The network for 'primary neural tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

primary neural tube formation

The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Pitx2paired-like homeodomain transcription factor 21.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Bmp7bone morphogenetic protein 71.000
Pax3paired box gene 31.000
Pax2paired box gene 21.000
Foxc1forkhead box C10.999
Gli2GLI-Kruppel family member GLI20.999
Lhx1LIM homeobox protein 10.999
Pax6paired box gene 60.998
Tcfap2atranscription factor AP-2, alpha0.998
Sall4sal-like 4 (Drosophila)0.998
Msx1homeobox, msh-like 10.998
Pbx1pre B-cell leukemia transcription factor 10.997
Smosmoothened homolog (Drosophila)0.997
Sox2SRY-box containing gene 20.995
Fgf10fibroblast growth factor 100.995
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.994
Hand1heart and neural crest derivatives expressed transcript 10.994
Fgfr1fibroblast growth factor receptor 10.993
Tgfb2transforming growth factor, beta 20.991
Eya1eyes absent 1 homolog (Drosophila)0.990
Bmp4bone morphogenetic protein 40.990
Msx2homeobox, msh-like 20.989
Zic3zinc finger protein of the cerebellum 30.987
Prrx1paired related homeobox 10.987
Pitx1paired-like homeodomain transcription factor 10.977
Fgf8fibroblast growth factor 80.973
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.971
Dlx5distal-less homeobox 50.968
Emx2empty spiracles homolog 2 (Drosophila)0.965
Ror2receptor tyrosine kinase-like orphan receptor 20.965
Dvl2dishevelled 2, dsh homolog (Drosophila)0.943
Sox9SRY-box containing gene 90.939
Rargretinoic acid receptor, gamma0.934
Fzd8frizzled homolog 8 (Drosophila)0.928
Efna2ephrin A20.919
Ptenphosphatase and tensin homolog0.917
Foxc2forkhead box C20.916
Hoxa13homeobox A130.909
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.905
Sox11SRY-box containing gene 110.904
Rarbretinoic acid receptor, beta0.898
Ascl1achaete-scute complex homolog 1 (Drosophila)0.897
Hand2heart and neural crest derivatives expressed transcript 20.895
Sfrp2secreted frizzled-related protein 20.895
Wnt3awingless-related MMTV integration site 3A0.894
Emx1empty spiracles homolog 1 (Drosophila)0.892
Hoxd13homeobox D130.887
Pax8paired box gene 80.887
Zic2zinc finger protein of the cerebellum 20.883
Tbx1T-box 10.876
Pou5f1POU domain, class 5, transcription factor 10.874
Wt1Wilms tumor 1 homolog0.866
Neurog2neurogenin 20.864
Foxh1forkhead box H10.862
Tbx15T-box 150.859
Jag1jagged 10.859
Wnt5awingless-related MMTV integration site 5A0.854
Gdf3growth differentiation factor 30.850
Chd7chromodomain helicase DNA binding protein 70.846
Fgfr3fibroblast growth factor receptor 30.846
Lrp6low density lipoprotein receptor-related protein 60.841
Otx1orthodenticle homolog 1 (Drosophila)0.835
Alx4aristaless-like homeobox 40.834
Foxg1forkhead box G10.832
Lmx1aLIM homeobox transcription factor 1 alpha0.830
Hoxa11homeobox A110.811
Dkk1dickkopf homolog 1 (Xenopus laevis)0.810
Megf8multiple EGF-like-domains 80.809
En1engrailed 10.807
Hoxa1homeobox A10.801
Fzd1frizzled homolog 1 (Drosophila)0.800
Gbx2gastrulation brain homeobox 20.798
Meox2mesenchyme homeobox 20.797
Dvl3dishevelled 3, dsh homolog (Drosophila)0.793
Prrx2paired related homeobox 20.784
Lhx3LIM homeobox protein 30.783
Ptch1patched homolog 10.779
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.765
Fgf15fibroblast growth factor 150.764
Isl1ISL1 transcription factor, LIM/homeodomain0.751
Runx2runt related transcription factor 20.745
Apcadenomatosis polyposis coli0.742
Vaspvasodilator-stimulated phosphoprotein0.741
Hoxd11homeobox D110.735
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.725
UncxUNC homeobox0.723
Tcfap2ctranscription factor AP-2, gamma0.718
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.712
Ebf3early B-cell factor 30.711
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.695
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.694
Smad6MAD homolog 6 (Drosophila)0.688
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.932
bocbrother of CDO0.865
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.774
gli1GLI-Kruppel family member 10.742
nkd1naked cuticle homolog 1 (Drosophila)0.681
ptch2patched 20.546
wnt5bwingless-type MMTV integration site family, member 5b0.508
crb2acrumbs homolog 2a0.507
foxd3forkhead box D30.485
sox9aSRY-box containing gene 9a0.442
fzd7afrizzled homolog 7a0.418
cdoncell adhesion molecule-related/down-regulated by oncogenes0.410
gli2aGLI-Kruppel family member GLI2a0.406
epb41l5erythrocyte membrane protein band 4.1 like 50.399
gdf6agrowth differentiation factor 6a0.362
hoxb1bhomeo box B1b0.361
ift88intraflagellar transport 88 homolog0.347
hoxb3ahomeo box B3a0.334
pkd2polycystic kidney disease 20.332
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.318
flhfloating head0.318
gpc4glypican 40.305
raraaretinoic acid receptor, alpha a0.299
efnb3bephrin B3b0.291
zic1zic family member 1 (odd-paired homolog, Drosophila)0.283
sp5lSp5 transcription factor-like0.282
foxi1forkhead box I10.279
cc2d2acoiled-coil and C2 domain containing 2A0.272
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.261
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.260
otx1borthodenticle homolog 1b0.259
shhasonic hedgehog a0.249
smosmoothened homolog (Drosophila)0.235
ptpraprotein tyrosine phosphatase, receptor type, A0.231
irx1airoquois homeobox protein 1, a0.230
lama5laminin, alpha 50.229
pax8paired box gene 80.222
meis3myeloid ecotropic viral integration site 30.219
prdm14PR domain containing 140.218
prickle1bprickle homolog 1 (Drosophila) b0.214
six2asine oculis-related homeobox 2a0.209
her8ahairy-related 8a0.209
pax2apaired box gene 2a0.203
kif17kinesin family member 170.199
bmp2bbone morphogenetic protein 2b0.198
robo3roundabout homolog 30.198
znf703zinc finger protein 7030.197
nrarpbnotch-regulated ankyrin repeat protein b0.195
znf503zinc finger protein 5030.195
rargaretinoic acid receptor gamma a0.180
alcambactivated leukocyte cell adhesion molecule b0.178
pitx3paired-like homeodomain transcription factor 30.177
mab21l2mab-21-like 20.176
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.175
nrp1aneuropilin 1a0.175
spry1sprouty homolog 1 (Drosophila)0.175
wnt11wingless-type MMTV integration site family, member 110.170
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.170
fgfr2fibroblast growth factor receptor 20.168
gyltl1bglycosyltransferase-like 1b0.165
meis2.2myeloid ecotropic viral integration site 2.20.159
wnt4awingless-type MMTV integration site family, member 4a0.157
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.156
efnb2aephrin B2a0.156
lrrc6leucine rich repeat containing 60.154
metmet proto-oncogene (hepatocyte growth factor receptor)0.154
hoxa3ahomeo box A3a0.152
lama1laminin, alpha 10.152
dbx1bdeveloping brain homeobox 1b0.149
prickle1aprickle-like 1 (Drosophila) a0.149
ephb4aeph receptor B4a0.147
osr1odd-skipped related 1 (Drosophila)0.145
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.145
ift57intraflagellar transport protein 570.144
dctn1adynactin 1a0.144
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.142
otx2orthodenticle homolog 20.138
bmperBMP binding endothelial regulator0.137
olig3oligodendrocyte transcription factor 30.134
tbx16T-box gene 160.130
etv5bets variant 5b0.130
zeb1zinc finger E-box binding homeobox 10.127
robo1roundabout homolog 10.126
odz4odd Oz/ten-m homolog 40.125
sox1aSRY-box containing gene 1a0.125
plxnb2aplexin b2a0.124
tbx2bT-box 2b0.122
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.121
lamb1alaminin, beta 1a0.120
myh10myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle0.119
pax6apaired box gene 6a0.118
emx1empty spiracles homeobox 10.116
itga3bintegrin, alpha 3b0.116
hoxb6bhomeo box B6b0.116
tbx1T-box 10.114
chaf1bchromatin assembly factor 1, subunit B0.114
tpbgltrophoblast glycoprotein-like0.113
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TSC2tuberous sclerosis 20.981
SMAD3SMAD family member 30.969
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.940
CASP9caspase 9, apoptosis-related cysteine peptidase0.902
APCadenomatous polyposis coli0.897
AXIN1axin 10.896
SMAD2SMAD family member 20.851
LRRK2leucine-rich repeat kinase 20.849
BBS2Bardet-Biedl syndrome 20.797
TRRAPtransformation/transcription domain-associated protein0.791
DVL3dishevelled, dsh homolog 3 (Drosophila)0.773
BCORBCL6 corepressor0.660
CASP3caspase 3, apoptosis-related cysteine peptidase0.643
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.633
MEOX2mesenchyme homeobox 20.585
MBD2methyl-CpG binding domain protein 20.551
MED16mediator complex subunit 160.532
RXRAretinoid X receptor, alpha0.531
CREBBPCREB binding protein0.519
CNKSR2connector enhancer of kinase suppressor of Ras 20.518
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.511
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.510
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.497
DVL1dishevelled, dsh homolog 1 (Drosophila)0.487
ZFXzinc finger protein, X-linked0.477
GLI1GLI family zinc finger 10.472
TRIP6thyroid hormone receptor interactor 60.465
ZFYVE9zinc finger, FYVE domain containing 90.426
POU3F2POU class 3 homeobox 20.409
SETD8SET domain containing (lysine methyltransferase) 80.394
ACTBactin, beta0.372
GSK3Bglycogen synthase kinase 3 beta0.363
EPAS1endothelial PAS domain protein 10.340
SEC24DSEC24 family, member D (S. cerevisiae)0.339
ZRANB1zinc finger, RAN-binding domain containing 10.334
RASA1RAS p21 protein activator (GTPase activating protein) 10.331
ACTG1actin, gamma 10.329
EXOC7exocyst complex component 70.328
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.326
SEC23ASec23 homolog A (S. cerevisiae)0.324
C9orf89chromosome 9 open reading frame 890.319
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.315
EP300E1A binding protein p3000.305
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.296
ARID1BAT rich interactive domain 1B (SWI1-like)0.287
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.281
DLG5discs, large homolog 5 (Drosophila)0.274
CTBP1C-terminal binding protein 10.270
SORBS3sorbin and SH3 domain containing 30.270
SASS6spindle assembly 6 homolog (C. elegans)0.265
XIAPX-linked inhibitor of apoptosis0.263
BBS10Bardet-Biedl syndrome 100.256
ERBB2IPerbb2 interacting protein0.255
WASF2WAS protein family, member 20.247
BBS1Bardet-Biedl syndrome 10.243
AKAP11A kinase (PRKA) anchor protein 110.243
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.237
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.223
KIF5Bkinesin family member 5B0.222
LDB1LIM domain binding 10.219
LIN28Blin-28 homolog B (C. elegans)0.219
USP9Xubiquitin specific peptidase 9, X-linked0.218
MED25mediator complex subunit 250.218
LMAN1lectin, mannose-binding, 10.210
ESR1estrogen receptor 10.205
WNT3Awingless-type MMTV integration site family, member 3A0.203
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.202
ZMYND11zinc finger, MYND-type containing 110.196
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.193
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.191
C14orf1chromosome 14 open reading frame 10.185
RPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 10.183
MDM2Mdm2 p53 binding protein homolog (mouse)0.181
CSNK1Dcasein kinase 1, delta0.178
CTBP2C-terminal binding protein 20.176
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.176
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.174
IRAK2interleukin-1 receptor-associated kinase 20.166
SIN3ASIN3 homolog A, transcription regulator (yeast)0.165
TSC1tuberous sclerosis 10.163
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.161
ABI1abl-interactor 10.161
HMOX2heme oxygenase (decycling) 20.156
TJP2tight junction protein 2 (zona occludens 2)0.155
ANKRD28ankyrin repeat domain 280.150
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, beta0.149
WASF1WAS protein family, member 10.144
BMP7bone morphogenetic protein 70.143
PCM1pericentriolar material 10.142
MTA1metastasis associated 10.141
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.140
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.139
NCOA6nuclear receptor coactivator 60.135
SQSTM1sequestosome 10.134
MLL3myeloid/lymphoid or mixed-lineage leukemia 30.133
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.133
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.131
ATXN1ataxin 10.130
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.128
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism