The network for 'negative regulation of ligase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ligase activity

Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.

NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.830
Lrrk2leucine-rich repeat kinase 20.669
Trp53transformation related protein 530.495
Notch2Notch gene homolog 2 (Drosophila)0.418
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.288
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.276
Psen1presenilin 10.271
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.198
Cdk2cyclin-dependent kinase 20.196
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.159
Ccne1cyclin E10.134
Axin1axin 10.112
Ptk2PTK2 protein tyrosine kinase 20.112
Itgb1integrin beta 1 (fibronectin receptor beta)0.101
Sgol1shugoshin-like 1 (S. pombe)0.096
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.089
Sgol2shugoshin-like 2 (S. pombe)0.068
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.053
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.049
H2afzH2A histone family, member Z0.048
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.047
Trp73transformation related protein 730.046
Mdm2transformed mouse 3T3 cell double minute 20.046
Irf6interferon regulatory factor 60.045
Cdkn1bcyclin-dependent kinase inhibitor 1B0.045
Cops6COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)0.040
Ccne2cyclin E20.040
Smurf1SMAD specific E3 ubiquitin protein ligase 10.039
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.035
Immtinner membrane protein, mitochondrial0.032
Tbc1d4TBC1 domain family, member 40.032
Tsc1tuberous sclerosis 10.032
Tsc2tuberous sclerosis 20.032
Mdm4transformed mouse 3T3 cell double minute 40.032
Rb1retinoblastoma 10.031
Skp2S-phase kinase-associated protein 2 (p45)0.031
Trp63transformation related protein 630.031
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.031
Ptch1patched homolog 10.030
1810019J16RikRIKEN cDNA 1810019J16 gene0.030
Clppcaseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)0.028
Ccna2cyclin A20.026
Appamyloid beta (A4) precursor protein0.025
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.025
Ripk4receptor-interacting serine-threonine kinase 40.025
Ect2ect2 oncogene0.025
Scocshort coiled-coil protein0.024
Dok2docking protein 20.024
Rxraretinoid X receptor alpha0.024
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.024
BadBCL2-associated agonist of cell death0.023
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.022
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.022
Psen2presenilin 20.022
Erlin2ER lipid raft associated 20.021
Nedd4neural precursor cell expressed, developmentally down-regulated 40.021
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.020
Spint1serine protease inhibitor, Kunitz type 10.019
Hmmrhyaluronan mediated motility receptor (RHAMM)0.019
E2f1E2F transcription factor 10.019
Efnb2ephrin B20.018
Nf2neurofibromatosis 20.018
AclyATP citrate lyase0.017
Ppardperoxisome proliferator activator receptor delta0.016
Psenenpresenilin enhancer 2 homolog (C. elegans)0.016
Rps16ribosomal protein S160.016
H2-Ke2H2-K region expressed gene 20.016
Hprthypoxanthine guanine phosphoribosyl transferase0.016
2410089E03RikRIKEN cDNA 2410089E03 gene0.016
Dok1docking protein 10.016
Gen1Gen homolog 1, endonuclease (Drosophila)0.015
Psmd11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.015
Raf1v-raf-leukemia viral oncogene 10.015
Hdgfhepatoma-derived growth factor0.015
Itga3integrin alpha 30.015
Ncapg2non-SMC condensin II complex, subunit G20.015
2610039C10RikRIKEN cDNA 2610039C10 gene0.015
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.015
Rpl7aribosomal protein L7A0.015
Dll1delta-like 1 (Drosophila)0.014
Msh2mutS homolog 2 (E. coli)0.014
Slc25a4solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 40.014
Mapk13mitogen-activated protein kinase 130.014
Rint1RAD50 interactor 10.014
CblCasitas B-lineage lymphoma0.014
Trim32tripartite motif-containing 320.014
Actr1aARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.014
Enoph1enolase-phosphatase 10.014
Ubqln4ubiquilin 40.013
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.013
Fkbp1aFK506 binding protein 1a0.013
Prdm16PR domain containing 160.013
Zbtb7azinc finger and BTB domain containing 7a0.013
Lasp1LIM and SH3 protein 10.013
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.013
Htatip2HIV-1 tat interactive protein 2, homolog (human)0.013
Xpaxeroderma pigmentosum, complementation group A0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycACyclin A0.015
Su(H)Suppressor of Hairless0.013
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
SMAD1SMAD family member 10.970
SMAD3SMAD family member 30.846
SMURF2SMAD specific E3 ubiquitin protein ligase 20.481
SMAD7SMAD family member 70.411
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.253
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.251
CCNB1cyclin B10.243
UHRF2ubiquitin-like with PHD and ring finger domains 20.186
CIB1calcium and integrin binding 1 (calmyrin)0.136
SMAD2SMAD family member 20.105
CCNA2cyclin A20.096
FLNBfilamin B, beta0.083
DNAJB2DnaJ (Hsp40) homolog, subfamily B, member 20.082
SMAD5SMAD family member 50.054
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.053
FBXW7F-box and WD repeat domain containing 70.050
SPRY4sprouty homolog 4 (Drosophila)0.049
PSEN1presenilin 10.046
CXXC5CXXC finger protein 50.042
CDK2cyclin-dependent kinase 20.041
RIN1Ras and Rab interactor 10.038
ARandrogen receptor0.034
FHL2four and a half LIM domains 20.033
MMP14matrix metallopeptidase 14 (membrane-inserted)0.028
PSEN2presenilin 2 (Alzheimer disease 4)0.027
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.026
CCNE1cyclin E10.024
HERC2hect domain and RLD 20.023
SMAD6SMAD family member 60.022
ANKRD52ankyrin repeat domain 520.021
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.021
BCAR1breast cancer anti-estrogen resistance 10.020
CCNE2cyclin E20.019
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.017
FBXL15F-box and leucine-rich repeat protein 150.017
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.016
SMURF1SMAD specific E3 ubiquitin protein ligase 10.016
SOX7SRY (sex determining region Y)-box 70.016
USP44ubiquitin specific peptidase 440.013
TRAF4TNF receptor-associated factor 40.013
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.013
SKILSKI-like oncogene0.013
ZFYVE1zinc finger, FYVE domain containing 10.012
HIPK2homeodomain interacting protein kinase 20.012
HMGB2high mobility group box 20.011
CDC27cell division cycle 27 homolog (S. cerevisiae)0.011
RBL1retinoblastoma-like 1 (p107)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism