The network for 'dibenzo p dioxin metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dibenzo p dioxin metabolic process

The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.

NameDescriptionProbabilityFunc Analog Organism
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.682
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.591
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.501
Ces3acarboxylesterase 3A0.421
Hoxa10homeobox A100.337
C9complement component 90.301
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.294
Akr1c21aldo-keto reductase family 1, member C210.275
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.272
Lhcgrluteinizing hormone/choriogonadotropin receptor0.203
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.186
Cps1carbamoyl-phosphate synthetase 10.169
Dmgdhdimethylglycine dehydrogenase precursor0.167
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.146
Nr1i3nuclear receptor subfamily 1, group I, member 30.143
Mbl2mannose-binding lectin (protein C) 20.143
Cdhr5cadherin-related family member 50.139
G6pcglucose-6-phosphatase, catalytic0.134
Hrghistidine-rich glycoprotein0.130
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.130
Slc12a1solute carrier family 12, member 10.124
Hgdhomogentisate 1, 2-dioxygenase0.118
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.111
Elovl3elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 30.102
Apoc4apolipoprotein C-IV0.094
Upp2uridine phosphorylase 20.093
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.093
Mc2rmelanocortin 2 receptor0.091
Adra2badrenergic receptor, alpha 2b0.084
Hao2hydroxyacid oxidase 20.084
Aadataminoadipate aminotransferase0.075
Otcornithine transcarbamylase0.073
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.071
Bhmtbetaine-homocysteine methyltransferase0.071
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.069
Mep1ameprin 1 alpha0.068
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.067
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.066
F13bcoagulation factor XIII, beta subunit0.065
Arandrogen receptor0.064
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.064
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.063
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.062
Akr1c6aldo-keto reductase family 1, member C60.060
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.059
Klk1b4kallikrein 1-related pepidase b40.058
Mug2murinoglobulin 20.057
Nr5a1nuclear receptor subfamily 5, group A, member 10.056
Hoxd8homeobox D80.055
Apohapolipoprotein H0.055
Klkb1kallikrein B, plasma 10.053
Masp1mannan-binding lectin serine peptidase 10.050
Inhbcinhibin beta-C0.048
Ces1gcarboxylesterase 1G0.048
Rdh7retinol dehydrogenase 70.047
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.047
Cdkn1bcyclin-dependent kinase inhibitor 1B0.045
Aqp8aquaporin 80.045
Tnp1transition protein 10.045
Crhcorticotropin releasing hormone0.044
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.044
Aadacarylacetamide deacetylase (esterase)0.043
Timd2T-cell immunoglobulin and mucin domain containing 20.043
Starsteroidogenic acute regulatory protein0.043
Tdo2tryptophan 2,3-dioxygenase0.042
Fshrfollicle stimulating hormone receptor0.041
Loxlysyl oxidase0.041
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.040
Agxtalanine-glyoxylate aminotransferase0.040
Nr0b2nuclear receptor subfamily 0, group B, member 20.039
Rdh16retinol dehydrogenase 160.038
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.038
Svs5seminal vesicle secretory protein 50.038
Acsm2acyl-CoA synthetase medium-chain family member 20.038
Dctdopachrome tautomerase0.038
Sardhsarcosine dehydrogenase0.037
Mup4major urinary protein 40.036
Fabp1fatty acid binding protein 1, liver0.036
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.034
Apobapolipoprotein B0.034
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.033
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.033
Slc26a1solute carrier family 26 (sulfate transporter), member 10.032
Azgp1alpha-2-glycoprotein 1, zinc0.031
Sult1b1sulfotransferase family 1B, member 10.031
Spam1sperm adhesion molecule 10.031
Dhhdesert hedgehog0.030
Prlrprolactin receptor0.030
Fbp1fructose bisphosphatase 10.030
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.030
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.030
Foxc1forkhead box C10.030
Slc22a1solute carrier family 22 (organic cation transporter), member 10.030
Hnf4ahepatic nuclear factor 4, alpha0.029
Lipclipase, hepatic0.029
Mas1MAS1 oncogene0.028
Car5acarbonic anhydrase 5a, mitochondrial0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il1binterleukin 1 beta0.186
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.141
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.087
Hrh2histamine receptor H 20.077
Mmp12matrix metallopeptidase 120.073
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.061
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.058
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.058
Ccl2chemokine (C-C motif) ligand 20.058
Fabp6fatty acid binding protein 6, ileal0.052
Eef2eukaryotic translation elongation factor 20.041
Clca4chloride channel accessory 40.038
Cxcl2chemokine (C-X-C motif) ligand 20.037
Gna12guanine nucleotide binding protein (G protein) alpha 120.032
Ptgs2prostaglandin-endoperoxide synthase 20.029
Il6interleukin 60.028
LOC293989cytochrome P450-like0.028
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.026
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.026
Ccr2chemokine (C-C motif) receptor 20.025
Hpd4-hydroxyphenylpyruvate dioxygenase0.025
Fcer1aFc fragment of IgE, high affinity I, receptor for; alpha polypeptide0.025
Slc9a2solute carrier family 9 (sodium/hydrogen exchanger), member 20.022
Nr5a2nuclear receptor subfamily 5, group A, member 20.022
Rgs1regulator of G-protein signaling 10.022
Rassf5Ras association (RalGDS/AF-6) domain family member 50.020
Vipvasoactive intestinal peptide0.019
Starsteroidogenic acute regulatory protein0.019
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.019
Cd83CD83 molecule0.018
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.018
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.018
Hcrtr2hypocretin (orexin) receptor 20.017
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.017
Reg3bregenerating islet-derived 3 beta0.017
Nkg7natural killer cell group 7 sequence0.016
Stat4signal transducer and activator of transcription 40.016
Csrp3cysteine and glycine-rich protein 30.016
Gna15guanine nucleotide binding protein, alpha 150.016
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.016
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.016
Dpep1dipeptidase 1 (renal)0.015
Dpp4dipeptidylpeptidase 40.015
Akr1c18aldo-keto reductase family 1, member C180.015
Gabregamma-aminobutyric acid (GABA) A receptor, epsilon0.015
Cxcl10chemokine (C-X-C motif) ligand 100.015
Clec2dC-type lectin domain family 2, member d0.014
Tacr2tachykinin receptor 20.014
Klk8kallikrein related-peptidase 80.014
F2rl2coagulation factor II (thrombin) receptor-like 20.014
Fbp1fructose-1,6-bisphosphatase 10.014
Dnahc6dynein, axonemal, heavy chain 60.013
Il1ainterleukin 1 alpha0.013
Ppardperoxisome proliferator-activated receptor delta0.013
Gmeb2glucocorticoid modulatory element binding protein 20.013
Fcn1ficolin (collagen/fibrinogen domain containing) 10.013
BokBCL2-related ovarian killer0.013
Dnase1l3deoxyribonuclease 1-like 30.012
Il2rbinterleukin 2 receptor, beta0.012
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.012
Nr0b2nuclear receptor subfamily 0, group B, member 20.012
Usf2upstream transcription factor 2, c-fos interacting0.012
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.012
Rims1regulating synaptic membrane exocytosis 10.012
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.012
Gzmkgranzyme K0.012
Ccl4chemokine (C-C motif) ligand 40.011
ND4NADH dehydrogenase subunit 40.011
Gzmcgranzyme C0.011
Drd1adopamine receptor D1A0.011
Fabp1fatty acid binding protein 1, liver0.011
Syngr2synaptogyrin 20.011
Slc9a3solute carrier family 9 (sodium/hydrogen exchanger), member 30.011
Seleselectin E0.011
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.011
Gstm2glutathione S-transferase mu 20.011
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.011
Guca2aguanylate cyclase activator 2a (guanylin)0.010
Xcl1chemokine (C motif) ligand 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism