The network for 'c21 steroid hormone biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

c21 steroid hormone biosynthetic process

The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.

NameDescriptionProbabilityFunc Analog Organism
Mc2rmelanocortin 2 receptor0.949
Slc12a1solute carrier family 12, member 10.875
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.755
Nr5a1nuclear receptor subfamily 5, group A, member 10.605
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.538
NanogNanog homeobox0.528
Ror2receptor tyrosine kinase-like orphan receptor 20.401
Bmp7bone morphogenetic protein 70.323
Runx2runt related transcription factor 20.321
Nostrinnitric oxide synthase trafficker0.303
Lrp2low density lipoprotein receptor-related protein 20.251
Mep1ameprin 1 alpha0.236
Acsm2acyl-CoA synthetase medium-chain family member 20.185
Lhcgrluteinizing hormone/choriogonadotropin receptor0.170
Akr1c21aldo-keto reductase family 1, member C210.163
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.147
Hoxa10homeobox A100.141
Prrx1paired related homeobox 10.135
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.119
Lypla1lysophospholipase 10.114
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.114
Prrx2paired related homeobox 20.109
Guca2aguanylate cyclase activator 2a (guanylin)0.101
Itm2cintegral membrane protein 2C0.101
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.100
Aldh6a1aldehyde dehydrogenase family 6, subfamily A10.099
Timd2T-cell immunoglobulin and mucin domain containing 20.097
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.094
Slc34a1solute carrier family 34 (sodium phosphate), member 10.089
Ren1renin 1 structural0.082
Ednrbendothelin receptor type B0.079
Tbx15T-box 150.078
Hand1heart and neural crest derivatives expressed transcript 10.070
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.068
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.063
Mioxmyo-inositol oxygenase0.060
IhhIndian hedgehog0.057
Arandrogen receptor0.055
Agtr1aangiotensin II receptor, type 1a0.055
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.054
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.054
Eif2c2eukaryotic translation initiation factor 2C, 20.053
Fgfr3fibroblast growth factor receptor 30.053
Ddr2discoidin domain receptor family, member 20.052
Hao2hydroxyacid oxidase 20.050
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.048
Bmp4bone morphogenetic protein 40.048
Ctskcathepsin K0.047
F13bcoagulation factor XIII, beta subunit0.047
Itga8integrin alpha 80.045
Pramel6preferentially expressed antigen in melanoma like 60.044
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.044
G6pcglucose-6-phosphatase, catalytic0.043
Nr5a2nuclear receptor subfamily 5, group A, member 20.043
Nr0b2nuclear receptor subfamily 0, group B, member 20.042
Inhbcinhibin beta-C0.042
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.041
Nr0b1nuclear receptor subfamily 0, group B, member 10.041
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.040
Phyhphytanoyl-CoA hydroxylase0.040
Upp2uridine phosphorylase 20.039
Smosmoothened homolog (Drosophila)0.039
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.037
Dmgdhdimethylglycine dehydrogenase precursor0.037
Keg1kidney expressed gene 10.037
Fshrfollicle stimulating hormone receptor0.037
Pcsk5proprotein convertase subtilisin/kexin type 50.036
Sox9SRY-box containing gene 90.035
Wnk4WNK lysine deficient protein kinase 40.034
Pde8bphosphodiesterase 8B0.034
Rspo2R-spondin 2 homolog (Xenopus laevis)0.034
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.033
Timp2tissue inhibitor of metalloproteinase 20.033
Ctgfconnective tissue growth factor0.033
Clrn3clarin 30.033
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.032
Hsd3b4hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 40.032
Starsteroidogenic acute regulatory protein0.032
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.032
Aqp8aquaporin 80.032
Zp2zona pellucida glycoprotein 20.031
Hsdl2hydroxysteroid dehydrogenase like 20.031
Kapkidney androgen regulated protein0.031
Hand2heart and neural crest derivatives expressed transcript 20.031
Alx1ALX homeobox 10.030
Mertkc-mer proto-oncogene tyrosine kinase0.030
Slc17a1solute carrier family 17 (sodium phosphate), member 10.030
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.030
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.029
Elk4ELK4, member of ETS oncogene family0.029
Khdc1bKH domain containing 1B0.029
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.028
F2rl2coagulation factor II (thrombin) receptor-like 20.028
Clcnkachloride channel Ka0.027
0610031J06RikRIKEN cDNA 0610031J06 gene0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.950
bmp4bone morphogenetic protein 40.594
bmp2abone morphogenetic protein 2a0.282
gdf6agrowth differentiation factor 6a0.070
dlx3bdistal-less homeobox gene 3b0.069
msxdmuscle segment homeobox D0.046
fgf24fibroblast growth factor 240.041
gpr126G protein-coupled receptor 1260.033
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.032
sp7Sp7 transcription factor0.031
bmp7abone morphogenetic protein 7a0.029
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.027
msxbmuscle segment homeobox B0.023
st3gal2lST3 beta-galactoside alpha-2,3-sialyltransferase 2, like0.022
inka1binduced in neural crest by AP2, 1b0.020
fgf8afibroblast growth factor 8 a0.019
apoebapolipoprotein Eb0.017
sall4sal-like 4 (Drosophila)0.017
sdc2syndecan 20.017
wnt5bwingless-type MMTV integration site family, member 5b0.016
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.016
dlx4bdistal-less homeobox gene 4b0.015
lama5laminin, alpha 50.014
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.013
nkx2.3NK2 transcription factor related 30.013
fn1bfibronectin 1b0.013
tp63tumor protein p630.012
msxemuscle segment homeobox E0.012
hoxc8ahomeo box C8a0.011
spry4sprouty (Drosophila) homolog 40.011
hoxb1bhomeo box B1b0.011
prdm1aPR domain containing 1a, with ZNF domain0.011
ints6integrator complex subunit 60.011
foxi1forkhead box I10.010
mgpmatrix Gla protein0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BMPR1Abone morphogenetic protein receptor, type IA0.893
BMPR1Bbone morphogenetic protein receptor, type IB0.638
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.473
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.068
ZFYVE9zinc finger, FYVE domain containing 90.061
FSTL1follistatin-like 10.055
MYO6myosin VI0.051
SMURF2SMAD specific E3 ubiquitin protein ligase 20.037
MAPK15mitogen-activated protein kinase 150.036
LAMP2lysosomal-associated membrane protein 20.034
FGF18fibroblast growth factor 180.031
ACADMacyl-CoA dehydrogenase, C-4 to C-12 straight chain0.025
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.024
COL2A1collagen, type II, alpha 10.023
ABCD3ATP-binding cassette, sub-family D (ALD), member 30.021
FOXF2forkhead box F20.021
FGF4fibroblast growth factor 40.018
PHYHphytanoyl-CoA 2-hydroxylase0.017
TGFB1transforming growth factor, beta 10.016
DECR12,4-dienoyl CoA reductase 1, mitochondrial0.016
SH3BGRLSH3 domain binding glutamic acid-rich protein like0.015
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.015
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.015
MMP11matrix metallopeptidase 11 (stromelysin 3)0.015
KREMEN2kringle containing transmembrane protein 20.015
SUCLG2succinate-CoA ligase, GDP-forming, beta subunit0.014
BMP2bone morphogenetic protein 20.013
FOXF1forkhead box F10.013
WIF1WNT inhibitory factor 10.012
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.012
BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide0.012
FOXD3forkhead box D30.011
PHKBphosphorylase kinase, beta0.011
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.011
DLX4distal-less homeobox 40.011
SOX21SRY (sex determining region Y)-box 210.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Starsteroidogenic acute regulatory protein0.502
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.397
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.377
Gabarapl2GABA(A) receptor-associated protein like 20.358
Apohapolipoprotein H (beta-2-glycoprotein I)0.293
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.164
Hbg1hemoglobin, gamma A0.158
Clca4chloride channel accessory 40.128
Prss3protease, serine, 30.122
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.121
Fabp1fatty acid binding protein 1, liver0.114
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.100
Hipk3homeodomain interacting protein kinase 30.092
Akr1c18aldo-keto reductase family 1, member C180.090
Lhcgrluteinizing hormone/choriogonadotropin receptor0.090
LOC293989cytochrome P450-like0.084
Fbp1fructose-1,6-bisphosphatase 10.077
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.072
Hrh2histamine receptor H 20.069
LOC100366002cytochrome P450 11B1, mitochondrial-like0.061
Nr5a2nuclear receptor subfamily 5, group A, member 20.059
Crisp2cysteine-rich secretory protein 20.059
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.059
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.054
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.054
Fapfibroblast activation protein, alpha0.054
Drd1adopamine receptor D1A0.051
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.049
Defb4defensin beta 40.049
Tacr3tachykinin receptor 30.049
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.047
Atxn1ataxin 10.047
Hes2hairy and enhancer of split 2 (Drosophila)0.046
Ppardperoxisome proliferator-activated receptor delta0.043
Pxmp2peroxisomal membrane protein 20.043
A1i3alpha-1-inhibitor III0.042
Impg2interphotoreceptor matrix proteoglycan 20.041
Slco4a1solute carrier organic anion transporter family, member 4a10.040
Tacr2tachykinin receptor 20.040
Hrh3histamine receptor H30.040
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.040
Spink1serine peptidase inhibitor, Kazal type 10.040
Ppp3r2protein phosphatase 3, regulatory subunit B, beta isoform0.037
Spt1salivary protein 10.037
P22k15cystatin related protein 20.036
Naglt1Na+ dependent glucose transporter 10.035
Sycp3synaptonemal complex protein 30.035
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.034
Col1a1collagen, type I, alpha 10.034
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.034
Egr4early growth response 40.034
Krt34keratin 340.034
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.033
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.032
Olr1701olfactory receptor 17010.032
Dnase1deoxyribonuclease I0.031
Syt13synaptotagmin XIII0.029
Cyb5acytochrome b5 type A (microsomal)0.029
Ces2ccarboxylesterase 2C0.028
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.028
Kcne1potassium voltage-gated channel, Isk-related family, member 10.027
Pou3f1POU class 3 homeobox 10.027
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.027
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.027
Abhd14babhydrolase domain containing 14b0.027
Gsta4glutathione S-transferase alpha 40.026
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.026
Cmklr1chemokine-like receptor 10.026
Pla2g5phospholipase A2, group V0.026
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.026
Cdcp1CUB domain containing protein 10.025
Apobapolipoprotein B0.025
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.025
Grik3glutamate receptor, ionotropic, kainate 30.025
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.025
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.025
G6pcglucose-6-phosphatase, catalytic subunit0.025
LOC498222similar to specifically androgen-regulated protein0.024
Cd59CD59 molecule, complement regulatory protein0.024
Fndc3bfibronectin type III domain containing 3B0.024
Oxtroxytocin receptor0.024
Cpa1carboxypeptidase A10.023
Nudt8nudix (nucleoside diphosphate linked moiety X)-type motif 80.023
Grifingalectin-related inter-fiber protein0.023
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.022
Drd5dopamine receptor D50.022
RbpmsRNA binding protein with multiple splicing0.022
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.022
Kcnh4potassium voltage-gated channel, subfamily H (eag-related), member 40.021
Col5a2collagen, type V, alpha 20.021
Sisucrase-isomaltase (alpha-glucosidase)0.021
Hibadh3-hydroxyisobutyrate dehydrogenase0.021
Lpar2lysophosphatidic acid receptor 20.021
Itga1integrin, alpha 10.020
Prss22protease, serine, 220.020
Dpep1dipeptidase 1 (renal)0.020
Pla2g1bphospholipase A2, group IB, pancreas0.020
Smad3SMAD family member 30.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism