The network for 'photoreceptor cell maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

photoreceptor cell maintenance

Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.

NameDescriptionProbabilityFunc Analog Organism
Pcdh15protocadherin 151.000
Cdh23cadherin 23 (otocadherin)0.994
Ush1gUsher syndrome 1G homolog (human)0.993
Ush1cUsher syndrome 1C homolog (human)0.983
Grxcr1glutaredoxin, cysteine rich 10.970
Myo7amyosin VIIA0.960
Ptprqprotein tyrosine phosphatase, receptor type, Q0.938
Nr2e1nuclear receptor subfamily 2, group E, member 10.938
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.923
Bbs4Bardet-Biedl syndrome 4 (human)0.913
Bbs2Bardet-Biedl syndrome 2 (human)0.828
Myo15myosin XV0.738
LOC100503041PDZ domain-containing protein 7-like0.619
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.609
Gpr98G protein-coupled receptor 980.512
Bbs1Bardet-Biedl syndrome 1 (human)0.508
Ift57intraflagellar transport 57 homolog (Chlamydomonas)0.417
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.403
Crxcone-rod homeobox containing gene0.384
Lrp1low density lipoprotein receptor-related protein 10.368
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.231
Apoeapolipoprotein E0.217
Dclk1doublecortin-like kinase 10.191
Try10trypsin 100.181
Myo6myosin VI0.179
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.170
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.163
Tmc1transmembrane channel-like gene family 10.148
Pde6gphosphodiesterase 6G, cGMP-specific, rod, gamma0.147
Cacna1fcalcium channel, voltage-dependent, alpha 1F subunit0.119
Ptenphosphatase and tensin homolog0.110
Lig4ligase IV, DNA, ATP-dependent0.106
Pou4f3POU domain, class 4, transcription factor 30.105
Tcp11t-complex protein 110.098
Bbs9Bardet-Biedl syndrome 9 (human)0.097
Ppm1nprotein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)0.096
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.095
Scn8asodium channel, voltage-gated, type VIII, alpha0.080
Npc1Niemann Pick type C10.078
Rdh8retinol dehydrogenase 80.077
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.076
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.072
Man2c1mannosidase, alpha, class 2C, member 10.071
ND6NADH dehydrogenase subunit 60.065
Kif3akinesin family member 3A0.063
Ift81intraflagellar transport 81 homolog (Chlamydomonas)0.063
Ubxn11UBX domain protein 110.062
Makmale germ cell-associated kinase0.060
Prph2peripherin 20.059
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)0.057
Gfi1growth factor independent 10.054
Iqcb1IQ calmodulin-binding motif containing 10.053
Cnga1cyclic nucleotide gated channel alpha 10.045
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.045
Thrbthyroid hormone receptor beta0.042
Arl6ADP-ribosylation factor-like 60.040
Hcn3hyperpolarization-activated, cyclic nucleotide-gated K+ 30.040
Slc26a5solute carrier family 26, member 50.036
Ift140intraflagellar transport 140 homolog (Chlamydomonas)0.034
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.034
Bbs7Bardet-Biedl syndrome 7 (human)0.034
Kif9kinesin family member 90.033
Rgs11regulator of G-protein signaling 110.032
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.032
Pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.032
Arr3arrestin 3, retinal0.032
Clrn1clarin 10.031
Mdm2transformed mouse 3T3 cell double minute 20.030
Crb2crumbs homolog 2 (Drosophila)0.030
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.030
Gzmmgranzyme M (lymphocyte met-ase 1)0.028
Ttc8tetratricopeptide repeat domain 80.028
Stk30serine/threonine kinase 300.028
Gli2GLI-Kruppel family member GLI20.028
Slc4a8solute carrier family 4 (anion exchanger), member 80.027
Pcyt1aphosphate cytidylyltransferase 1, choline, alpha isoform0.026
Crb1crumbs homolog 1 (Drosophila)0.026
Mzf1myeloid zinc finger 10.026
Dpf3D4, zinc and double PHD fingers, family 30.026
Lrrc48leucine rich repeat containing 480.026
Cfhcomplement component factor h0.025
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.025
BC027072cDNA sequence BC0270720.024
Gjd2gap junction protein, delta 20.024
Nme5non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)0.022
Xpaxeroderma pigmentosum, complementation group A0.022
Zfp444zinc finger protein 4440.022
Trpm1transient receptor potential cation channel, subfamily M, member 10.022
Mast3microtubule associated serine/threonine kinase 30.022
Wdr31WD repeat domain 310.022
Drd4dopamine receptor D40.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ift88intraflagellar transport 88 homolog0.983
cc2d2acoiled-coil and C2 domain containing 2A0.510
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.321
ift52intraflagellar transport protein 520.208
epb41l5erythrocyte membrane protein band 4.1 like 50.178
ptch1patched 10.128
kif17kinesin family member 170.089
dync1h1dynein, cytoplasmic 1, heavy chain 10.069
bbs2Bardet-Biedl syndrome 20.065
aanat2arylalkylamine N-acetyltransferase0.046
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.044
dctn1adynactin 1a0.040
cluap1clusterin associated protein 10.038
bbs4Bardet-Biedl syndrome 40.032
rbp4lretinol binding protein 4, like0.030
mtormechanistic target of rapamycin (serine/threonine kinase)0.025
gc3guanylyl cyclase 30.024
foxa2forkhead box A20.023
foxa1forkhead box A10.022
tbx2bT-box 2b0.022
kif3bkinesin family member 3B0.021
bbs7Bardet-Biedl syndrome 70.021
col10a1collagen, type X, alpha 10.020
spna2spectrin alpha 20.020
ttc26tetratricopeptide repeat domain 260.020
cdh2cadherin 2, neuronal0.020
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.019
crxcone-rod homeobox0.019
jag1bjagged 1b0.019
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.017
ap1b1adaptor-related protein complex 1, beta 1 subunit0.017
ahcyl2S-adenosylhomocysteine hydrolase-like 20.016
guca1cguanylate cyclase activator 1C0.015
ift80intraflagellar transport 80 homolog (Chlamydomonas)0.015
ift46intraflagellar transport protein 460.015
LOC799612prolactin 20.015
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.015
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.015
pdzd7aPDZ domain containing 7a0.014
makmale germ cell-associated kinase0.014
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.014
actr10actin-related protein 10 homolog (S. cerevisiae)0.014
grk7aG-protein-coupled receptor kinase 7a0.013
cacnb2bcalcium channel, voltage-dependent, beta 2b0.012
crb2acrumbs homolog 2a0.012
stk11serine/threonine kinase 110.012
hoxa13ahomeo box A13a0.012
wwp2WW domain containing E3 ubiquitin protein ligase 20.012
mesp2mesoderm posterior 2 homolog (mouse)0.012
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.012
tbpl2TATA box binding protein like 20.011
dcaf7ddb1 and cul4 associated factor 70.011
cep290centrosomal protein 2900.011
ptbp2polypyrimidine tract binding protein 20.011
cdc42cell division cycle 420.011
mks1meckel syndrome, type 10.011
ppp1cblprotein phosphatase 1, catalytic subunit, beta isoform, like0.010
guk1guanylate kinase 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
trptransient receptor potential0.700
Arr2Arrestin 20.499
Galpha49BG protein alpha49B0.338
ninaEneither inactivation nor afterpotential E0.336
inaCinactivation no afterpotential C0.274
ninaCneither inactivation nor afterpotential C0.195
norpAno receptor potential A0.172
inaDinactivation no afterpotential D0.138
Kap-alpha3karyopherin alpha30.090
tadrtorn and diminished rhabdomeres0.079
retinophilinCG10233 gene product from transcript CG10233-RA0.079
sosine oculis0.069
Rh3Rhodopsin 30.060
unc-13CG2999 gene product from transcript CG2999-RA0.055
rdgCretinal degeneration C0.045
Vha100-1CG1709 gene product from transcript CG1709-RF0.044
rdgBretinal degeneration B0.043
gbbglass bottom boat0.043
Gbeta76CG protein beta-subunit 76C0.041
Pph13PvuII-PstI homology 130.041
Prosalpha1Proteasome alpha1 subunit0.039
endoAendophilin A0.038
Rh5Rhodopsin 50.035
Rab11Rab-protein 110.031
ninaAneither inactivation nor afterpotential A0.031
cicubitus interruptus0.029
l(2)gllethal (2) giant larvae0.029
CG6116CG6116 gene product from transcript CG6116-RA0.028
Traf4TNF-receptor-associated factor 40.028
Vhlvon Hippel-Lindau0.027
Tak1TGF-beta activated kinase 10.026
CalxNa/Ca-exchange protein0.025
G-salpha60AG protein salpha 60A0.024
Ten-mTenascin major0.022
argosCG4531 gene product from transcript CG4531-RA0.020
Ggamma1G protein gamma 10.020
lkb1CG9374 gene product from transcript CG9374-RJ0.020
dvedefective proventriculus0.019
rdgAretinal degeneration A0.018
CG4567CG4567 gene product from transcript CG4567-RA0.018
stopsslow termination of phototransduction0.017
Drp1Dynamin related protein 10.017
sinaseven in absentia0.015
nudECG8104 gene product from transcript CG8104-RB0.014
PdhPhotoreceptor dehydrogenase0.014
CG6751CG6751 gene product from transcript CG6751-RA0.014
Arr1Arrestin 10.013
frcfringe connection0.013
kkvkrotzkopf verkehrt0.012
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.012
DadDaughters against dpp0.011
CG7077CG7077 gene product from transcript CG7077-RA0.011
Nipped-ACG33554 gene product from transcript CG33554-RE0.011
GgaCG3002 gene product from transcript CG3002-RB0.011
CG13792CG13792 gene product from transcript CG13792-RA0.011
RalaRas-related protein0.010
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BBS2Bardet-Biedl syndrome 20.977
BBS7Bardet-Biedl syndrome 70.791
CLIP1CAP-GLY domain containing linker protein 10.728
BBS9Bardet-Biedl syndrome 90.698
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.651
USHBP1Usher syndrome 1C binding protein 10.411
ATMINATM interactor0.303
TP53BP1tumor protein p53 binding protein 10.285
DISC1disrupted in schizophrenia 10.268
MAP3K7mitogen-activated protein kinase kinase kinase 70.206
TTC8tetratricopeptide repeat domain 80.159
FRZBfrizzled-related protein0.154
PCM1pericentriolar material 10.144
MAPK6mitogen-activated protein kinase 60.136
RGS2regulator of G-protein signaling 2, 24kDa0.130
KRT18keratin 180.113
C7orf36chromosome 7 open reading frame 360.109
ARL6ADP-ribosylation factor-like 60.105
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.093
ENAHenabled homolog (Drosophila)0.092
NR4A1nuclear receptor subfamily 4, group A, member 10.089
RASA1RAS p21 protein activator (GTPase activating protein) 10.087
HSCBHscB iron-sulfur cluster co-chaperone homolog (E. coli)0.083
NLKnemo-like kinase0.082
USH1CUsher syndrome 1C (autosomal recessive, severe)0.074
DCLRE1CDNA cross-link repair 1C0.066
MAP2K4mitogen-activated protein kinase kinase 40.064
TERF1telomeric repeat binding factor (NIMA-interacting) 10.062
PAX2paired box 20.061
BBS12Bardet-Biedl syndrome 120.057
USH1GUsher syndrome 1G (autosomal recessive)0.053
PTK2PTK2 protein tyrosine kinase 20.045
CEP290centrosomal protein 290kDa0.043
HES1hairy and enhancer of split 1, (Drosophila)0.040
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.037
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.030
HOMER3homer homolog 3 (Drosophila)0.029
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.027
ZNF331zinc finger protein 3310.027
UNC119Bunc-119 homolog B (C. elegans)0.026
MAPK8mitogen-activated protein kinase 80.026
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.022
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.022
EXOC4exocyst complex component 40.020
CSNK1Ecasein kinase 1, epsilon0.020
CDHR5cadherin-related family member 50.019
DVL2dishevelled, dsh homolog 2 (Drosophila)0.019
TP63tumor protein p630.017
SMC1Astructural maintenance of chromosomes 1A0.017
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.016
BBS5Bardet-Biedl syndrome 50.016
TUBB8tubulin, beta 80.016
MYST1MYST histone acetyltransferase 10.015
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.015
CRMP1collapsin response mediator protein 10.014
CEP164centrosomal protein 164kDa0.014
TINF2TERF1 (TRF1)-interacting nuclear factor 20.014
NACADNAC alpha domain containing0.013
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.013
RAB2ARAB2A, member RAS oncogene family0.013
BICD2bicaudal D homolog 2 (Drosophila)0.013
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.012
DZIP3DAZ interacting protein 3, zinc finger0.012
RANBP9RAN binding protein 90.011
MDC1mediator of DNA-damage checkpoint 10.011
ZNF579zinc finger protein 5790.011
RAD17RAD17 homolog (S. pombe)0.010
SYT13synaptotagmin XIII0.010
RAD50RAD50 homolog (S. cerevisiae)0.010
EIF1eukaryotic translation initiation factor 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism