The network for 'neural tube closure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube closure

The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Tcfap2atranscription factor AP-2, alpha1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax3paired box gene 31.000
Fgfr1fibroblast growth factor receptor 11.000
Foxc1forkhead box C11.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Gli2GLI-Kruppel family member GLI21.000
Rargretinoic acid receptor, gamma1.000
Bmp4bone morphogenetic protein 41.000
Smosmoothened homolog (Drosophila)1.000
Msx1homeobox, msh-like 11.000
Pbx1pre B-cell leukemia transcription factor 11.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Prrx1paired related homeobox 11.000
Pax6paired box gene 61.000
Foxc2forkhead box C21.000
Rarbretinoic acid receptor, beta1.000
Fgf8fibroblast growth factor 81.000
Lhx1LIM homeobox protein 10.999
Sox2SRY-box containing gene 20.999
Chrdchordin0.999
Bmp7bone morphogenetic protein 70.999
Pax2paired box gene 20.999
Dlx5distal-less homeobox 50.999
Hand1heart and neural crest derivatives expressed transcript 10.998
Sox9SRY-box containing gene 90.998
Hand2heart and neural crest derivatives expressed transcript 20.998
Hoxa1homeobox A10.997
Msx2homeobox, msh-like 20.997
Rararetinoic acid receptor, alpha0.996
Foxg1forkhead box G10.996
Sall4sal-like 4 (Drosophila)0.996
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.994
Tbx1T-box 10.993
Nodalnodal0.991
Chd7chromodomain helicase DNA binding protein 70.991
Gbx2gastrulation brain homeobox 20.990
Prrx2paired related homeobox 20.990
Ednraendothelin receptor type A0.989
Acvr1activin A receptor, type 10.987
Tgfb2transforming growth factor, beta 20.986
Emx2empty spiracles homolog 2 (Drosophila)0.986
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.984
Isl1ISL1 transcription factor, LIM/homeodomain0.982
Ror2receptor tyrosine kinase-like orphan receptor 20.980
Nognoggin0.978
En1engrailed 10.977
Fzd8frizzled homolog 8 (Drosophila)0.975
Apcadenomatosis polyposis coli0.974
Vegfavascular endothelial growth factor A0.972
Zic3zinc finger protein of the cerebellum 30.972
Ptch1patched homolog 10.969
Hoxa2homeobox A20.960
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.959
Gscgoosecoid homeobox0.956
Fgfr3fibroblast growth factor receptor 30.955
Sox11SRY-box containing gene 110.952
Otx1orthodenticle homolog 1 (Drosophila)0.950
Zic2zinc finger protein of the cerebellum 20.950
Pou5f1POU domain, class 5, transcription factor 10.945
Pitx1paired-like homeodomain transcription factor 10.945
Fgf10fibroblast growth factor 100.943
Ptenphosphatase and tensin homolog0.940
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.936
Ptk7PTK7 protein tyrosine kinase 70.934
Dvl2dishevelled 2, dsh homolog (Drosophila)0.933
Wnt3awingless-related MMTV integration site 3A0.932
Jag1jagged 10.930
Efna2ephrin A20.928
Lhx9LIM homeobox protein 90.924
Hoxa3homeobox A30.923
Meox2mesenchyme homeobox 20.922
Tbrachyury0.899
Neurod1neurogenic differentiation 10.898
Smad4MAD homolog 4 (Drosophila)0.891
Tead2TEA domain family member 20.887
Pax8paired box gene 80.878
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.873
Foxh1forkhead box H10.868
Wt1Wilms tumor 1 homolog0.863
Emx1empty spiracles homolog 1 (Drosophila)0.862
Mks1Meckel syndrome, type 10.862
Wnt5awingless-related MMTV integration site 5A0.861
Dkk1dickkopf homolog 1 (Xenopus laevis)0.856
Ctnnb1catenin (cadherin associated protein), beta 10.852
Ascl1achaete-scute complex homolog 1 (Drosophila)0.850
Dvl3dishevelled 3, dsh homolog (Drosophila)0.849
Runx2runt related transcription factor 20.838
Sox4SRY-box containing gene 40.837
Tbx3T-box 30.821
Tsc2tuberous sclerosis 20.816
Neurog2neurogenin 20.812
Tcfap2ctranscription factor AP-2, gamma0.811
Hoxa11homeobox A110.806
Efsembryonal Fyn-associated substrate0.802
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.603
DVL3dishevelled, dsh homolog 3 (Drosophila)0.601
TSC2tuberous sclerosis 20.581
CASP9caspase 9, apoptosis-related cysteine peptidase0.570
ZFYVE9zinc finger, FYVE domain containing 90.553
LRRK2leucine-rich repeat kinase 20.517
BCORBCL6 corepressor0.513
SASS6spindle assembly 6 homolog (C. elegans)0.473
AXIN1axin 10.472
SMAD2SMAD family member 20.460
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.426
APCadenomatous polyposis coli0.401
SMAD3SMAD family member 30.372
ZFXzinc finger protein, X-linked0.342
SEC23ASec23 homolog A (S. cerevisiae)0.314
DVL1dishevelled, dsh homolog 1 (Drosophila)0.309
RXRAretinoid X receptor, alpha0.302
SETD8SET domain containing (lysine methyltransferase) 80.293
TRRAPtransformation/transcription domain-associated protein0.288
C9orf89chromosome 9 open reading frame 890.279
MEOX2mesenchyme homeobox 20.279
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.276
SORBS3sorbin and SH3 domain containing 30.271
PCM1pericentriolar material 10.242
CNKSR2connector enhancer of kinase suppressor of Ras 20.230
SOX10SRY (sex determining region Y)-box 100.214
MED16mediator complex subunit 160.210
ABI1abl-interactor 10.202
MBD2methyl-CpG binding domain protein 20.183
SEC24DSEC24 family, member D (S. cerevisiae)0.172
DLG5discs, large homolog 5 (Drosophila)0.159
CASP3caspase 3, apoptosis-related cysteine peptidase0.159
NCOA1nuclear receptor coactivator 10.149
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.145
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.143
CREBBPCREB binding protein0.142
WASF2WAS protein family, member 20.142
RASA1RAS p21 protein activator (GTPase activating protein) 10.141
GLI1GLI family zinc finger 10.136
PKP4plakophilin 40.132
CTBP2C-terminal binding protein 20.122
ZRANB1zinc finger, RAN-binding domain containing 10.121
CSNK1Dcasein kinase 1, delta0.116
CTBP1C-terminal binding protein 10.104
SH3BP4SH3-domain binding protein 40.104
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.103
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.103
USP9Xubiquitin specific peptidase 9, X-linked0.102
LDB1LIM domain binding 10.101
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.098
CSNK1Ecasein kinase 1, epsilon0.098
ERBB2IPerbb2 interacting protein0.098
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.097
BBS2Bardet-Biedl syndrome 20.096
MED25mediator complex subunit 250.096
USP22ubiquitin specific peptidase 220.087
SKIv-ski sarcoma viral oncogene homolog (avian)0.085
VASPvasodilator-stimulated phosphoprotein0.084
MED24mediator complex subunit 240.084
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.083
SIN3ASIN3 homolog A, transcription regulator (yeast)0.082
NCOA6nuclear receptor coactivator 60.082
EP300E1A binding protein p3000.081
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.081
TJP2tight junction protein 2 (zona occludens 2)0.080
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.080
TSC1tuberous sclerosis 10.080
ESR1estrogen receptor 10.078
ORC6origin recognition complex, subunit 60.076
AKIP1A kinase (PRKA) interacting protein 10.071
BMP7bone morphogenetic protein 70.064
WASF1WAS protein family, member 10.061
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.061
BAIAP2BAI1-associated protein 20.060
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.060
HMOX2heme oxygenase (decycling) 20.060
SGSM2small G protein signaling modulator 20.058
EPAS1endothelial PAS domain protein 10.058
BBS9Bardet-Biedl syndrome 90.058
PBRM1polybromo 10.058
MTA1metastasis associated 10.058
NCF1neutrophil cytosolic factor 10.058
STRN3striatin, calmodulin binding protein 30.058
BMP2bone morphogenetic protein 20.057
FZD1frizzled homolog 1 (Drosophila)0.057
ZMYND11zinc finger, MYND-type containing 110.056
KIAA1377KIAA13770.056
ARID1BAT rich interactive domain 1B (SWI1-like)0.056
WT1Wilms tumor 10.055
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.055
SMURF1SMAD specific E3 ubiquitin protein ligase 10.055
WNT5Awingless-type MMTV integration site family, member 5A0.055
LGALS8lectin, galactoside-binding, soluble, 80.054
SP1Sp1 transcription factor0.054
SMAD4SMAD family member 40.054
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.054
CRMP1collapsin response mediator protein 10.054
FHL1four and a half LIM domains 10.053
NCOR1nuclear receptor corepressor 10.052
KIF14kinesin family member 140.051
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism