The network for 'cellular sodium ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular sodium ion homeostasis

Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.

NameDescriptionProbabilityFunc Analog Organism
Agtr1aangiotensin II receptor, type 1a0.351
Ren1renin 1 structural0.171
Leprleptin receptor0.120
Vdrvitamin D receptor0.097
Prnpprion protein0.049
Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C10.045
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.044
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.042
Tgfb1transforming growth factor, beta 10.035
Hif1ahypoxia inducible factor 1, alpha subunit0.032
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.030
Nos3nitric oxide synthase 3, endothelial cell0.029
Atp6v1b2ATPase, H+ transporting, lysosomal V1 subunit B20.027
Lifleukemia inhibitory factor0.027
Esr1estrogen receptor 1 (alpha)0.026
Arandrogen receptor0.024
Cav1caveolin 1, caveolae protein0.022
Slc12a1solute carrier family 12, member 10.021
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.018
Vegfavascular endothelial growth factor A0.017
Epas1endothelial PAS domain protein 10.016
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.016
Amhr2anti-Mullerian hormone type 2 receptor0.016
Vamp2vesicle-associated membrane protein 20.015
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.014
Nos1nitric oxide synthase 1, neuronal0.014
Vav3vav 3 oncogene0.014
Ptpn11protein tyrosine phosphatase, non-receptor type 110.013
NsfN-ethylmaleimide sensitive fusion protein0.013
Apoeapolipoprotein E0.013
Drd2dopamine receptor D20.013
Atp6v1hATPase, H+ transporting, lysosomal V1 subunit H0.013
Vav2vav 2 oncogene0.013
Scnn1asodium channel, nonvoltage-gated 1 alpha0.012
Synj1synaptojanin 10.012
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.011
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.011
Clstn1calsyntenin 10.011
Ptgs2prostaglandin-endoperoxide synthase 20.011
Stat3signal transducer and activator of transcription 30.011
Kiss1KiSS-1 metastasis-suppressor0.011
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.010
Erlin2ER lipid raft associated 20.010
Errfi1ERBB receptor feedback inhibitor 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.982
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.949
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.917
pvalb8parvalbumin 80.853
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.762
cldnhclaudin h0.681
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.679
agr2anterior gradient homolog 2 (Xenopus laevis)0.489
cyp1acytochrome P450, family 1, subfamily A0.256
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.198
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.166
LOC100000433hypothetical LOC1000004330.156
tnnt2atroponin T2a, cardiac0.126
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.117
edn1endothelin 10.098
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.086
rhcgbRhesus blood group, C glycoprotein b0.085
cdh17cadherin 17, LI cadherin (liver-intestine)0.074
ncs1aneuronal calcium sensor 1a0.074
atp2b1aATPase, Ca++ transporting, plasma membrane 1a0.067
hspa5heat shock protein 50.063
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.062
hsp90a.2heat shock protein 90-alpha 20.061
dnajaDnaJ (Hsp40) homolog, subfamily A member0.055
cmlc1cardiac myosin light chain-10.049
glulbglutamate-ammonia ligase (glutamine synthase) b0.049
alcambactivated leukocyte cell adhesion molecule b0.045
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.042
mvpmajor vault protein0.038
eef2l2eukaryotic translation elongation factor 2, like 20.037
arg2arginase, type II0.037
ca2carbonic anhydrase II0.036
sh3gl2SH3-domain GRB2-like 20.033
ahcyl1S-adenosylhomocysteine hydrolase-like 10.032
bcl2l1bcl2-like 10.031
kitakit receptor a0.030
aqp8a.1aquaporin 8a, tandem duplicate 10.029
esrrdestrogen-related receptor delta0.029
slc16a3solute carrier family 16 (monocarboxylic acid transporters), member 30.028
rbp4retinol binding protein 4, plasma0.028
tsc22d1TSC22 domain family, member 10.027
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.027
atp6v1fATPase, H+ transporting, V1 subunit F0.026
calb2acalbindin 2a0.025
foxi3aforkhead box I3a0.025
dlg1discs, large (Drosophila) homolog 10.025
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.025
gpiaglucose phosphate isomerase a0.025
csnk1dbcasein kinase 1, delta b0.024
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.024
tdhL-threonine dehydrogenase0.023
LOC553527hypothetical protein LOC5535270.023
klf3Kruppel-like factor 3 (basic)0.022
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.022
syt11asynaptotagmin XIa0.021
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.020
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.020
cldn1claudin 10.020
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.020
aspnasporin (LRR class 1)0.020
dlx4adistal-less homeobox gene 4a0.019
hapln3hyaluronan and proteoglycan link protein 30.019
ivns1abpainfluenza virus NS1A binding protein a0.019
elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.019
mid1ip1bMID1 interacting protein 1b0.019
lmo7aLIM domain only 7a0.018
ulk2unc-51-like kinase 2 (C. elegans)0.017
six2asine oculis-related homeobox 2a0.017
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.017
lmbrd2aLMBR1 domain containing 2a0.017
trpm7transient receptor potential cation channel, subfamily M, member 70.016
chac1ChaC, cation transport regulator-like 10.016
prr15laproline rich 15-like a0.016
c21orf59lc21orf59 homolog (H. sapiens), like0.016
pvalb4parvalbumin 40.016
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.016
ell2elongation factor, RNA polymerase II, 20.016
usp2aubiquitin specific peptidase 2a0.015
ckbbcreatine kinase, brain b0.015
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.014
igfbp1ainsulin-like growth factor binding protein 1a0.014
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.014
rhbgRhesus blood group, B glycoprotein0.014
bmp4bone morphogenetic protein 40.014
apoeaapolipoprotein Ea0.014
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.013
junbjun B proto-oncogene0.013
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.940
