IMP: Integrative Multi-species Prediction

The network for 'regulation of transcription by chromatin organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transcription by chromatin organization

Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription.

Mus musculus

Name	Description	Probability
Smc1a	structural maintenance of chromosomes 1A	0.984
Trim28	tripartite motif-containing 28	0.798
Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)	0.754
Kdm2b	lysine (K)-specific demethylase 2B	0.694
Trim24	tripartite motif-containing 24	0.631
Srsf1	serine/arginine-rich splicing factor 1	0.566
Timeless	timeless homolog (Drosophila)	0.552
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.383
Rnf2	ring finger protein 2	0.355
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.297
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.289
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.283
Cdt1	chromatin licensing and DNA replication factor 1	0.253
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.235
Stag1	stromal antigen 1	0.232
Rcc2	regulator of chromosome condensation 2	0.218
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.215
Lig1	ligase I, DNA, ATP-dependent	0.213
Smc3	structural maintenace of chromosomes 3	0.170
Casp8ap2	caspase 8 associated protein 2	0.152
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.150
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.134
Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)	0.132
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.120
Baz1a	bromodomain adjacent to zinc finger domain 1A	0.108
Mecp2	methyl CpG binding protein 2	0.092
Ep400	E1A binding protein p400	0.092
Pou5f1	POU domain, class 5, transcription factor 1	0.091
Rif1	Rap1 interacting factor 1 homolog (yeast)	0.091
Nucks1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.091
Thoc2	THO complex 2	0.090
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.087
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.087
Ctcf	CCCTC-binding factor	0.086
Rnpc3	RNA-binding region (RNP1, RRM) containing 3	0.086
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.082
Wdr5	WD repeat domain 5	0.082
Atxn7	ataxin 7	0.078
Ddx10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	0.077
Baz1b	bromodomain adjacent to zinc finger domain, 1B	0.076
E2f1	E2F transcription factor 1	0.075
Bcor	BCL6 interacting corepressor	0.073
Msl2	male-specific lethal 2 homolog (Drosophila)	0.073
Pcm1	pericentriolar material 1	0.068
Pole	polymerase (DNA directed), epsilon	0.063
Bclaf1	BCL2-associated transcription factor 1	0.062
Arid1b	AT rich interactive domain 1B (SWI-like)	0.062
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.061
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.060
Prim1	DNA primase, p49 subunit	0.059
Kdm1a	lysine (K)-specific demethylase 1A	0.056
Rfc5	replication factor C (activator 1) 5	0.055
Sae1	SUMO1 activating enzyme subunit 1	0.054
Ppig	peptidyl-prolyl isomerase G (cyclophilin G)	0.051
Ubap2	ubiquitin-associated protein 2	0.051
Epc2	enhancer of polycomb homolog 2 (Drosophila)	0.051
Trrap	transformation/transcription domain-associated protein	0.050
Rsbn1	rosbin, round spermatid basic protein 1	0.050
Smc6	structural maintenance of chromosomes 6	0.050
Csrp2bp	cysteine and glycine-rich protein 2 binding protein	0.047
Ythdc1	YTH domain containing 1	0.047
Rb1	retinoblastoma 1	0.045
Klhl24	kelch-like 24 (Drosophila)	0.045
Mael	maelstrom homolog (Drosophila)	0.045
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.045
Rrm1	ribonucleotide reductase M1	0.043
Cdca5	cell division cycle associated 5	0.043
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.042
Rbm26	RNA binding motif protein 26	0.042
Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	0.041
Nup153	nucleoporin 153	0.041
Chaf1a	chromatin assembly factor 1, subunit A (p150)	0.040
Hmgb1	high mobility group box 1	0.040
Creb1	cAMP responsive element binding protein 1	0.040
Rad21	RAD21 homolog (S. pombe)	0.040
Usp7	ubiquitin specific peptidase 7	0.039
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.039
Rrm2	ribonucleotide reductase M2	0.039
Ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.039
Hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.039
Nanog	Nanog homeobox	0.038
Mga	MAX gene associated	0.038
Hcfc1	host cell factor C1	0.038
Brca2	breast cancer 2	0.037
Cad	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.036
Dmap1	DNA methyltransferase 1-associated protein 1	0.036
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.035
Mms22l	MMS22-like, DNA repair protein	0.034
L3mbtl2	l(3)mbt-like 2 (Drosophila)	0.034
Anapc5	anaphase-promoting complex subunit 5	0.034
Sp1	trans-acting transcription factor 1	0.033
Max	Max protein	0.033
Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.033
Pparg	peroxisome proliferator activated receptor gamma	0.032
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.032
Bod1l	biorientation of chromosomes in cell division 1-like	0.030
Ing3	inhibitor of growth family, member 3	0.029
Hells	helicase, lymphoid specific	0.028
Cnot4	CCR4-NOT transcription complex, subunit 4	0.028
Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.028

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Caenorhabditis elegans

Name	Description	Probability	Func Analog Organism

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Danio rerio

Name	Description	Probability	Func Analog Organism

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Drosophila melanogaster

Name	Description	Probability
Jarid2	CG3654 gene product from transcript CG3654-RD	0.221
CTCF	CG8591 gene product from transcript CG8591-RA	0.175
Su(var)2-10	Suppressor of variegation 2-10	0.120
Mcm2	Minichromosome maintenance 2	0.098
Su(var)2-HP2	CG12864 gene product from transcript CG12864-RB	0.094
Nup98	Nucleoporin 98	0.086
Su(var)3-3	Suppressor of variegation 3-3	0.080
MBD-like	CG8208 gene product from transcript CG8208-RA	0.075
SuUR	Suppressor of Under-Replication	0.071
Rpd3	CG7471 gene product from transcript CG7471-RA	0.064
pasha	partner of drosha	0.055
pr-set7	CG3307 gene product from transcript CG3307-RC	0.049
Grip84	gamma-tubulin ring protein 84	0.043
Hel25E	Helicase at 25E	0.040
Acf1	ATP-dependent chromatin assembly factor large subunit	0.040
BEAF-32	Boundary element-associated factor of 32kD	0.039
Dek	CG5935 gene product from transcript CG5935-RA	0.036
hkl	hook-like	0.036
Top2	Topoisomerase 2	0.034
E(var)3-9	Enhancer of variegation 3-9	0.034
Suv4-20	CG13363 gene product from transcript CG13363-RA	0.033
Su(var)205	Suppressor of variegation 205	0.033
otu	ovarian tumor	0.032
Su(var)3-7	Suppressor of variegation 3-7	0.032
XNP	CG4548 gene product from transcript CG4548-RA	0.032
Sir2	CG5216 gene product from transcript CG5216-RA	0.032
Mi-2	CG8103 gene product from transcript CG8103-RA	0.030
spn-E	spindle E	0.028
plu	plutonium	0.027
Fs(2)Ket	Female sterile (2) Ketel	0.027
mael	maelstrom	0.026
piwi	CG6122 gene product from transcript CG6122-RA	0.026
fs(2)ltoPP43	female sterile (2) ltoPP43	0.026
SMC1	CG6057 gene product from transcript CG6057-RA	0.025
CG14438	CG14438 gene product from transcript CG14438-RA	0.025
png	pan gu	0.023
stwl	stonewall	0.023
PPP4R2r	Protein phosphatase 4 regulatory subunit 2-related protein	0.021
chm	chameau	0.021
His2Av	Histone H2A variant	0.021
CG11137	CG11137 gene product from transcript CG11137-RA	0.020
asf1	anti-silencing factor 1	0.020
AGO2	Argonaute 2	0.019
mip120	Myb-interacting protein 120	0.019
Gef26	CG9491 gene product from transcript CG9491-RB	0.019
Cypl	Cyclophilin-like	0.019
dup	double parked	0.019
MEP-1	CG1244 gene product from transcript CG1244-RG	0.018
WRNexo	WRN exonuclease	0.018
trr	trithorax-related	0.017
BG4	CG12297 gene product from transcript CG12297-RA	0.017
msl-3	male-specific lethal 3	0.017
mus209	mutagen-sensitive 209	0.017
enc	encore	0.017
icln	CG4924 gene product from transcript CG4924-RA	0.016
CG31122	CG31122 gene product from transcript CG31122-RA	0.016
Gr28b	Gustatory receptor 28b	0.016
HP4	Heterochromatin protein 4	0.016
crm	cramped	0.016
ash1	absent, small, or homeotic discs 1	0.016
Nup160	Nucleoporin 160	0.015
Mekk1	CG7717 gene product from transcript CG7717-RB	0.015
jumu	jumeau	0.015
SMC2	CG10212 gene product from transcript CG10212-RA	0.015
Snm1	CG10018 gene product from transcript CG10018-RA	0.015
pzg	putzig	0.015
gkt	glaikit	0.015
CG14183	CG14183 gene product from transcript CG14183-RA	0.015
CG7427	CG7427 gene product from transcript CG7427-RA	0.015
bgcn	benign gonial cell neoplasm	0.014
Ulp1	CG12359 gene product from transcript CG12359-RA	0.014
CG7239	CG7239 gene product from transcript CG7239-RA	0.014
ird5	immune response deficient 5	0.014
CG3125	CG3125 gene product from transcript CG3125-RA	0.014
CG13022	CG13022 gene product from transcript CG13022-RB	0.014
PGRP-LC	Peptidoglycan recognition protein LC	0.014
Df31	Decondensation factor 31	0.014
row	relative of woc	0.014
RfC38	Replication factor C 38kD subunit	0.013
enok	enoki mushroom	0.013
Nf-YB	Nuclear factor Y-box B	0.013
E(z)	Enhancer of zeste	0.013
Pgam5	Phosphoglycerate mutase 5	0.013
Grip163	CG5688 gene product from transcript CG5688-RA	0.013
mof	males absent on the first	0.013
Map60	Microtubule-associated protein 60	0.013
rod	rough deal	0.013
dhd	deadhead	0.013
Kmn1	kinetochore Mis12-Ndc80 network component 1	0.013
ph-d	polyhomeotic distal	0.013
CG5098	CG5098 gene product from transcript CG5098-RA	0.012
CG6752	CG6752 gene product from transcript CG6752-RA	0.012
CG7713	CG7713 gene product from transcript CG7713-RA	0.012
egg	eggless	0.012
Hsp68	Heat shock protein 68	0.012
atms	antimeros	0.012
CG2931	CG2931 gene product from transcript CG2931-RA	0.012
CG6418	CG6418 gene product from transcript CG6418-RB	0.012
pie	pineapple eye	0.012
Sce	Sex combs extra	0.012

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Homo sapiens

Name	Description	Probability
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.872
NBN	nibrin	0.715
CREBBP	CREB binding protein	0.597
CBX5	chromobox homolog 5	0.543
EP300	E1A binding protein p300	0.494
TRRAP	transformation/transcription domain-associated protein	0.456
MCM7	minichromosome maintenance complex component 7	0.429
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.335
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.299
RB1	retinoblastoma 1	0.240
RAD50	RAD50 homolog (S. cerevisiae)	0.229
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.227
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.209
SSRP1	structure specific recognition protein 1	0.201
TGIF1	TGFB-induced factor homeobox 1	0.196
HIST1H3B	histone cluster 1, H3b	0.168
LBR	lamin B receptor	0.154
WRN	Werner syndrome, RecQ helicase-like	0.135
ADNP	activity-dependent neuroprotector homeobox	0.119
NRIP1	nuclear receptor interacting protein 1	0.103
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.102
RAD21	RAD21 homolog (S. pombe)	0.102
CBX1	chromobox homolog 1	0.101
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.099
ATXN7	ataxin 7	0.093
PRRC2C	proline-rich coiled-coil 2C	0.085
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.084
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.083
MCM2	minichromosome maintenance complex component 2	0.081
CDK2	cyclin-dependent kinase 2	0.080
RANBP2	RAN binding protein 2	0.078
INCENP	inner centromere protein antigens 135/155kDa	0.077
BCLAF1	BCL2-associated transcription factor 1	0.075
CREB1	cAMP responsive element binding protein 1	0.070
USP22	ubiquitin specific peptidase 22	0.068
CHRAC1	chromatin accessibility complex 1	0.067
SMC1A	structural maintenance of chromosomes 1A	0.065
RBBP4	retinoblastoma binding protein 4	0.063
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.063
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.058
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.055
HIPK2	homeodomain interacting protein kinase 2	0.053
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.052
MCM3	minichromosome maintenance complex component 3	0.050
RBBP8	retinoblastoma binding protein 8	0.050
KAT2B	K(lysine) acetyltransferase 2B	0.049
ORC6	origin recognition complex, subunit 6	0.048
PML	promyelocytic leukemia	0.047
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.047
MBD1	methyl-CpG binding domain protein 1	0.047
DAXX	death-domain associated protein	0.046
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.044
NCOA3	nuclear receptor coactivator 3	0.043
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.040
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.038
MCMBP	minichromosome maintenance complex binding protein	0.038
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.037
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.035
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.033
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.033
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.032
APC	adenomatous polyposis coli	0.032
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.031
MDC1	mediator of DNA-damage checkpoint 1	0.031
EED	embryonic ectoderm development	0.030
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.029
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.029
AR	androgen receptor	0.028
NUP50	nucleoporin 50kDa	0.028
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.027
MCM4	minichromosome maintenance complex component 4	0.027
TADA2A	transcriptional adaptor 2A	0.027
FOXO3	forkhead box O3	0.027
CDK6	cyclin-dependent kinase 6	0.027
HDAC1	histone deacetylase 1	0.026
NCOA1	nuclear receptor coactivator 1	0.026
ADNP2	ADNP homeobox 2	0.025
MORC3	MORC family CW-type zinc finger 3	0.025
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.025
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.025
RSF1	remodeling and spacing factor 1	0.025
MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe)	0.025
H2AFV	H2A histone family, member V	0.025
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.024
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.024
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.024
TADA3	transcriptional adaptor 3	0.023
H3F3B	H3 histone, family 3B (H3.3B)	0.023
CRY1	cryptochrome 1 (photolyase-like)	0.023
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.023
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.022
MSH6	mutS homolog 6 (E. coli)	0.022
POGZ	pogo transposable element with ZNF domain	0.021
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.021
TOP1	topoisomerase (DNA) I	0.021
HMGXB4	HMG box domain containing 4	0.021
ZEB1	zinc finger E-box binding homeobox 1	0.020
NCOA6	nuclear receptor coactivator 6	0.020
ANKRD17	ankyrin repeat domain 17	0.020
H2AFX	H2A histone family, member X	0.020

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Rattus norvegicus

Name	Description	Probability	Func Analog Organism

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Saccharomyces cerevisiae

Name	Description	Probability
HHT1	Hht1p	0.776
RTF1	Rtf1p	0.330
ITC1	Itc1p	0.256
SGF73	Sgf73p	0.184
SPT16	Spt16p	0.140
SAS4	Sas4p	0.125
MIG2	Mig2p	0.125
ISW1	Isw1p	0.107
TRA1	Tra1p	0.106
HHO1	Hho1p	0.102
ADA2	Ada2p	0.099
MIG1	Mig1p	0.094
NRG1	Nrg1p	0.093
DLS1	Dls1p	0.093
BDF1	Bdf1p	0.090
POB3	Pob3p	0.089
HOS4	Hos4p	0.087
LEO1	Leo1p	0.084
RCO1	Rco1p	0.078
HHT2	Hht2p	0.073
BDF2	Bdf2p	0.072
SPT6	Spt6p	0.072
SPT5	Spt5p	0.071
NUP170	Nup170p	0.069
CHD1	Chd1p	0.061
SWI1	Swi1p	0.060
YKR075C	hypothetical protein	0.059
CKA1	Cka1p	0.058
SIN3	Sin3p	0.057
DPB2	Dpb2p	0.057
SAS5	Sas5p	0.055
YCL021W-A	hypothetical protein	0.055
TAF12	Taf12p	0.053
VAC7	Vac7p	0.053
MIG3	Mig3p	0.052
HAL5	Hal5p	0.051
GAT2	Gat2p	0.051
CSR2	Csr2p	0.050
LYS5	Lys5p	0.050
YTA7	Yta7p	0.050
HHF2	Hhf2p	0.049
NTO1	Nto1p	0.046
SPT8	Spt8p	0.046
SET3	Set3p	0.046
HDA3	Hda3p	0.046
HTB2	Htb2p	0.044
NGG1	Ngg1p	0.043
SET2	Set2p	0.043
HAA1	Haa1p	0.040
CTR9	Ctr9p	0.040
MDN1	Mdn1p	0.039
YNG1	Yng1p	0.039
ROX1	Rox1p	0.038
OPI1	Opi1p	0.037
TIF4632	Tif4632p	0.037
MOT1	Mot1p	0.036
RIF1	Rif1p	0.035
SPT20	Spt20p	0.035
SNT1	Snt1p	0.035
HDA2	Hda2p	0.034
IOC4	Ioc4p	0.034
HST1	Hst1p	0.033
TMA22	Tma22p	0.033
SIW14	Siw14p	0.032
UBP14	Ubp14p	0.032
SIR2	Sir2p	0.032
HAL1	Hal1p	0.032
KIC1	Kic1p	0.032
HIR2	Hir2p	0.031
GIP2	Gip2p	0.031
BUD4	Bud4p	0.031
YKL187C	hypothetical protein	0.031
MBR1	Mbr1p	0.031
HXT3	Hxt3p	0.030
CUP9	Cup9p	0.030
PSH1	Psh1p	0.030
HOS3	Hos3p	0.030
RSC30	Rsc30p	0.029
CPR1	Cpr1p	0.029
NUP157	Nup157p	0.029
KEM1	Kem1p	0.028
SWR1	Swr1p	0.028
ZEO1	Zeo1p	0.028
ARP4	Arp4p	0.027
SIR3	Sir3p	0.027
MLC1	Mlc1p	0.027
RLM1	Rlm1p	0.027
POG1	Pog1p	0.026
CYC8	Cyc8p	0.026
ATG29	Atg29p	0.026
RIM8	Rim8p	0.026
IRC23	Irc23p	0.026
YPL014W	hypothetical protein	0.026
YIL151C	hypothetical protein	0.025
GIS4	Gis4p	0.025
CKB1	Ckb1p	0.025
RAP1	Rap1p	0.025
EPL1	Epl1p	0.025
MMR1	Mmr1p	0.024
TAF6	Taf6p	0.024