The network for 'mitral valve development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitral valve development

The progression of the mitral valve over time, from its formation to the mature structure.

NameDescriptionProbabilityFunc Analog Organism
Gata4GATA binding protein 41.000
Sox9SRY-box containing gene 90.999
Pax3paired box gene 30.998
Gli3GLI-Kruppel family member GLI30.997
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.997
Pitx2paired-like homeodomain transcription factor 20.996
Ntf3neurotrophin 30.996
Tgfb2transforming growth factor, beta 20.996
Smosmoothened homolog (Drosophila)0.995
Isl1ISL1 transcription factor, LIM/homeodomain0.994
Fgf8fibroblast growth factor 80.993
Ascl1achaete-scute complex homolog 1 (Drosophila)0.992
Hand2heart and neural crest derivatives expressed transcript 20.990
Tcfap2atranscription factor AP-2, alpha0.977
Ephb2Eph receptor B20.976
Foxc2forkhead box C20.962
Hey2hairy/enhancer-of-split related with YRPW motif 20.949
Bmp4bone morphogenetic protein 40.940
Shhsonic hedgehog0.938
Foxc1forkhead box C10.929
Jag1jagged 10.927
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.921
Msx1homeobox, msh-like 10.909
Neurod1neurogenic differentiation 10.909
Prrx1paired related homeobox 10.904
Gata6GATA binding protein 60.891
Smad6MAD homolog 6 (Drosophila)0.886
Pax6paired box gene 60.848
Meox1mesenchyme homeobox 10.825
Gata1GATA binding protein 10.820
Fgf10fibroblast growth factor 100.820
Neurog3neurogenin 30.809
Ednraendothelin receptor type A0.808
Pitx1paired-like homeodomain transcription factor 10.764
Gscgoosecoid homeobox0.752
Lhx3LIM homeobox protein 30.746
Gpr50G-protein-coupled receptor 500.744
Efnb2ephrin B20.736
Hes1hairy and enhancer of split 1 (Drosophila)0.701
Rxraretinoid X receptor alpha0.697
Rargretinoic acid receptor, gamma0.681
Ptpn11protein tyrosine phosphatase, non-receptor type 110.679
Onecut1one cut domain, family member 10.675
Vegfavascular endothelial growth factor A0.667
Insm1insulinoma-associated 10.645
Efna2ephrin A20.639
Meox2mesenchyme homeobox 20.636
Hoxd13homeobox D130.621
Hand1heart and neural crest derivatives expressed transcript 10.604
Nhlh1nescient helix loop helix 10.603
Mesp1mesoderm posterior 10.603
Sox2SRY-box containing gene 20.594
Tbx1T-box 10.587
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.578
Dlx2distal-less homeobox 20.575
Epha4Eph receptor A40.570
Foxd2forkhead box D20.564
Hey1hairy/enhancer-of-split related with YRPW motif 10.554
Alx3aristaless-like homeobox 30.549
Ptf1apancreas specific transcription factor, 1a0.549
Notch1Notch gene homolog 1 (Drosophila)0.538
Gli2GLI-Kruppel family member GLI20.531
Nr5a1nuclear receptor subfamily 5, group A, member 10.523
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.519
Snai1snail homolog 1 (Drosophila)0.517
Ebf3early B-cell factor 30.512
Neurog2neurogenin 20.507
Otx2orthodenticle homolog 2 (Drosophila)0.504
Sox7SRY-box containing gene 70.494
Prrx2paired related homeobox 20.487
Dlx5distal-less homeobox 50.487
Atoh7atonal homolog 7 (Drosophila)0.484
Hoxa1homeobox A10.453
MecomMDS1 and EVI1 complex locus0.448
Fgfr2fibroblast growth factor receptor 20.445
Lhx5LIM homeobox protein 50.443
Dlx1distal-less homeobox 10.436
Efnb1ephrin B10.435
Fgfr1fibroblast growth factor receptor 10.418
Pdx1pancreatic and duodenal homeobox 10.417
Alx4aristaless-like homeobox 40.416
Eya1eyes absent 1 homolog (Drosophila)0.404
Pou3f3POU domain, class 3, transcription factor 30.394
Shesrc homology 2 domain-containing transforming protein E0.386
Lhcgrluteinizing hormone/choriogonadotropin receptor0.382
Sall3sal-like 3 (Drosophila)0.381
Tbx3T-box 30.379
Col2a1collagen, type II, alpha 10.374
Sox18SRY-box containing gene 180.358
Tcf15transcription factor 150.348
Cldn5claudin 50.344
Engendoglin0.334
Dll4delta-like 4 (Drosophila)0.322
Nos3nitric oxide synthase 3, endothelial cell0.321
Hoxa13homeobox A130.320
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.318
Sox11SRY-box containing gene 110.315
Tlx3T-cell leukemia, homeobox 30.315
Ece1endothelin converting enzyme 10.300
Hoxc4homeobox C40.298
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 11.000
TGFB1transforming growth factor, beta 10.996
FKBP1AFK506 binding protein 1A, 12kDa0.995
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.993
FSTL1follistatin-like 10.967
TGFB3transforming growth factor, beta 30.950
BMP2bone morphogenetic protein 20.932
GDF5growth differentiation factor 50.888
SMAD7SMAD family member 70.856
ENGendoglin0.837
SETD8SET domain containing (lysine methyltransferase) 80.722
MAML1mastermind-like 1 (Drosophila)0.702
PRKG1protein kinase, cGMP-dependent, type I0.674
NRP1neuropilin 10.660
DLL1delta-like 1 (Drosophila)0.646
ZMYND11zinc finger, MYND-type containing 110.638
NOTCH1notch 10.462
NOTCH2notch 20.393
XIAPX-linked inhibitor of apoptosis0.334
JAG2jagged 20.320
PDGFCplatelet derived growth factor C0.275
MAPK8mitogen-activated protein kinase 80.258
GSK3Bglycogen synthase kinase 3 beta0.202
SMAD2SMAD family member 20.193
MARCKSL1MARCKS-like 10.183
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.173
RBBP4retinoblastoma binding protein 40.169
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.163
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.143
RXRAretinoid X receptor, alpha0.102
GFI1Bgrowth factor independent 1B transcription repressor0.100
IQGAP1IQ motif containing GTPase activating protein 10.096
NOTCH3notch 30.089
EGFL7EGF-like-domain, multiple 70.084
NOTCH2NLnotch 2 N-terminal like0.082
TGFBR1transforming growth factor, beta receptor 10.081
BMP4bone morphogenetic protein 40.076
NPR1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.073
MTORmechanistic target of rapamycin (serine/threonine kinase)0.071
CTBP2C-terminal binding protein 20.065
APPamyloid beta (A4) precursor protein0.064
SPENspen homolog, transcriptional regulator (Drosophila)0.061
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.056
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.050
VEGFAvascular endothelial growth factor A0.048
TGFBR3transforming growth factor, beta receptor III0.047
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.047
FNDC3Bfibronectin type III domain containing 3B0.045
ACVR1activin A receptor, type I0.044
ATXN1Lataxin 1-like0.044
TACC1transforming, acidic coiled-coil containing protein 10.042
ACVR1Bactivin A receptor, type IB0.039
EFNB2ephrin-B20.038
LRP6low density lipoprotein receptor-related protein 60.037
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.032
SMURF2SMAD specific E3 ubiquitin protein ligase 20.031
KLK10kallikrein-related peptidase 100.031
RAMP2receptor (G protein-coupled) activity modifying protein 20.030
ATP2B4ATPase, Ca++ transporting, plasma membrane 40.030
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.030
ANTXR2anthrax toxin receptor 20.029
ICAM2intercellular adhesion molecule 20.029
HIC1hypermethylated in cancer 10.029
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.028
BICD1bicaudal D homolog 1 (Drosophila)0.028
C20orf4chromosome 20 open reading frame 40.027
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.027
CDH5cadherin 5, type 2 (vascular endothelium)0.027
SOX13SRY (sex determining region Y)-box 130.027
VWFvon Willebrand factor0.027
DOCK8dedicator of cytokinesis 80.026
GJB5gap junction protein, beta 5, 31.1kDa0.026
CD34CD34 molecule0.026
GATA2GATA binding protein 20.026
ACVRL1activin A receptor type II-like 10.026
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.025
HIPK2homeodomain interacting protein kinase 20.024
ACVR2Aactivin A receptor, type IIA0.023
FOXF2forkhead box F20.022
FGFBP1fibroblast growth factor binding protein 10.022
SOX7SRY (sex determining region Y)-box 70.022
AQP5aquaporin 50.021
NBPF10neuroblastoma breakpoint family, member 100.021
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.020
AXIN1axin 10.020
RBMS1RNA binding motif, single stranded interacting protein 10.020
TMEM44transmembrane protein 440.020
PCDH12protocadherin 120.019
PDGFAplatelet-derived growth factor alpha polypeptide0.019
MED25mediator complex subunit 250.019
CD248CD248 molecule, endosialin0.019
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.018
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.018
ACVR2Bactivin A receptor, type IIB0.018
INHBBinhibin, beta B0.018
GJB3gap junction protein, beta 3, 31kDa0.018
GATA1GATA binding protein 1 (globin transcription factor 1)0.018
USP15ubiquitin specific peptidase 150.018
CLUclusterin0.017
FZD7frizzled homolog 7 (Drosophila)0.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism