The network for 'response to type i interferon' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to type i interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

NameDescriptionProbabilityFunc Analog Organism
Irf9interferon regulatory factor 90.997
Stat2signal transducer and activator of transcription 20.969
Stat1signal transducer and activator of transcription 10.925
Usp18ubiquitin specific peptidase 180.806
Ifi35interferon-induced protein 350.756
Stat3signal transducer and activator of transcription 30.727
Irf1interferon regulatory factor 10.697
Stat5bsignal transducer and activator of transcription 5B0.668
Uba7ubiquitin-like modifier activating enzyme 70.603
Myd88myeloid differentiation primary response gene 880.513
Trim21tripartite motif-containing 210.476
Irf7interferon regulatory factor 70.423
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.397
Il1r1interleukin 1 receptor, type I0.385
Isg15ISG15 ubiquitin-like modifier0.345
Rsad2radical S-adenosyl methionine domain containing 20.342
Stat5asignal transducer and activator of transcription 5A0.340
Irgm2immunity-related GTPase family M member 20.331
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.329
Irgm1immunity-related GTPase family M member 10.321
Igtpinterferon gamma induced GTPase0.320
Parp14poly (ADP-ribose) polymerase family, member 140.319
Ifit3interferon-induced protein with tetratricopeptide repeats 30.298
H2-K1histocompatibility 2, K1, K region0.244
Ifit1interferon-induced protein with tetratricopeptide repeats 10.211
Oasl22'-5' oligoadenylate synthetase-like 20.211
Bcl3B-cell leukemia/lymphoma 30.186
Unc93b1unc-93 homolog B1 (C. elegans)0.179
Mx1myxovirus (influenza virus) resistance 10.168
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.168
Ppargperoxisome proliferator activated receptor gamma0.150
H2-D1histocompatibility 2, D region locus 10.135
Trim30atripartite motif-containing 30A0.131
TapbpTAP binding protein0.124
Tgtp2T-cell specific GTPase 20.118
Tor3atorsin family 3, member A0.111
Parp10poly (ADP-ribose) polymerase family, member 100.101
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.089
Ifi47interferon gamma inducible protein 470.081
Rtp4receptor transporter protein 40.078
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.077
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.077
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.074
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.072
Map3k8mitogen-activated protein kinase kinase kinase 80.063
Gbp7guanylate binding protein 70.062
Stat6signal transducer and activator of transcription 60.061
Traf3TNF receptor-associated factor 30.060
Ncoa3nuclear receptor coactivator 30.059
Znfx1zinc finger, NFX1-type containing 10.058
Ifnar2interferon (alpha and beta) receptor 20.058
NmiN-myc (and STAT) interactor0.057
Mx2myxovirus (influenza virus) resistance 20.055
Il4rainterleukin 4 receptor, alpha0.055
Oas1a2'-5' oligoadenylate synthetase 1A0.052
Ifnar1interferon (alpha and beta) receptor 10.052
Ifi44interferon-induced protein 440.051
Socs3suppressor of cytokine signaling 30.050
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.050
BC006779cDNA sequence BC0067790.050
Leprleptin receptor0.043
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.042
Lgals9lectin, galactose binding, soluble 90.041
Sfpi1SFFV proviral integration 10.041
Csf1colony stimulating factor 1 (macrophage)0.040
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.039
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.038
Icam1intercellular adhesion molecule 10.038
FasFas (TNF receptor superfamily member 6)0.037
Irf8interferon regulatory factor 80.037
Ube2l6ubiquitin-conjugating enzyme E2L 60.036
Gbp3guanylate binding protein 30.035
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.035
Trim30dtripartite motif-containing 30D0.035
Pmlpromyelocytic leukemia0.035
1810019J16RikRIKEN cDNA 1810019J16 gene0.033
Lyz2lysozyme 20.033
JunbJun-B oncogene0.032
Irf4interferon regulatory factor 40.032
Ticam1toll-like receptor adaptor molecule 10.032
Gbp2guanylate binding protein 20.030
Ifitm2interferon induced transmembrane protein 20.030
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.029
Pyhin1pyrin and HIN domain family, member 10.029
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.028
Cxcl10chemokine (C-X-C motif) ligand 100.028
Parp12poly (ADP-ribose) polymerase family, member 120.028
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.027
Zbp1Z-DNA binding protein 10.026
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.026
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.025
Adaradenosine deaminase, RNA-specific0.025
Tmem176atransmembrane protein 176A0.024
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.024
Tnfaip3tumor necrosis factor, alpha-induced protein 30.023
Oasl12'-5' oligoadenylate synthetase-like 10.023
Batfbasic leucine zipper transcription factor, ATF-like0.023
Slfn2schlafen 20.021
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.021
Prlrprolactin receptor0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ndr2nodal-related 20.011
LOC100331568breast cancer anti-estrogen resistance protein 3 homolog0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IFIT1interferon-induced protein with tetratricopeptide repeats 10.786
IFITM3interferon induced transmembrane protein 3 (1-8U)0.464
IRF9interferon regulatory factor 90.460
IFITM1interferon induced transmembrane protein 1 (9-27)0.434
IFITM2interferon induced transmembrane protein 2 (1-8D)0.344
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.158
ISG15ISG15 ubiquitin-like modifier0.136
IFIT2interferon-induced protein with tetratricopeptide repeats 20.109
GHRgrowth hormone receptor0.108
UBE2L6ubiquitin-conjugating enzyme E2L 60.097
HLA-Amajor histocompatibility complex, class I, A0.091
IFIT3interferon-induced protein with tetratricopeptide repeats 30.086
HSPA8heat shock 70kDa protein 80.080
JAK1Janus kinase 10.076
HLA-Cmajor histocompatibility complex, class I, C0.073
HLA-Emajor histocompatibility complex, class I, E0.070
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.052
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.048
SP110SP110 nuclear body protein0.046
IFIT5interferon-induced protein with tetratricopeptide repeats 50.039
TBK1TANK-binding kinase 10.033
PARP12poly (ADP-ribose) polymerase family, member 120.031
USP18ubiquitin specific peptidase 180.030
BST2bone marrow stromal cell antigen 20.025
IFI44Linterferon-induced protein 44-like0.024
IFI6interferon, alpha-inducible protein 60.022
CASP10caspase 10, apoptosis-related cysteine peptidase0.022
RIPK2receptor-interacting serine-threonine kinase 20.022
FZD1frizzled homolog 1 (Drosophila)0.022
CASP8caspase 8, apoptosis-related cysteine peptidase0.021
IFI44interferon-induced protein 440.021
PTPRBprotein tyrosine phosphatase, receptor type, B0.020
PTPN1protein tyrosine phosphatase, non-receptor type 10.020
IFI35interferon-induced protein 350.020
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.019
HLA-Fmajor histocompatibility complex, class I, F0.019
ZNFX1zinc finger, NFX1-type containing 10.017
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.017
HERC5hect domain and RLD 50.016
CYLDcylindromatosis (turban tumor syndrome)0.016
HLA-Bmajor histocompatibility complex, class I, B0.015
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.015
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.014
TMEM173transmembrane protein 1730.014
IFIH1interferon induced with helicase C domain 10.014
C19orf66chromosome 19 open reading frame 660.013
IRF3interferon regulatory factor 30.012
HLA-Gmajor histocompatibility complex, class I, G0.011
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.011
ADARadenosine deaminase, RNA-specific0.011
LY6Elymphocyte antigen 6 complex, locus E0.011
MX2myxovirus (influenza virus) resistance 2 (mouse)0.011
UBA7ubiquitin-like modifier activating enzyme 70.010
TRIM21tripartite motif containing 210.010
FASFas (TNF receptor superfamily, member 6)0.010
RARRES3retinoic acid receptor responder (tazarotene induced) 30.010
LRP6low density lipoprotein receptor-related protein 60.010
ITGA1integrin, alpha 10.010
MYD88myeloid differentiation primary response gene (88)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism