The network for 'regulation of histone modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of histone modification

Any process that modulates the frequency, rate or extent of the covalent alteration of a histone.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.981
Arid1aAT rich interactive domain 1A (SWI-like)0.946
Kdm2blysine (K)-specific demethylase 2B0.916
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.901
Runx1runt related transcription factor 10.892
Shhsonic hedgehog0.892
Gata1GATA binding protein 10.811
Ezh2enhancer of zeste homolog 2 (Drosophila)0.746
CrebbpCREB binding protein0.740
Emx1empty spiracles homolog 1 (Drosophila)0.702
Kat2aK(lysine) acetyltransferase 2A0.689
Sin3atranscriptional regulator, SIN3A (yeast)0.650
Dnmt3aDNA methyltransferase 3A0.629
Ep300E1A binding protein p3000.616
JunJun oncogene0.597
SkilSKI-like0.597
Vegfavascular endothelial growth factor A0.559
Jarid2jumonji, AT rich interactive domain 20.537
Ncor1nuclear receptor co-repressor 10.532
Tbx1T-box 10.518
Trim28tripartite motif-containing 280.501
Dlx2distal-less homeobox 20.496
Pax3paired box gene 30.492
Trraptransformation/transcription domain-associated protein0.484
Msx1homeobox, msh-like 10.473
Prrx1paired related homeobox 10.471
Suz12suppressor of zeste 12 homolog (Drosophila)0.457
Dlx5distal-less homeobox 50.451
Ncoa6nuclear receptor coactivator 60.447
Zeb1zinc finger E-box binding homeobox 10.447
Hdac1histone deacetylase 10.411
Trp63transformation related protein 630.393
Ciccapicua homolog (Drosophila)0.391
Lepleptin0.389
FosFBJ osteosarcoma oncogene0.386
Ptf1apancreas specific transcription factor, 1a0.362
Gli2GLI-Kruppel family member GLI20.360
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.355
Gscgoosecoid homeobox0.342
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.341
Trim24tripartite motif-containing 240.339
Brd4bromodomain containing 40.337
Ednraendothelin receptor type A0.336
Gata6GATA binding protein 60.332
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.308
Hand1heart and neural crest derivatives expressed transcript 10.306
Tal1T-cell acute lymphocytic leukemia 10.295
Ighimmunoglobulin heavy chain complex0.284
Ylpm1YLP motif containing 10.279
Foxc2forkhead box C20.278
Thrathyroid hormone receptor alpha0.274
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.256
Rararetinoic acid receptor, alpha0.245
Ptenphosphatase and tensin homolog0.244
Ncoa1nuclear receptor coactivator 10.238
Ascl1achaete-scute complex homolog 1 (Drosophila)0.235
Nos2nitric oxide synthase 2, inducible0.233
Med23mediator complex subunit 230.232
Hoxa1homeobox A10.231
Rnf44ring finger protein 440.217
Huwe1HECT, UBA and WWE domain containing 10.216
Egr1early growth response 10.212
Mdm4transformed mouse 3T3 cell double minute 40.198
Tcf3transcription factor 30.195
Mdm2transformed mouse 3T3 cell double minute 20.194
Smc3structural maintenace of chromosomes 30.194
Srfserum response factor0.193
Gata4GATA binding protein 40.193
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.190
Foxf1aforkhead box F1a0.186
Zfp292zinc finger protein 2920.183
Rbbp4retinoblastoma binding protein 40.182
Neurod1neurogenic differentiation 10.181
Notch1Notch gene homolog 1 (Drosophila)0.177
Hdac2histone deacetylase 20.176
Zfp362zinc finger protein 3620.176
Kiss1KiSS-1 metastasis-suppressor0.174
Otx2orthodenticle homolog 2 (Drosophila)0.169
Pax9paired box gene 90.168
Nr4a1nuclear receptor subfamily 4, group A, member 10.165
Rb1retinoblastoma 10.163
Mapk1mitogen-activated protein kinase 10.161
Pax7paired box gene 70.161
Tcfap2atranscription factor AP-2, alpha0.160
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.160
Fosl2fos-like antigen 20.158
Atg12autophagy-related 12 (yeast)0.156
Rxraretinoid X receptor alpha0.154
Cyr61cysteine rich protein 610.153
Trip12thyroid hormone receptor interactor 120.150
Ptgs2prostaglandin-endoperoxide synthase 20.149
Atxn7l3ataxin 7-like 30.149
MecomMDS1 and EVI1 complex locus0.146
Hoxa11homeobox A110.145
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.143
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.141
BC018507cDNA sequence BC0185070.140
Hoxa2homeobox A20.139
Myf5myogenic factor 50.136
Ruvbl1RuvB-like protein 10.126
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_F19F10.9Protein F19F10.90.023
bra-2Protein BRA-20.015
skih-2Protein SKIH-20.015
B0464.2Protein B0464.20.014
nhr-49Protein NHR-490.013
mdt-1.2Protein MDT-1.20.013
F33H2.3Protein F33H2.30.013
gei-4Protein GEI-40.013
C32D5.11Protein C32D5.110.013
lin-7Protein LIN-70.013
attf-2Protein ATTF-20.013
suf-1Protein SUF-10.012
CELE_C17E4.6Protein C17E4.60.012
mat-3Protein MAT-30.012
hse-5Protein HSE-50.012
F33H2.5Protein F33H2.50.012
hcp-2Protein HCP-20.012
aat-9Protein AAT-90.012
hil-2Protein HIL-20.012
npp-21Protein NPP-210.012
epn-1Protein EPN-10.012
dcr-1Protein DCR-10.012
his-24Protein HIS-240.012
ubxn-1Protein UBXN-10.012
rnp-6Protein RNP-60.012
pde-2Protein PDE-20.012
uaf-1Protein UAF-10.012
mig-38Protein MIG-380.012
elt-6Protein ELT-60.012
F38A5.2Protein F38A5.20.011
C07H6.4Protein C07H6.40.011
sdc-1Protein SDC-10.011
unc-37Protein UNC-370.011
cfim-2Protein CFIM-20.011
T08G11.1Protein T08G11.10.011
T08G11.4Protein T08G11.40.011
top-2Protein TOP-20.011
rev-1Protein REV-10.011
iff-1Protein IFF-10.011
sedl-1Protein SEDL-10.011
nfya-1Protein NFYA-10.011
K10B3.5Protein K10B3.50.011
F52D10.2Protein F52D10.20.011
prp-8Protein PRP-80.011
F28B3.1Protein F28B3.10.011
Y71G12B.8Protein Y71G12B.80.011
spr-5Protein SPR-50.011
btbd-10Protein BTBD-100.011
egl-26Protein EGL-260.011
swsn-7Protein SWSN-70.011
sop-2Protein SOP-20.011
lin-25Protein LIN-250.010
CELE_R09B3.2Protein R09B3.20.010
egl-5Protein EGL-50.010
F31C3.5Protein F31C3.50.010
dpl-1Protein DPL-10.010
egl-38Protein EGL-380.010
mog-4Protein MOG-40.010
egl-18Protein EGL-180.010
CELE_C17E4.2Protein C17E4.20.010
CELE_C46H3.2Protein C46H3.20.010
ZK154.5Protein ZK154.50.010
rec-8Protein REC-80.010
C34D10.2Protein C34D10.20.010
rgr-1Protein RGR-10.010
F09D1.1Protein F09D1.10.010
F54C9.9Protein F54C9.90.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxi1forkhead box I10.059
pax7apaired box gene 7a0.047
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.034
msxcmuscle segment homeobox C0.033
twist1atwist1a0.025
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.024
brd4bromodomain containing 40.022
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.022
kdrlkinase insert domain receptor like0.022
rif1RAP1 interacting factor homolog (yeast)0.020
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.018
setdb1aSET domain, bifurcated 1a0.016
dnmt1DNA (cytosine-5-)-methyltransferase 10.016
hirip3HIRA interacting protein 30.015
dlx2adistal-less homeobox gene 2a0.014
naspnuclear autoantigenic sperm protein (histone-binding)0.013
aurkbaurora kinase B0.013
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.013
plagl2pleiomorphic adenoma gene-like 20.012
mpxmyeloid-specific peroxidase0.012
cse1lchromosome segregation 1-like (S. cerevisiae)0.011
wu:fv91b12wu:fv91b120.011
gro2groucho 20.011
dnmt5DNA (cytosine-5-)-methyltransferase 50.011
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.011
usp1ubiquitin specific protease 10.011
LOC100536021spectrin beta chain, brain 1-like0.010
whsc1Wolf-Hirschhorn syndrome candidate 10.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Sir2CG5216 gene product from transcript CG5216-RA0.365
gsbgooseberry0.203
nocno ocelli0.160
ash1absent, small, or homeotic discs 10.123
fzyfizzy0.121
DrefDNA replication-related element factor0.112
slp1sloppy paired 10.102
HcfHost cell factor0.102
UtxCG5640 gene product from transcript CG5640-RD0.091
snasnail0.087
prdpaired0.083
Mi-2CG8103 gene product from transcript CG8103-RA0.076
cgcombgap0.068
pdm2POU domain protein 20.065
tldtolloid0.060
His1:CG33813CG33813 gene product from transcript CG33813-RA0.058
His1:CG33846CG33846 gene product from transcript CG33846-RA0.058
dikdiskette0.057
His1:CG33864CG33864 gene product from transcript CG33864-RA0.054
His1:CG33804CG33804 gene product from transcript CG33804-RA0.052
SoxNSoxNeuro0.052
His1:CG33831CG33831 gene product from transcript CG33831-RA0.051
UbxUltrabithorax0.050
His1:CG33834CG33834 gene product from transcript CG33834-RA0.050
His1:CG33852CG33852 gene product from transcript CG33852-RA0.050
His1:CG33825CG33825 gene product from transcript CG33825-RA0.050
runrunt0.050
ChroChromator0.049
His1:CG33855CG33855 gene product from transcript CG33855-RA0.048
His1:CG33861CG33861 gene product from transcript CG33861-RA0.048
His1:CG33843CG33843 gene product from transcript CG33843-RA0.048
His1:CG33837CG33837 gene product from transcript CG33837-RA0.048
His1:CG33822CG33822 gene product from transcript CG33822-RA0.047
gcmglial cells missing0.047
His1:CG33807CG33807 gene product from transcript CG33807-RA0.046
His1:CG33840CG33840 gene product from transcript CG33840-RA0.043
His1:CG33816CG33816 gene product from transcript CG33816-RA0.043
Nf-YBNuclear factor Y-box B0.042
His1:CG33801CG33801 gene product from transcript CG33801-RA0.041
His1:CG33828CG33828 gene product from transcript CG33828-RA0.041
edechinoid0.040
Snr1Snf5-related 10.040
Sin3ACG8815 gene product from transcript CG8815-RC0.040
His1:CG33858CG33858 gene product from transcript CG33858-RA0.040
His1:CG33810CG33810 gene product from transcript CG33810-RA0.038
His1:CG33819CG33819 gene product from transcript CG33819-RA0.037
His1:CG33849CG33849 gene product from transcript CG33849-RA0.037
jumujumeau0.037
Gap1GTPase-activating protein 10.035
pzgputzig0.033
kniknirps0.032
arrarrow0.031
Atac1ATAC component 10.030
captcapulet0.030
cyp33cyclophilin-330.030
pr-set7CG3307 gene product from transcript CG3307-RC0.029
hthhomothorax0.026
gsb-ngooseberry-neuro0.026
btlbreathless0.026
dshdishevelled0.026
IM23Immune induced molecule 230.025
Atg8aAutophagy-specific gene 8a0.025
CG9986CG9986 gene product from transcript CG9986-RA0.023
CG3363CG3363 gene product from transcript CG3363-RB0.023
His1:CG31617CG31617 gene product from transcript CG31617-RA0.023
PclPolycomblike0.022
emcextra macrochaetae0.021
htlheartless0.021
MBD-likeCG8208 gene product from transcript CG8208-RA0.021
CG4119CG4119 gene product from transcript CG4119-RA0.021
twstwins0.021
tlltailless0.020
p53CG33336 gene product from transcript CG33336-RB0.020
emsempty spiracles0.020
Chrac-14CG13399 gene product from transcript CG13399-RA0.020
HGTXCG13475 gene product from transcript CG13475-RB0.019
bynbrachyenteron0.018
zzeste0.018
lealeak0.018
nkdnaked cuticle0.018
comtcomatose0.018
exexpanded0.018
MEP-1CG1244 gene product from transcript CG1244-RG0.018
CG14005CG14005 gene product from transcript CG14005-RA0.018
cicubitus interruptus0.018
mblmuscleblind0.018
calypsoCG8445 gene product from transcript CG8445-RB0.017
CG1523CG1523 gene product from transcript CG1523-RA0.017
mod(mdg4)modifier of mdg40.017
Chd1Chromodomain-helicase-DNA-binding protein 10.017
l(3)mbtlethal (3) malignant brain tumor0.016
oddodd skipped0.016
waplwings apart-like0.016
His3:CG31613CG31613 gene product from transcript CG31613-RA0.016
rprreaper0.016
Ext2CG8433 gene product from transcript CG8433-RA0.016
Bre1CG10542 gene product from transcript CG10542-RA0.015
dupdouble parked0.015
tintinman0.015
pucpuckered0.015
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
WDR5WD repeat domain 50.909
SIN3ASIN3 homolog A, transcription regulator (yeast)0.824
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.696
BRCA1breast cancer 1, early onset0.665
RB1retinoblastoma 10.561
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.542
TAL1T-cell acute lymphocytic leukemia 10.535
MAPK14mitogen-activated protein kinase 140.493
GSK3Bglycogen synthase kinase 3 beta0.475
HIST1H3Bhistone cluster 1, H3b0.467
HIPK2homeodomain interacting protein kinase 20.425
TP53tumor protein p530.392
CREBBPCREB binding protein0.381
RBBP5retinoblastoma binding protein 50.370
SUZ12suppressor of zeste 12 homolog (Drosophila)0.369
PARP1poly (ADP-ribose) polymerase 10.329
HTThuntingtin0.320
DNMT1DNA (cytosine-5-)-methyltransferase 10.318
HDAC1histone deacetylase 10.313
UHRF1ubiquitin-like with PHD and ring finger domains 10.297
SMAD4SMAD family member 40.293
MAP2K4mitogen-activated protein kinase kinase 40.283
ATF2activating transcription factor 20.277
JUNjun proto-oncogene0.252
ARRB1arrestin, beta 10.251
EP300E1A binding protein p3000.247
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.213
HCFC1host cell factor C1 (VP16-accessory protein)0.204
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.192
DUSP1dual specificity phosphatase 10.184
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.174
PMLpromyelocytic leukemia0.170
MED15mediator complex subunit 150.164
SMAD3SMAD family member 30.158
CSNK2A1casein kinase 2, alpha 1 polypeptide0.157
ZNF496zinc finger protein 4960.149
BCL9B-cell CLL/lymphoma 90.143
NCOR2nuclear receptor corepressor 20.140
KAT2AK(lysine) acetyltransferase 2A0.137
CBX5chromobox homolog 50.135
NCOR1nuclear receptor corepressor 10.131
TRRAPtransformation/transcription domain-associated protein0.129
TGIF1TGFB-induced factor homeobox 10.126
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.123
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.115
MAPK3mitogen-activated protein kinase 30.109
MDM4Mdm4 p53 binding protein homolog (mouse)0.105
VEGFAvascular endothelial growth factor A0.104
ARRB2arrestin, beta 20.104
ADNPactivity-dependent neuroprotector homeobox0.103
MAPK8mitogen-activated protein kinase 80.101
RBBP4retinoblastoma binding protein 40.100
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.100
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.099
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.096
PIAS4protein inhibitor of activated STAT, 40.094
SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)0.084
MAGEA2melanoma antigen family A, 20.083
NCOA6nuclear receptor coactivator 60.083
SETD7SET domain containing (lysine methyltransferase) 70.081
VAC14Vac14 homolog (S. cerevisiae)0.077
IRF2BP1interferon regulatory factor 2 binding protein 10.071
WRNWerner syndrome, RecQ helicase-like0.069
NRIP1nuclear receptor interacting protein 10.067
KDM2Blysine (K)-specific demethylase 2B0.058
RFWD2ring finger and WD repeat domain 20.058
E2F3E2F transcription factor 30.057
LIN9lin-9 homolog (C. elegans)0.057
LIN54lin-54 homolog (C. elegans)0.056
TSC22D1TSC22 domain family, member 10.056
MAPTmicrotubule-associated protein tau0.056
MBIPMAP3K12 binding inhibitory protein 10.056
PUM2pumilio homolog 2 (Drosophila)0.055
MDM2Mdm2 p53 binding protein homolog (mouse)0.053
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.053
NIPBLNipped-B homolog (Drosophila)0.053
RUNX1runt-related transcription factor 10.051
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.050
LRIF1ligand dependent nuclear receptor interacting factor 10.050
PAIP2poly(A) binding protein interacting protein 20.050
GATA2GATA binding protein 20.049
NRP1neuropilin 10.049
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.049
MAPK10mitogen-activated protein kinase 100.048
CUL7cullin 70.048
UBR5ubiquitin protein ligase E3 component n-recognin 50.048
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.048
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.047
TONSLtonsoku-like, DNA repair protein0.046
TRIM28tripartite motif containing 280.046
DUSP7dual specificity phosphatase 70.045
COASYCoA synthase0.044
MBD1methyl-CpG binding domain protein 10.042
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.041
PRPF40APRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)0.041
SIRT1sirtuin 10.040
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.040
ATF3activating transcription factor 30.039
SETD8SET domain containing (lysine methyltransferase) 80.039
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.039
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Smc1astructural maintenance of chromosomes 1A0.011
Ehmt1euchromatic histone-lysine N-methyltransferase 10.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CTR9Ctr9p0.970
RTF1Rtf1p0.927
SPT16Spt16p0.762
SET2Set2p0.352
LEO1Leo1p0.249
CKA1Cka1p0.232
CHD1Chd1p0.208
SPT6Spt6p0.181
PAF1Paf1p0.171
NGG1Ngg1p0.157
ASF1Asf1p0.153
SPT5Spt5p0.134
CLB1Clb1p0.130
LOC1Loc1p0.129
CLB3Clb3p0.112
ESF1Esf1p0.089
DST1Dst1p0.088
CKS1Cks1p0.083
TAF4Taf4p0.082
SPT8Spt8p0.079
WWM1Wwm1p0.074
KSS1Kss1p0.073
FPR3Fpr3p0.065
CDC28Cdc28p0.064
POB3Pob3p0.064
STE5Ste5p0.062
HIR1Hir1p0.060
SGV1Sgv1p0.059
MDM20Mdm20p0.057
BDF1Bdf1p0.057
HHT1Hht1p0.056
SAP190Sap190p0.054
FUS3Fus3p0.051
SEN1Sen1p0.050
CLB4Clb4p0.048
UBR1Ubr1p0.045
TAF6Taf6p0.042
CLN1Cln1p0.040
HDA2Hda2p0.039
MSG5Msg5p0.037
NUP157Nup157p0.037
SUB1Sub1p0.034
HHO1Hho1p0.032
UME1Ume1p0.031
SWC3Swc3p0.031
CAB3Cab3p0.031
CAK1Cak1p0.030
NOP2Nop2p0.030
SPT2Spt2p0.030
SRD1Srd1p0.029
CRP1Crp1p0.029
YLR264C-Ahypothetical protein0.028
CLB6Clb6p0.027
CLB5Clb5p0.027
KIN3Kin3p0.027
CDC6Cdc6p0.025
LEU2Leu2p0.025
SPT7Spt7p0.025
TAF13Taf13p0.024
YLR162Whypothetical protein0.024
HOT1Hot1p0.023
TEC1Tec1p0.023
GCN5Gcn5p0.023
TRA1Tra1p0.023
CDC20Cdc20p0.022
TAF11Taf11p0.021
YOL038C-Ahypothetical protein0.021
SWI4Swi4p0.021
ADA2Ada2p0.021
VIK1Vik1p0.021
RTT109Rtt109p0.021
TMA22Tma22p0.020
SPT20Spt20p0.020
CKB1Ckb1p0.020
YIL151Chypothetical protein0.020
UBP8Ubp8p0.020
CLU1Clu1p0.020
MER1Mer1p0.020
OPT2Opt2p0.020
HXT3Hxt3p0.020
SWR1Swr1p0.020
GBP2Gbp2p0.019
ARP10Arp10p0.019
TYE7Tye7p0.019
TAF5Taf5p0.019
UBP3Ubp3p0.018
TAF8Taf8p0.018
ADH2Adh2p0.018
HFI1Hfi1p0.018
BUL1Bul1p0.018
URA3Ura3p0.018
YPL014Whypothetical protein0.017
SPL2Spl2p0.017
URA1Ura1p0.017
YPL066Whypothetical protein0.017
HOHop0.017
STE2Ste2p0.017
GZF3Gzf3p0.017
IOC2Ioc2p0.017
YLR042Chypothetical protein0.017