The network for 'centrosome separation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.

NameDescriptionProbabilityFunc Analog Organism
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.967
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.866
Ccnb1cyclin B10.839
Hmmrhyaluronan mediated motility receptor (RHAMM)0.478
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.452
Prc1protein regulator of cytokinesis 10.437
Kif4kinesin family member 40.423
Ccna2cyclin A20.421
Kif2ckinesin family member 2C0.419
Ncoa2nuclear receptor coactivator 20.398
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.376
Plk1polo-like kinase 1 (Drosophila)0.375
Anlnanillin, actin binding protein0.364
Cdk1cyclin-dependent kinase 10.345
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.324
Mis18bp1MIS18 binding protein 10.310
Kif23kinesin family member 230.294
Kif20akinesin family member 20A0.291
1110004F10RikRIKEN cDNA 1110004F10 gene0.260
Rab18RAB18, member RAS oncogene family0.227
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.214
Dtldenticleless homolog (Drosophila)0.182
Dlgap5discs, large (Drosophila) homolog-associated protein 50.180
StilScl/Tal1 interrupting locus0.179
Pcnaproliferating cell nuclear antigen0.173
Rab5aRAB5A, member RAS oncogene family0.173
Plk4polo-like kinase 4 (Drosophila)0.165
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.161
Cenpacentromere protein A0.159
E2f8E2F transcription factor 80.156
Strn3striatin, calmodulin binding protein 30.155
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.151
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.151
Kif11kinesin family member 110.149
Ccnb2cyclin B20.148
Ckap2cytoskeleton associated protein 20.148
Erhenhancer of rudimentary homolog (Drosophila)0.140
Racgap1Rac GTPase-activating protein 10.132
Cenpfcentromere protein F0.128
C330027C09RikRIKEN cDNA C330027C09 gene0.128
Smc2structural maintenance of chromosomes 20.127
Mastlmicrotubule associated serine/threonine kinase-like0.126
Ncaphnon-SMC condensin I complex, subunit H0.125
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.125
Top2atopoisomerase (DNA) II alpha0.111
Zfand5zinc finger, AN1-type domain 50.110
TtkTtk protein kinase0.109
Fam64afamily with sequence similarity 64, member A0.108
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.104
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.097
H2afxH2A histone family, member X0.094
Dync1i1dynein cytoplasmic 1 intermediate chain 10.093
Dna2DNA replication helicase 2 homolog (yeast)0.091
Dynll1dynein light chain LC8-type 10.082
Zfp617zinc finger protein 6170.076
Gtse1G two S phase expressed protein 10.072
Eif4a2eukaryotic translation initiation factor 4A20.072
Csde1cold shock domain containing E1, RNA binding0.072
Gsg2germ cell-specific gene 20.069
Clip1CAP-GLY domain containing linker protein 10.067
Thoc4THO complex 40.064
Cdc25ccell division cycle 25 homolog C (S. pombe)0.062
Kif22kinesin family member 220.062
Lmnb1lamin B10.058
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.058
Exo1exonuclease 10.055
Dtnbdystrobrevin, beta0.054
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.054
Hccsholocytochrome c synthetase0.054
Serinc1serine incorporator 10.054
Aurkbaurora kinase B0.053
Rnf11ring finger protein 110.053
Igbp1immunoglobulin (CD79A) binding protein 10.053
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.052
Ect2ect2 oncogene0.051
Azin1antizyme inhibitor 10.049
Eif3jeukaryotic translation initiation factor 3, subunit J0.046
Foxm1forkhead box M10.046
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.045
Rab1RAB1, member RAS oncogene family0.043
Brca1breast cancer 10.042
Ska1spindle and kinetochore associated complex subunit 10.041
Ccdc99coiled-coil domain containing 990.041
Kif5akinesin family member 5A0.040
Tfdp1transcription factor Dp 10.040
Iqgap3IQ motif containing GTPase activating protein 30.039
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.039
Ccnfcyclin F0.039
Diap3diaphanous homolog 3 (Drosophila)0.037
Eme1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.037
Golph3golgi phosphoprotein 30.036
Bzw1basic leucine zipper and W2 domains 10.036
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.035
Ubl3ubiquitin-like 30.035
Ppihpeptidyl prolyl isomerase H0.035
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.035
Sult4a1sulfotransferase family 4A, member 10.035
Srsf2serine/arginine-rich splicing factor 20.034
Capza2capping protein (actin filament) muscle Z-line, alpha 20.033
Vapavesicle-associated membrane protein, associated protein A0.033
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Sas-4CG10061 gene product from transcript CG10061-RA0.969
marsCG17064 gene product from transcript CG17064-RB0.890
Dhc64CDynein heavy chain 64C0.820
aspabnormal spindle0.737
spd-2spindle defective 20.673
SAKSak kinase0.660
Klp10ACG1453 gene product from transcript CG1453-RA0.555
larpLa related protein0.425
Spc25CG7242 gene product from transcript CG7242-RA0.399
BubR1Bub1-related kinase0.371
lkb1CG9374 gene product from transcript CG9374-RJ0.322
sas-6spindle assembly abnormal 60.253
ana3anastral spindle 30.219
ana2anastral spindle 20.186
CycB3Cyclin B30.143
IncenpInner centromere protein0.140
Poc1Proteome of centrioles 10.132
Klp61FKinesin-like protein at 61F0.126
rodrough deal0.122
Cep135CG17081 gene product from transcript CG17081-RB0.072
cidcentromere identifier0.071
Klp3AKinesin-like protein at 3A0.067
Nek2CG17256 gene product from transcript CG17256-RA0.063
ana1anastral spindle 10.060
tacctransforming acidic coiled-coil protein0.059
BicDBicaudal D0.059
CG14814CG14814 gene product from transcript CG14814-RA0.058
nudECG8104 gene product from transcript CG8104-RB0.057
CG8478CG8478 gene product from transcript CG8478-RD0.056
SNF1ASNF1A/AMP-activated protein kinase0.055
Grip71CG10346 gene product from transcript CG10346-RA0.051
Orc5Origin recognition complex subunit 50.045
Grip163CG5688 gene product from transcript CG5688-RA0.044
Cp110CG14617 gene product from transcript CG14617-RB0.036
pitaCG3941 gene product from transcript CG3941-RA0.032
Grip128CG9201 gene product from transcript CG9201-RB0.030
CycBCyclin B0.029
Ndc80CG9938 gene product from transcript CG9938-RA0.027
cp309CG33957 gene product from transcript CG33957-RB0.026
hydhyperplastic discs0.026
DNApol-alpha60DNA polymerase alpha 60kD0.025
Hsp83Heat shock protein 830.024
PPP4R2rProtein phosphatase 4 regulatory subunit 2-related protein0.024
Klp67AKinesin-like protein at 67A0.024
dpadisc proliferation abnormal0.023
CG13144CG13144 gene product from transcript CG13144-RA0.022
fwdfour wheel drive0.022
Hr39Hormone receptor-like in 390.022
Cdc37CG12019 gene product from transcript CG12019-RA0.022
CG5690CG5690 gene product from transcript CG5690-RA0.020
DlicDynein light intermediate chain0.020
ncdnon-claret disjunctional0.020
CG4680CG4680 gene product from transcript CG4680-RA0.019
Sgt1CG9617 gene product from transcript CG9617-RA0.019
dgt4dim gamma-tubulin 40.019
pAbppolyA-binding protein0.018
locolocomotion defects0.017
CG14561CG14561 gene product from transcript CG14561-RA0.017
CG14215CG14215 gene product from transcript CG14215-RA0.017
boraaurora borealis0.016
CG5543CG5543 gene product from transcript CG5543-RA0.016
Cks30ACyclin-dependent kinase subunit 30A0.016
MybMyb oncogene-like0.015
Grip75CG6176 gene product from transcript CG6176-RA0.014
mei-38meiotic 380.014
gammaTub37Cgamma-Tubulin at 37C0.014
CycJCyclin J0.014
sinaseven in absentia0.014
Mkk4MAP kinase kinase 40.013
CG8173CG8173 gene product from transcript CG8173-RA0.013
Eb1CG3265 gene product from transcript CG3265-RF0.013
CG6954CG6954 gene product from transcript CG6954-RB0.013
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.965
INCENPinner centromere protein antigens 135/155kDa0.465
KIF23kinesin family member 230.452
FBXW11F-box and WD repeat domain containing 110.320
BIRC5baculoviral IAP repeat containing 50.318
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.289
CDCA8cell division cycle associated 80.282
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.279
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.216
RAD18RAD18 homolog (S. cerevisiae)0.215
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.212
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.191
APCadenomatous polyposis coli0.185
CLIP1CAP-GLY domain containing linker protein 10.184
MAPK1mitogen-activated protein kinase 10.169
STILSCL/TAL1 interrupting locus0.168
TOP2Atopoisomerase (DNA) II alpha 170kDa0.161
CHEK2CHK2 checkpoint homolog (S. pombe)0.159
GSK3Bglycogen synthase kinase 3 beta0.158
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.158
CDC25Ccell division cycle 25 homolog C (S. pombe)0.145
KIF1Bkinesin family member 1B0.132
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.128
UBR1ubiquitin protein ligase E3 component n-recognin 10.094
CCT8chaperonin containing TCP1, subunit 8 (theta)0.089
TROAPtrophinin associated protein (tastin)0.084
TTKTTK protein kinase0.077
RANBP2RAN binding protein 20.074
RACGAP1Rac GTPase activating protein 10.068
LBRlamin B receptor0.065
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.063
BTRCbeta-transducin repeat containing0.062
NEK2NIMA (never in mitosis gene a)-related kinase 20.060
NEURL4neuralized homolog 4 (Drosophila)0.059
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.052
GAS2L3growth arrest-specific 2 like 30.052
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.050
PLK1polo-like kinase 10.047
KIF20Akinesin family member 20A0.044
KIF2Ckinesin family member 2C0.043
HDAC1histone deacetylase 10.043
CDK1cyclin-dependent kinase 10.042
CENPJcentromere protein J0.042
MAP2K1mitogen-activated protein kinase kinase 10.040
MAPRE1microtubule-associated protein, RP/EB family, member 10.040
SKA1spindle and kinetochore associated complex subunit 10.039
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.038
MAP2K4mitogen-activated protein kinase kinase 40.038
CCNFcyclin F0.038
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.038
FAM64Afamily with sequence similarity 64, member A0.038
AURKBaurora kinase B0.037
KIF14kinesin family member 140.037
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.036
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.036
CDC27cell division cycle 27 homolog (S. cerevisiae)0.035
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.035
CCNB1cyclin B10.035
DLGAP5discs, large (Drosophila) homolog-associated protein 50.035
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.033
CDC20cell division cycle 20 homolog (S. cerevisiae)0.033
CENPEcentromere protein E, 312kDa0.033
YAP1Yes-associated protein 10.033
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.033
RAB21RAB21, member RAS oncogene family0.033
UBE2Cubiquitin-conjugating enzyme E2C0.033
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.032
TP53tumor protein p530.031
TP53BP2tumor protein p53 binding protein, 20.031
CUL1cullin 10.031
STRN3striatin, calmodulin binding protein 30.031
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.030
SGOL1shugoshin-like 1 (S. pombe)0.029
PPP6Cprotein phosphatase 6, catalytic subunit0.029
CCNB2cyclin B20.028
DTLdenticleless homolog (Drosophila)0.027
HMMRhyaluronan-mediated motility receptor (RHAMM)0.025
SASS6spindle assembly 6 homolog (C. elegans)0.024
ZWINTZW10 interactor0.024
PSRC1proline/serine-rich coiled-coil 10.024
CENPFcentromere protein F, 350/400kDa (mitosin)0.023
CBX5chromobox homolog 50.023
THRAP3thyroid hormone receptor associated protein 30.023
PPP2R2Cprotein phosphatase 2, regulatory subunit B, gamma0.023
TCTEX1D2Tctex1 domain containing 20.022
CP110CP110 protein0.021
CCNA2cyclin A20.021
FEM1Cfem-1 homolog c (C. elegans)0.020
CALM1calmodulin 1 (phosphorylase kinase, delta)0.020
MDM4Mdm4 p53 binding protein homolog (mouse)0.020
UBE2G1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.018
MPRIPmyosin phosphatase Rho interacting protein0.018
CDC25Acell division cycle 25 homolog A (S. pombe)0.018
PTTG1pituitary tumor-transforming 10.017
SIAH1seven in absentia homolog 1 (Drosophila)0.017
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.017
PPP2R5Eprotein phosphatase 2, regulatory subunit B', epsilon isoform0.017
AXIN2axin 20.017
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism