The network for 'cell killing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell killing

Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

NameDescriptionProbabilityFunc Analog Organism
Prf1perforin 1 (pore forming protein)0.970
FaslFas ligand (TNF superfamily, member 6)0.950
Klrk1killer cell lectin-like receptor subfamily K, member 10.933
TapbpTAP binding protein0.930
Il6interleukin 60.928
Il2rginterleukin 2 receptor, gamma chain0.914
Klra9killer cell lectin-like receptor subfamily A, member 90.914
Slamf1signaling lymphocytic activation molecule family member 10.896
Stat1signal transducer and activator of transcription 10.892
B2mbeta-2 microglobulin0.890
Gzmkgranzyme K0.858
Klrc1killer cell lectin-like receptor subfamily C, member 10.835
Xcl1chemokine (C motif) ligand 10.831
Ncr1natural cytotoxicity triggering receptor 10.825
Klra7killer cell lectin-like receptor, subfamily A, member 70.818
Gzmagranzyme A0.806
Pnp2purine-nucleoside phosphorylase 20.796
H2-K1histocompatibility 2, K1, K region0.716
Icosinducible T-cell co-stimulator0.697
Rab27aRAB27A, member RAS oncogene family0.674
Il18rapinterleukin 18 receptor accessory protein0.666
Klrd1killer cell lectin-like receptor, subfamily D, member 10.651
Stat5bsignal transducer and activator of transcription 5B0.649
Gzmbgranzyme B0.649
Mcpt8mast cell protease 80.630
Casp8caspase 80.619
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.598
ItkIL2-inducible T-cell kinase0.596
Campcathelicidin antimicrobial peptide0.587
Klf1Kruppel-like factor 1 (erythroid)0.582
Ngpneutrophilic granule protein0.528
H2-D1histocompatibility 2, D region locus 10.509
Cma1chymase 1, mast cell0.504
Cd244CD244 natural killer cell receptor 2B40.501
Il1rninterleukin 1 receptor antagonist0.497
Ccl22chemokine (C-C motif) ligand 220.497
H2-Q7histocompatibility 2, Q region locus 70.495
Fpr1formyl peptide receptor 10.458
Ctswcathepsin W0.455
Ctsbcathepsin B0.447
Ifnar2interferon (alpha and beta) receptor 20.436
Klrg1killer cell lectin-like receptor subfamily G, member 10.434
Ifnginterferon gamma0.427
Ccl3chemokine (C-C motif) ligand 30.422
Il2rbinterleukin 2 receptor, beta chain0.413
Lcn4lipocalin 40.387
Cd160CD160 antigen0.383
Trem3triggering receptor expressed on myeloid cells 30.374
Gzmcgranzyme C0.373
FcrlaFc receptor-like A0.372
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.365
FynFyn proto-oncogene0.362
Il18r1interleukin 18 receptor 10.350
Selpselectin, platelet0.346
Cd22CD22 antigen0.334
Mmp8matrix metallopeptidase 80.325
Cst7cystatin F (leukocystatin)0.324
Ccr3chemokine (C-C motif) receptor 30.314
Ptgirprostaglandin I receptor (IP)0.305
Stx11syntaxin 110.296
Mpomyeloperoxidase0.289
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.288
Stat5asignal transducer and activator of transcription 5A0.288
Gfi1growth factor independent 10.286
Ciitaclass II transactivator0.278
Grb2growth factor receptor bound protein 20.268
Trim21tripartite motif-containing 210.268
Cxcr3chemokine (C-X-C motif) receptor 30.265
Latlinker for activation of T cells0.262
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.259
Ccr1chemokine (C-C motif) receptor 10.244
Cpa3carboxypeptidase A3, mast cell0.240
Itgalintegrin alpha L0.240
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.238
H2-Q5histocompatibility 2, Q region locus 50.238
Stat3signal transducer and activator of transcription 30.237
Il2rainterleukin 2 receptor, alpha chain0.235
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.233
Gbp1guanylate binding protein 10.223
S100a9S100 calcium binding protein A9 (calgranulin B)0.221
Cd7CD7 antigen0.216
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.213
Cd8aCD8 antigen, alpha chain0.211
Bex6brain expressed gene 60.209
Glrp1glutamine repeat protein 10.207
Il2interleukin 20.206
Gfi1bgrowth factor independent 1B0.205
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.200
Cd40CD40 antigen0.199
Ccl4chemokine (C-C motif) ligand 40.198
Cmahcytidine monophospho-N-acetylneuraminic acid hydroxylase0.193
Klra2killer cell lectin-like receptor, subfamily A, member 20.191
Irf9interferon regulatory factor 90.191
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.188
Mmp13matrix metallopeptidase 130.185
Prg2proteoglycan 2, bone marrow0.182
Cd247CD247 antigen0.179
Il10interleukin 100.178
S100a8S100 calcium binding protein A8 (calgranulin A)0.176
Sellselectin, lymphocyte0.175
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
zgc:64115zgc:641150.256
rhogbras homolog gene family, member Gb0.220
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.204
zgc:110010zgc:1100100.146
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.100
cxcr3.2chemokine (C-X-C motif) receptor 3.20.099
sqstm1sequestosome 10.095
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.091
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.070
lrrc33leucine rich repeat containing 330.062
ctszcathepsin Z0.057
npy4rneuropeptide Y receptor Y40.056
etnk1ethanolamine kinase 10.053
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.050
iqgap1IQ motif containing GTPase activating protein 10.049
coro1acoronin, actin binding protein, 1A0.049
creb3l3lcAMP responsive element binding protein 3-like 3 like0.047
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.042
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.041
tnfaip8l2atumor necrosis factor, alpha-induced protein 8, like 2a0.039
defbl3defensin, beta-like 30.037
mcl1amyeloid cell leukemia sequence 1a0.036
sdcbpsyndecan binding protein (syntenin)0.035
itln1intelectin 10.035
mitfamicrophthalmia-associated transcription factor a0.034
LOC566708FL cytokine receptor-like0.034
LOC566020Gig2-like protein DreO0.034
gmfgglia maturation factor, gamma0.033
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.033
g6pdglucose-6-phosphate dehydrogenase0.033
im:7135980im:71359800.032
zgc:162329zgc:1623290.031
ptpn6protein tyrosine phosphatase, non-receptor type 60.030
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.029
illr1immune-related, lectin-like receptor 10.029
itln3intelectin 30.029
trim25tripartite motif-containing 250.028
zgc:55671zgc:556710.028
ptk6aPTK6 protein tyrosine kinase 6a0.027
zgc:63831zgc:638310.027
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.026
c3ccomplement component c3c0.026
b2mbeta-2-microglobulin0.026
gstalglutathione S-transferase, alpha-like0.026
nitr8novel immune-type receptor 80.026
tfap2etranscription factor AP-2 epsilon0.025
rpl13aribosomal protein L13a0.025
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.025
samsn1aSAM domain, SH3 domain and nuclear localisation signals, 1a0.025
crestincrestin0.024
wnt5awingless-type MMTV integration site family, member 5a0.024
bidaBH3 interacting domain death agonist0.024
irf11interferon regulatory factor 110.023
arl4aaADP-ribosylation factor-like 4aa0.023
im:7141132im:71411320.023
insrainsulin receptor a0.023
abp1amiloride binding protein 1 (amine oxidase (copper-containing))0.023
zgc:174863zgc:1748630.023
tpsntapasin0.023
pcsk2proprotein convertase subtilisin/kexin type 20.023
mmp13amatrix metalloproteinase 13a0.023
sypl2bsynaptophysin-like 2b0.022
illr3immune-related, lectin-like receptor 30.022
pcsk1proprotein convertase subtilisin/kexin type 10.022
zgc:101614zgc:1016140.022
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.022
npy7rneuropeptide Y receptor Y70.022
fcho2FCH domain only 20.021
zgc:152984zgc:1529840.021
zgc:64051zgc:640510.021
wu:fb80e01wu:fb80e010.021
nitr4anovel immune-type receptor 4a0.021
slc34a2asolute carrier family 34 (sodium phosphate), member 2a0.021
cd8aCD8 antigen, alpha polypeptide0.021
clcn7chloride channel 70.021
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.021
il10interleukin 100.021
apaf1apoptotic protease activating factor 10.021
figlafactor in the germline alpha0.020
tlr22toll-like receptor 220.020
styk1serine/threonine/tyrosine kinase 10.020
pdcd6ipprogrammed cell death 6 interacting protein0.020
mxamyxovirus (influenza) resistance A0.020
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.020
sb:cb134sb:cb1340.020
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.020
c3bcomplement component c3b0.020
cflarCASP8 and FADD-like apoptosis regulator0.020
rnd1lRho family GTPase 1 like0.020
nos2anitric oxide synthase 2a, inducible0.019
casp9caspase 9, apoptosis-related cysteine protease0.019
baxabcl2-associated X protein, a0.019
nitr12novel immune-type receptor 120.019
sec31bSec31 homolog B (S. cerevisiae)0.019
zgc:63691zgc:636910.019
foxp3aforkhead box P3a0.019
rab5cRAB5C, member RAS oncogene family0.019
tbpTATA box binding protein0.019
LOC100000934hypothetical protein LOC1000009340.019
nos1nitric oxide synthase 1 (neuronal)0.019
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Amajor histocompatibility complex, class I, A0.985
HLA-Cmajor histocompatibility complex, class I, C0.978
HLA-Gmajor histocompatibility complex, class I, G0.929
HLA-Bmajor histocompatibility complex, class I, B0.888
B2Mbeta-2-microglobulin0.859
IL2RBinterleukin 2 receptor, beta0.849
IL8interleukin 80.840
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.833
CCL5chemokine (C-C motif) ligand 50.755
TAPBPTAP binding protein (tapasin)0.742
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.739
CCL4chemokine (C-C motif) ligand 40.738
KLRD1killer cell lectin-like receptor subfamily D, member 10.731
CXCL9chemokine (C-X-C motif) ligand 90.726
SH2D1ASH2 domain containing 1A0.682
PTPN6protein tyrosine phosphatase, non-receptor type 60.677
KLRK1killer cell lectin-like receptor subfamily K, member 10.666
HLA-Fmajor histocompatibility complex, class I, F0.643
SLAMF1signaling lymphocytic activation molecule family member 10.627
HLA-Emajor histocompatibility complex, class I, E0.625
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.622
CCR5chemokine (C-C motif) receptor 50.518
PRF1perforin 1 (pore forming protein)0.446
CD84CD84 molecule0.414
SNAP23synaptosomal-associated protein, 23kDa0.387
CD22CD22 molecule0.344
IFNGinterferon, gamma0.335
PILRApaired immunoglobin-like type 2 receptor alpha0.301
GNLYgranulysin0.273
CXCL2chemokine (C-X-C motif) ligand 20.267
CAV1caveolin 1, caveolae protein, 22kDa0.260
SIGLEC7sialic acid binding Ig-like lectin 70.254
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.250
NKG7natural killer cell group 7 sequence0.244
IL18RAPinterleukin 18 receptor accessory protein0.236
DDIT3DNA-damage-inducible transcript 30.209
NOSTRINnitric oxide synthase trafficker0.206
GBAglucosidase, beta, acid0.204
CXCL10chemokine (C-X-C motif) ligand 100.203
CST7cystatin F (leukocystatin)0.200
CCR1chemokine (C-C motif) receptor 10.196
CD33CD33 molecule0.189
GZMKgranzyme K (granzyme 3; tryptase II)0.163
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.141
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.141
CD2CD2 molecule0.134
ITM2Bintegral membrane protein 2B0.128
IGSF6immunoglobulin superfamily, member 60.112
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.110
HK3hexokinase 3 (white cell)0.110
FCN1ficolin (collagen/fibrinogen domain containing) 10.099
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.094
CD48CD48 molecule0.093
CCR7chemokine (C-C motif) receptor 70.086
ARRB1arrestin, beta 10.086
KLRB1killer cell lectin-like receptor subfamily B, member 10.085
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.084
KLRC3killer cell lectin-like receptor subfamily C, member 30.083
IL2RGinterleukin 2 receptor, gamma0.082
GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)0.081
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.080
IL6interleukin 6 (interferon, beta 2)0.079
NCSTNnicastrin0.077
EPORerythropoietin receptor0.077
ITKIL2-inducible T-cell kinase0.076
SRGNserglycin0.075
CCL13chemokine (C-C motif) ligand 130.073
PVRL4poliovirus receptor-related 40.073
SYKspleen tyrosine kinase0.071
CCL22chemokine (C-C motif) ligand 220.070
GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)0.069
LGALS3lectin, galactoside-binding, soluble, 30.067
CCL8chemokine (C-C motif) ligand 80.065
CXCR6chemokine (C-X-C motif) receptor 60.064
FCARFc fragment of IgA, receptor for0.064
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.064
NCF4neutrophil cytosolic factor 4, 40kDa0.062
CCR2chemokine (C-C motif) receptor 20.059
RAB14RAB14, member RAS oncogene family0.059
KLRC2killer cell lectin-like receptor subfamily C, member 20.058
CD3DCD3d molecule, delta (CD3-TCR complex)0.055
CXCL3chemokine (C-X-C motif) ligand 30.055
CCL2chemokine (C-C motif) ligand 20.054
BAXBCL2-associated X protein0.053
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.052
FPR3formyl peptide receptor 30.051
PTAFRplatelet-activating factor receptor0.050
RGS1regulator of G-protein signaling 10.049
CLEC4DC-type lectin domain family 4, member D0.049
GPR65G protein-coupled receptor 650.047
SH2D1BSH2 domain containing 1B0.047
DPP4dipeptidyl-peptidase 40.047
GPR171G protein-coupled receptor 1710.047
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.046
CLEC10AC-type lectin domain family 10, member A0.045
IL1Binterleukin 1, beta0.044
CCL7chemokine (C-C motif) ligand 70.044
IL32interleukin 320.044
MAPK1mitogen-activated protein kinase 10.044
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.817
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.564
Hsph1heat shock 105/110 protein 10.385
Gzmkgranzyme K0.310
Gzmbgranzyme B0.194
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.159
Klrd1killer cell lectin-like receptor, subfamily D, member 10.141
B2mbeta-2 microglobulin0.140
Oas1a2'-5' oligoadenylate synthetase 1A0.137
Neurl3neuralized homolog 3 (Drosophila)0.119
RT1-ClRT1 class Ib, locus Cl0.113
Cd2Cd2 molecule0.090
Cxcl10chemokine (C-X-C motif) ligand 100.084
RT1-CE12RT1 class I, locus CE120.073
Atf3activating transcription factor 30.064
Rt1.aaMHC class I RT1.Aa alpha-chain0.063
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.063
RT1-DaRT1 class II, locus Da0.062
Nkg7natural killer cell group 7 sequence0.060
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.060
Spnsialophorin0.059
Cd8aCD8a molecule0.039
Arhgap4Rho GTPase activating protein 40.037
Prf1perforin 1 (pore forming protein)0.037
Ly6allymphocyte antigen 6 complex, locus A-like0.036
Mcpt8mast cell protease 80.034
RGD1304644similar to RIKEN cDNA 2310046K010.033
Ccl7chemokine (C-C motif) ligand 70.032
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.032
Fut2fucosyltransferase 2 (secretor status included)0.031
Sellselectin L0.031
Xcl1chemokine (C motif) ligand 10.029
Sept1septin 10.026
Ccl5chemokine (C-C motif) ligand 50.026
Cd53Cd53 molecule0.026
Gimap4GTPase, IMAP family member 40.026
Il7rinterleukin 7 receptor0.025
Cd247Cd247 molecule0.024
Hspb1heat shock protein 10.023
Gbp2guanylate binding protein 20.023
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.023
LOC100364500RT1 class I, locus CE11-like0.022
Tfectranscription factor EC0.022
Ripk3receptor-interacting serine-threonine kinase 30.022
Igsf6immunoglobulin superfamily, member 60.022
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.021
Mx1myxovirus (influenza virus) resistance 10.021
Dctn4dynactin 40.021
Apoeapolipoprotein E0.020
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.019
TcrbT-cell receptor beta chain0.019
Fam70bfamily with sequence similarity 70, member B0.018
Ubbubiquitin B0.018
Rgs1regulator of G-protein signaling 10.018
Il2rbinterleukin 2 receptor, beta0.018
Casp1caspase 10.018
Ly6cLy6-C antigen0.018
Uba7ubiquitin-like modifier activating enzyme 70.017
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.017
Plcg2phospholipase C, gamma 20.017
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.016
RT1-S3RT1 class Ib, locus S30.016
Mmp12matrix metallopeptidase 120.016
BlnkB-cell linker0.016
Clec9aC-type lectin domain family 9, member a0.016
Il7interleukin 70.015
Emcnendomucin0.015
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.015
Pim1pim-1 oncogene0.015
Rhohras homolog gene family, member H0.015
Il2rginterleukin 2 receptor, gamma0.015
Msx2msh homeobox 20.014
Gzmagranzyme A0.014
Cd5Cd5 molecule0.014
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.014
Actbactin, beta0.014
Klra5killer cell lectin-like receptor, subfamily A, member 50.014
Slfn2schlafen 20.014
Anxa2annexin A20.014
Zap70zeta-chain (TCR) associated protein kinase0.013
Slc22a25solute carrier family 22, member 250.013
Ptpreprotein tyrosine phosphatase, receptor type, E0.013
LOC100363783rCG53773-like0.012
Cd3gCD3 molecule, gamma0.012
Irf2interferon regulatory factor 20.012
Ddr1discoidin domain receptor tyrosine kinase 10.012
Ptprcapprotein tyrosine phosphatase, receptor type, C-associated protein0.012
Il10interleukin 100.012
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.012
Cd8bCD8b molecule0.012
RT1-N3RT1 class Ib, locus N30.012
Cxcl9chemokine (C-X-C motif) ligand 90.012
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.012
Arhgap15Rho GTPase activating protein 150.011
Irf1interferon regulatory factor 10.011
Nr1h3nuclear receptor subfamily 1, group H, member 30.011
Vom1r93vomeronasal 1 receptor 930.011
Ccr2chemokine (C-C motif) receptor 20.011
Aif1allograft inflammatory factor 10.010
LOC100364485mCG1051031-like0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism