The network for 'mitotic g2 dna damage checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic g2 dna damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.

NameDescriptionProbabilityFunc Analog Organism
Brca1breast cancer 10.964
Trp53transformation related protein 530.878
Brca2breast cancer 20.764
Gps1G protein pathway suppressor 10.564
Cdk4cyclin-dependent kinase 40.438
Atmataxia telangiectasia mutated homolog (human)0.346
Cdkn1bcyclin-dependent kinase inhibitor 1B0.304
E2f1E2F transcription factor 10.276
Rb1retinoblastoma 10.229
Hellshelicase, lymphoid specific0.154
Mdm2transformed mouse 3T3 cell double minute 20.144
Cops6COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)0.140
Ezh2enhancer of zeste homolog 2 (Drosophila)0.137
Stag1stromal antigen 10.119
Smad4MAD homolog 4 (Drosophila)0.119
Rbl1retinoblastoma-like 1 (p107)0.112
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.109
Eif2c2eukaryotic translation initiation factor 2C, 20.085
Cdca7cell division cycle associated 70.080
Notch1Notch gene homolog 1 (Drosophila)0.076
Ptenphosphatase and tensin homolog0.063
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.061
Egr2early growth response 20.058
Ncoa3nuclear receptor coactivator 30.055
Cops2COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)0.053
Smc2structural maintenance of chromosomes 20.053
Pola1polymerase (DNA directed), alpha 10.049
Msh2mutS homolog 2 (E. coli)0.048
Sufusuppressor of fused homolog (Drosophila)0.042
Suz12suppressor of zeste 12 homolog (Drosophila)0.040
Apcadenomatosis polyposis coli0.040
Naspnuclear autoantigenic sperm protein (histone-binding)0.038
Cdk2cyclin-dependent kinase 20.038
Mdm4transformed mouse 3T3 cell double minute 40.036
Dtldenticleless homolog (Drosophila)0.036
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.035
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.032
Ccna2cyclin A20.031
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.030
Setdb1SET domain, bifurcated 10.030
Haus6HAUS augmin-like complex, subunit 60.030
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.030
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.029
Parp1poly (ADP-ribose) polymerase family, member 10.028
Men1multiple endocrine neoplasia 10.027
Akap9A kinase (PRKA) anchor protein (yotiao) 90.027
Ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.025
Topbp1topoisomerase (DNA) II binding protein 10.025
Rpa2replication protein A20.024
Ruvbl2RuvB-like protein 20.023
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.023
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.022
Mms22lMMS22-like, DNA repair protein0.022
Cdc7cell division cycle 7 (S. cerevisiae)0.022
Pkm2pyruvate kinase, muscle0.021
Tial1Tia1 cytotoxic granule-associated RNA binding protein-like 10.021
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.021
Pcnaproliferating cell nuclear antigen0.021
Plk4polo-like kinase 4 (Drosophila)0.021
Cdt1chromatin licensing and DNA replication factor 10.021
Casp8ap2caspase 8 associated protein 20.021
Ccnd1cyclin D10.020
Pdpk13-phosphoinositide dependent protein kinase 10.020
Cops3COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)0.020
Ccne1cyclin E10.020
H2afxH2A histone family, member X0.020
E2f8E2F transcription factor 80.020
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.019
Zmym2zinc finger, MYM-type 20.018
Foxo3forkhead box O30.018
Rbbp5retinoblastoma binding protein 50.018
Ube3aubiquitin protein ligase E3A0.017
Trim28tripartite motif-containing 280.017
Scaf11SR-related CTD-associated factor 110.017
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.017
Lsm2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.017
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.016
Kif23kinesin family member 230.016
Rfc2replication factor C (activator 1) 20.016
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.016
Gspt1G1 to S phase transition 10.016
Chd2chromodomain helicase DNA binding protein 20.015
Orc1origin recognition complex, subunit 10.015
Ptch1patched homolog 10.015
Tomm70atranslocase of outer mitochondrial membrane 70 homolog A (yeast)0.014
Atrataxia telangiectasia and Rad3 related0.014
Zmym5zinc finger, MYM-type 50.014
Ankhd1ankyrin repeat and KH domain containing 10.014
Prc1protein regulator of cytokinesis 10.014
Timelesstimeless homolog (Drosophila)0.014
Wdhd1WD repeat and HMG-box DNA binding protein 10.014
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.013
Rcc2regulator of chromosome condensation 20.013
TtkTtk protein kinase0.013
Plk1polo-like kinase 1 (Drosophila)0.012
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.012
Rps28ribosomal protein S280.012
Kat2aK(lysine) acetyltransferase 2A0.012
Pou5f1POU domain, class 5, transcription factor 10.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
zff9zinc finger protein 90.606
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.580
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.468
stilTAL1 (SCL) interrupting locus0.413
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.396
ube2i2ubiquitin-conjugating enzyme E2I20.354
tfamtranscription factor A, mitochondrial0.352
snrpd1small nuclear ribonucleoprotein D1 polypeptide0.302
hdac1histone deacetylase 10.294
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.290
cand1cullin-associated and neddylation-dissociated 10.254
cops3COP9 constitutive photomorphogenic homolog subunit 30.247
cul3acullin 3a0.239
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.229
scube2signal peptide, CUB domain, EGF-like 20.194
fanciFanconi anemia, complementation group I0.182
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.176
naa15bN(alpha)-acetyltransferase 15, NatA auxiliary subunit b0.176
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.165
caprin1acell cycle associated protein 1a0.163
arhgap11aRho GTPase activating protein 11A0.160
ctcfCCCTC-binding factor (zinc finger protein)0.158
smc1alstructural maintenance of chromosomes 1A, like0.146
psmb2proteasome (prosome, macropain) subunit, beta type, 20.113
fmnl2bformin-like 2b0.111
eif2deukaryotic translation initiation factor 2D0.111
unguracil-DNA glycosylase0.110
chaf1bchromatin assembly factor 1, subunit B0.108
faf1Fas associated factor 10.105
LOC557062hypothetical protein LOC5570620.100
snrpcsmall nuclear ribonucleoprotein polypeptide C0.100
brd2abromodomain-containing 2a0.095
trip13thyroid hormone receptor interactor 130.095
pld1aphospholipase D1a0.091
csnk1g2bcasein kinase 1, gamma 2b0.090
rqcd1RCD1 required for cell differentiation1 homolog (S. pombe)0.090
hspa4bheat shock protein 4b0.087
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.080
mrpl15mitochondrial ribosomal protein L150.079
rtkn2rhotekin 20.079
taf7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.075
sf3b5splicing factor 3b, subunit 50.074
usp4ubiquitin specific protease 4 (proto-oncogene)0.074
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.074
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.072
ube2nbubiquitin-conjugating enzyme E2Nb0.072
pola1polymerase (DNA directed), alpha 10.070
ubinataxin-1 ubiquitin-like interacting protein0.069
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.068
morf4l1mortality factor 4 like 10.065
psma5proteasome (prosome, macropain) subunit, alpha type,50.065
ythdf1YTH domain family, member 10.064
brd2bbromodomain containing 2b0.063
ncbp2nuclear cap binding protein subunit 20.063
ppp2r5ebprotein phosphatase 2, regulatory subunit B', epsilon isoform b0.062
atad5aATPase family, AAA domain containing 5a0.061
ccdc94coiled-coil domain containing 940.061
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.058
glrx3glutaredoxin 30.058
ck2bcasein kinase 2 beta0.057
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.055
eif4e1ceukaryotic translation initiation factor 4E family member 1c0.055
csnk1g2acasein kinase 1, gamma 2a0.055
med27mediator complex subunit 270.055
smc3structural maintenance of chromosomes 30.054
mrps31mitochondrial ribosomal protein S310.054
pola2polymerase (DNA directed), alpha 20.054
pa2g4bproliferation-associated 2G4, b0.053
smarcb1aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a0.053
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.052
papolbpoly(A) polymerase beta (testis specific)0.052
usp1ubiquitin specific protease 10.052
pcbp2poly(rC) binding protein 20.052
tbc1d23TBC1 domain family, member 230.051
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.050
strapserine/threonine kinase receptor associated protein0.050
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.050
gabpb2aGA repeat binding protein, beta 2a0.049
lsm8LSM8 homolog, U6 small nuclear RNA associated0.049
chek1CHK1 checkpoint homolog (S. pombe)0.049
ddx42DEAD (Asp-Glu-Ala-Asp) box polypeptide 420.049
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.049
senp3aSUMO1/sentrin/SMT3 specific peptidase 3a0.048
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.048
rbb4retinoblastoma binding protein 40.048
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.048
hbs1lHBS1-like (S. cerevisiae)0.047
etaa1Ewing tumor-associated antigen 10.047
dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.047
tmpoathymopoietin a0.047
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
skpACG16983 gene product from transcript CG16983-RD0.913
MED6Mediator complex subunit 60.909
mus101mutagen-sensitive 1010.886
IswiImitation SWI0.830
CSN5COP9 complex homolog subunit 50.811
His2AvHistone H2A variant0.801
Brca2Breast cancer 2, early onset homolog0.748
mus205mutagen-sensitive 2050.719
BRWD3CG31132 gene product from transcript CG31132-RA0.703
polyCG9829 gene product from transcript CG9829-RB0.699
CG5524CG5524 gene product from transcript CG5524-RA0.680
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.634
eIF4AIIICG7483 gene product from transcript CG7483-RA0.577
CSN3COP9 complex homolog subunit 30.559
cdc2cCG10498 gene product from transcript CG10498-RC0.550
mus312mutagen-sensitive 3120.524
smt3CG4494 gene product from transcript CG4494-RA0.509
mei-9meiotic 90.508
CG6066CG6066 gene product from transcript CG6066-RA0.505
Rcd1Reduction in Cnn dots 10.501
DNApol-etaCG7143 gene product from transcript CG7143-RA0.488
rad50CG6339 gene product from transcript CG6339-RD0.484
Rpd3CG7471 gene product from transcript CG7471-RA0.458
Caf1Chromatin assembly factor 1 subunit0.451
Cdk4Cyclin-dependent kinase 40.444
Mcm3Minichromosome maintenance 30.433
MED17Mediator complex subunit 170.411
RecQ5homolog of RecQ0.405
CSN4COP9 complex homolog subunit 40.380
eEF1deltaCG4912 gene product from transcript CG4912-RB0.377
Pp2A-29BProtein phosphatase 2A at 29B0.376
tefutelomere fusion0.362
Fcp1CG12252 gene product from transcript CG12252-RA0.355
RanGapRan GTPase activating protein0.343
mus201mutagen-sensitive 2010.343
l(2)NC136lethal (2) NC1360.336
CSN7COP9 complex homolog subunit 70.335
Ge-1CG6181 gene product from transcript CG6181-RA0.334
Klp3AKinesin-like protein at 3A0.331
mus309mutagen-sensitive 3090.322
Npc1aNiemann-Pick type C-1a0.292
Acf1ATP-dependent chromatin assembly factor large subunit0.288
p53CG33336 gene product from transcript CG33336-RB0.286
Rev1CG12189 gene product from transcript CG12189-RA0.275
CDC45LCG3658 gene product from transcript CG3658-RA0.268
U2af50U2 small nuclear riboprotein auxiliary factor 500.265
magomago nashi0.265
Smc5CG32438 gene product from transcript CG32438-RE0.249
RecQ4CG7487 gene product from transcript CG7487-RA0.240
eIF5CG9177 gene product from transcript CG9177-RE0.235
MED20Mediator complex subunit 200.235
CG34159CG34159 gene product from transcript CG34159-RA0.235
cdc2CG5363 gene product from transcript CG5363-RA0.226
CG8159CG8159 gene product from transcript CG8159-RB0.222
Bap55Brahma associated protein 55kD0.218
mus308mutagen-sensitive 3080.208
CG10414CG10414 gene product from transcript CG10414-RA0.206
Vap-33-1CG5014 gene product from transcript CG5014-RB0.204
CycCCyclin C0.204
MED31Mediator complex subunit 310.198
mre11meiotic recombination 110.198
CG6506CG6506 gene product from transcript CG6506-RA0.188
swmsecond mitotic wave missing0.185
Tip60CG6121 gene product from transcript CG6121-RA0.183
CG13298CG13298 gene product from transcript CG13298-RA0.180
CG9797CG9797 gene product from transcript CG9797-RA0.180
CSN1bCOP9 complex homolog subunit 1 b0.179
Cdc37CG12019 gene product from transcript CG12019-RA0.173
Rpb11CG6840 gene product from transcript CG6840-RA0.171
CG7386CG7386 gene product from transcript CG7386-RA0.171
CG2183CG2183 gene product from transcript CG2183-RA0.168
Pros29Proteasome 29kD subunit0.167
RpII15RNA polymerase II 15kD subunit0.166
CG9705CG9705 gene product from transcript CG9705-RA0.160
MAGECG10059 gene product from transcript CG10059-RA0.160
alphaTub67Calpha-Tubulin at 67C0.160
psidinphagocyte signaling impaired0.155
CG10139CG10139 gene product from transcript CG10139-RA0.152
spn-Bspindle B0.150
sxcsuper sex combs0.144
mus209mutagen-sensitive 2090.135
BEAF-32Boundary element-associated factor of 32kD0.132
cutletCG33122 gene product from transcript CG33122-RA0.129
CSN6COP9 complex homolog subunit 60.127
Chrac-14CG13399 gene product from transcript CG13399-RA0.127
Smnsurvival motor neuron0.126
Rsf1Repressor splicing factor 10.124
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset0.924
PARP1poly (ADP-ribose) polymerase 10.803
CDK2cyclin-dependent kinase 20.788
RB1retinoblastoma 10.776
TP53tumor protein p530.666
PCNAproliferating cell nuclear antigen0.535
E2F1E2F transcription factor 10.458
H2AFXH2A histone family, member X0.385
CDK8cyclin-dependent kinase 80.286
CUL1cullin 10.207
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.185
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.145
CDC6cell division cycle 6 homolog (S. cerevisiae)0.123
MSH6mutS homolog 6 (E. coli)0.090
RBL1retinoblastoma-like 1 (p107)0.089
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.088
RAD50RAD50 homolog (S. cerevisiae)0.083
TOPBP1topoisomerase (DNA) II binding protein 10.083
RBBP8retinoblastoma binding protein 80.081
MCM2minichromosome maintenance complex component 20.080
MED1mediator complex subunit 10.080
CNOT6CCR4-NOT transcription complex, subunit 60.066
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.053
CCNA2cyclin A20.048
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.047
MDC1mediator of DNA-damage checkpoint 10.047
HDAC1histone deacetylase 10.045
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.044
CSNK2Bcasein kinase 2, beta polypeptide0.043
MED13mediator complex subunit 130.042
BRIP1BRCA1 interacting protein C-terminal helicase 10.042
FANCD2Fanconi anemia, complementation group D20.042
MED10mediator complex subunit 100.041
DDB1damage-specific DNA binding protein 1, 127kDa0.037
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.037
ORC2origin recognition complex, subunit 20.036
RPA2replication protein A2, 32kDa0.035
CNOT1CCR4-NOT transcription complex, subunit 10.034
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.032
TFDP1transcription factor Dp-10.031
GPIglucose-6-phosphate isomerase0.031
MCM6minichromosome maintenance complex component 60.030
FOXM1forkhead box M10.029
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.029
ATMataxia telangiectasia mutated0.028
CUL4Acullin 4A0.028
BTG1B-cell translocation gene 1, anti-proliferative0.028
MED28mediator complex subunit 280.026
UBXN7UBX domain protein 70.025
MED23mediator complex subunit 230.025
MCM7minichromosome maintenance complex component 70.024
UBA1ubiquitin-like modifier activating enzyme 10.023
CNOT8CCR4-NOT transcription complex, subunit 80.023
WRNWerner syndrome, RecQ helicase-like0.023
ATRXalpha thalassemia/mental retardation syndrome X-linked0.022
MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)0.022
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.021
CHAF1Achromatin assembly factor 1, subunit A (p150)0.021
RBL2retinoblastoma-like 2 (p130)0.020
RFWD2ring finger and WD repeat domain 20.019
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.019
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.019
MED29mediator complex subunit 290.019
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.018
CNOT3CCR4-NOT transcription complex, subunit 30.018
MED26mediator complex subunit 260.018
PRMT1protein arginine methyltransferase 10.018
E2F4E2F transcription factor 4, p107/p130-binding0.018
MED4mediator complex subunit 40.017
COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.017
ATRataxia telangiectasia and Rad3 related0.017
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.017
HDGFhepatoma-derived growth factor0.016
CCNCcyclin C0.016
UBE2Mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.016
CCNE1cyclin E10.015
BLMBloom syndrome, RecQ helicase-like0.014
FBXO11F-box protein 110.014
SIRT1sirtuin 10.014
TPI1triosephosphate isomerase 10.014
MCM5minichromosome maintenance complex component 50.014
TP53BP1tumor protein p53 binding protein 10.013
PGK1phosphoglycerate kinase 10.013
GPS1G protein pathway suppressor 10.012
CDT1chromatin licensing and DNA replication factor 10.012
NEDD8neural precursor cell expressed, developmentally down-regulated 80.012
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.012
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.012
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.011
CDK1cyclin-dependent kinase 10.011
SKP2S-phase kinase-associated protein 2 (p45)0.011
RECQLRecQ protein-like (DNA helicase Q1-like)0.011
CNOT7CCR4-NOT transcription complex, subunit 70.011
PKM2pyruvate kinase, muscle0.011
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.011
CHEK1CHK1 checkpoint homolog (S. pombe)0.010
CUL3cullin 30.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism