt3p0.020
YLR042Chypothetical protein0.019
YAR068Whypothetical protein0.019
ARG8Arg8p0.018
YPR157Whypothetical protein0.018
BAT2Bat2p0.018
TFA1Tfa1p0.017
ATP6Atp6p0.017
CUP1-1Cup1-1p0.017
ZPS1Zps1p0.016
AUA1Aua1p0.016
PRS2Prs2p0.015
FMT1Fmt1p0.015
YBR013Chypothetical protein0.015
YIL151Chypothetical protein0.015
URA3Ura3p0.015
YIR035Chypothetical protein0.014
HOHop0.014
PAF1Paf1p0.014
OPT2Opt2p0.014
HPF1Hpf1p0.014
BSC1Bsc1p0.014
YJL181Whypothetical protein0.014
IZH4Izh4p0.014
YLR040Chypothetical protein0.014
WWM1Wwm1p0.014
SCM4Scm4p0.014
CHA1Cha1p0.014
SPL2Spl2p0.013
TYE7Tye7p0.013
DIC1Dic1p0.013
YOL013W-Ahypothetical protein0.013
ADH2Adh2p0.013
YAR066Whypothetical protein0.013
YPR096Chypothetical protein0.013
RKR1Rkr1p0.013
MF(ALPHA)2Mf(alpha)2p0.012
ARR2Arr2p0.012
COS12Cos12p0.012
YKR075Chypothetical protein0.012
RRN5Rrn5p0.012
YAL037C-Ahypothetical protein0.012
SWC7Swc7p0.012
BNA4Bna4p0.011
CPD1Cpd1p0.011
YAL064Whypothetical protein0.011
MET8Met8p0.011
YPL067Chypothetical protein0.011
ALT2Alt2p0.011
CRP1Crp1p0.011
YDR222Whypothetical protein0.010
UPS3Ups3p0.010
YNL058Chypothetical protein0.010
YGL006W-Ahypothetical protein0.010
NRG2Nrg2p0.010
RNP1Rnp1p0.010