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.668
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.345
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C10.274
ANXA7annexin A70.238
PLEKHB2pleckstrin homology domain containing, family B (evectins) member 20.117
DDAH2dimethylarginine dimethylaminohydrolase 20.099
RAB1ARAB1A, member RAS oncogene family0.067
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.051
ZNF431zinc finger protein 4310.039
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.037
TMSB4Xthymosin beta 4, X-linked0.036
NDRG2NDRG family member 20.034
WFDC2WAP four-disulfide core domain 20.033
EXT2exostosin 20.031
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.029
DOCK7dedicator of cytokinesis 70.028
GADD45Ggrowth arrest and DNA-damage-inducible, gamma0.027
GLP1Rglucagon-like peptide 1 receptor0.023
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.022
ATP6V1G1ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G10.022
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 20.022
A1BGalpha-1-B glycoprotein0.021
ARL8BADP-ribosylation factor-like 8B0.019
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.019
CRIP2cysteine-rich protein 20.018
NPYneuropeptide Y0.017
NMT2N-myristoyltransferase 20.017
MUC4mucin 4, cell surface associated0.016
FXYD3FXYD domain containing ion transport regulator 30.015
SCARB2scavenger receptor class B, member 20.015
SMN1survival of motor neuron 1, telomeric0.014
ATP6V0A1ATPase, H+ transporting, lysosomal V0 subunit a10.013
LAMP2lysosomal-associated membrane protein 20.013
RNF13ring finger protein 130.012
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.012
TMPRSS4transmembrane protease, serine 40.012
ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide0.012
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.011
PICALMphosphatidylinositol binding clathrin assembly protein0.011
PGCprogastricsin (pepsinogen C)0.011
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.011
SERINC3serine incorporator 30.011
SLC5A1solute carrier family 5 (sodium/glucose cotransporter), member 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Errfi1ERBB receptor feedback inhibitor 10.424
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.199
Rup2urinary protein 20.141
A1i3alpha-1-inhibitor III0.125
Pemtphosphatidylethanolamine N-methyltransferase0.105
Apohapolipoprotein H (beta-2-glycoprotein I)0.099
Spp2secreted phosphoprotein 20.093
Procprotein C0.089
Apoa5apolipoprotein A-V0.088
Aqp9aquaporin 90.088
Rab1bRAB1B, member RAS oncogene family0.088
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.088
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.085
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.079
Mapk3mitogen activated protein kinase 30.073
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.066
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.066
Hk1hexokinase 10.065
Fgafibrinogen alpha chain0.061
S100bS100 calcium binding protein B0.058
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.053
Asgr1asialoglycoprotein receptor 10.053
F9coagulation factor IX0.050
Ank2ankyrin 2, neuronal0.049
Gucy1b2guanylate cyclase 1, soluble, beta 20.049
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.045
Pla1aphospholipase A1 member A0.043
Spink1serine peptidase inhibitor, Kazal type 10.043
Itih3inter-alpha trypsin inhibitor, heavy chain 30.042
Agxt2alanine-glyoxylate aminotransferase 20.041
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.039
Klkb1kallikrein B, plasma 10.038
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.038
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.036
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.034
Igf2insulin-like growth factor 20.034
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.034
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.033
Apcsamyloid P component, serum0.033
F2coagulation factor II (thrombin)0.031
Kynukynureninase (L-kynurenine hydrolase)0.030
Bhlha15basic helix-loop-helix family, member a150.029
Mcpt4mast cell protease 40.027
Apoa1apolipoprotein A-I0.027
Slco1a4solute carrier organic anion transporter family, member 1a40.027
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.026
Cyp2b12cytochrome P450, family 2, subfamily b, polypeptide 120.025
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.025
Azgp1alpha-2-glycoprotein 1, zinc-binding0.025
Olr1398olfactory receptor 13980.024
C8bcomplement component 8, beta polypeptide0.024
Fbp1fructose-1,6-bisphosphatase 10.023
Gcgroup specific component0.023
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.023
Fgf1fibroblast growth factor 10.023
Itih4inter alpha-trypsin inhibitor, heavy chain 40.022
Pdk2pyruvate dehydrogenase kinase, isozyme 20.021
C9complement component 90.021
Igfbp1insulin-like growth factor binding protein 10.021
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.021
Aqp8aquaporin 80.020
Olr1413olfactory receptor 14130.020
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.020
Sisucrase-isomaltase (alpha-glucosidase)0.020
Orm1orosomucoid 10.019
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.019
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.019
Lbplipopolysaccharide binding protein0.019
Otcornithine carbamoyltransferase0.019
Klrg1killer cell lectin-like receptor subfamily G, member 10.018
Fn3kfructosamine 3 kinase0.018
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.018
Vom1r100vomeronasal 1 receptor 1000.017
Sycp1synaptonemal complex protein 10.017
C4bpacomplement component 4 binding protein, alpha0.017
Apoa2apolipoprotein A-II0.017
NsfN-ethylmaleimide-sensitive factor0.017
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.017
Olr59olfactory receptor 590.017
Foxa2forkhead box A20.016
Cdh17cadherin 170.016
Thrspthyroid hormone responsive0.016
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.016
Faim2Fas apoptotic inhibitory molecule 20.016
Clec9aC-type lectin domain family 9, member a0.016
Nr1h4nuclear receptor subfamily 1, group H, member 40.015
LOC680711hypothetical protein LOC6807110.015
Tpothyroid peroxidase0.015
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.015
Cckarcholecystokinin A receptor0.015
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism