The network for 't cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell proliferation

The expansion of a T cell population by cell division. Follows T cell activation.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ikzf1IKAROS family zinc finger 10.997
Foxp3forkhead box P30.995
Efnb2ephrin B20.995
Ptpn11protein tyrosine phosphatase, non-receptor type 110.985
Il2interleukin 20.984
Socs1suppressor of cytokine signaling 10.979
Ighimmunoglobulin heavy chain complex0.979
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.975
Casp4caspase 4, apoptosis-related cysteine peptidase0.974
Tnfaip3tumor necrosis factor, alpha-induced protein 30.973
BtkBruton agammaglobulinemia tyrosine kinase0.972
Cd40CD40 antigen0.971
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.968
Ccl2chemokine (C-C motif) ligand 20.964
Foxn1forkhead box N10.960
CblCasitas B-lineage lymphoma0.958
Il4interleukin 40.944
Stat3signal transducer and activator of transcription 30.939
Cd4CD4 antigen0.933
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.931
Birc3baculoviral IAP repeat-containing 30.926
Pdcd1programmed cell death 10.921
Tnftumor necrosis factor0.919
FasFas (TNF receptor superfamily member 6)0.911
Casp1caspase 10.906
Cd80CD80 antigen0.900
Cd19CD19 antigen0.897
Ctnnb1catenin (cadherin associated protein), beta 10.874
Tnfrsf18tumor necrosis factor receptor superfamily, member 180.867
Ank1ankyrin 1, erythroid0.865
Nckap1lNCK associated protein 1 like0.865
Selpselectin, platelet0.865
FaslFas ligand (TNF superfamily, member 6)0.864
Itgb1integrin beta 1 (fibronectin receptor beta)0.860
Map3k14mitogen-activated protein kinase kinase kinase 140.859
Dkk1dickkopf homolog 1 (Xenopus laevis)0.857
Dok1docking protein 10.851
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.851
Ltalymphotoxin A0.844
Icosinducible T-cell co-stimulator0.839
Fgfr2fibroblast growth factor receptor 20.836
Stat5bsignal transducer and activator of transcription 5B0.834
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.818
Il2rbinterleukin 2 receptor, beta chain0.816
Lyz2lysozyme 20.813
Card11caspase recruitment domain family, member 110.796
Cdk6cyclin-dependent kinase 60.796
Clec4dC-type lectin domain family 4, member d0.794
WasWiskott-Aldrich syndrome homolog (human)0.792
Stat1signal transducer and activator of transcription 10.785
Grb2growth factor receptor bound protein 20.780
Retret proto-oncogene0.765
Il1binterleukin 1 beta0.764
Cdk4cyclin-dependent kinase 40.760
Cd3eCD3 antigen, epsilon polypeptide0.756
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.755
Inpp5dinositol polyphosphate-5-phosphatase D0.750
Nf1neurofibromatosis 10.750
Casp8caspase 80.747
Cdkn1bcyclin-dependent kinase inhibitor 1B0.747
Ptpn6protein tyrosine phosphatase, non-receptor type 60.743
Gli3GLI-Kruppel family member GLI30.732
Emx1empty spiracles homolog 1 (Drosophila)0.728
Ltblymphotoxin B0.727
Kitkit oncogene0.724
Itgb2integrin beta 20.724
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.723
RybpRING1 and YY1 binding protein0.722
Traf6TNF receptor-associated factor 60.717
Irf5interferon regulatory factor 50.707
Nlrp3NLR family, pyrin domain containing 30.702
Wnt3awingless-related MMTV integration site 3A0.701
Ptenphosphatase and tensin homolog0.695
Csf1colony stimulating factor 1 (macrophage)0.692
Spna1spectrin alpha 10.688
Ccr7chemokine (C-C motif) receptor 70.684
Ccr1chemokine (C-C motif) receptor 10.682
Shhsonic hedgehog0.682
Cd28CD28 antigen0.680
Cd86CD86 antigen0.665
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.665
Rag2recombination activating gene 20.663
Ttc7tetratricopeptide repeat domain 70.661
Bcl2B-cell leukemia/lymphoma 20.660
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.651
Il12binterleukin 12b0.647
Gpr132G protein-coupled receptor 1320.643
Ccnd1cyclin D10.638
Lcklymphocyte protein tyrosine kinase0.636
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.634
Prf1perforin 1 (pore forming protein)0.631
Jak2Janus kinase 20.627
Ccl3chemokine (C-C motif) ligand 30.626
Clec4nC-type lectin domain family 4, member n0.625
Batfbasic leucine zipper transcription factor, ATF-like0.622
Ccl5chemokine (C-C motif) ligand 50.622
Sh2d2aSH2 domain protein 2A0.621
Dock2dedicator of cyto-kinesis 20.621
Ephb2Eph receptor B20.619
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.967
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.932
CD80CD80 molecule0.930
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.926
BIRC3baculoviral IAP repeat containing 30.882
SOCS3suppressor of cytokine signaling 30.830
LCKlymphocyte-specific protein tyrosine kinase0.823
CD86CD86 molecule0.751
ICAM1intercellular adhesion molecule 10.708
CD2CD2 molecule0.693
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.690
LATlinker for activation of T cells0.675
HLA-Fmajor histocompatibility complex, class I, F0.667
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.660
BTN3A3butyrophilin, subfamily 3, member A30.653
HLA-Gmajor histocompatibility complex, class I, G0.620
CTLA4cytotoxic T-lymphocyte-associated protein 40.614
TRAF1TNF receptor-associated factor 10.607
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.603
HLA-Bmajor histocompatibility complex, class I, B0.573
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.540
BTN3A2butyrophilin, subfamily 3, member A20.537
CXCL9chemokine (C-X-C motif) ligand 90.492
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.479
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.427
PSEN1presenilin 10.396
BTN3A1butyrophilin, subfamily 3, member A10.387
CCR5chemokine (C-C motif) receptor 50.353
CD247CD247 molecule0.352
SYKspleen tyrosine kinase0.340
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.336
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.309
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.309
IL2RGinterleukin 2 receptor, gamma0.305
BCL10B-cell CLL/lymphoma 100.305
CASP8caspase 8, apoptosis-related cysteine peptidase0.294
CCL22chemokine (C-C motif) ligand 220.280
CCR7chemokine (C-C motif) receptor 70.276
IL1R1interleukin 1 receptor, type I0.274
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.268
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.268
HLA-DRB5major histocompatibility complex, class II, DR beta 50.247
NLRC4NLR family, CARD domain containing 40.238
AOAHacyloxyacyl hydrolase (neutrophil)0.235
CASP9caspase 9, apoptosis-related cysteine peptidase0.219
IL2RBinterleukin 2 receptor, beta0.219
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.206
IL23Ainterleukin 23, alpha subunit p190.177
IRF1interferon regulatory factor 10.176
EGFRepidermal growth factor receptor0.175
BIRC2baculoviral IAP repeat containing 20.167
RUNX1runt-related transcription factor 10.161
SOS1son of sevenless homolog 1 (Drosophila)0.159
RARRES3retinoic acid receptor responder (tazarotene induced) 30.154
IL1Binterleukin 1, beta0.146
GRB2growth factor receptor-bound protein 20.144
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.140
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.139
FSTL1follistatin-like 10.138
DPP4dipeptidyl-peptidase 40.135
CCL13chemokine (C-C motif) ligand 130.131
JAK1Janus kinase 10.131
PTPN6protein tyrosine phosphatase, non-receptor type 60.130
HLA-DPB1major histocompatibility complex, class II, DP beta 10.130
LST1leukocyte specific transcript 10.130
PMLpromyelocytic leukemia0.129
BMPR1Abone morphogenetic protein receptor, type IA0.124
PTPRCprotein tyrosine phosphatase, receptor type, C0.124
CD52CD52 molecule0.122
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.122
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.121
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.119
CCL4chemokine (C-C motif) ligand 40.117
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.116
HCKhemopoietic cell kinase0.113
CXCL10chemokine (C-X-C motif) ligand 100.111
TNFRSF9tumor necrosis factor receptor superfamily, member 90.108
CCL8chemokine (C-C motif) ligand 80.108
CLEC10AC-type lectin domain family 10, member A0.106
IFI35interferon-induced protein 350.106
FCN1ficolin (collagen/fibrinogen domain containing) 10.106
CXCL11chemokine (C-X-C motif) ligand 110.106
CD3GCD3g molecule, gamma (CD3-TCR complex)0.105
IGF2insulin-like growth factor 2 (somatomedin A)0.105
TRADDTNFRSF1A-associated via death domain0.104
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.100
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.100
HLA-DRB4major histocompatibility complex, class II, DR beta 40.099
SIGLEC7sialic acid binding Ig-like lectin 70.098
IL6Rinterleukin 6 receptor0.096
MEFVMediterranean fever0.094
UBCubiquitin C0.092
CCL2chemokine (C-C motif) ligand 20.091
CFPcomplement factor properdin0.090
IFI30interferon, gamma-inducible protein 300.090
XIAPX-linked inhibitor of apoptosis0.089
IL10interleukin 100.088
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.086
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.082
IRF4interferon regulatory factor 40.079
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.944
RT1-BaRT1 class II, locus Ba0.936
Cd37CD37 molecule0.909
RT1-Db1RT1 class II, locus Db10.660
RT1-DaRT1 class II, locus Da0.461
RT1-BbRT1 class II, locus Bb0.358
Ptprcprotein tyrosine phosphatase, receptor type, C0.350
RT1-DMbRT1 class II, locus DMb0.341
Hckhemopoietic cell kinase0.304
Cd44Cd44 molecule0.258
Il2rbinterleukin 2 receptor, beta0.252
Il1binterleukin 1 beta0.230
Psme2proteasome (prosome, macropain) activator subunit 20.213
Ccl5chemokine (C-C motif) ligand 50.177
Cd247Cd247 molecule0.169
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.126
Fggfibrinogen gamma chain0.104
RT1-DMaRT1 class II, locus DMa0.098
Bin2bridging integrator 20.077
Cd2Cd2 molecule0.073
Cfpcomplement factor properdin0.073
Aif1allograft inflammatory factor 10.072
Ly86lymphocyte antigen 860.068
Dock8dedicator of cytokinesis 80.066
Grngranulin0.063
Slfn2schlafen 20.061
Taok1TAO kinase 10.058
Anxa5annexin A50.057
Scp2sterol carrier protein 20.056
Inpp5dinositol polyphosphate-5-phosphatase D0.055
Batf3basic leucine zipper transcription factor, ATF-like 30.054
Ccl3chemokine (C-C motif) ligand 30.054
Mybpc2myosin binding protein C, fast-type0.053
Il6interleukin 60.052
Sellselectin L0.050
Casp1caspase 10.046
Arhgap4Rho GTPase activating protein 40.045
Aldh6a1aldehyde dehydrogenase 6 family, member A10.045
FynFYN oncogene related to SRC, FGR, YES0.043
Gzmkgranzyme K0.042
Ehfets homologous factor0.042
Ctsbcathepsin B0.039
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.038
Hn1hematological and neurological expressed 10.038
Vom2r27vomeronasal 2 receptor, 270.037
Zbp1Z-DNA binding protein 10.036
Nedd4neural precursor cell expressed, developmentally down-regulated 40.035
Neurl3neuralized homolog 3 (Drosophila)0.035
Nckap1NCK-associated protein 10.031
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.030
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.029
Lst1leukocyte specific transcript 10.029
Il10interleukin 100.028
Arrb2arrestin, beta 20.027
Cd5Cd5 molecule0.027
Plcg2phospholipase C, gamma 20.026
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.026
Itgb7integrin, beta 70.026
C5ar1complement component 5a receptor 10.025
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.025
Alox5aparachidonate 5-lipoxygenase activating protein0.025
Igh-6immunoglobulin heavy chain 60.025
Nkg7natural killer cell group 7 sequence0.025
Jak1Janus kinase 10.024
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.024
Fgbfibrinogen beta chain0.024
Cd86CD86 molecule0.024
Rab7aRAB7A, member RAS oncogene family0.024
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.023
Klrk1killer cell lectin-like receptor subfamily K, member 10.023
Ptpn6protein tyrosine phosphatase, non-receptor type 60.023
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.022
Ptafrplatelet-activating factor receptor0.022
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.022
Il7rinterleukin 7 receptor0.021
Psme1proteasome (prosome, macropain) activator subunit 10.021
Cd53Cd53 molecule0.021
Pecam1platelet/endothelial cell adhesion molecule 10.021
Taldo1transaldolase 10.021
Laptm5lysosomal protein transmembrane 50.021
Il1ainterleukin 1 alpha0.021
Gfra1GDNF family receptor alpha 10.020
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.020
Cxcl10chemokine (C-X-C motif) ligand 100.020
Has2hyaluronan synthase 20.020
Fgfr2fibroblast growth factor receptor 20.020
Bmp7bone morphogenetic protein 70.019
Sirpasignal-regulatory protein alpha0.019
Spnsialophorin0.019
Ccl4chemokine (C-C motif) ligand 40.019
Pfn1profilin 10.019
Cd3dCD3 molecule, delta0.019
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.018
Tfectranscription factor EC0.018
Il2rginterleukin 2 receptor, gamma0.018
TcrbT-cell receptor beta chain0.018
Cyp2a3cytochrome P450, family 2, subfamily a, polypeptide 30.017
Celcarboxyl ester lipase0.017
Irf5interferon regulatory factor 50.017
Cd8aCD8a molecule0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism