The network for 'positive regulation of plasminogen activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of plasminogen activation

Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.

NameDescriptionProbabilityFunc Analog Organism
Itih1inter-alpha trypsin inhibitor, heavy chain 10.650
Cldn3claudin 30.532
Asgr2asialoglycoprotein receptor 20.487
Ambpalpha 1 microglobulin/bikunin0.440
F2coagulation factor II0.363
Apoa1apolipoprotein A-I0.292
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.251
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.225
Akr1c6aldo-keto reductase family 1, member C60.170
Pzppregnancy zone protein0.168
Hchemolytic complement0.155
Ageradvanced glycosylation end product-specific receptor0.149
Prodh2proline dehydrogenase (oxidase) 20.145
Clic3chloride intracellular channel 30.141
Ces1ccarboxylesterase 1C0.130
Itih4inter alpha-trypsin inhibitor, heavy chain 40.121
Lipclipase, hepatic0.120
Cpn1carboxypeptidase N, polypeptide 10.112
Agxtalanine-glyoxylate aminotransferase0.108
Kng1kininogen 10.100
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.099
Mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.096
BikBCL2-interacting killer0.091
Foxa2forkhead box A20.086
Cficomplement component factor i0.085
Fgfr4fibroblast growth factor receptor 40.082
F13bcoagulation factor XIII, beta subunit0.072
Fxyd1FXYD domain-containing ion transport regulator 10.071
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.070
H1fooH1 histone family, member O, oocyte-specific0.070
Col13a1collagen, type XIII, alpha 10.066
Tff2trefoil factor 2 (spasmolytic protein 1)0.065
Mat1amethionine adenosyltransferase I, alpha0.065
Apoc4apolipoprotein C-IV0.061
Asgr1asialoglycoprotein receptor 10.060
Igfbp6insulin-like growth factor binding protein 60.059
Pcdh12protocadherin 120.057
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.053
Gm6484predicted gene 64840.053
Tnxbtenascin XB0.052
Nr1i3nuclear receptor subfamily 1, group I, member 30.052
Ttc36tetratricopeptide repeat domain 360.052
Cpn2carboxypeptidase N, polypeptide 20.052
Procprotein C0.051
Gcgroup specific component0.051
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.050
Snx2sorting nexin 20.050
Slc22a1solute carrier family 22 (organic cation transporter), member 10.049
F12coagulation factor XII (Hageman factor)0.045
Apofapolipoprotein F0.043
Krt79keratin 790.043
Apohapolipoprotein H0.042
Csrp3cysteine and glycine-rich protein 30.042
Itih2inter-alpha trypsin inhibitor, heavy chain 20.041
Inhbeinhibin beta E0.041
Pluncpalate, lung, and nasal epithelium associated0.041
Apoa5apolipoprotein A-V0.041
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.036
Hgdhomogentisate 1, 2-dioxygenase0.036
Tekt2tektin 20.035
U46068cDNA sequence U460680.035
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.034
1300017J02RikRIKEN cDNA 1300017J02 gene0.034
Mfap5microfibrillar associated protein 50.033
C4bpcomplement component 4 binding protein0.033
NmiN-myc (and STAT) interactor0.033
Gjb1gap junction protein, beta 10.032
Fggfibrinogen gamma chain0.032
Mt4metallothionein 40.032
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.032
Hamphepcidin antimicrobial peptide0.032
Wnt5bwingless-related MMTV integration site 5B0.031
Cldn7claudin 70.031
Sdslserine dehydratase-like0.031
C9complement component 90.030
Cnn1calponin 10.030
Apomapolipoprotein M0.030
Wfdc2WAP four-disulfide core domain 20.030
Fabp1fatty acid binding protein 1, liver0.029
Rdh7retinol dehydrogenase 70.029
Fgbfibrinogen beta chain0.028
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.027
Prozprotein Z, vitamin K-dependent plasma glycoprotein0.027
Mug2murinoglobulin 20.026
Foxa1forkhead box A10.026
Ccbp2chemokine binding protein 20.026
Fut2fucosyltransferase 20.026
AU021092expressed sequence AU0210920.026
Sftpbsurfactant associated protein B0.026
Amdhd1amidohydrolase domain containing 10.025
Habp2hyaluronic acid binding protein 20.025
Gja4gap junction protein, alpha 40.025
Aadataminoadipate aminotransferase0.025
Apoa4apolipoprotein A-IV0.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11.000
PLAURplasminogen activator, urokinase receptor0.895
METmet proto-oncogene (hepatocyte growth factor receptor)0.721
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.447
APOHapolipoprotein H (beta-2-glycoprotein I)0.285
KNG1kininogen 10.259
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.158
PIGRpolymeric immunoglobulin receptor0.110
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.110
ORM1orosomucoid 10.083
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.081
WFDC2WAP four-disulfide core domain 20.075
ICAM1intercellular adhesion molecule 10.070
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.069
FGBfibrinogen beta chain0.069
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.068
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.062
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.055
STC1stanniocalcin 10.052
IL8interleukin 80.050
TNFAIP6tumor necrosis factor, alpha-induced protein 60.050
GJB1gap junction protein, beta 1, 32kDa0.050
SAA4serum amyloid A4, constitutive0.048
ECM1extracellular matrix protein 10.047
C4BPBcomplement component 4 binding protein, beta0.045
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.044
FOSL1FOS-like antigen 10.043
LCN2lipocalin 20.043
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.042
PRSS8protease, serine, 80.041
IGFBP3insulin-like growth factor binding protein 30.040
LAMC3laminin, gamma 30.039
MUC4mucin 4, cell surface associated0.039
TMPRSS11Dtransmembrane protease, serine 11D0.038
C8Acomplement component 8, alpha polypeptide0.036
TMPRSS2transmembrane protease, serine 20.036
RAB17RAB17, member RAS oncogene family0.036
TFR2transferrin receptor 20.035
HNF4Ahepatocyte nuclear factor 4, alpha0.035
AMBPalpha-1-microglobulin/bikunin precursor0.034
CPN1carboxypeptidase N, polypeptide 10.034
RDH16retinol dehydrogenase 16 (all-trans)0.033
FXYD3FXYD domain containing ion transport regulator 30.033
CRPC-reactive protein, pentraxin-related0.032
TFF1trefoil factor 10.031
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.031
S100A2S100 calcium binding protein A20.030
TFF3trefoil factor 3 (intestinal)0.030
SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.029
C8Gcomplement component 8, gamma polypeptide0.029
F2coagulation factor II (thrombin)0.029
AZGP1alpha-2-glycoprotein 1, zinc-binding0.029
XDHxanthine dehydrogenase0.028
GCGRglucagon receptor0.027
SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 30.027
MTA2metastasis associated 1 family, member 20.027
SPHK1sphingosine kinase 10.026
GCKRglucokinase (hexokinase 4) regulator0.026
CPA3carboxypeptidase A3 (mast cell)0.025
SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 50.025
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.025
CEACAM5carcinoembryonic antigen-related cell adhesion molecule 50.025
PDZK1IP1PDZK1 interacting protein 10.025
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.024
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.024
GPRC5AG protein-coupled receptor, family C, group 5, member A0.024
GBA3glucosidase, beta, acid 3 (cytosolic)0.023
APOBapolipoprotein B (including Ag(x) antigen)0.023
HAAO3-hydroxyanthranilate 3,4-dioxygenase0.023
LAMB3laminin, beta 30.023
SPP2secreted phosphoprotein 2, 24kDa0.022
C9complement component 90.022
IGFALSinsulin-like growth factor binding protein, acid labile subunit0.022
CPceruloplasmin (ferroxidase)0.022
CEACAM7carcinoembryonic antigen-related cell adhesion molecule 70.021
CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 10.021
PRSS22protease, serine, 220.021
TMPRSS4transmembrane protease, serine 40.020
VIL1villin 10.020
G0S2G0/G1switch 20.020
ITIH1inter-alpha (globulin) inhibitor H10.020
PON3paraoxonase 30.020
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.020
FTCDformiminotransferase cyclodeaminase0.019
APCSamyloid P component, serum0.019
LECT2leukocyte cell-derived chemotaxin 20.019
TNCtenascin C0.019
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.019
C1orf116chromosome 1 open reading frame 1160.019
DMBT1deleted in malignant brain tumors 10.019
TATtyrosine aminotransferase0.019
GPTglutamic-pyruvate transaminase (alanine aminotransferase)0.019
SLPIsecretory leukocyte peptidase inhibitor0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism