The network for 'natural killer cell degranulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

natural killer cell degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.

NameDescriptionProbabilityFunc Analog Organism
Rab27aRAB27A, member RAS oncogene family1.000
Prf1perforin 1 (pore forming protein)0.966
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.926
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.916
Lystlysosomal trafficking regulator0.907
Sytl5synaptotagmin-like 50.871
Ctsbcathepsin B0.712
Plbd2phospholipase B domain containing 20.704
Ctsdcathepsin D0.516
Stat1signal transducer and activator of transcription 10.463
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.329
Stx11syntaxin 110.245
Rab27bRAB27b, member RAS oncogene family0.214
Hexahexosaminidase A0.137
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.129
Hps6Hermansky-Pudlak syndrome 60.069
Lamp2lysosomal-associated membrane protein 20.066
Mfsd1major facilitator superfamily domain containing 10.049
Hexbhexosaminidase B0.048
RragcRas-related GTP binding C0.039
Npc2Niemann Pick type C20.035
Gnsglucosamine (N-acetyl)-6-sulfatase0.030
Gabarapgamma-aminobutyric acid receptor associated protein0.023
Ikbkginhibitor of kappaB kinase gamma0.023
Tcn2transcobalamin 20.022
Atp6v0cATPase, H+ transporting, lysosomal V0 subunit C0.022
Tpp1tripeptidyl peptidase I0.021
0610031J06RikRIKEN cDNA 0610031J06 gene0.020
Lrp10low-density lipoprotein receptor-related protein 100.019
Sytl1synaptotagmin-like 10.018
Fth1ferritin heavy chain 10.018
Igf2rinsulin-like growth factor 2 receptor0.018
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.017
Ap1m1adaptor-related protein complex AP-1, mu subunit 10.017
Akr1a4aldo-keto reductase family 1, member A4 (aldehyde reductase)0.017
Nucb1nucleobindin 10.015
Tmbim6transmembrane BAX inhibitor motif containing 60.015
Sat1spermidine/spermine N1-acetyl transferase 10.015
Itm2bintegral membrane protein 2B0.014
Inpp5dinositol polyphosphate-5-phosphatase D0.013
Kdelr1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 10.013
2400001E08RikRIKEN cDNA 2400001E08 gene0.013
Esrp1epithelial splicing regulatory protein 10.012
Sumf1sulfatase modifying factor 10.012
Arrdc1arrestin domain containing 10.012
Ftl1ferritin light chain 10.012
Tlr4toll-like receptor 40.011
Sytl3synaptotagmin-like 30.011
Pof1bpremature ovarian failure 1B0.011
Nlrp3NLR family, pyrin domain containing 30.011
Ctslcathepsin L0.010
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.010
Pttg1ippituitary tumor-transforming 1 interacting protein0.010
Rab38RAB38, member of RAS oncogene family0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GBAglucosidase, beta, acid0.141
SNAP23synaptosomal-associated protein, 23kDa0.140
RAB14RAB14, member RAS oncogene family0.137
GNSglucosamine (N-acetyl)-6-sulfatase0.128
ITM2Bintegral membrane protein 2B0.048
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.043
HEXBhexosaminidase B (beta polypeptide)0.024
RABEP1rabaptin, RAB GTPase binding effector protein 10.023
IL13RA1interleukin 13 receptor, alpha 10.021
LEPROTleptin receptor overlapping transcript0.017
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 20.016
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 50.014
RNF13ring finger protein 130.013
CTBSchitobiase, di-N-acetyl-0.013
MFSD1major facilitator superfamily domain containing 10.012
TGOLN2trans-golgi network protein 20.012
CREG1cellular repressor of E1A-stimulated genes 10.011
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.011
LAPTM4Alysosomal protein transmembrane 4 alpha0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism