The network for 'male germ line stem cell asymmetric division' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

male germ line stem cell asymmetric division

The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.

NameDescriptionProbabilityFunc Analog Organism
Irs2insulin receptor substrate 20.937
Grb10growth factor receptor bound protein 100.886
Insrinsulin receptor0.874
Ghrgrowth hormone receptor0.533
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.236
Hrh1histamine receptor H10.170
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.156
Irs1insulin receptor substrate 10.142
Igf2rinsulin-like growth factor 2 receptor0.136
Zfp592zinc finger protein 5920.135
Kiss1KiSS-1 metastasis-suppressor0.134
Cdkn1bcyclin-dependent kinase inhibitor 1B0.117
Nedd4neural precursor cell expressed, developmentally down-regulated 40.083
Igf2insulin-like growth factor 20.071
Ins2insulin II0.068
Cav1caveolin 1, caveolae protein0.061
Piwil2piwi-like homolog 2 (Drosophila)0.060
Lipelipase, hormone sensitive0.058
Pnpla2patatin-like phospholipase domain containing 20.055
Drd2dopamine receptor D20.050
Sik3SIK family kinase 30.044
Ppargperoxisome proliferator activated receptor gamma0.042
Mark2MAP/microtubule affinity-regulating kinase 20.042
Thrathyroid hormone receptor alpha0.042
Tsxtestis specific X-linked gene0.040
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.039
Ptpn14protein tyrosine phosphatase, non-receptor type 140.039
Esr1estrogen receptor 1 (alpha)0.032
Tex14testis expressed gene 140.031
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.031
Arandrogen receptor0.031
Kiss1rKISS1 receptor0.030
Igf1rinsulin-like growth factor I receptor0.030
Lepleptin0.030
Klf13Kruppel-like factor 130.028
Eif2c2eukaryotic translation initiation factor 2C, 20.028
Tcam1testicular cell adhesion molecule 10.027
Neo1neogenin0.025
Dscaml1Down syndrome cell adhesion molecule-like 10.024
Foxf1aforkhead box F1a0.024
Hoxa13homeobox A130.023
Map3k6mitogen-activated protein kinase kinase kinase 60.022
RestRE1-silencing transcription factor0.022
Zfhx3zinc finger homeobox 30.021
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.021
Il12rb1interleukin 12 receptor, beta 10.021
Brd4bromodomain containing 40.020
Med13lmediator complex subunit 13-like0.020
Sim1single-minded homolog 1 (Drosophila)0.020
Maelmaelstrom homolog (Drosophila)0.020
Hoxa10homeobox A100.020
Tcf23transcription factor 230.019
Irf2bp2interferon regulatory factor 2 binding protein 20.019
Cdh23cadherin 23 (otocadherin)0.019
Adipoqadiponectin, C1Q and collagen domain containing0.018
Nr1h4nuclear receptor subfamily 1, group H, member 40.018
Amhr2anti-Mullerian hormone type 2 receptor0.017
Nos3nitric oxide synthase 3, endothelial cell0.017
Amdhd1amidohydrolase domain containing 10.017
H1f0H1 histone family, member 00.017
Pcsk5proprotein convertase subtilisin/kexin type 50.017
Plin4perilipin 40.016
Wwc2WW, C2 and coiled-coil domain containing 20.015
Klf7Kruppel-like factor 7 (ubiquitous)0.015
Wfikkn1WAP, FS, Ig, KU, and NTR-containing protein 10.015
Npc1Niemann Pick type C10.015
Fgf21fibroblast growth factor 210.014
Trp53bp2transformation related protein 53 binding protein 20.014
Fabp9fatty acid binding protein 9, testis0.013
Nhlh2nescient helix loop helix 20.013
Defb3defensin beta 30.013
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.013
Igf2bp2insulin-like growth factor 2 mRNA binding protein 20.013
Rsph6aradial spoke head 6 homolog A (Chlamydomonas)0.013
Smc1bstructural maintenance of chromosomes 1B0.013
Per1period homolog 1 (Drosophila)0.013
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.012
Lhx3LIM homeobox protein 30.012
Enahenabled homolog (Drosophila)0.012
Angpt4angiopoietin 40.012
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.012
Lpin1lipin 10.012
Nfianuclear factor I/A0.011
Tnfrsf13ctumor necrosis factor receptor superfamily, member 13c0.011
4933407C03RikRIKEN cDNA 4933407C03 gene0.011
Fzd4frizzled homolog 4 (Drosophila)0.011
Klf3Kruppel-like factor 3 (basic)0.011
Zbtb7azinc finger and BTB domain containing 7a0.011
Hoxd11homeobox D110.011
Prok2prokineticin 20.011
Tcfl5transcription factor-like 5 (basic helix-loop-helix)0.011
Sorbs1sorbin and SH3 domain containing 10.011
Rhox6reproductive homeobox 60.011
Ellelongation factor RNA polymerase II0.011
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.011
Krtcap3keratinocyte associated protein 30.011
Adcy9adenylate cyclase 90.011
H1fntH1 histone family, member N, testis-specific0.011
Klhl10kelch-like 10 (Drosophila)0.011
Pim3proviral integration site 30.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Elk3ELK3, ETS-domain protein0.098
Gucy1b3guanylate cyclase 1, soluble, beta 30.081
Insrinsulin receptor0.068
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.065
A1cfAPOBEC1 complementation factor0.062
Pax8paired box 80.042
Flt1FMS-related tyrosine kinase 10.037
Dlg4discs, large homolog 4 (Drosophila)0.034
Chrm2cholinergic receptor, muscarinic 20.034
Rararetinoic acid receptor, alpha0.027
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.026
Calcrlcalcitonin receptor-like0.025
Slc14a2solute carrier family 14 (urea transporter), member 20.025
Lhbluteinizing hormone beta0.025
Cyyr1cysteine/tyrosine-rich 10.023
Wipf1WAS/WASL interacting protein family, member 10.023
Unc5bunc-5 homolog B (C. elegans)0.022
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.021
Lamc1laminin, gamma 10.019
Timp3TIMP metallopeptidase inhibitor 30.019
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.018
Lims1LIM and senescent cell antigen-like domains 10.018
Nf1neurofibromin 10.018
Brunol4bruno-like 4, RNA binding protein (Drosophila)0.017
Ddr1discoidin domain receptor tyrosine kinase 10.015
Pla2g3phospholipase A2, group III0.015
Grb2growth factor receptor bound protein 20.015
Jak2Janus kinase 20.015
Piglphosphatidylinositol glycan anchor biosynthesis, class L0.015
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.014
Gabra6gamma-aminobutyric acid (GABA) A receptor, alpha 60.014
Marcksmyristoylated alanine rich protein kinase C substrate0.013
Casq2calsequestrin 2 (cardiac muscle)0.013
Rasgrp3RAS guanyl releasing protein 3 (calcium and DAG-regulated)0.012
Olr1361olfactory receptor 13610.012
Bcl2B-cell CLL/lymphoma 20.012
Nkx6-1NK6 homeobox 10.012
Abcc9ATP-binding cassette, subfamily C (CFTR/MRP), member 90.012
Stc1stanniocalcin 10.012
Krt33bkeratin 33B0.011
Pigmphosphatidylinositol glycan anchor biosynthesis, class M0.011
Agtr2angiotensin II receptor, type 20.011
RGD1562291similar to Human T-cell leukemia virus enhancer factor (Forkhead box protein N2)0.011
Thbdthrombomodulin0.011
Emp1epithelial membrane protein 10.011
Itpr1inositol 1,4,5-triphosphate receptor, type 10.011
Leprleptin receptor0.010
Irs2insulin receptor substrate 20.010
Acvr1activin A receptor, type I0.010
Kremen1kringle containing transmembrane protein 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism