The network for 'embryonic limb morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic limb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.

NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Pax3paired box gene 31.000
Pax6paired box gene 61.000
Shhsonic hedgehog1.000
Tbx3T-box 31.000
Smosmoothened homolog (Drosophila)0.999
Msx2homeobox, msh-like 20.999
Pbx1pre B-cell leukemia transcription factor 10.999
Alx4aristaless-like homeobox 40.998
Hoxd11homeobox D110.998
Hoxa10homeobox A100.998
Gli2GLI-Kruppel family member GLI20.998
Bmp7bone morphogenetic protein 70.997
Dlx5distal-less homeobox 50.997
Hoxa11homeobox A110.997
Fgf8fibroblast growth factor 80.996
Pitx2paired-like homeodomain transcription factor 20.995
Tcfap2atranscription factor AP-2, alpha0.995
Msx1homeobox, msh-like 10.994
Pax2paired box gene 20.993
Ptenphosphatase and tensin homolog0.991
Hoxa13homeobox A130.991
Ror2receptor tyrosine kinase-like orphan receptor 20.990
Sox2SRY-box containing gene 20.990
Rargretinoic acid receptor, gamma0.989
Lef1lymphoid enhancer binding factor 10.988
Wnt5awingless-related MMTV integration site 5A0.986
Wnt3awingless-related MMTV integration site 3A0.984
Fgfr1fibroblast growth factor receptor 10.984
Rararetinoic acid receptor, alpha0.983
Foxc1forkhead box C10.976
Gpc3glypican 30.974
Otx2orthodenticle homolog 2 (Drosophila)0.969
Sox9SRY-box containing gene 90.963
Ascl1achaete-scute complex homolog 1 (Drosophila)0.958
Prrx2paired related homeobox 20.954
Runx2runt related transcription factor 20.952
Sall4sal-like 4 (Drosophila)0.947
Prrx1paired related homeobox 10.947
Twist2twist homolog 2 (Drosophila)0.944
Lhx1LIM homeobox protein 10.939
Pax8paired box gene 80.934
Hoxd13homeobox D130.932
Dkk1dickkopf homolog 1 (Xenopus laevis)0.925
Bmp4bone morphogenetic protein 40.919
Pkd1polycystic kidney disease 1 homolog0.919
Hoxa1homeobox A10.912
Tbx15T-box 150.911
Trp63transformation related protein 630.905
Zic3zinc finger protein of the cerebellum 30.896
Gscgoosecoid homeobox0.894
Trp53transformation related protein 530.890
Gdf5growth differentiation factor 50.888
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.881
Mks1Meckel syndrome, type 10.863
Rarbretinoic acid receptor, beta0.861
Tcfap2ctranscription factor AP-2, gamma0.860
Megf8multiple EGF-like-domains 80.859
Hand1heart and neural crest derivatives expressed transcript 10.848
Amhr2anti-Mullerian hormone type 2 receptor0.839
Pitx1paired-like homeodomain transcription factor 10.833
Alx3aristaless-like homeobox 30.831
Fgf9fibroblast growth factor 90.824
Ptf1apancreas specific transcription factor, 1a0.822
Pax9paired box gene 90.821
Insm1insulinoma-associated 10.821
Npr3natriuretic peptide receptor 30.813
Hoxd9homeobox D90.807
Foxc2forkhead box C20.797
Hoxa9homeobox A90.794
Smad6MAD homolog 6 (Drosophila)0.786
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.786
Fgf15fibroblast growth factor 150.784
Thrathyroid hormone receptor alpha0.782
Wt1Wilms tumor 1 homolog0.781
Acvr1activin A receptor, type 10.779
Hoxd10homeobox D100.778
Hand2heart and neural crest derivatives expressed transcript 20.771
Tbx1T-box 10.768
Twist1twist homolog 1 (Drosophila)0.767
Cdx2caudal type homeobox 20.762
Neurog1neurogenin 10.761
Gbx2gastrulation brain homeobox 20.758
Wnt6wingless-related MMTV integration site 60.756
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.753
Hoxc4homeobox C40.750
Bcl2B-cell leukemia/lymphoma 20.744
Grem1gremlin 10.732
Sfrp2secreted frizzled-related protein 20.726
Hoxa2homeobox A20.723
Fuzfuzzy homolog (Drosophila)0.722
Fgf10fibroblast growth factor 100.720
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.719
Notch2Notch gene homolog 2 (Drosophila)0.714
Hoxa5homeobox A50.702
UncxUNC homeobox0.700
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hoxa9bhomeo box A9b0.984
hoxa11bhomeo box A11b0.966
hoxd11ahomeo box D11a0.964
bmp2bbone morphogenetic protein 2b0.963
dlx2adistal-less homeobox gene 2a0.957
hoxd10ahomeo box D10a0.954
hoxa13bhomeo box A13b0.952
wnt5bwingless-type MMTV integration site family, member 5b0.946
bmp2abone morphogenetic protein 2a0.945
hoxd13ahomeo box D13a0.940
msxcmuscle segment homeobox C0.929
fgf24fibroblast growth factor 240.923
sox9aSRY-box containing gene 9a0.922
osr2odd-skipped related 2 (Drosophila)0.912
pitx3paired-like homeodomain transcription factor 30.907
dlx3bdistal-less homeobox gene 3b0.904
fstafollistatin a0.898
hoxc6ahomeo box C6a0.890
dlx5adistal-less homeobox gene 5a0.889
pcdh18bprotocadherin 18b0.882
tbx18T-box 180.882
hoxd9ahomeo box D9a0.868
msxbmuscle segment homeobox B0.867
bmp4bone morphogenetic protein 40.865
hoxa11ahomeo box A11a0.861
shhasonic hedgehog a0.851
hoxd12ahomeo box D12a0.803
prdm1aPR domain containing 1a, with ZNF domain0.791
wnt9awingless-type MMTV integration site family, member 9A0.785
gli1GLI-Kruppel family member 10.782
msxdmuscle segment homeobox D0.759
hoxa10bhomeo box A10b0.755
wnt3awingless-type MMTV integration site family, member 3A0.745
osr1odd-skipped related 1 (Drosophila)0.738
tbx2bT-box 2b0.727
col2a1acollagen type II, alpha-1a0.688
fgf10afibroblast growth factor 10a0.654
tbx5aT-box 5a0.620
hoxa13ahomeo box A13a0.610
runx2brunt-related transcription factor 2b0.608
gbx2gastrulation brain homeo box 20.601
evx1even-skipped homeobox 10.582
barx2BarH-like homeobox 20.573
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.539
wnt9bwingless-type MMTV integration site family, member 9B0.531
pax9paired box gene 90.520
fzd7afrizzled homolog 7a0.516
dlx4bdistal-less homeobox gene 4b0.510
meis3myeloid ecotropic viral integration site 30.509
vcanbversican b0.496
dkk1bdickkopf 1b0.494
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.478
hoxa9ahomeo box A9a0.470
wnt7aawingless-type MMTV integration site family, member 7Aa0.456
fgfr1bfibroblast growth factor receptor 1b0.432
ntn2netrin 20.429
dusp6dual specificity phosphatase 60.412
barx1BarH-like homeobox 10.409
tcf7transcription factor 7 (T-cell specific, HMG-box)0.400
coblcordon-bleu homolog (mouse)0.400
smad9MAD homolog 9 (Drosophila)0.399
pax3apaired box gene 3a0.397
pcdh18aprotocadherin 18a0.393
tp53tumor protein p530.384
hand2heart and neural crest derivatives expressed transcript 20.381
sema3hsemaphorin 3h0.375
hoxa2bhomeo box A2b0.370
myod1myogenic differentiation 10.365
notch1anotch homolog 1a0.353
mibmind bomb0.351
tbx2aT-box gene 2a0.345
smosmoothened homolog (Drosophila)0.341
wnt2bbwingless-type MMTV integration site family, member 2Bb0.338
tbx15T-box 150.326
eya1eyes absent homolog 10.322
mecomMDS1 and EVI1 complex locus0.301
crabp2acellular retinoic acid binding protein 2, a0.300
sp9sp9 transcription factor0.297
lmx1b.2LIM homeobox transcription factor 1, beta 20.296
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.294
pax2bpaired box gene 2b0.294
wnt10awingless-type MMTV integration site family, member 10a0.294
frem3Fras1 related extracellular matrix 30.290
frem2aFras1 related extracellular matrix protein 2a0.285
gli2bGLI-Kruppel family member GLI2b0.284
LOC100002342carboxypeptidase A6-like0.283
eng1aengrailed 1a0.280
rx3retinal homeobox gene 30.279
fras1Fraser syndrome 10.277
epha4aeph receptor A4a0.276
fgf20afibroblast growth factor 20a0.276
lef1lymphocyte enhancer binding factor 10.274
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.929
HDAC2histone deacetylase 20.689
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.504
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.280
BMP2bone morphogenetic protein 20.225
MEIS1Meis homeobox 10.224
PSEN1presenilin 10.185
SIN3ASIN3 homolog A, transcription regulator (yeast)0.166
SETD8SET domain containing (lysine methyltransferase) 80.135
ARRB1arrestin, beta 10.098
YY1YY1 transcription factor0.061
TJP1tight junction protein 1 (zona occludens 1)0.058
RBBP4retinoblastoma binding protein 40.055
BCL2L1BCL2-like 10.055
HOXD13homeobox D130.054
MSX1msh homeobox 10.050
MDM2Mdm2 p53 binding protein homolog (mouse)0.046
AFF1AF4/FMR2 family, member 10.041
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.041
BMP7bone morphogenetic protein 70.040
MSX2msh homeobox 20.039
MEIS2Meis homeobox 20.034
TRIP6thyroid hormone receptor interactor 60.033
LRP6low density lipoprotein receptor-related protein 60.033
MED13Lmediator complex subunit 13-like0.032
CHD8chromodomain helicase DNA binding protein 80.031
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.030
BAK1BCL2-antagonist/killer 10.030
FGF18fibroblast growth factor 180.029
HOXA11homeobox A110.028
BMPR1Bbone morphogenetic protein receptor, type IB0.028
BAXBCL2-associated X protein0.028
SATB2SATB homeobox 20.026
ZFYVE9zinc finger, FYVE domain containing 90.024
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.024
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.024
CREBBPCREB binding protein0.023
ZNF148zinc finger protein 1480.022
COL2A1collagen, type II, alpha 10.022
BARX1BARX homeobox 10.020
CCNT1cyclin T10.020
FOXF2forkhead box F20.020
HOXD9homeobox D90.020
JAG1jagged 10.019
MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.019
FOXC1forkhead box C10.018
DKK1dickkopf homolog 1 (Xenopus laevis)0.018
PSEN2presenilin 2 (Alzheimer disease 4)0.017
HOXA10homeobox A100.017
HOXC11homeobox C110.016
DLX4distal-less homeobox 40.016
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.016
ELL2elongation factor, RNA polymerase II, 20.016
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.016
SFRP1secreted frizzled-related protein 10.016
PMLpromyelocytic leukemia0.016
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.015
GATA4GATA binding protein 40.015
NCOR2nuclear receptor corepressor 20.015
FGF3fibroblast growth factor 30.015
SMAD1SMAD family member 10.015
HOXC6homeobox C60.015
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.015
SKIv-ski sarcoma viral oncogene homolog (avian)0.014
PRRX2paired related homeobox 20.014
PAX3paired box 30.014
BMP4bone morphogenetic protein 40.014
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.014
ATN1atrophin 10.014
APCadenomatous polyposis coli0.013
DLX5distal-less homeobox 50.013
ERBB2IPerbb2 interacting protein0.013
DAXXdeath-domain associated protein0.013
HOXD11homeobox D110.013
WNT1wingless-type MMTV integration site family, member 10.013
NGFRnerve growth factor receptor0.013
CELF1CUGBP, Elav-like family member 10.012
ARandrogen receptor0.012
WISP1WNT1 inducible signaling pathway protein 10.012
FLNBfilamin B, beta0.012
NR2E3nuclear receptor subfamily 2, group E, member 30.012
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.012
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.011
BECN1beclin 1, autophagy related0.011
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.011
HOXC8homeobox C80.011
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.011
FZD1frizzled homolog 1 (Drosophila)0.011
BCL2L11BCL2-like 11 (apoptosis facilitator)0.011
MAML1mastermind-like 1 (Drosophila)0.011
EP300E1A binding protein p3000.011
CABLES1Cdk5 and Abl enzyme substrate 10.011
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.011
HOXC13homeobox C130.011
MMP11matrix metallopeptidase 11 (stromelysin 3)0.011
HOXD10homeobox D100.011
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.011
HUWE1HECT, UBA and WWE domain containing 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.154
Msx1msh homeobox 10.133
Sc65synaptonemal complex protein SC650.066
Jak1Janus kinase 10.058
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.058
Nexnnexilin (F actin binding protein)0.057
Nkd1naked cuticle homolog 1 (Drosophila)0.056
Nedd4neural precursor cell expressed, developmentally down-regulated 40.053
Nraddneurotrophin receptor associated death domain0.052
RGD1309414similar to KIAA0913 protein0.050
Pde4aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)0.049
Galgalanin prepropeptide0.047
Mmp9matrix metallopeptidase 90.047
Igfbp5insulin-like growth factor binding protein 50.045
Glg1golgi apparatus protein 10.044
Shox2short stature homeobox 20.041
Hrasls5HRAS-like suppressor family, member 50.041
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.040
Ccl4chemokine (C-C motif) ligand 40.040
Lef1lymphoid enhancer binding factor 10.040
MrgprfMAS-related GPR, member F0.038
Fgfr1Fibroblast growth factor receptor 10.036
Fgf7fibroblast growth factor 70.035
Ccr1chemokine (C-C motif) receptor 10.034
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.033
Pipprolactin induced protein0.033
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.032
MefvMediterranean fever0.032
Mybpc1myosin binding protein C, slow type0.031
LOC207127similar to preprotein translocase0.031
C1qtnf5C1q and tumor necrosis factor related protein 50.031
Cpxm2carboxypeptidase X (M14 family), member 20.030
Mybphmyosin binding protein H0.030
Cox6b2cytochrome c oxidase subunit VIb polypeptide 20.030
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.029
Timp3TIMP metallopeptidase inhibitor 30.029
Ednrbendothelin receptor type B0.029
Mcpt1mast cell protease 10.028
Olfml2bolfactomedin-like 2B0.028
Tnftumor necrosis factor (TNF superfamily, member 2)0.028
RGD1305627hypothetical LOC3144670.028
Mmp13matrix metallopeptidase 130.027
Slc34a2solute carrier family 34 (sodium phosphate), member 20.027
Bmp4bone morphogenetic protein 40.027
Dpm3dolichyl-phosphate mannosyltransferase polypeptide 30.026
Expiextracellular proteinase inhibitor0.026
Fzd2frizzled homolog 2 (Drosophila)0.026
Tacr1tachykinin receptor 10.026
Capn6calpain 60.026
Klf2Kruppel-like factor 2 (lung)0.026
Mmp2matrix metallopeptidase 20.025
Ccna1cyclin A10.025
Nr4a3nuclear receptor subfamily 4, group A, member 30.025
Scarf2scavenger receptor class F, member 20.025
Chd4chromodomain helicase DNA binding protein 40.025
Bst1bone marrow stromal cell antigen 10.025
Glycam1glycosylation dependent cell adhesion molecule 10.025
Arsbarylsulfatase B0.025
BikBCL2-interacting killer (apoptosis-inducing)0.025
Cdh13cadherin 130.025
Cdk2cyclin dependent kinase 20.024
Mmp7matrix metallopeptidase 70.024
Dock1dedicator of cyto-kinesis 10.024
Twist2twist homolog 2 (Drosophila)0.024
Arl9ADP-ribosylation factor-like 90.023
Icosinducible T-cell co-stimulator0.023
Accn3amiloride-sensitive cation channel 30.023
Lect1leukocyte cell derived chemotaxin 10.023
Il27rainterleukin 27 receptor, alpha0.023
Slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.022
Gprc5aG protein-coupled receptor, family C, group 5, member A0.022
Dact1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)0.022
Chrac1chromatin accessibility complex 10.022
Trem2triggering receptor expressed on myeloid cells 20.022
Pld1phospholipase D10.022
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.022
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.022
Plcd1phospholipase C, delta 10.022
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.022
Zfp423zinc finger protein 4230.021
Ddr2discoidin domain receptor tyrosine kinase 20.021
Als2clALS2 C-terminal like0.021
Il17reinterleukin 17 receptor E0.021
Ppypancreatic polypeptide0.021
Hdac1lhistone deacetylase 1-like0.021
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.021
Odf4outer dense fiber of sperm tails 40.020
Prrx2paired related homeobox 20.020
Acvr1activin A receptor, type I0.020
Lpar4lysophosphatidic acid receptor 40.020
Mcpt2mast cell protease 20.020
LOC305103cell surface glycoprotein gp420.020
Sod3superoxide dismutase 3, extracellular0.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism