The network for 'optic nerve development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

optic nerve development

The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.

NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)0.968
Gli2GLI-Kruppel family member GLI20.965
Pax6paired box gene 60.965
Shhsonic hedgehog0.939
Pou4f2POU domain, class 4, transcription factor 20.904
Gli3GLI-Kruppel family member GLI30.820
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.783
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.713
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.644
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.628
Ephb2Eph receptor B20.552
Epha4Eph receptor A40.531
Scn5asodium channel, voltage-gated, type V, alpha0.414
Msx1homeobox, msh-like 10.307
Pax2paired box gene 20.275
Ascl1achaete-scute complex homolog 1 (Drosophila)0.274
Sox11SRY-box containing gene 110.274
Lhx1LIM homeobox protein 10.268
Fgf10fibroblast growth factor 100.252
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.251
Bmp7bone morphogenetic protein 70.247
Pde6bphosphodiesterase 6B, cGMP, rod receptor, beta polypeptide0.209
Retret proto-oncogene0.202
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.202
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.193
Efnb2ephrin B20.189
Rtn4rreticulon 4 receptor0.187
Emid2EMI domain containing 20.176
Lmx1aLIM homeobox transcription factor 1 alpha0.176
Wnt6wingless-related MMTV integration site 60.175
Hmx1H6 homeobox 10.168
Neurod1neurogenic differentiation 10.167
Fgfr2fibroblast growth factor receptor 20.162
Tbx3T-box 30.158
Emx2empty spiracles homolog 2 (Drosophila)0.156
Prox1prospero-related homeobox 10.153
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.153
Otx1orthodenticle homolog 1 (Drosophila)0.139
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.138
Hand1heart and neural crest derivatives expressed transcript 10.133
Efnb1ephrin B10.129
Gdf11growth differentiation factor 110.127
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.126
Ompolfactory marker protein0.109
Adam11a disintegrin and metallopeptidase domain 110.107
Gpr12G-protein coupled receptor 120.092
Mab21l2mab-21-like 2 (C. elegans)0.090
Lef1lymphoid enhancer binding factor 10.089
Ephb3Eph receptor B30.089
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.087
Dccdeleted in colorectal carcinoma0.087
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.086
Gdnfglial cell line derived neurotrophic factor0.085
Dlx5distal-less homeobox 50.084
Neurod2neurogenic differentiation 20.083
Zic1zinc finger protein of the cerebellum 10.081
Msx2homeobox, msh-like 20.077
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.071
Foxc1forkhead box C10.071
Chrna9cholinergic receptor, nicotinic, alpha polypeptide 90.067
St6galnac3ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 30.065
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.065
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.059
Drd4dopamine receptor D40.057
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.057
Sox2SRY-box containing gene 20.056
Syt1synaptotagmin I0.056
Ebf3early B-cell factor 30.056
Kcnk4potassium channel, subfamily K, member 40.055
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.055
Stx1bsyntaxin 1B0.055
Wnt9bwingless-type MMTV integration site 9B0.054
Rararetinoic acid receptor, alpha0.053
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.053
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.051
Foxd2forkhead box D20.049
Cbln3cerebellin 3 precursor protein0.048
Pou3f3POU domain, class 3, transcription factor 30.048
Ror1receptor tyrosine kinase-like orphan receptor 10.048
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.047
Vsx2visual system homeobox 20.046
Unc5cunc-5 homolog C (C. elegans)0.046
Twist2twist homolog 2 (Drosophila)0.046
Gpr27G protein-coupled receptor 270.045
Rargretinoic acid receptor, gamma0.044
Emx1empty spiracles homolog 1 (Drosophila)0.043
Kcnd3potassium voltage-gated channel, Shal-related family, member 30.043
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.043
Pbx1pre B-cell leukemia transcription factor 10.042
Plxna3plexin A30.042
Efna4ephrin A40.042
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.042
Efna3ephrin A30.041
Rbms1RNA binding motif, single stranded interacting protein 10.040
Nkx2-9NK2 transcription factor related, locus 9 (Drosophila)0.040
Gja5gap junction protein, alpha 50.040
Efna2ephrin A20.039
Rspo2R-spondin 2 homolog (Xenopus laevis)0.039
Gpr3G-protein coupled receptor 30.038
Hoxd11homeobox D110.038
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mibmind bomb0.848
lhx2bLIM homeobox 2b0.745
tubb5tubulin, beta 50.431
dladeltaA0.369
shhasonic hedgehog a0.366
pax2apaired box gene 2a0.282
tbx16T-box gene 160.264
ndr2nodal-related 20.229
isl1islet10.166
dlddeltaD0.159
cdh2cadherin 2, neuronal0.159
dlcdeltaC0.136
atoh7atonal homolog 70.136
tbx5aT-box 5a0.135
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.129
dlbdeltaB0.129
tgfb2transforming growth factor, beta 20.087
scn1basodium channel, voltage-gated, type I, beta a0.083
bmp4bone morphogenetic protein 40.077
neurog1neurogenin 10.074
dccdeleted in colorectal carcinoma0.073
spawsouthpaw0.072
robo2roundabout homolog 20.071
barhl1.2BarH-like 1.20.070
tbx2bT-box 2b0.068
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.068
her1hairy-related 10.068
jag2jagged 20.068
fn1fibronectin 10.064
olig2oligodendrocyte lineage transcription factor 20.062
foxp2forkhead box P20.061
fezf2FEZ family zinc finger 20.060
sall1asal-like 1a (Drosophila)0.058
isl2aislet2a0.058
zgc:195154zgc:1951540.057
rtn1areticulon 1a0.054
eng2bengrailed 2b0.054
ascl1aachaete-scute complex-like 1a (Drosophila)0.053
barhl2BarH-like 20.053
foxg1aforkhead box G1a0.051
mitfamicrophthalmia-associated transcription factor a0.051
vcanaversican a0.051
eya1eyes absent homolog 10.047
aldh1a2aldehyde dehydrogenase 1 family, member A20.046
oepone-eyed pinhead0.043
rtn4areticulon 4a0.043
rx3retinal homeobox gene 30.041
tgfb3transforming growth factor, beta 30.041
flhfloating head0.040
dhrs3adehydrogenase/reductase (SDR family) member 3a0.040
chrna2acholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)0.039
six4bsine oculis homeobox homolog 4b0.039
nt5c2l15'-nucleotidase, cytosolic II, like 10.038
sncbsynuclein, beta0.038
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.037
grem2gremlin 2, cysteine knot superfamily0.037
emx3empty spiracles homeobox 30.036
insm1binsulinoma-associated 1b0.036
cntn2contactin 20.036
foxn4forkhead box N40.035
pou3f3bPOU class 3 homeobox 3b0.034
lhx5LIM homeobox 50.034
tac1tachykinin 10.033
foxa1forkhead box A10.033
hand2heart and neural crest derivatives expressed transcript 20.032
axin1axin 10.032
ptch1patched 10.031
vldlrvery low density lipoprotein receptor0.030
dlx2bdistal-less homeobox gene 2b0.029
flot1flotillin 10.029
si:dkey-24g18.2si:dkey-24g18.20.028
dbx1adeveloping brain homeobox 1a0.028
cdh4cadherin 4, retinal0.028
oprd1bopioid receptor, delta 1b0.027
her7hairy and enhancer of split related-70.027
ctnnd2bcatenin (cadherin-associated protein), delta 2b0.026
hoxa13bhomeo box A13b0.026
nr2e1nuclear receptor subfamily 2, group E, member 10.026
dpysl3dihydropyrimidinase-like 30.026
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.026
itgavintegrin, alpha V0.025
tgfbitransforming growth factor, beta-induced0.025
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.025
coe2coe20.024
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.024
osr2odd-skipped related 2 (Drosophila)0.024
myl7myosin, light polypeptide 7, regulatory0.024
ppp1cblprotein phosphatase 1, catalytic subunit, beta isoform, like0.024
alcamaactivated leukocyte cell adhesion molecule a0.023
evlbEnah/Vasp-like b0.023
pea3ETS-domain transcription factor pea30.023
marcksamyristoylated alanine rich protein kinase C substrate a0.023
has2hyaluronan synthase 20.022
ncam1bneural cell adhesion molecule 1b0.022
dlx2adistal-less homeobox gene 2a0.022
cntn1acontactin 1a0.022
otx1aorthodenticle homolog 1a0.022
dspadesmoplakin a0.022
wnt8bwingless-type MMTV integration site family, member 8b0.022
unc45bunc-45 homolog B (C. elegans)0.022
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.998
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.917
GATA2GATA binding protein 20.884
CYLDcylindromatosis (turban tumor syndrome)0.714
SETD8SET domain containing (lysine methyltransferase) 80.423
GATA4GATA binding protein 40.348
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.292
KLF4Kruppel-like factor 4 (gut)0.273
GATA1GATA binding protein 1 (globin transcription factor 1)0.270
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.243
COL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding protein0.239
RUNX1runt-related transcription factor 10.230
GRB7growth factor receptor-bound protein 70.228
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.180
PDX1pancreatic and duodenal homeobox 10.171
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.151
C11orf73chromosome 11 open reading frame 730.131
DUSP1dual specificity phosphatase 10.119
JUNjun proto-oncogene0.118
ALAS1aminolevulinate, delta-, synthase 10.110
PRR13proline rich 130.107
LRRK2leucine-rich repeat kinase 20.088
CABLES1Cdk5 and Abl enzyme substrate 10.081
PAX6paired box 60.080
STK36serine/threonine kinase 360.077
LMO2LIM domain only 2 (rhombotin-like 1)0.076
TUBB3tubulin, beta 30.067
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.066
HIPK2homeodomain interacting protein kinase 20.059
HOXD12homeobox D120.056
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.053
CWC15CWC15 spliceosome-associated protein homolog (S. cerevisiae)0.053
MYT1myelin transcription factor 10.052
MRPS22mitochondrial ribosomal protein S220.051
SIX6SIX homeobox 60.051
FOSFBJ murine osteosarcoma viral oncogene homolog0.051
FGF3fibroblast growth factor 30.051
BBS1Bardet-Biedl syndrome 10.050
KCNJ16potassium inwardly-rectifying channel, subfamily J, member 160.048
RTN3reticulon 30.048
LRRN2leucine rich repeat neuronal 20.045
TAL1T-cell acute lymphocytic leukemia 10.044
POU4F2POU class 4 homeobox 20.043
MRPL1mitochondrial ribosomal protein L10.043
LMO1LIM domain only 1 (rhombotin 1)0.041
LHX5LIM homeobox 50.041
TCF12transcription factor 120.040
NDUFA12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 120.040
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.039
GRB10growth factor receptor-bound protein 100.037
HOXD13homeobox D130.037
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.036
TMSB4Xthymosin beta 4, X-linked0.036
TCF4transcription factor 40.036
CCND3cyclin D30.036
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.034
NEUROD1neurogenic differentiation 10.034
BBS2Bardet-Biedl syndrome 20.034
FOXF2forkhead box F20.033
NEUROD2neurogenic differentiation 20.033
VSX1visual system homeobox 10.032
FOXG1forkhead box G10.032
MYOD1myogenic differentiation 10.030
FEVFEV (ETS oncogene family)0.030
CDK9cyclin-dependent kinase 90.030
HOXD3homeobox D30.030
COL2A1collagen, type II, alpha 10.030
FOXE3forkhead box E30.029
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.029
ZIC3Zic family member 3 (odd-paired homolog, Drosophila)0.028
VCLvinculin0.028
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 10.027
CDK6cyclin-dependent kinase 60.027
SPTBN4spectrin, beta, non-erythrocytic 40.027
SOX11SRY (sex determining region Y)-box 110.027
TBX1T-box 10.026
HOXB9homeobox B90.026
C1QL1complement component 1, q subcomponent-like 10.026
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.026
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.026
PYYpeptide YY0.025
C14orf166chromosome 14 open reading frame 1660.025
A1BGalpha-1-B glycoprotein0.024
ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.024
SHOX2short stature homeobox 20.024
MYADMmyeloid-associated differentiation marker0.024
HCN4hyperpolarization activated cyclic nucleotide-gated potassium channel 40.024
SFRP5secreted frizzled-related protein 50.024
TLX2T-cell leukemia homeobox 20.023
IER2immediate early response 20.023
SLC30A3solute carrier family 30 (zinc transporter), member 30.023
ZNF263zinc finger protein 2630.023
DPYSL2dihydropyrimidinase-like 20.023
NRG2neuregulin 20.023
KLF7Kruppel-like factor 7 (ubiquitous)0.023
PTS6-pyruvoyltetrahydropterin synthase0.023
TBR1T-box, brain, 10.023
FOSL2FOS-like antigen 20.023
MNX1motor neuron and pancreas homeobox 10.023
POU4F1POU class 4 homeobox 10.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Kykyphoscoliosis peptidase0.055
Tuba1btubulin, alpha 1B0.043
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.038
Kcnt1potassium channel, subfamily T, member 10.032
Col4a4collagen, type IV, alpha 40.027
JunJun oncogene0.026
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.024
Kcnk3potassium channel, subfamily K, member 30.022
Fgf14fibroblast growth factor 140.021
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.020
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.019
Nlgn3neuroligin 30.019
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.019
Rab3bRAB3B, member RAS oncogene family0.019
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.019
Lrrc10leucine-rich repeat-containing 100.017
Cacna1icalcium channel, voltage-dependent, T type, alpha 1I subunit0.017
Naglt1Na+ dependent glucose transporter 10.016
Slc22a6solute carrier family 22 (organic anion transporter), member 60.015
Folh1folate hydrolase 10.015
Tff2trefoil factor 20.015
Pygmphosphorylase, glycogen, muscle0.015
Cx3cr1chemokine (C-X3-C motif) receptor 10.015
Dlg4discs, large homolog 4 (Drosophila)0.014
Adra2cadrenergic, alpha-2C-, receptor0.014
Lrrc14bleucine rich repeat containing 14B0.014
Lrrc7leucine rich repeat containing 70.013
Aplnrapelin receptor0.012
Gzmcgranzyme C0.012
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.012
Syngr1synaptogyrin 10.012
Znf394zinc finger protein 3940.012
Pde4aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)0.011
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.011
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.011
Wfdc6aWAP four-disulfide core domain 6A0.011
RGD1309036hypothetical LOC2928740.011
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.011
Ldb3LIM domain binding 30.011
Hapln2hyaluronan and proteoglycan link protein 20.011
Gnrh1gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)0.011
Gnalguanine nucleotide binding protein, alpha stimulating, olfactory type0.011
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.011
Cdk5r2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.011
Neurl2neuralized homolog 2 (Drosophila)0.010
Oxtoxytocin, prepropeptide0.010
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism