The network for 'cellular response to mechanical stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.553
Ctnnb1catenin (cadherin associated protein), beta 10.277
Runx2runt related transcription factor 20.271
Pax3paired box gene 30.183
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.137
Pax6paired box gene 60.107
FasFas (TNF receptor superfamily member 6)0.088
Tnftumor necrosis factor0.081
Col3a1collagen, type III, alpha 10.074
Ptpn11protein tyrosine phosphatase, non-receptor type 110.072
Neurod1neurogenic differentiation 10.064
Col1a2collagen, type I, alpha 20.063
Ptgs2prostaglandin-endoperoxide synthase 20.061
Lmnalamin A0.058
Col6a2collagen, type VI, alpha 20.046
Ren1renin 1 structural0.044
Vegfavascular endothelial growth factor A0.042
Otx2orthodenticle homolog 2 (Drosophila)0.041
Ascl1achaete-scute complex homolog 1 (Drosophila)0.039
Shhsonic hedgehog0.038
Nos2nitric oxide synthase 2, inducible0.038
Gdnfglial cell line derived neurotrophic factor0.037
Ptenphosphatase and tensin homolog0.033
Col5a2collagen, type V, alpha 20.033
Fgfr2fibroblast growth factor receptor 20.032
Meox2mesenchyme homeobox 20.030
Il6interleukin 60.029
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.026
Col6a1collagen, type VI, alpha 10.025
Dlx6distal-less homeobox 60.025
Tcfap2atranscription factor AP-2, alpha0.024
Foxc2forkhead box C20.024
Tlr4toll-like receptor 40.023
Isl1ISL1 transcription factor, LIM/homeodomain0.022
Prrx1paired related homeobox 10.021
Aplnrapelin receptor0.021
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.021
Col6a3collagen, type VI, alpha 30.020
Foxc1forkhead box C10.020
Msx1homeobox, msh-like 10.020
Lhx3LIM homeobox protein 30.019
Apcadenomatosis polyposis coli0.019
Gli3GLI-Kruppel family member GLI30.018
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.018
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.018
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.017
Tgfb1transforming growth factor, beta 10.017
Atoh7atonal homolog 7 (Drosophila)0.017
Smosmoothened homolog (Drosophila)0.016
MecomMDS1 and EVI1 complex locus0.016
Ror2receptor tyrosine kinase-like orphan receptor 20.016
Leprleptin receptor0.016
Mmp9matrix metallopeptidase 90.015
Prrx2paired related homeobox 20.015
Hand1heart and neural crest derivatives expressed transcript 10.015
Lyz2lysozyme 20.015
Pou4f2POU domain, class 4, transcription factor 20.014
Sparcsecreted acidic cysteine rich glycoprotein0.014
Il9rinterleukin 9 receptor0.014
Shesrc homology 2 domain-containing transforming protein E0.014
Fgf8fibroblast growth factor 80.014
Slc12a1solute carrier family 12, member 10.014
Agtr1aangiotensin II receptor, type 1a0.014
Nr5a1nuclear receptor subfamily 5, group A, member 10.013
Trp53transformation related protein 530.013
Plxnd1plexin D10.012
Prph2peripherin 20.012
Nos3nitric oxide synthase 3, endothelial cell0.012
Casp8caspase 80.012
Cldn5claudin 50.012
Cd44CD44 antigen0.011
Il10interleukin 100.011
Btbd17BTB (POZ) domain containing 170.011
Map3k7mitogen-activated protein kinase kinase kinase 70.011
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.011
Hand2heart and neural crest derivatives expressed transcript 20.011
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.011
Col15a1collagen, type XV, alpha 10.011
Adamts2a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20.011
Mef2dmyocyte enhancer factor 2D0.011
Tnfaip3tumor necrosis factor, alpha-induced protein 30.010
Col5a1collagen, type V, alpha 10.010
Cd19CD19 antigen0.010
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.010
Fstl1follistatin-like 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
18w18 wheeler0.259
ird5immune response deficient 50.128
BG4CG12297 gene product from transcript CG12297-RA0.127
cathDCG1548 gene product from transcript CG1548-RA0.106
amosabsent MD neurons and olfactory sensilla0.075
fz2frizzled 20.069
cv-2crossveinless 20.057
Irk3Inwardly rectifying potassium channel 30.056
Irk2Inwardly rectifying potassium channel 20.056
imdimmune deficiency0.052
Atg9Autophagy-specific gene 90.051
S6kRPS6-p70-protein kinase0.048
Spn27ASerpin 27A0.045
Nipped-BCG17704 gene product from transcript CG17704-RI0.043
DreddDeath related ced-3/Nedd2-like protein0.042
Pkc98EProtein C kinase 98E0.041
Pink1PTEN-induced putative kinase 10.040
Sox14Sox box protein 140.039
nanarrow abdomen0.038
CG4168CG4168 gene product from transcript CG4168-RA0.037
PRL-1CG4993 gene product from transcript CG4993-RB0.034
dandistal antenna0.033
Cyp6g1CG8453 gene product from transcript CG8453-RA0.033
Myd88CG2078 gene product from transcript CG2078-RA0.033
NPFR1neuropeptide F receptor0.032
Mkp3Mitogen-activated protein kinase phosphatase 30.031
CG42369CG42369 gene product from transcript CG42369-RA0.028
Eaat1Excitatory amino acid transporter 10.027
Ilp6Insulin-like peptide 60.027
PGRP-LFPeptidoglycan recognition protein LF0.027
ThorCG8846 gene product from transcript CG8846-RA0.025
CycJCyclin J0.023
Wnt2Wnt oncogene analog 20.023
Cyp12d1-pCG30489 gene product from transcript CG30489-RA0.022
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase0.021
l(3)82FdCG32464 gene product from transcript CG32464-RR0.021
PoxnPox neuro0.021
Sp1CG1343 gene product from transcript CG1343-RB0.021
pxbCG33207 gene product from transcript CG33207-RB0.020
NLazNeural Lazarillo0.020
CG5195CG5195 gene product from transcript CG5195-RA0.020
Toll-7CG8595 gene product from transcript CG8595-RA0.020
cicubitus interruptus0.020
foxoforkhead box, sub-group O0.020
fredfriend of echinoid0.020
CG5890CG5890 gene product from transcript CG5890-RB0.019
TolloCG6890 gene product from transcript CG6890-RA0.019
Cp1Cysteine proteinase-10.019
PGRP-LCPeptidoglycan recognition protein LC0.019
CG3759CG3759 gene product from transcript CG3759-RB0.019
nabCG33545 gene product from transcript CG33545-RC0.019
CG12187CG12187 gene product from transcript CG12187-RA0.019
IP3K1Inositol 1,4,5-triphosphate kinase 10.018
Hnf4Hepatocyte nuclear factor 40.018
GLazGlial Lazarillo0.018
nocno ocelli0.018
CG13784CG13784 gene product from transcript CG13784-RC0.018
Toll-6CG7250 gene product from transcript CG7250-RA0.018
AceAcetylcholine esterase0.018
Syn2Syntrophin-like 20.018
DoaDarkener of apricot0.018
DJ-1alphaCG6646 gene product from transcript CG6646-RA0.017
Hsp68Heat shock protein 680.017
Tango2Transport and Golgi organization 20.017
CREGCellular Repressor of E1A-stimulated Genes0.017
vvlventral veins lacking0.017
CG14545CG14545 gene product from transcript CG14545-RA0.017
RfxCG6312 gene product from transcript CG6312-RA0.017
CG3011CG3011 gene product from transcript CG3011-RA0.017
CG10200CG10200 gene product from transcript CG10200-RB0.016
CG3967CG3967 gene product from transcript CG3967-RC0.016
gfAgiant fibre A0.016
RpS28aRibosomal protein S28a0.016
kibrakibra ortholog0.016
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.999
CFLARCASP8 and FADD-like apoptosis regulator0.998
CASP8caspase 8, apoptosis-related cysteine peptidase0.997
BCL2L1BCL2-like 10.996
TRAF1TNF receptor-associated factor 10.990
MAPK14mitogen-activated protein kinase 140.988
CASP3caspase 3, apoptosis-related cysteine peptidase0.986
FADDFas (TNFRSF6)-associated via death domain0.983
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.975
MYD88myeloid differentiation primary response gene (88)0.971
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.915
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.913
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.893
XIAPX-linked inhibitor of apoptosis0.860
BCL2L11BCL2-like 11 (apoptosis facilitator)0.859
CASP10caspase 10, apoptosis-related cysteine peptidase0.822
FASFas (TNF receptor superfamily, member 6)0.759
IL1R1interleukin 1 receptor, type I0.758
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.713
BCL3B-cell CLL/lymphoma 30.687
APAF1apoptotic peptidase activating factor 10.664
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.653
ATF2activating transcription factor 20.643
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.643
MAPK8mitogen-activated protein kinase 80.636
CASP2caspase 2, apoptosis-related cysteine peptidase0.588
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.508
BIDBH3 interacting domain death agonist0.502
BMPR1Abone morphogenetic protein receptor, type IA0.458
PLAURplasminogen activator, urokinase receptor0.429
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.428
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.402
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.379
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.376
CASP7caspase 7, apoptosis-related cysteine peptidase0.362
TP53tumor protein p530.350
CASP4caspase 4, apoptosis-related cysteine peptidase0.345
GBP2guanylate binding protein 2, interferon-inducible0.340
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.337
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.328
TRAF5TNF receptor-associated factor 50.324
CD40CD40 molecule, TNF receptor superfamily member 50.321
BAK1BCL2-antagonist/killer 10.316
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.303
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.302
NLRC4NLR family, CARD domain containing 40.297
IRF1interferon regulatory factor 10.295
STAT2signal transducer and activator of transcription 2, 113kDa0.294
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.288
PLAUplasminogen activator, urokinase0.283
TRADDTNFRSF1A-associated via death domain0.270
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.269
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.267
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.256
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.250
NOSTRINnitric oxide synthase trafficker0.245
PRKD2protein kinase D20.244
HSPB8heat shock 22kDa protein 80.242
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.241
LRDDleucine-rich repeats and death domain containing0.236
CASP9caspase 9, apoptosis-related cysteine peptidase0.214
ARRB2arrestin, beta 20.212
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.204
TLR2toll-like receptor 20.201
LRRK2leucine-rich repeat kinase 20.199
SOCS3suppressor of cytokine signaling 30.199
KCNIP2Kv channel interacting protein 20.194
BAXBCL2-associated X protein0.184
IL8interleukin 80.179
MAP3K1mitogen-activated protein kinase kinase kinase 10.178
IFNAR2interferon (alpha, beta and omega) receptor 20.170
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.159
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.159
MAP2K4mitogen-activated protein kinase kinase 40.156
MAPK9mitogen-activated protein kinase 90.155
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.154
DUSP1dual specificity phosphatase 10.151
C9orf89chromosome 9 open reading frame 890.151
LY96lymphocyte antigen 960.148
JUNjun proto-oncogene0.147
CHUKconserved helix-loop-helix ubiquitous kinase0.138
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.136
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.132
MAP3K4mitogen-activated protein kinase kinase kinase 40.125
BADBCL2-associated agonist of cell death0.121
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.119
TLR4toll-like receptor 40.118
FAM101Bfamily with sequence similarity 101, member B0.118
TRAF2TNF receptor-associated factor 20.115
VAC14Vac14 homolog (S. cerevisiae)0.108
FLNAfilamin A, alpha0.106
HSPB1heat shock 27kDa protein 10.105
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.100
ICAM1intercellular adhesion molecule 10.099
HSPA1Bheat shock 70kDa protein 1B0.093
CRYABcrystallin, alpha B0.092
ARandrogen receptor0.091
KAT2BK(lysine) acetyltransferase 2B0.090
PIAS4protein inhibitor of activated STAT, 40.084
TRIM21tripartite motif containing 210.083
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.396
Col10a1collagen, type X, alpha 10.178
Inhbainhibin beta-A0.170
Col3a1collagen, type III, alpha 10.169
Col1a2collagen, type I, alpha 20.158
Fgf16fibroblast growth factor 160.153
LOC100362824caveolin 2-like0.150
Flt1FMS-related tyrosine kinase 10.148
Nr4a1nuclear receptor subfamily 4, group A, member 10.144
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.143
Hspb7heat shock protein family, member 7 (cardiovascular)0.128
Col4a2collagen, type IV, alpha 20.114
Gja1gap junction protein, alpha 10.110
Adrb1adrenergic, beta-1-, receptor0.109
Tcf21transcription factor 210.105
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.099
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.094
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.092
Ctsdcathepsin D0.089
Sftpa1surfactant protein A10.088
Egr1early growth response 10.084
Vdac1voltage-dependent anion channel 10.083
Ppardperoxisome proliferator-activated receptor delta0.077
Gja5gap junction protein, alpha 50.071
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.070
Litaflipopolysaccharide-induced TNF factor0.069
Col5a1collagen, type V, alpha 10.068
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.068
C5ar1complement component 5a receptor 10.067
Syt10synaptotagmin X0.067
Cav2caveolin 20.066
Ccl4chemokine (C-C motif) ligand 40.064
Cabp1calcium binding protein 10.064
Prss1protease, serine, 1 (trypsin 1)0.061
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.060
Fgf2fibroblast growth factor 20.056
Il1ainterleukin 1 alpha0.056
Egr2early growth response 20.055
Plcb2phospholipase C, beta 20.055
Apohapolipoprotein H (beta-2-glycoprotein I)0.055
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.054
Adora2aadenosine A2a receptor0.054
Il6interleukin 60.054
LOC687856similar to Myeloid cell surface antigen CD33 precursor (Siglec-3)0.052
Spink1serine peptidase inhibitor, Kazal type 10.052
Pzppregnancy-zone protein0.051
FosFBJ osteosarcoma oncogene0.050
Vat1vesicle amine transport protein 1 homolog (T californica)0.050
Syngr2synaptogyrin 20.049
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.048
Cdh17cadherin 170.048
Il1rl1interleukin 1 receptor-like 10.048
Rararetinoic acid receptor, alpha0.047
Aqp8aquaporin 80.046
Mbl1mannose-binding lectin (protein A) 10.046
Postnperiostin, osteoblast specific factor0.046
Dab2disabled homolog 2 (Drosophila)0.046
Fndc1fibronectin type III domain containing 10.045
Cficomplement factor I0.045
Nos3nitric oxide synthase 3, endothelial cell0.044
Ptprcprotein tyrosine phosphatase, receptor type, C0.043
Crhbpcorticotropin releasing hormone binding protein0.043
Ednrbendothelin receptor type B0.042
Arcactivity-regulated cytoskeleton-associated protein0.041
Stat6signal transducer and activator of transcription 60.041
Ier2immediate early response 20.040
Aqp4aquaporin 40.040
Fcgr1aFc fragment of IgG, high affinity Ia, receptor (CD64)0.040
Pspparotid secretory protein0.039
Ngfnerve growth factor (beta polypeptide)0.039
Wt1Wilms tumor 10.038
Junbjun B proto-oncogene0.038
Clic4chloride intracellular channel 40.038
Col15a1collagen, type XV, alpha 10.038
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.037
Leprleptin receptor0.037
Cmklr1chemokine-like receptor 10.037
Rab32RAB32, member RAS oncogene family0.037
F10coagulation factor X0.037
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.037
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.037
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.037
S1pr2sphingosine-1-phosphate receptor 20.036
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.036
Tbxa2rthromboxane A2 receptor0.036
Hbg1hemoglobin, gamma A0.036
Mmp12matrix metallopeptidase 120.035
Agtr1aangiotensin II receptor, type 1a0.035
Dusp6dual specificity phosphatase 60.035
P2ry2purinergic receptor P2Y, G-protein coupled, 20.035
Cspg4chondroitin sulfate proteoglycan 40.034
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.034
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism