The network for 'negative regulation of axon extension' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of axon extension

Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Pax2paired box gene 20.999
Fgf8fibroblast growth factor 80.997
Foxc1forkhead box C10.997
Bmp4bone morphogenetic protein 40.996
Ednraendothelin receptor type A0.994
Tbx1T-box 10.993
Rargretinoic acid receptor, gamma0.983
Gli2GLI-Kruppel family member GLI20.983
Sox9SRY-box containing gene 90.981
Rarbretinoic acid receptor, beta0.979
Robo1roundabout homolog 1 (Drosophila)0.979
Fgfr1fibroblast growth factor receptor 10.978
Prrx1paired related homeobox 10.977
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.974
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.971
Lhx1LIM homeobox protein 10.967
Rararetinoic acid receptor, alpha0.960
Eya1eyes absent 1 homolog (Drosophila)0.957
Pax3paired box gene 30.955
Dlx5distal-less homeobox 50.947
Foxc2forkhead box C20.945
Otx2orthodenticle homolog 2 (Drosophila)0.927
Fgfr2fibroblast growth factor receptor 20.919
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.902
Bmp7bone morphogenetic protein 70.901
Fgf10fibroblast growth factor 100.897
Acvr1activin A receptor, type 10.887
Slit2slit homolog 2 (Drosophila)0.878
Pbx1pre B-cell leukemia transcription factor 10.847
Msx1homeobox, msh-like 10.828
Tgfb2transforming growth factor, beta 20.822
Ctnnb1catenin (cadherin associated protein), beta 10.820
Wnt4wingless-related MMTV integration site 40.807
Efnb2ephrin B20.799
Emx2empty spiracles homolog 2 (Drosophila)0.792
Vegfavascular endothelial growth factor A0.791
Smosmoothened homolog (Drosophila)0.768
Slit3slit homolog 3 (Drosophila)0.759
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.736
Hand2heart and neural crest derivatives expressed transcript 20.732
Chd7chromodomain helicase DNA binding protein 70.715
Nrp1neuropilin 10.710
Robo2roundabout homolog 2 (Drosophila)0.630
Retret proto-oncogene0.618
Tcfap2atranscription factor AP-2, alpha0.603
Epha4Eph receptor A40.575
Hoxa1homeobox A10.572
Hoxa3homeobox A30.562
Jag1jagged 10.554
Gab1growth factor receptor bound protein 2-associated protein 10.548
Plxnd1plexin D10.538
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.524
Prrx2paired related homeobox 20.465
Vangl2vang-like 2 (van gogh, Drosophila)0.455
Ece1endothelin converting enzyme 10.452
Nrp2neuropilin 20.442
Pcdh12protocadherin 120.415
Gbx2gastrulation brain homeobox 20.415
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.411
Pou3f3POU domain, class 3, transcription factor 30.410
Fzd1frizzled homolog 1 (Drosophila)0.403
Foxg1forkhead box G10.403
Matn4matrilin 40.351
Dlg4discs, large homolog 4 (Drosophila)0.336
Ephb2Eph receptor B20.328
Otx1orthodenticle homolog 1 (Drosophila)0.325
Fgf18fibroblast growth factor 180.324
Lmx1aLIM homeobox transcription factor 1 alpha0.320
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.307
Rxraretinoid X receptor alpha0.307
Apc2adenomatosis polyposis coli 20.298
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.298
Fzd8frizzled homolog 8 (Drosophila)0.291
Dkk1dickkopf homolog 1 (Xenopus laevis)0.283
Fjx1four jointed box 1 (Drosophila)0.261
Hand1heart and neural crest derivatives expressed transcript 10.258
Bmp2bone morphogenetic protein 20.257
Pax8paired box gene 80.256
Wnt3awingless-related MMTV integration site 3A0.254
Unc5cunc-5 homolog C (C. elegans)0.242
Hoxd11homeobox D110.240
Gli1GLI-Kruppel family member GLI10.240
Ephb3Eph receptor B30.238
Ror1receptor tyrosine kinase-like orphan receptor 10.234
Wnt10bwingless related MMTV integration site 10b0.234
Hoxa2homeobox A20.232
Bmp5bone morphogenetic protein 50.231
Pitx2paired-like homeodomain transcription factor 20.228
Tcf21transcription factor 210.225
Zeb1zinc finger E-box binding homeobox 10.214
Cdh6cadherin 60.212
Itga3integrin alpha 30.210
Wnt7awingless-related MMTV integration site 7A0.203
Alx4aristaless-like homeobox 40.197
Gpr27G protein-coupled receptor 270.196
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cam-1Protein CAM-10.293
egl-18Protein EGL-180.135
clh-5Protein CLH-50.080
mef-2Protein MEF-20.079
lin-25Protein LIN-250.067
unc-9Protein UNC-90.066
set-16Protein SET-160.061
sel-12Protein SEL-120.060
sax-3Protein SAX-30.041
R90.1Protein R90.10.040
zoo-1Protein ZOO-10.037
unc-94Protein UNC-940.036
eor-2Protein EOR-20.034
lir-1Protein LIR-10.034
egl-30Protein EGL-300.033
lin-12Protein LIN-120.030
pqn-65Protein PQN-650.028
unc-53Protein UNC-530.026
cwn-1Protein CWN-10.026
lin-17Protein LIN-170.026
CELE_W05H9.4Protein W05H9.40.025
cpna-5Protein CPNA-50.025
egl-23Protein EGL-230.024
tbb-4Protein TBB-40.024
ugt-57Protein UGT-570.023
K10C3.4Protein K10C3.40.023
rig-6Protein RIG-60.023
unc-40Protein UNC-400.022
egl-46Protein EGL-460.022
ZK822.4Protein ZK822.40.022
CELE_R09F10.3Protein R09F10.30.020
F21D12.3Protein F21D12.30.020
alg-2Protein ALG-20.019
unc-104Protein UNC-1040.019
T28B11.1Protein T28B11.10.019
zfp-1Protein ZFP-10.019
daf-19Protein DAF-190.018
F28E10.1Protein F28E10.10.018
egl-36Protein EGL-360.018
dpy-19Protein DPY-190.017
rab-14Protein RAB-140.017
ncam-1Protein NCAM-10.017
unc-5Protein UNC-50.017
hlh-1Protein HLH-10.017
ZK154.5Protein ZK154.50.017
mig-38Protein MIG-380.016
bar-1Protein BAR-10.016
sdz-28Protein SDZ-280.016
F55C12.5Protein F55C12.50.016
max-1Protein MAX-10.016
C14H10.2Protein C14H10.20.016
flt-1Protein FLT-10.016
glr-4Protein GLR-40.016
sedl-1Protein SEDL-10.015
dmsr-1Protein DMSR-10.015
agr-1Protein AGR-10.015
ceh-6Protein CEH-60.015
cpt-1Protein CPT-10.015
unc-36Protein UNC-360.015
sgn-1Protein SGN-10.015
gex-2Protein GEX-20.015
pdfr-1Protein PDFR-10.014
acy-1Protein ACY-10.014
cdh-4Protein CDH-40.014
lgc-39Protein LGC-390.014
dpf-6Protein DPF-60.014
gmeb-1Protein GMEB-10.014
fmi-1Protein FMI-10.014
ten-1Protein TEN-10.014
ins-2Protein INS-20.014
jac-1Protein JAC-10.013
F57B7.2Protein F57B7.20.013
ccb-1Protein CCB-10.013
sem-4Protein SEM-40.013
R08E3.3Protein R08E3.30.012
tyr-1Protein TYR-10.012
R151.1Protein R151.10.012
lin-28Protein LIN-280.012
syd-9Protein SYD-90.012
jmjd-3.1Protein JMJD-3.10.012
unc-38Protein UNC-380.012
cyp-13A2Protein CYP-13A20.012
CELE_C27D8.3Protein C27D8.30.012
R08D7.7Protein R08D7.70.012
C03A3.1Protein C03A3.10.012
F53B3.5Protein F53B3.50.012
F35D2.3Protein F35D2.30.012
rab-35Protein RAB-350.012
nhr-67Protein NHR-670.012
slo-1Protein SLO-10.011
daf-1Protein DAF-10.011
ceh-58Protein CEH-580.011
ceh-13Protein CEH-130.011
clr-1Protein CLR-10.011
CELE_W05H9.2Protein W05H9.20.011
glc-2Protein GLC-20.011
nac-1Protein NAC-10.011
C43H6.4Protein C43H6.40.011
sul-1Protein SUL-10.011
lin-32Protein LIN-320.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lhx2bLIM homeobox 2b0.947
epha4aeph receptor A4a0.944
bocbrother of CDO0.912
nrp1aneuropilin 1a0.798
cdh2cadherin 2, neuronal0.722
sema3aasemaphorin 3aa0.677
slit3slit (Drosophila) homolog 30.542
fgfr1bfibroblast growth factor receptor 1b0.537
nrp2bneuropilin 2b0.525
fgfr3fibroblast growth factor receptor 30.455
efnb3bephrin B3b0.442
gro1groucho 10.381
nkd1naked cuticle homolog 1 (Drosophila)0.364
pax6bpaired box gene 6b0.244
robo2roundabout homolog 20.222
sulf1sulfatase 10.205
gro2groucho 20.202
evx1even-skipped homeobox 10.196
ephb4beph receptor B4b0.186
ntn1anetrin 1a0.173
slit2slit (Drosophila) homolog 20.166
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.161
emx3empty spiracles homeobox 30.153
gli1GLI-Kruppel family member 10.149
gli2aGLI-Kruppel family member GLI2a0.149
ntn1bnetrin 1b0.145
robo3roundabout homolog 30.138
tfectranscription factor EC0.133
epb4.1l4erythrocyte protein band 4.1-like 40.127
igfbp3insulin-like growth factor binding protein 30.126
robo1roundabout homolog 10.122
nr2f2nuclear receptor subfamily 2, group F, member 20.118
foxp2forkhead box P20.110
ptpraprotein tyrosine phosphatase, receptor type, A0.108
mecomMDS1 and EVI1 complex locus0.099
fstl1bfollistatin-like 1b0.094
nrxn1aneurexin 1a0.093
smoc1SPARC related modular calcium binding 10.091
foxg1aforkhead box G1a0.090
irx1airoquois homeobox protein 1, a0.089
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.087
neo1neogenin 10.086
sema3dsemaphorin 3d0.084
axin1axin 10.082
znf503zinc finger protein 5030.078
pax6apaired box gene 6a0.077
tnctenascin C0.077
rargaretinoic acid receptor gamma a0.076
fzd7afrizzled homolog 7a0.075
six3bsine oculis homeobox homolog 3b0.072
meis2.2myeloid ecotropic viral integration site 2.20.072
phox2apaired-like homeobox 2a0.070
irx5airoquois homeobox protein 5a0.068
LOC567452G protein-coupled receptor kinase 5-like0.068
grem2gremlin 2, cysteine knot superfamily0.068
unc5bunc-5 homolog B (C. elegans)0.068
six3asine oculis homeobox homolog 3a0.068
notch2notch homolog 20.065
sox2SRY-box containing gene 20.055
LOC797832similar to signal peptide, CUB domain, EGF-like 10.054
tbx1T-box 10.052
pcdh10aprotocadherin 10a0.051
ephb3aeph receptor B3a0.050
sox1aSRY-box containing gene 1a0.050
efnb2aephrin B2a0.050
zbtb16azinc finger and BTB domain containing 16a0.046
irx2airoquois homeobox protein 2, a0.045
sox21bSRY-box containing gene 21 b0.044
otx1borthodenticle homolog 1b0.043
nova2neuro-oncological ventral antigen 20.039
pcdh19protocadherin 190.038
ptproprotein tyrosine phosphatase, receptor type, O0.037
wnt3wingless-type MMTV integration site family, member 30.037
gyltl1bglycosyltransferase-like 1b0.035
smad1MAD homolog 1 (Drosophila)0.034
foxa1forkhead box A10.034
alcamaactivated leukocyte cell adhesion molecule a0.033
barhl2BarH-like 20.031
flncbfilamin C, gamma b (actin binding protein 280)0.030
slit1aslit homolog 1a (Drosophila)0.030
foxd3forkhead box D30.030
metmet proto-oncogene (hepatocyte growth factor receptor)0.029
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.028
hoxb2ahomeo box B2a0.027
ebf3early B-cell factor 30.027
hoxb3ahomeo box B3a0.026
grhl2bgrainyhead-like 2b (Drosophila)0.026
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.026
ptprkprotein tyrosine phosphatase, receptor type, K0.026
sfrp1asecreted frizzled-related protein 1a0.025
lama1laminin, alpha 10.025
rx3retinal homeobox gene 30.025
ptgs1prostaglandin-endoperoxide synthase 10.025
fbn2bfibrillin 2b0.025
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Wnt5Wnt oncogene analog 50.560
stumpsCG31317 gene product from transcript CG31317-RC0.469
plexBplexin B0.381
unc-5CG8166 gene product from transcript CG8166-RA0.355
EphrinCG1862 gene product from transcript CG1862-RA0.327
robo3CG5423 gene product from transcript CG5423-RA0.188
CG33960CG33960 gene product from transcript CG33960-RB0.182
CG12424CG12424 gene product from transcript CG12424-RC0.128
vndventral nervous system defective0.126
futschCG34387 gene product from transcript CG34387-RC0.110
wbwing blister0.093
DscamDown syndrome cell adhesion molecule0.082
Ptp69DProtein tyrosine phosphatase 69D0.072
reporeversed polarity0.067
trioCG18214 gene product from transcript CG18214-RA0.066
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.065
Sema-1aCG18405 gene product from transcript CG18405-RD0.063
Trim9CG31721 gene product from transcript CG31721-RB0.061
HGTXCG13475 gene product from transcript CG13475-RB0.058
pdm3pou domain motif 30.054
Drl-2Derailed 20.052
jebjelly belly0.047
Fas3Fasciclin 30.045
jingCG9397 gene product from transcript CG9397-RI0.043
MicalMolecule interacting with CasL0.038
Hr51Hormone receptor 510.034
snssticks and stones0.032
dntdoughnut on 20.030
gcmglial cells missing0.029
Fak56DFocal Adhesion Kinase0.025
bchsblue cheese0.024
nerfin-1nervous fingers 10.024
oafout at first0.021
DAAMDishevelled Associated Activator of Morphogenesis0.021
SAKSak kinase0.021
Ptp52FCG18243 gene product from transcript CG18243-RB0.020
Vrp1Verprolin 10.020
pod1CG4532 gene product from transcript CG4532-RF0.020
mewmultiple edematous wings0.019
l(2)k16918lethal (2) k169180.019
vavCG7893 gene product from transcript CG7893-RB0.018
bibbig brain0.018
AlkCG8250 gene product from transcript CG8250-RA0.018
stanstarry night0.017
VGlutVesicular glutamate transporter0.017
nrv2nervana 20.017
OliOlig family0.016
ShalShaker cognate l0.016
AblAbl tyrosine kinase0.016
emsempty spiracles0.015
elavembryonic lethal abnormal vision0.015
vvlventral veins lacking0.014
CG42256CG42256 gene product from transcript CG42256-RH0.014
NT1Neurotrophin 10.014
FucTACG6869 gene product from transcript CG6869-RA0.014
zfh1Zn finger homeodomain 10.013
lmdlame duck0.013
nocno ocelli0.013
spz5spatzle 50.013
CG6490CG6490 gene product from transcript CG6490-RB0.013
mbcmyoblast city0.013
slp1sloppy paired 10.013
Tre1trapped in endoderm-10.013
CBPsarcoplasmic calcium-binding protein0.012
fasfaint sausage0.012
cal1chromosome alignment defect 10.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGF1fibroblast growth factor 1 (acidic)1.000
VEGFAvascular endothelial growth factor A1.000
FGF10fibroblast growth factor 100.998
FGFR2fibroblast growth factor receptor 20.997
FGF2fibroblast growth factor 2 (basic)0.994
FGFR1fibroblast growth factor receptor 10.992
GRB7growth factor receptor-bound protein 70.983
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.971
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.939
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.908
NEDD4neural precursor cell expressed, developmentally down-regulated 40.853
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.846
FRS2fibroblast growth factor receptor substrate 20.824
COL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding protein0.823
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.794
FGF7fibroblast growth factor 70.793
PLCG1phospholipase C, gamma 10.789
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.763
CDK5cyclin-dependent kinase 50.685
FZD1frizzled homolog 1 (Drosophila)0.670
FGFR3fibroblast growth factor receptor 30.617
NOSTRINnitric oxide synthase trafficker0.585
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.559
LATlinker for activation of T cells0.492
CPEcarboxypeptidase E0.454
CTGFconnective tissue growth factor0.433
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.405
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.384
CABLES1Cdk5 and Abl enzyme substrate 10.367
DCCdeleted in colorectal carcinoma0.362
TGFB3transforming growth factor, beta 30.309
FN1fibronectin 10.266
FIBPfibroblast growth factor (acidic) intracellular binding protein0.244
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.238
FAM160A2family with sequence similarity 160, member A20.231
RTN4reticulon 40.227
RTN3reticulon 30.223
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.177
NR4A1nuclear receptor subfamily 4, group A, member 10.156
LRP6low density lipoprotein receptor-related protein 60.143
ALAS1aminolevulinate, delta-, synthase 10.140
PRR13proline rich 130.138
HSPG2heparan sulfate proteoglycan 20.103
PGFplacental growth factor0.102
SLIT2slit homolog 2 (Drosophila)0.094
INSRinsulin receptor0.089
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.080
NCK2NCK adaptor protein 20.080
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.080
HLA-DPB1major histocompatibility complex, class II, DP beta 10.074
GRB10growth factor receptor-bound protein 100.074
KRT8keratin 80.073
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.071
RBP4retinol binding protein 4, plasma0.068
TGFB2transforming growth factor, beta 20.067
NTRK2neurotrophic tyrosine kinase, receptor, type 20.066
FZD8frizzled homolog 8 (Drosophila)0.065
EGFRepidermal growth factor receptor0.061
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.058
MPV17MpV17 mitochondrial inner membrane protein0.051
RNF11ring finger protein 110.051
CABLES2Cdk5 and Abl enzyme substrate 20.049
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.048
CRY1cryptochrome 1 (photolyase-like)0.046
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.046
NTRK3neurotrophic tyrosine kinase, receptor, type 30.046
CDK9cyclin-dependent kinase 90.045
SHBSrc homology 2 domain containing adaptor protein B0.045
CPNE6copine VI (neuronal)0.043
KCNRGpotassium channel regulator0.043
KAL1Kallmann syndrome 1 sequence0.042
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.040
DDR1discoidin domain receptor tyrosine kinase 10.040
NTRK1neurotrophic tyrosine kinase, receptor, type 10.039
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.039
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)0.039
LTBP4latent transforming growth factor beta binding protein 40.038
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.037
SDC2syndecan 20.036
RAB5ARAB5A, member RAS oncogene family0.035
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.035
AATKapoptosis-associated tyrosine kinase0.035
TGFB1transforming growth factor, beta 10.035
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.035
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.034
ARandrogen receptor0.034
ATN1atrophin 10.034
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.033
LRPAP1low density lipoprotein receptor-related protein associated protein 10.033
NRP2neuropilin 20.033
JAG2jagged 20.032
SH3BP2SH3-domain binding protein 20.032
PDGFCplatelet derived growth factor C0.031
ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix protein0.031
FGF5fibroblast growth factor 50.031
FGBfibrinogen beta chain0.031
FLRT2fibronectin leucine rich transmembrane protein 20.030
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism