The network for 'lung development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgf8fibroblast growth factor 81.000
Foxc1forkhead box C11.000
Gli2GLI-Kruppel family member GLI21.000
Bmp4bone morphogenetic protein 41.000
Ptenphosphatase and tensin homolog1.000
Fgfr1fibroblast growth factor receptor 10.999
Fgfr2fibroblast growth factor receptor 20.999
Pitx2paired-like homeodomain transcription factor 20.997
Gli3GLI-Kruppel family member GLI30.997
Ednraendothelin receptor type A0.997
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.996
Tcf21transcription factor 210.996
Tgfbr2transforming growth factor, beta receptor II0.996
Sox2SRY-box containing gene 20.994
Vangl2vang-like 2 (van gogh, Drosophila)0.994
Col1a1collagen, type I, alpha 10.993
Pax2paired box gene 20.992
Tgfb2transforming growth factor, beta 20.991
Rargretinoic acid receptor, gamma0.988
Meox2mesenchyme homeobox 20.986
Ror2receptor tyrosine kinase-like orphan receptor 20.985
Ece1endothelin converting enzyme 10.985
Prrx1paired related homeobox 10.983
Hand1heart and neural crest derivatives expressed transcript 10.980
Hand2heart and neural crest derivatives expressed transcript 20.980
Gata6GATA binding protein 60.978
Nkx2-1NK2 homeobox 10.977
Foxc2forkhead box C20.972
Gata4GATA binding protein 40.972
Tbx3T-box 30.969
Nos3nitric oxide synthase 3, endothelial cell0.967
Foxa2forkhead box A20.965
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.964
Fgfr3fibroblast growth factor receptor 30.959
Tbx2T-box 20.959
Pbx1pre B-cell leukemia transcription factor 10.957
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.955
Twist2twist homolog 2 (Drosophila)0.954
Tbx1T-box 10.951
Hoxa3homeobox A30.950
Smad4MAD homolog 4 (Drosophila)0.945
Rarbretinoic acid receptor, beta0.942
Flt4FMS-like tyrosine kinase 40.942
Hoxa1homeobox A10.939
Pax8paired box gene 80.938
Prrx2paired related homeobox 20.929
Sox9SRY-box containing gene 90.928
Fgf10fibroblast growth factor 100.928
Gdf1growth differentiation factor 10.921
Pitx1paired-like homeodomain transcription factor 10.918
Pax3paired box gene 30.915
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.913
Smad6MAD homolog 6 (Drosophila)0.912
Jag1jagged 10.907
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.898
Foxh1forkhead box H10.897
Zic3zinc finger protein of the cerebellum 30.894
Foxg1forkhead box G10.894
Bmp7bone morphogenetic protein 70.893
Hspg2perlecan (heparan sulfate proteoglycan 2)0.890
Mesp1mesoderm posterior 10.878
Msx1homeobox, msh-like 10.864
Ptk7PTK7 protein tyrosine kinase 70.864
Mapk8mitogen-activated protein kinase 80.857
Hoxb3homeobox B30.852
Pthlhparathyroid hormone-like peptide0.850
Hoxa2homeobox A20.847
Hoxd9homeobox D90.840
Hoxd13homeobox D130.828
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.824
Vegfavascular endothelial growth factor A0.819
Foxf1aforkhead box F1a0.815
Pou5f1POU domain, class 5, transcription factor 10.812
Hes1hairy and enhancer of split 1 (Drosophila)0.809
Nfibnuclear factor I/B0.806
Hoxc6homeobox C60.798
Hoxb6homeobox B60.791
Hoxb5homeobox B50.789
Dkk1dickkopf homolog 1 (Xenopus laevis)0.788
Ptpn11protein tyrosine phosphatase, non-receptor type 110.775
Ptch1patched homolog 10.766
Tcfap2atranscription factor AP-2, alpha0.765
Sall4sal-like 4 (Drosophila)0.759
Fbn1fibrillin 10.756
Smad3MAD homolog 3 (Drosophila)0.755
Mmp2matrix metallopeptidase 20.754
Hoxa9homeobox A90.754
Eya1eyes absent 1 homolog (Drosophila)0.748
Gscgoosecoid homeobox0.745
Gli1GLI-Kruppel family member GLI10.737
Smosmoothened homolog (Drosophila)0.734
Sox4SRY-box containing gene 40.733
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.728
Emx1empty spiracles homolog 1 (Drosophila)0.724
Zeb1zinc finger E-box binding homeobox 10.723
Epas1endothelial PAS domain protein 10.721
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.998
FGF1fibroblast growth factor 1 (acidic)0.978
FHL2four and a half LIM domains 20.899
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.897
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.814
NRP1neuropilin 10.606
TBX5T-box 50.559
SMAD2SMAD family member 20.517
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.471
BMPR1Abone morphogenetic protein receptor, type IA0.469
SMAD3SMAD family member 30.467
VEGFAvascular endothelial growth factor A0.456
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.413
JAG1jagged 10.325
FGFR1fibroblast growth factor receptor 10.315
BMP2bone morphogenetic protein 20.289
FGF10fibroblast growth factor 100.270
GH1growth hormone 10.257
SRSF4serine/arginine-rich splicing factor 40.222
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.204
FLNAfilamin A, alpha0.187
SREBF2sterol regulatory element binding transcription factor 20.154
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.150
NCOR2nuclear receptor corepressor 20.140
NCOA6nuclear receptor coactivator 60.136
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.131
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.118
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.108
KAT2BK(lysine) acetyltransferase 2B0.108
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.107
ACVR1activin A receptor, type I0.104
PAX8paired box 80.102
GH2growth hormone 20.098
NLRC4NLR family, CARD domain containing 40.093
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.092
PKD2polycystic kidney disease 2 (autosomal dominant)0.087
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.082
ARNTaryl hydrocarbon receptor nuclear translocator0.081
NR4A1nuclear receptor subfamily 4, group A, member 10.080
RPTORregulatory associated protein of MTOR, complex 10.078
ATXN1ataxin 10.077
U2AF1U2 small nuclear RNA auxiliary factor 10.075
STK3serine/threonine kinase 30.075
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.071
FN1fibronectin 10.069
CYR61cysteine-rich, angiogenic inducer, 610.065
JAG2jagged 20.065
PSEN1presenilin 10.062
FADS1fatty acid desaturase 10.061
FGF8fibroblast growth factor 8 (androgen-induced)0.057
FHL3four and a half LIM domains 30.054
ARandrogen receptor0.051
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.050
CSH2chorionic somatomammotropin hormone 20.049
ITGB4integrin, beta 40.048
SIRT1sirtuin 10.048
SHC2SHC (Src homology 2 domain containing) transforming protein 20.046
FGF18fibroblast growth factor 180.044
PDZD11PDZ domain containing 110.042
NKX3-1NK3 homeobox 10.042
CSHL1chorionic somatomammotropin hormone-like 10.041
MAML1mastermind-like 1 (Drosophila)0.040
FLNBfilamin B, beta0.039
EGLN1egl nine homolog 1 (C. elegans)0.039
SPENspen homolog, transcriptional regulator (Drosophila)0.038
FGF4fibroblast growth factor 40.037
NUMA1nuclear mitotic apparatus protein 10.037
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.035
ATXN1Lataxin 1-like0.035
SORBS3sorbin and SH3 domain containing 30.034
COL2A1collagen, type II, alpha 10.034
PUM1pumilio homolog 1 (Drosophila)0.034
GATA4GATA binding protein 40.033
BMP4bone morphogenetic protein 40.033
SEC23ASec23 homolog A (S. cerevisiae)0.032
SRSF6serine/arginine-rich splicing factor 60.032
HSPG2heparan sulfate proteoglycan 20.031
SRPK1SRSF protein kinase 10.031
TGFB3transforming growth factor, beta 30.031
FKBP4FK506 binding protein 4, 59kDa0.030
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.029
SPRY4sprouty homolog 4 (Drosophila)0.028
GPSM2G-protein signaling modulator 20.028
EHMT2euchromatic histone-lysine N-methyltransferase 20.028
SKIv-ski sarcoma viral oncogene homolog (avian)0.027
EBPemopamil binding protein (sterol isomerase)0.027
PLCG1phospholipase C, gamma 10.027
PGRprogesterone receptor0.026
UHRF2ubiquitin-like with PHD and ring finger domains 20.026
CACYBPcalcyclin binding protein0.026
WNT1wingless-type MMTV integration site family, member 10.026
FSTL1follistatin-like 10.025
KLF13Kruppel-like factor 130.025
POU5F1POU class 5 homeobox 10.025
ARL4DADP-ribosylation factor-like 4D0.025
CREBBPCREB binding protein0.025
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sc4molsterol-C4-methyl oxidase-like0.136
Fn1fibronectin 10.092
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.091
Sox17SRY (sex determining region Y)-box 170.069
Aebp1AE binding protein 10.067
Id3inhibitor of DNA binding 30.063
Loxl1lysyl oxidase-like 10.059
Lyz2lysozyme 20.057
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.050
Lamc1laminin, gamma 10.043
Hyal2hyaluronoglucosaminidase 20.043
Ednraendothelin receptor type A0.042
Prrx1paired related homeobox 10.041
Psgb1pregnancy-specific beta 1-glycoprotein0.040
PawrPRKC, apoptosis, WT1, regulator0.040
Prl3c1Prolactin family 3, subfamily c, member 10.040
Leprleptin receptor0.039
Col8a1collagen, type VIII, alpha 10.038
Il11interleukin 110.037
Stx2syntaxin 20.036
Sod3superoxide dismutase 3, extracellular0.036
Cd40lgCD40 ligand0.036
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.036
Pmp22peripheral myelin protein 220.035
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.035
Scpep1serine carboxypeptidase 10.034
Smad7SMAD family member 70.033
A3galt2alpha 1,3-galactosyltransferase 20.032
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.031
Il1r1interleukin 1 receptor, type I0.031
Loxlysyl oxidase0.030
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.030
Fgfr1Fibroblast growth factor receptor 10.030
Rab7aRAB7A, member RAS oncogene family0.029
Pipprolactin induced protein0.029
Hoxb8homeo box B80.029
Sc65synaptonemal complex protein SC650.028
Adam10ADAM metallopeptidase domain 100.028
Wisp1WNT1 inducible signaling pathway protein 10.028
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.028
Cpxm2carboxypeptidase X (M14 family), member 20.028
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.027
Adarb2adenosine deaminase, RNA-specific, B20.027
Mfrpmembrane frizzled-related protein0.027
KitlgKIT ligand0.026
Smcpsperm mitochondria-associated cysteine-rich protein0.026
Pthparathyroid hormone0.026
Cfbcomplement factor B0.026
Gpx3glutathione peroxidase 30.026
Hist1h1dhistone cluster 1, H1d0.026
Foxs1forkhead box S10.026
Fgf10fibroblast growth factor 100.025
Chrnb3cholinergic receptor, nicotinic, beta 30.025
FcgrtFc fragment of IgG, receptor, transporter, alpha0.025
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.025
Cdk2cyclin dependent kinase 20.024
Ccr1chemokine (C-C motif) receptor 10.024
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.024
Fgl2fibrinogen-like 20.024
Megf6multiple EGF-like-domains 60.024
Mark2MAP/microtubule affinity-regulating kinase 20.024
Gpr116G protein-coupled receptor 1160.023
Slc30a1solute carrier family 30 (zinc transporter), member 10.023
Foxo1forkhead box O10.023
Scgb1a1secretoglobin, family 1A, member 1 (uteroglobin)0.023
Tpc1808tropic 18080.023
Prl7a4prolactin family 7, subfamily a, member 40.023
Map3k3mitogen activated protein kinase kinase kinase 30.023
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.023
Foxe3forkhead box E30.022
Mmp3matrix metallopeptidase 30.022
Sfrp4secreted frizzled-related protein 40.022
Akt2v-akt murine thymoma viral oncogene homolog 20.022
Zfxzinc finger protein X-linked0.022
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.022
Nfianuclear factor I/A0.022
Wnt5awingless-type MMTV integration site family, member 5A0.021
Chrna10cholinergic receptor, nicotinic, alpha 100.021
Oprk1opioid receptor, kappa 10.021
Six1SIX homeobox 10.021
Fgfr3fibroblast growth factor receptor 30.021
Frzbfrizzled-related protein0.021
Plac1placenta-specific 10.021
Kcns1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 10.021
Nr2f2nuclear receptor subfamily 2, group F, member 20.021
Clphcasein-like phosphoprotein0.021
Olfml2bolfactomedin-like 2B0.021
Tgfb2transforming growth factor, beta 20.020
Otx1orthodenticle homeobox 10.020
Fgd4FYVE, RhoGEF and PH domain containing 40.020
Slc7a12solute carrier family 7 (cationic amino acid transporter, y+ system), member 120.020
Col11a1collagen, type XI, alpha 10.020
Gp5glycoprotein V (platelet)0.020
Rgs4regulator of G-protein signaling 40.020
F2rl3coagulation factor II (thrombin) receptor-like 30.020
Tcp11t-complex protein 110.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism