The network for 'secretory granule organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

secretory granule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.

NameDescriptionProbabilityFunc Analog Organism
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.971
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.760
Mitfmicrophthalmia-associated transcription factor0.725
Gtf2a1general transcription factor II A, 10.591
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.580
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.565
Rab27aRAB27A, member RAS oncogene family0.537
Hps6Hermansky-Pudlak syndrome 60.403
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.400
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.390
Taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.313
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.213
Sh3gl3SH3-domain GRB2-like 30.185
Apoeapolipoprotein E0.183
Slc24a5solute carrier family 24, member 50.179
Amelxamelogenin X chromosome0.177
Fads2fatty acid desaturase 20.152
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.134
Npc1Niemann Pick type C10.133
Myo5amyosin VA0.131
Tyrp1tyrosinase-related protein 10.122
Uba2ubiquitin-like modifier activating enzyme 20.112
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.112
Pou5f1POU domain, class 5, transcription factor 10.111
Atf1activating transcription factor 10.089
Pmelpremelanosome protein0.085
Lbrlamin B receptor0.079
Hnrpllheterogeneous nuclear ribonucleoprotein L-like0.074
DekDEK oncogene (DNA binding)0.067
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.063
Mta2metastasis-associated gene family, member 20.063
Btbd10BTB (POZ) domain containing 100.051
Capza1capping protein (actin filament) muscle Z-line, alpha 10.050
Dtnbdystrobrevin, beta0.047
Smndc1survival motor neuron domain containing 10.047
Agfg1ArfGAP with FG repeats 10.045
Rab38RAB38, member of RAS oncogene family0.044
Gucy1a3guanylate cyclase 1, soluble, alpha 30.043
Oca2oculocutaneous albinism II0.042
Tinagl1tubulointerstitial nephritis antigen-like 10.041
Zfp143zinc finger protein 1430.039
Hps3Hermansky-Pudlak syndrome 3 homolog (human)0.039
Sec23ipSec23 interacting protein0.039
Ptpn2protein tyrosine phosphatase, non-receptor type 20.039
Nfyanuclear transcription factor-Y alpha0.038
Pknox1Pbx/knotted 1 homeobox0.037
Fam49bfamily with sequence similarity 49, member B0.036
Fam20afamily with sequence similarity 20, member A0.036
Lrp5low density lipoprotein receptor-related protein 50.035
Eps15epidermal growth factor receptor pathway substrate 150.035
Itga5integrin alpha 5 (fibronectin receptor alpha)0.034
Zfpm1zinc finger protein, multitype 10.034
Gtf2bgeneral transcription factor IIB0.033
Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.032
Tnks1bp1tankyrase 1 binding protein 10.031
Lsm14aLSM14 homolog A (SCD6, S. cerevisiae)0.031
Gdap2ganglioside-induced differentiation-associated-protein 20.030
Foxp4forkhead box P40.029
Epha2Eph receptor A20.029
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.028
Cyr61cysteine rich protein 610.027
Cldn3claudin 30.027
Ifrd1interferon-related developmental regulator 10.026
Procrprotein C receptor, endothelial0.025
Ptgs2prostaglandin-endoperoxide synthase 20.025
Lrp1low density lipoprotein receptor-related protein 10.025
Api5apoptosis inhibitor 50.024
Nrasneuroblastoma ras oncogene0.024
Clip1CAP-GLY domain containing linker protein 10.024
Nck1non-catalytic region of tyrosine kinase adaptor protein 10.024
MaxMax protein0.023
Tbpl1TATA box binding protein-like 10.023
Tmprss11etransmembrane protease, serine 11e0.023
Sntb2syntrophin, basic 20.023
Zfp131zinc finger protein 1310.023
XiapX-linked inhibitor of apoptosis0.023
Rnf2ring finger protein 20.023
Muc1mucin 1, transmembrane0.023
Crebl2cAMP responsive element binding protein-like 20.022
Taf5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.022
Kitlkit ligand0.022
Lystlysosomal trafficking regulator0.022
Dtnadystrobrevin alpha0.022
Epha1Eph receptor A10.022
Rad17RAD17 homolog (S. pombe)0.021
S1pr1sphingosine-1-phosphate receptor 10.021
Atf3activating transcription factor 30.021
Elf3E74-like factor 30.020
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.020
Hbegfheparin-binding EGF-like growth factor0.019
Samd4bsterile alpha motif domain containing 4B0.019
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.019
Il2rginterleukin 2 receptor, gamma chain0.019
Errfi1ERBB receptor feedback inhibitor 10.019
CebpgCCAAT/enhancer binding protein (C/EBP), gamma0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
AP-1gammaCG9113 gene product from transcript CG9113-RD0.416
Vps16BVacuolar protein sorting 16B0.307
Tango1Transport and Golgi organization 10.228
CG14568CG14568 gene product from transcript CG14568-RA0.142
GM130CG11061 gene product from transcript CG11061-RB0.071
beta'Copbeta'-coatomer protein0.066
betaCopbeta-coatomer protein0.056
sec63CG8583 gene product from transcript CG8583-RA0.052
CG9132CG9132 gene product from transcript CG9132-RA0.039
CG30069CG30069 gene product from transcript CG30069-RA0.033
CG8683CG8683 gene product from transcript CG8683-RB0.031
CsatCG2675 gene product from transcript CG2675-RA0.028
CG5850CG5850 gene product from transcript CG5850-RC0.025
Aats-thrThreonyl-tRNA synthetase0.024
Gfat2Glutamine:fructose-6-phosphate aminotransferase 20.022
pgant3polypeptide GalNAc transferase 30.022
CerkCeramide kinase0.017
CG10777CG10777 gene product from transcript CG10777-RB0.015
CG15099CG15099 gene product from transcript CG15099-RA0.013
rtettetracycline resistance0.013
pgant4polypeptide GalNAc transferase 40.012
CG30463CG30463 gene product from transcript CG30463-RB0.012
Unc-76CG3981 gene product from transcript CG3981-RB0.012
CG10413CG10413 gene product from transcript CG10413-RA0.011
EafELL-associated factor0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
AP2B1adaptor-related protein complex 2, beta 1 subunit0.568
VIPARVPS33B interacting protein, apical-basolateral polarity regulator0.386
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.271
CREBBPCREB binding protein0.119
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.108
RAB14RAB14, member RAS oncogene family0.075
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.068
RABEP1rabaptin, RAB GTPase binding effector protein 10.047
OCRLoculocerebrorenal syndrome of Lowe0.046
MTF1metal-regulatory transcription factor 10.044
STX12syntaxin 120.037
LDOC1leucine zipper, down-regulated in cancer 10.036
GATAD2BGATA zinc finger domain containing 2B0.029
FXR2fragile X mental retardation, autosomal homolog 20.028
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.024
NCOA3nuclear receptor coactivator 30.023
CSNK1G2casein kinase 1, gamma 20.022
CHD3chromodomain helicase DNA binding protein 30.022
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.022
DVL2dishevelled, dsh homolog 2 (Drosophila)0.022
MAP2K4mitogen-activated protein kinase kinase 40.020
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.020
APCadenomatous polyposis coli0.019
CLINT1clathrin interactor 10.019
G3BP2GTPase activating protein (SH3 domain) binding protein 20.019
CCDC6coiled-coil domain containing 60.018
NCOA2nuclear receptor coactivator 20.018
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.018
HSF1heat shock transcription factor 10.018
RAB5ARAB5A, member RAS oncogene family0.016
AP1B1adaptor-related protein complex 1, beta 1 subunit0.016
KAT2BK(lysine) acetyltransferase 2B0.016
RNF111ring finger protein 1110.016
EP300E1A binding protein p3000.016
MTA3metastasis associated 1 family, member 30.016
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.016
MTA2metastasis associated 1 family, member 20.016
WAPALwings apart-like homolog (Drosophila)0.015
UBR4ubiquitin protein ligase E3 component n-recognin 40.015
NCOA1nuclear receptor coactivator 10.015
EPS15epidermal growth factor receptor pathway substrate 150.014
SAMSN1SAM domain, SH3 domain and nuclear localization signals 10.014
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.014
GTF2Bgeneral transcription factor IIB0.014
YTHDF3YTH domain family, member 30.014
KPNA1karyopherin alpha 1 (importin alpha 5)0.013
FCHO2FCH domain only 20.013
EGLN3egl nine homolog 3 (C. elegans)0.012
FOXO1forkhead box O10.012
UBE2G1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.011
PVRL4poliovirus receptor-related 40.011
RAB35RAB35, member RAS oncogene family0.011
SYNRGsynergin, gamma0.011
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.011
GATAD2AGATA zinc finger domain containing 2A0.011
TRIP12thyroid hormone receptor interactor 120.011
NFYAnuclear transcription factor Y, alpha0.011
MBD3methyl-CpG binding domain protein 30.011
KDM1Alysine (K)-specific demethylase 1A0.011
SS18synovial sarcoma translocation, chromosome 180.011
HIPK3homeodomain interacting protein kinase 30.010
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.010
NCOA6nuclear receptor coactivator 60.010
SP1Sp1 transcription factor0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism