The network for 'second messenger mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

second messenger mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.

NameDescriptionProbabilityFunc Analog Organism
Slc34a1solute carrier family 34 (sodium phosphate), member 10.938
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.932
Mef2dmyocyte enhancer factor 2D0.908
Ptpn11protein tyrosine phosphatase, non-receptor type 110.848
Neurod1neurogenic differentiation 10.838
Drd2dopamine receptor D20.806
Nos3nitric oxide synthase 3, endothelial cell0.780
Mef2cmyocyte enhancer factor 2C0.690
Leprleptin receptor0.683
Adrb1adrenergic receptor, beta 10.679
Ntf3neurotrophin 30.669
Mt1metallothionein 10.646
Clec4dC-type lectin domain family 4, member d0.642
Mt2metallothionein 20.638
Ccr1chemokine (C-C motif) receptor 10.604
Nos1nitric oxide synthase 1, neuronal0.587
Ldb3LIM domain binding 30.587
Pcdh12protocadherin 120.577
Rgs9regulator of G-protein signaling 90.573
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.568
Dlg4discs, large homolog 4 (Drosophila)0.547
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.525
Rims2regulating synaptic membrane exocytosis 20.515
Kitlkit ligand0.511
Ptprcprotein tyrosine phosphatase, receptor type, C0.503
Cckbrcholecystokinin B receptor0.501
Mmp8matrix metallopeptidase 80.500
Ascl1achaete-scute complex homolog 1 (Drosophila)0.495
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.488
Lcp2lymphocyte cytosolic protein 20.486
Pthlhparathyroid hormone-like peptide0.483
Zap70zeta-chain (TCR) associated protein kinase0.482
Gucy1b3guanylate cyclase 1, soluble, beta 30.479
Htr75-hydroxytryptamine (serotonin) receptor 70.476
Pax6paired box gene 60.472
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.468
Homer1homer homolog 1 (Drosophila)0.458
Cd247CD247 antigen0.458
Trpc4transient receptor potential cation channel, subfamily C, member 40.453
Il7rinterleukin 7 receptor0.441
Gp9glycoprotein 9 (platelet)0.439
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.423
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.415
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.414
Kiss1KiSS-1 metastasis-suppressor0.405
L1camL1 cell adhesion molecule0.400
Lhx6LIM homeobox protein 60.389
FasFas (TNF receptor superfamily member 6)0.388
Nppbnatriuretic peptide type B0.383
Plcb1phospholipase C, beta 10.381
Neurog3neurogenin 30.374
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.373
Hand1heart and neural crest derivatives expressed transcript 10.370
Galnt6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 60.369
Clec4eC-type lectin domain family 4, member e0.365
Edn3endothelin 30.362
Dnm1dynamin 10.359
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.354
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.350
Sstr4somatostatin receptor 40.349
Sim1single-minded homolog 1 (Drosophila)0.346
Dlg2discs, large homolog 2 (Drosophila)0.343
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.342
Itgb1integrin beta 1 (fibronectin receptor beta)0.338
Cybbcytochrome b-245, beta polypeptide0.338
Msr1macrophage scavenger receptor 10.337
Pdx1pancreatic and duodenal homeobox 10.335
Mrvi1MRV integration site 10.333
C3ar1complement component 3a receptor 10.330
Jarid2jumonji, AT rich interactive domain 20.329
AF251705cDNA sequence AF2517050.327
Shc3src homology 2 domain-containing transforming protein C30.322
Npy2rneuropeptide Y receptor Y20.320
Prkg1protein kinase, cGMP-dependent, type I0.319
Edil3EGF-like repeats and discoidin I-like domains 30.317
Tac2tachykinin 20.314
Thrbthyroid hormone receptor beta0.309
Pkd1polycystic kidney disease 1 homolog0.306
Selpselectin, platelet0.306
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.301
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.300
Tgfb2transforming growth factor, beta 20.296
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.294
Lcklymphocyte protein tyrosine kinase0.292
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.292
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.291
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.288
Kcnk3potassium channel, subfamily K, member 30.288
Ldb2LIM domain binding 20.288
Zfpm2zinc finger protein, multitype 20.287
Gnao1guanine nucleotide binding protein, alpha O0.281
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.278
Ccl3chemokine (C-C motif) ligand 30.276
Cd86CD86 antigen0.267
Grm1glutamate receptor, metabotropic 10.266
Prkccprotein kinase C, gamma0.264
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.264
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CCL5chemokine (C-C motif) ligand 50.987
LATlinker for activation of T cells0.975
PAX3paired box 30.970
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.948
CCR5chemokine (C-C motif) receptor 50.944
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.911
CXCL2chemokine (C-X-C motif) ligand 20.901
IL8interleukin 80.869
LCKlymphocyte-specific protein tyrosine kinase0.869
CCL4chemokine (C-C motif) ligand 40.859
GRB2growth factor receptor-bound protein 20.844
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.843
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.841
MEOX2mesenchyme homeobox 20.833
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.813
ARRB1arrestin, beta 10.796
CXCL3chemokine (C-X-C motif) ligand 30.780
CD247CD247 molecule0.762
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.761
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.743
CCL22chemokine (C-C motif) ligand 220.711
FYBFYN binding protein0.709
CXCL5chemokine (C-X-C motif) ligand 50.685
GUCY1A3guanylate cyclase 1, soluble, alpha 30.646
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.620
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.612
SPTBspectrin, beta, erythrocytic0.583
CXCL9chemokine (C-X-C motif) ligand 90.577
CD28CD28 molecule0.571
DPP4dipeptidyl-peptidase 40.571
SH3BP2SH3-domain binding protein 20.537
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.520
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.505
CCR7chemokine (C-C motif) receptor 70.488
SKP1S-phase kinase-associated protein 10.482
CCR4chemokine (C-C motif) receptor 40.477
FYNFYN oncogene related to SRC, FGR, YES0.470
IFNGinterferon, gamma0.447
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.440
MPDZmultiple PDZ domain protein0.438
IL1Binterleukin 1, beta0.437
TBXA2Rthromboxane A2 receptor0.435
GUCY1B3guanylate cyclase 1, soluble, beta 30.432
CXCL10chemokine (C-X-C motif) ligand 100.414
IL10interleukin 100.406
SSTR2somatostatin receptor 20.403
SSTR3somatostatin receptor 30.397
CXCR5chemokine (C-X-C motif) receptor 50.394
PTENphosphatase and tensin homolog0.392
CCL20chemokine (C-C motif) ligand 200.377
CCL11chemokine (C-C motif) ligand 110.366
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.362
CCL7chemokine (C-C motif) ligand 70.348
VAV1vav 1 guanine nucleotide exchange factor0.336
CALCAcalcitonin-related polypeptide alpha0.335
SYKspleen tyrosine kinase0.316
POU5F1POU class 5 homeobox 10.312
SHC2SHC (Src homology 2 domain containing) transforming protein 20.308
MAPTmicrotubule-associated protein tau0.302
CCL13chemokine (C-C motif) ligand 130.298
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.292
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.289
IL2RBinterleukin 2 receptor, beta0.285
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.282
CCL2chemokine (C-C motif) ligand 20.274
SOCS3suppressor of cytokine signaling 30.260
CCR2chemokine (C-C motif) receptor 20.260
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.257
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.255
INF2inverted formin, FH2 and WH2 domain containing0.253
CRHcorticotropin releasing hormone0.251
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.250
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.249
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.246
CD3DCD3d molecule, delta (CD3-TCR complex)0.244
NRP1neuropilin 10.240
CCL3chemokine (C-C motif) ligand 30.238
SETD8SET domain containing (lysine methyltransferase) 80.235
FOXD3forkhead box D30.232
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.231
NFE2L2nuclear factor (erythroid-derived 2)-like 20.226
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.226
CCL8chemokine (C-C motif) ligand 80.217
CXCL13chemokine (C-X-C motif) ligand 130.209
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.207
NEUROD1neurogenic differentiation 10.205
IL16interleukin 16 (lymphocyte chemoattractant factor)0.200
CXCR3chemokine (C-X-C motif) receptor 30.197
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.195
PSEN2presenilin 2 (Alzheimer disease 4)0.195
CD163CD163 molecule0.187
GFAPglial fibrillary acidic protein0.184
APOC1apolipoprotein C-I0.182
PTPRBprotein tyrosine phosphatase, receptor type, B0.180
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.179
PKD1polycystic kidney disease 1 (autosomal dominant)0.171
PCDH17protocadherin 170.170
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Syt7synaptotagmin VII0.383
Shank2SH3 and multiple ankyrin repeat domains 20.353
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.299
Smr3asubmaxillary gland androgen regulated protein 3A0.292
Ncr3natural cytotoxicity triggering receptor 30.228
St18suppression of tumorigenicity 180.197
Adora2aadenosine A2a receptor0.196
Gucy1a3guanylate cyclase 1, soluble, alpha 30.195
Scn3asodium channel, voltage-gated, type III, alpha0.163
Calcrlcalcitonin receptor-like0.153
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.151
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.149
Cd4Cd4 molecule0.140
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.136
Grprgastrin releasing peptide receptor0.133
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.129
Pex5lperoxisomal biogenesis factor 5-like0.125
Pde1bphosphodiesterase 1B, calmodulin-dependent0.124
Rims1regulating synaptic membrane exocytosis 10.123
Accn2amiloride-sensitive cation channel 2, neuronal0.122
Grpgastrin releasing peptide0.120
Mc4rmelanocortin 4 receptor0.120
Prkcgprotein kinase C, gamma0.119
Gria1glutamate receptor, ionotropic, AMPA 10.118
Il4interleukin 40.112
Crhr2corticotropin releasing hormone receptor 20.106
Map2microtubule-associated protein 20.103
Gucy1b3guanylate cyclase 1, soluble, beta 30.103
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.103
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.102
Nrp2neuropilin 20.101
Gnrhrgonadotropin releasing hormone receptor0.101
Notch3Notch homolog 3 (Drosophila)0.101
Gzmkgranzyme K0.097
Sycp1synaptonemal complex protein 10.095
Odf4outer dense fiber of sperm tails 40.094
Gfra2GDNF family receptor alpha 20.092
Grm2glutamate receptor, metabotropic 20.092
Prdm2PR domain containing 2, with ZNF domain0.092
Oprl1opiate receptor-like 10.090
Cacna1dcalcium channel, voltage-dependent, L type, alpha 1D subunit0.086
Grm8glutamate receptor, metabotropic 80.085
Ccl4chemokine (C-C motif) ligand 40.085
Neurod2neurogenic differentiation 20.081
Iappislet amyloid polypeptide0.081
Sdc3syndecan 30.081
Cldn1claudin 10.080
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.080
Cx3cr1chemokine (C-X3-C motif) receptor 10.080
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.080
Robo2roundabout homolog 2 (Drosophila)0.079
RT1-A3RT1 class I, locus A30.079
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.079
Ephb1Eph receptor B10.079
Pja2praja 2, RING-H2 motif containing0.078
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.078
Tff1trefoil factor 10.077
Prss2protease, serine, 20.077
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.076
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.074
Olr287olfactory receptor 2870.074
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.074
Semg1semenogelin I0.069
Il6interleukin 60.068
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.068
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.066
Gjb4gap junction protein, beta 40.066
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.066
Sellselectin L0.065
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.065
Il1ainterleukin 1 alpha0.065
Cnga3cyclic nucleotide gated channel alpha 30.064
Faim2Fas apoptotic inhibitory molecule 20.064
Hrh2histamine receptor H 20.064
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.064
Shox2short stature homeobox 20.063
Phkg1phosphorylase kinase, gamma 10.063
Znf483zinc finger protein 4830.062
Olr416olfactory receptor 4160.062
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.061
Cntn3contactin 3 (plasmacytoma associated)0.061
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.061
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.060
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.060
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.059
Adora1adenosine A1 receptor0.058
Ednraendothelin receptor type A0.058
Chrna3cholinergic receptor, nicotinic, alpha 30.057
Ptgfrprostaglandin F receptor0.057
Grm5glutamate receptor, metabotropic 50.057
Arandrogen receptor0.056
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.056
CadpsCa++-dependent secretion activator0.055
Pde3aphosphodiesterase 3A, cGMP inhibited0.055
Gng7guanine nucleotide binding protein (G protein), gamma 70.054
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism