The network for 'germ line stem cell division' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

germ line stem cell division

The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.

NameDescriptionProbabilityFunc Analog Organism
Smad4MAD homolog 4 (Drosophila)1.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Bmpr1abone morphogenetic protein receptor, type 1A0.999
Shhsonic hedgehog0.999
Fgfr2fibroblast growth factor receptor 20.998
Apcadenomatosis polyposis coli0.996
Foxc1forkhead box C10.988
Smad3MAD homolog 3 (Drosophila)0.984
Jarid2jumonji, AT rich interactive domain 20.934
Ptch1patched homolog 10.926
Sox9SRY-box containing gene 90.926
Grb10growth factor receptor bound protein 100.913
Gli3GLI-Kruppel family member GLI30.910
Tgfbr2transforming growth factor, beta receptor II0.907
Ptenphosphatase and tensin homolog0.905
Mtf2metal response element binding transcription factor 20.885
Fgfr1fibroblast growth factor receptor 10.872
Smad2MAD homolog 2 (Drosophila)0.870
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.866
Acvr1activin A receptor, type 10.863
Fgfr3fibroblast growth factor receptor 30.827
Ptpn11protein tyrosine phosphatase, non-receptor type 110.755
Bmp7bone morphogenetic protein 70.748
Meox2mesenchyme homeobox 20.725
Tgfb2transforming growth factor, beta 20.717
Fgf8fibroblast growth factor 80.674
Hand2heart and neural crest derivatives expressed transcript 20.659
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.619
Ednraendothelin receptor type A0.601
Psen1presenilin 10.597
Prrx1paired related homeobox 10.569
Smad1MAD homolog 1 (Drosophila)0.538
Gata4GATA binding protein 40.535
Pbx1pre B-cell leukemia transcription factor 10.535
Notch1Notch gene homolog 1 (Drosophila)0.501
Eedembryonic ectoderm development0.484
Map3k7mitogen-activated protein kinase kinase kinase 70.468
Stk38serine/threonine kinase 380.437
Gpc3glypican 30.410
Hand1heart and neural crest derivatives expressed transcript 10.409
Nf1neurofibromatosis 10.385
Egfrepidermal growth factor receptor0.374
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.369
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.359
Vegfavascular endothelial growth factor A0.340
Pitx2paired-like homeodomain transcription factor 20.327
Runx2runt related transcription factor 20.327
Gja1gap junction protein, alpha 10.323
Irs1insulin receptor substrate 10.322
Lrp6low density lipoprotein receptor-related protein 60.299
Hes1hairy and enhancer of split 1 (Drosophila)0.292
Insrinsulin receptor0.289
Ghrgrowth hormone receptor0.282
Otx2orthodenticle homolog 2 (Drosophila)0.274
Cdkn1bcyclin-dependent kinase inhibitor 1B0.266
Irs2insulin receptor substrate 20.256
Bptfbromodomain PHD finger transcription factor0.247
Smosmoothened homolog (Drosophila)0.245
Gsk3bglycogen synthase kinase 3 beta0.237
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.235
Prrx2paired related homeobox 20.231
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.227
Msx1homeobox, msh-like 10.226
Npc1Niemann Pick type C10.224
Gli2GLI-Kruppel family member GLI20.223
Amhr2anti-Mullerian hormone type 2 receptor0.218
Tgfbr1transforming growth factor, beta receptor I0.213
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.205
Tgfbr3transforming growth factor, beta receptor III0.203
Hoxd13homeobox D130.202
Aebp2AE binding protein 20.198
Prkg1protein kinase, cGMP-dependent, type I0.192
Igf1rinsulin-like growth factor I receptor0.192
Jag1jagged 10.188
Ror2receptor tyrosine kinase-like orphan receptor 20.183
Zeb1zinc finger E-box binding homeobox 10.177
Esr1estrogen receptor 1 (alpha)0.171
Rbbp4retinoblastoma binding protein 40.164
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.158
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.157
Col2a1collagen, type II, alpha 10.154
Tcfap2atranscription factor AP-2, alpha0.147
Nos3nitric oxide synthase 3, endothelial cell0.139
Prop1paired like homeodomain factor 10.134
Bmp2bone morphogenetic protein 20.133
Tdgf1teratocarcinoma-derived growth factor 10.132
Bmp4bone morphogenetic protein 40.130
Twsg1twisted gastrulation homolog 1 (Drosophila)0.127
Smad6MAD homolog 6 (Drosophila)0.125
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.125
Hoxa11homeobox A110.123
BmperBMP-binding endothelial regulator0.123
Alx4aristaless-like homeobox 40.117
Thrathyroid hormone receptor alpha0.116
Hoxd11homeobox D110.115
Erbb2ipErbb2 interacting protein0.112
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.110
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
glh-4Protein GLH-40.417
glh-1Protein GLH-10.268
pgl-1Protein PGL-10.155
csr-1Protein CSR-10.146
hpo-40Protein HPO-400.102
rod-1Protein ROD-10.085
mcm-2Protein MCM-20.079
coh-3Protein COH-30.069
syp-4Protein SYP-40.061
htp-3Protein HTP-30.054
D2096.11Protein D2096.110.049
lst-3Protein LST-30.045
sma-6Protein SMA-60.039
klp-10Protein KLP-100.039
ZK1127.6Protein ZK1127.60.038
K07H8.10Protein K07H8.100.037
C28A5.1Protein C28A5.10.036
mcm-7Protein MCM-70.035
glh-2Protein GLH-20.034
CELE_C34D4.10Protein C34D4.100.032
B0261.1Protein B0261.10.031
zwl-1Protein ZWL-10.029
scc-3Protein SCC-30.029
xpo-1Protein XPO-10.028
cgh-1Protein CGH-10.028
CELE_W03F9.10Protein W03F9.100.027
daf-14Protein DAF-140.026
spr-5Protein SPR-50.026
klp-18Protein KLP-180.026
npp-12Protein NPP-120.025
npp-9Protein NPP-90.024
mrp-7Protein MRP-70.024
mut-7Protein MUT-70.022
CELE_Y48B6A.1Protein Y48B6A.10.022
mcm-3Protein MCM-30.022
prg-1Protein PRG-10.022
fkb-6Protein FKB-60.022
ppw-2Protein PPW-20.021
npp-21Protein NPP-210.021
F57B10.4Protein F57B10.40.021
rad-50Protein RAD-500.021
ani-2Protein ANI-20.020
fbf-1Protein FBF-10.019
toca-2Protein TOCA-20.019
tba-1Protein TBA-10.019
sel-8Protein SEL-80.019
cdc-48.1Protein CDC-48.10.019
dpf-3Protein DPF-30.018
chl-1Protein CHL-10.018
bath-7Protein BATH-70.018
F31C3.3Protein F31C3.30.018
isw-1Protein ISW-10.017
D1081.7Protein D1081.70.017
btf-1Protein BTF-10.017
C30G12.6Protein C30G12.60.017
hpo-10Protein HPO-100.016
M01E11.3Protein M01E11.30.016
CELE_K08F4.2Protein K08F4.20.015
T14B4.1Protein T14B4.10.015
mcm-5Protein MCM-50.015
tbc-2Protein TBC-20.015
ucr-2.3Protein UCR-2.30.015
rpn-2Protein RPN-20.014
eef-1A.1Protein EEF-1A.10.014
skp-1Protein SKP-10.014
sec-6Protein SEC-60.014
K06A5.1Protein K06A5.10.014
crm-1Protein CRM-10.014
glh-3Protein GLH-30.014
mre-11Protein MRE-110.013
atl-1Protein ATL-10.013
mes-2Protein MES-20.013
mcm-4Protein MCM-40.013
egl-18Protein EGL-180.013
ego-1Protein EGO-10.013
sacy-1Protein SACY-10.013
T27A3.2Protein T27A3.20.013
trcs-2Protein TRCS-20.013
wago-9Protein WAGO-90.013
F33G12.3Protein F33G12.30.012
pqn-85Protein PQN-850.012
dsh-2Protein DSH-20.012
C16A11.5Protein C16A11.50.012
CELE_F54D5.9Protein F54D5.90.012
tbb-2Protein TBB-20.012
rbc-1Protein RBC-10.012
R05H10.3Protein R05H10.30.012
rsp-7Protein RSP-70.012
lin-12Protein LIN-120.012
sago-2Protein SAGO-20.012
ife-3Protein IFE-30.012
mat-3Protein MAT-30.012
rpl-11.1Protein RPL-11.10.011
CELE_F25B4.5Protein F25B4.50.011
got-2.1Protein GOT-2.10.011
hum-2Protein HUM-20.011
tba-2Protein TBA-20.011
B0035.6Protein B0035.60.011
C53H9.2Protein C53H9.20.011
B0412.3Protein B0412.30.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b1.000
nanos3nanos homolog 30.988
bmp4bone morphogenetic protein 40.987
tbx1T-box 10.958
vasavasa homolog0.753
igf1rbinsulin-like growth factor 1b receptor0.746
gro1groucho 10.692
tbx5aT-box 5a0.590
gro2groucho 20.582
acvr1lactivin A receptor, type I like0.569
ripk2receptor-interacting serine-threonine kinase 20.425
ndr1nodal-related 10.423
tp53tumor protein p530.400
ca15bcarbonic anhydrase XV b0.343
mmp2matrix metalloproteinase 20.315
ptprbprotein tyrosine phosphatase, receptor type, b0.297
brca2breast cancer 2, early onset0.284
eomesaeomesodermin homolog a0.265
wlswntless homolog (Drosophila)0.178
fgf8afibroblast growth factor 8 a0.173
smad5MAD homolog 5 (Drosophila)0.169
chsy1chondroitin sulfate synthase 10.159
lppLIM domain containing preferred translocation partner in lipoma0.158
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.156
insrbinsulin receptor b0.136
foxi1forkhead box I10.134
per3period homolog 3 (Drosophila)0.131
pou5f1POU domain, class 5, transcription factor 10.130
mapk3mitogen-activated protein kinase 30.125
cx30.3connexin 30.30.118
wnt5bwingless-type MMTV integration site family, member 5b0.117
rcn1reticulocalbin 1, EF-hand calcium binding domain0.114
bokbBCL2-related ovarian killer b0.113
vdravitamin D receptor a0.105
tdrd1tudor domain containing 10.103
bmp2abone morphogenetic protein 2a0.102
spns2spinster homolog 2 (Drosophila)0.099
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.096
fanclFanconi anemia, complementation group L0.092
sdc2syndecan 20.091
msxdmuscle segment homeobox D0.089
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.085
esyt3extended synaptotagmin-like protein 30.083
tbx16T-box gene 160.082
tmem2transmembrane protein 20.080
c11orf2c11orf2 homolog (H. sapiens)0.075
zorbaOrb/CPEB-related RNA-binding protein0.074
aldh1l1aldehyde dehydrogenase 1 family, member L10.073
tgfb3transforming growth factor, beta 30.071
shdbSrc homology 2 domain containing transforming protein D, b0.070
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.070
retsatlretinol saturase (all-trans-retinol 13,14-reductase) like0.070
rbpms2RNA binding protein with multiple splicing 20.069
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.069
sox19bSRY-box containing gene 19b0.069
oepone-eyed pinhead0.068
acvr1bactivin A receptor, type IB0.068
kif23kinesin family member 230.066
tbpl2TATA box binding protein like 20.061
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.060
trim3atripartite motif-containing 3a0.060
spry2sprouty homolog 20.059
foxh1forkhead box H10.058
ror2receptor tyrosine kinase-like orphan receptor 20.058
sox9aSRY-box containing gene 9a0.058
rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.057
supt6hsuppressor of Ty 6 homolog0.053
rhpn2rhophilin, Rho GTPase binding protein 20.053
h1mlinker histone H1M0.053
axin1axin 10.052
zbtb4zinc finger and BTB domain containing 40.052
bmpr1abbone morphogenetic protein receptor, type 1ab0.052
mtmr8myotubularin related protein 80.051
antxr2aanthrax toxin receptor 2a0.051
capn9calpain 90.051
tll1tolloid-like 10.050
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.050
fancd2Fanconi anemia, complementation group D20.049
ptgs1prostaglandin-endoperoxide synthase 10.049
cul1bcullin 1b0.047
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.047
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.046
plxnb2aplexin b2a0.046
st3gal2lST3 beta-galactoside alpha-2,3-sialyltransferase 2, like0.046
pld1aphospholipase D1a0.046
tgfbr2transforming growth factor, beta receptor II0.045
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.045
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.045
vps35vacuolar protein sorting 35 (yeast)0.045
odc1ornithine decarboxylase 10.045
furinafurin (paired basic amino acid cleaving enzyme) a0.044
ptpraprotein tyrosine phosphatase, receptor type, A0.044
wnt8awingless-type MMTV integration site family, member 8a0.044
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.043
piwil1piwi-like 1 (Drosophila)0.043
grk5G protein-coupled receptor kinase 50.043
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp1.000
InRInsulin-like receptor0.974
Pi3K92ECG4141 gene product from transcript CG4141-RB0.964
bratbrain tumor0.963
Fmr1CG6203 gene product from transcript CG6203-RC0.945
piwiCG6122 gene product from transcript CG6122-RA0.939
Ras85DRas oncogene at 85D0.743
twinCG31137 gene product from transcript CG31137-RB0.692
Akt1CG4006 gene product from transcript CG4006-RA0.666
Src64BSrc oncogene at 64B0.629
bgcnbenign gonial cell neoplasm0.588
htshu li tai shao0.578
Vap-33-1CG5014 gene product from transcript CG5014-RB0.418
dallydivision abnormally delayed0.410
Pabp2CG2163 gene product from transcript CG2163-RA0.388
EcREcdysone receptor0.376
CG4771CG4771 gene product from transcript CG4771-RA0.355
zpgzero population growth0.279
aspabnormal spindle0.261
CG8443CG8443 gene product from transcript CG8443-RA0.256
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.241
FBX011FBX011 ortholog0.235
slmbsupernumerary limbs0.228
enokenoki mushroom0.214
CSN4COP9 complex homolog subunit 40.211
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.201
Rac1CG2248 gene product from transcript CG2248-RA0.192
Su(H)Suppressor of Hairless0.189
pUf68poly U binding factor 68kD0.171
spn-Espindle E0.156
jebjelly belly0.136
gbbglass bottom boat0.136
Top1Topoisomerase 10.133
Stat92ESignal-transducer and activator of transcription protein at 92E0.129
chbchromosome bows0.127
eyaeyes absent0.126
DadDaughters against dpp0.110
poloCG12306 gene product from transcript CG12306-RA0.109
PargPoly(ADP-ribose) glycohydrolase0.094
otuovarian tumor0.085
ScmSex comb on midleg0.082
CycACyclin A0.082
Dhc64CDynein heavy chain 64C0.080
Irk2Inwardly rectifying potassium channel 20.074
Cap-GCG34438 gene product from transcript CG34438-RF0.073
stetstem cell tumor0.071
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.055
bambag of marbles0.054
Cdc42CG12530 gene product from transcript CG12530-RA0.048
phlpole hole0.045
pashapartner of drosha0.045
CycECyclin E0.044
BicDBicaudal D0.043
SnooSno oncogene0.042
CG2926CG2926 gene product from transcript CG2926-RA0.042
Nup154Nucleoporin 1540.037
Pk61CProtein kinase 61C0.037
CG42709CG42709 gene product from transcript CG42709-RC0.036
EgfrEpidermal growth factor receptor0.034
NotumCG13076 gene product from transcript CG13076-RB0.033
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism