The network for 'centromere complex assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

centromere complex assembly

The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere.

NameDescriptionProbabilityFunc Analog Organism
Ect2ect2 oncogene0.503
Haus6HAUS augmin-like complex, subunit 60.419
Dckdeoxycytidine kinase0.270
Plk4polo-like kinase 4 (Drosophila)0.199
Casp8ap2caspase 8 associated protein 20.183
Smc2structural maintenance of chromosomes 20.164
Smc4structural maintenance of chromosomes 40.138
C330027C09RikRIKEN cDNA C330027C09 gene0.118
Srsf7serine/arginine-rich splicing factor 70.111
Trim59tripartite motif-containing 590.091
Ezh2enhancer of zeste homolog 2 (Drosophila)0.079
Tmpothymopoietin0.078
Cenpkcentromere protein K0.075
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.072
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.063
Ncapg2non-SMC condensin II complex, subunit G20.063
Srsf5serine/arginine-rich splicing factor 50.054
Chek1checkpoint kinase 1 homolog (S. pombe)0.052
Atad2ATPase family, AAA domain containing 20.044
Rfc3replication factor C (activator 1) 30.043
Cenpqcentromere protein Q0.040
Dnmt3bDNA methyltransferase 3B0.036
2610039C10RikRIKEN cDNA 2610039C10 gene0.034
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.033
Eri2exoribonuclease 20.033
1110004F10RikRIKEN cDNA 1110004F10 gene0.030
Siah1bseven in absentia 1B0.030
5830433M19RikRIKEN cDNA 5830433M19 gene0.030
Hmgb2high mobility group box 20.030
Topbp1topoisomerase (DNA) II binding protein 10.027
Slbpstem-loop binding protein0.027
Caprin1cell cycle associated protein 10.026
Lin9lin-9 homolog (C. elegans)0.026
PacrglPARK2 co-regulated-like0.026
Terf1telomeric repeat binding factor 10.025
Dsn1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)0.025
Stag1stromal antigen 10.025
Eri1exoribonuclease 10.025
Wsb1WD repeat and SOCS box-containing 10.024
G2e3G2/M-phase specific E3 ubiquitin ligase0.023
StilScl/Tal1 interrupting locus0.023
Adssadenylosuccinate synthetase, non muscle0.022
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.021
Rrm2ribonucleotide reductase M20.021
Myef2myelin basic protein expression factor 2, repressor0.021
Cklfchemokine-like factor0.020
Rbm26RNA binding motif protein 260.020
Rad51ap1RAD51 associated protein 10.020
Fmr1fragile X mental retardation syndrome 1 homolog0.019
Racgap1Rac GTPase-activating protein 10.018
Msh6mutS homolog 6 (E. coli)0.018
Top2atopoisomerase (DNA) II alpha0.017
ZwilchZwilch, kinetochore associated, homolog (Drosophila)0.017
Lrrc40leucine rich repeat containing 400.017
BC016423cDNA sequence BC0164230.017
Ncaphnon-SMC condensin I complex, subunit H0.017
Shcbp1Shc SH2-domain binding protein 10.016
Ccne2cyclin E20.016
Dr1down-regulator of transcription 10.016
Cirbpcold inducible RNA binding protein0.016
Mki67antigen identified by monoclonal antibody Ki 670.016
Rnf138ring finger protein 1380.016
Ccna2cyclin A20.015
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.015
Cnot6CCR4-NOT transcription complex, subunit 60.015
Depdc1aDEP domain containing 1a0.015
D030056L22RikRIKEN cDNA D030056L22 gene0.015
Rad51RAD51 homolog (S. cerevisiae)0.014
Ccnb2cyclin B20.014
Cdc7cell division cycle 7 (S. cerevisiae)0.014
Cenplcentromere protein L0.013
Etaa1Ewing's tumor-associated antigen 10.013
Ythdc2YTH domain containing 20.013
Trip13thyroid hormone receptor interactor 130.012
Melkmaternal embryonic leucine zipper kinase0.012
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.012
Cdca7cell division cycle associated 70.012
Actr3ARP3 actin-related protein 3 homolog (yeast)0.012
Efcab7EF-hand calcium binding domain 70.012
Pola1polymerase (DNA directed), alpha 10.012
Ube2cubiquitin-conjugating enzyme E2C0.012
Nup205nucleoporin 2050.012
Cenpacentromere protein A0.012
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.011
Dnmt3aDNA methyltransferase 3A0.011
Morc3microrchidia 30.011
Dna2DNA replication helicase 2 homolog (yeast)0.011
Cenpc1centromere protein C10.011
Rbl1retinoblastoma-like 1 (p107)0.011
Suz12suppressor of zeste 12 homolog (Drosophila)0.011
Hnrnpa2b1heterogeneous nuclear ribonucleoprotein A2/B10.011
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.011
Nup50nucleoporin 500.011
Rbbp8retinoblastoma binding protein 80.011
Pnrc2proline-rich nuclear receptor coactivator 20.010
Pdk3pyruvate dehydrogenase kinase, isoenzyme 30.010
Srsf1serine/arginine-rich splicing factor 10.010
Ino80cINO80 complex subunit C0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hcp-1Protein HCP-10.541
bub-1Protein BUB-10.521
aspm-1Protein ASPM-10.352
CELE_Y53F4B.9Protein Y53F4B.90.323
klp-19Protein KLP-190.225
cyk-4Protein CYK-40.179
mel-28Protein MEL-280.173
hcp-6Protein HCP-60.169
him-10Protein HIM-100.165
tac-1Protein TAC-10.119
rpl-11.1Protein RPL-11.10.116
ect-2Protein ECT-20.096
mcm-7Protein MCM-70.094
mcm-2Protein MCM-20.058
klp-10Protein KLP-100.052
gpr-1Protein GPR-10.050
icp-1Protein ICP-10.048
csc-1Protein CSC-10.044
spdl-1Protein SPDL-10.044
gpr-2Protein GPR-20.043
pri-1Protein PRI-10.042
set-21Protein SET-210.041
F25B5.2Protein F25B5.20.041
npp-11Protein NPP-110.041
T07C4.10Protein T07C4.100.039
knl-1Protein KNL-10.038
B0001.7Protein B0001.70.037
dna-2Protein DNA-20.036
iff-1Protein IFF-10.034
hil-4Protein HIL-40.031
klp-7Protein KLP-70.031
CELE_C39E9.12Protein C39E9.120.029
klp-18Protein KLP-180.028
hcp-2Protein HCP-20.025
B0261.7Protein B0261.70.025
cyb-1Protein CYB-10.024
cye-1Protein CYE-10.024
top-2Protein TOP-20.023
lin-5Protein LIN-50.022
pig-1Protein PIG-10.018
rnr-1Protein RNR-10.018
ndc-80Protein NDC-800.017
F20A1.9Protein F20A1.90.016
ZK430.7Protein ZK430.70.016
Y4C6B.1Protein Y4C6B.10.016
bir-1Protein BIR-10.016
perm-1Protein PERM-10.016
air-2Protein AIR-20.016
hcp-3Protein HCP-30.015
brd-1Protein BRD-10.015
CELE_C24H12.5Protein C24H12.50.014
F33H2.5Protein F33H2.50.014
ubxn-1Protein UBXN-10.013
pie-1Protein PIE-10.012
T20F5.7Protein T20F5.70.012
CELE_F23C8.9Protein F23C8.90.012
sas-4Protein SAS-40.011
CELE_F59A6.5Protein F59A6.50.011
dao-5Protein DAO-50.011
lig-1Protein LIG-10.011
obr-3Protein OBR-30.011
CELE_R09B3.2Protein R09B3.20.011
F54E12.2Protein F54E12.20.010
ani-1Protein ANI-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ndc80CG9938 gene product from transcript CG9938-RA0.324
Nuf2CG8902 gene product from transcript CG8902-RA0.208
Cenp-CCG31258 gene product from transcript CG31258-RA0.058
marsCG17064 gene product from transcript CG17064-RB0.038
cmetCENP-meta0.026
Kmn1kinetochore Mis12-Ndc80 network component 10.025
Spc25CG7242 gene product from transcript CG7242-RA0.019
Mis12CG18156 gene product from transcript CG18156-RA0.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CUL1cullin 10.376
NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)0.254
SKP2S-phase kinase-associated protein 2 (p45)0.250
CENPMcentromere protein M0.217
BTRCbeta-transducin repeat containing0.192
CENPAcentromere protein A0.083
CBX5chromobox homolog 50.082
NUP133nucleoporin 133kDa0.077
CACYBPcalcyclin binding protein0.071
POLE4polymerase (DNA-directed), epsilon 4 (p12 subunit)0.048
CHRAC1chromatin accessibility complex 10.034
FAM83Dfamily with sequence similarity 83, member D0.033
FAM64Afamily with sequence similarity 64, member A0.031
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.031
YBX1Y box binding protein 10.028
E2F3E2F transcription factor 30.020
CENPEcentromere protein E, 312kDa0.018
TCEA2transcription elongation factor A (SII), 20.015
DIAPH3diaphanous homolog 3 (Drosophila)0.015
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.014
HIST1H3Bhistone cluster 1, H3b0.013
RNF111ring finger protein 1110.013
CENPHcentromere protein H0.012
SPAG5sperm associated antigen 50.012
FBXO4F-box protein 40.012
GLRX3glutaredoxin 30.012
TRPS1trichorhinophalangeal syndrome I0.011
FBXW11F-box and WD repeat domain containing 110.011
FBXW2F-box and WD repeat domain containing 20.011
CENPNcentromere protein N0.011
CBX1chromobox homolog 10.011
PRR14proline rich 140.011
MELKmaternal embryonic leucine zipper kinase0.011
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.010
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.010
KIF2Ckinesin family member 2C0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SKP1Skp1p0.035
MAD2Mad2p0.025
CSE4Cse4p0.021
CBF1Cbf1p0.016
SWC4Swc4p0.016
MIF2Mif2p0.014
CBF2Cbf2p0.014
CTF3Ctf3p0.012
IPL1Ipl1p0.012
MTW1Mtw1p0.012
SWC7Swc7p0.011
SRD1Srd1p0.011