The network for 'ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

NameDescriptionProbabilityFunc Analog Organism
Rnf11ring finger protein 110.916
Cyldcylindromatosis (turban tumor syndrome)0.767
Rac1RAS-related C3 botulinum substrate 10.712
Pdcd6programmed cell death 60.661
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.655
Ndfip1Nedd4 family interacting protein 10.557
Rab5aRAB5A, member RAS oncogene family0.537
Nedd4neural precursor cell expressed, developmentally down-regulated 40.434
Tmem64transmembrane protein 640.412
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.395
Tbcbtubulin folding cofactor B0.393
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.358
Grb10growth factor receptor bound protein 100.345
Git1G protein-coupled receptor kinase-interactor 10.343
Pgrmc1progesterone receptor membrane component 10.343
Mea1male enhanced antigen 10.314
Trappc2ltrafficking protein particle complex 2-like0.307
Hsbp1heat shock factor binding protein 10.295
Tmem9bTMEM9 domain family, member B0.293
Pde6dphosphodiesterase 6D, cGMP-specific, rod, delta0.282
Itfg1integrin alpha FG-GAP repeat containing 10.262
Anapc2anaphase promoting complex subunit 20.261
Itm2bintegral membrane protein 2B0.205
Per1period homolog 1 (Drosophila)0.199
Katnb1katanin p80 (WD40-containing) subunit B 10.187
Cry2cryptochrome 2 (photolyase-like)0.173
Hsf1heat shock factor 10.173
Use1unconventional SNARE in the ER 1 homolog (S. cerevisiae)0.144
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.140
Traf6TNF receptor-associated factor 60.138
Syap1synapse associated protein 10.138
Rab18RAB18, member RAS oncogene family0.135
Rab11aRAB11a, member RAS oncogene family0.134
BC031181cDNA sequence BC0311810.133
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.132
Trp53bp1transformation related protein 53 binding protein 10.128
Smad6MAD homolog 6 (Drosophila)0.119
Nptnneuroplastin0.119
Tmem30atransmembrane protein 30A0.116
Vcpvalosin containing protein0.102
Ubcubiquitin C0.101
Surf1surfeit gene 10.098
Dctn3dynactin 30.094
Pard6apar-6 (partitioning defective 6,) homolog alpha (C. elegans)0.091
Tm2d2TM2 domain containing 20.088
Rnf103ring finger protein 1030.086
Ugp2UDP-glucose pyrophosphorylase 20.085
Tprgltransformation related protein 63 regulated like0.084
Ap1m1adaptor-related protein complex AP-1, mu subunit 10.081
Serinc1serine incorporator 10.081
Rbm42RNA binding motif protein 420.081
Dctn2dynactin 20.078
Vdac2voltage-dependent anion channel 20.076
C78339expressed sequence C783390.076
Rab7RAB7, member RAS oncogene family0.075
Mllt1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.075
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.073
Pmepa1prostate transmembrane protein, androgen induced 10.073
Dazap2DAZ associated protein 20.073
Xrcc1X-ray repair complementing defective repair in Chinese hamster cells 10.070
Dstndestrin0.069
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.067
Gga1golgi associated, gamma adaptin ear containing, ARF binding protein 10.064
Tmed7transmembrane emp24 protein transport domain containing 70.061
Pttg1ippituitary tumor-transforming 1 interacting protein0.061
Slc25a28solute carrier family 25, member 280.060
Purbpurine rich element binding protein B0.059
0610007C21RikRIKEN cDNA 0610007C21 gene0.058
Vti1bvesicle transport through interaction with t-SNAREs 1B homolog0.057
Bag6BCL2-associated athanogene 60.057
Psenenpresenilin enhancer 2 homolog (C. elegans)0.057
Chmp2achromatin modifying protein 2A0.055
Ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.055
Capza2capping protein (actin filament) muscle Z-line, alpha 20.053
Zfp574zinc finger protein 5740.053
Trim28tripartite motif-containing 280.052
Atp6v1fATPase, H+ transporting, lysosomal V1 subunit F0.052
Mcrs1microspherule protein 10.052
Dvl2dishevelled 2, dsh homolog (Drosophila)0.052
CflarCASP8 and FADD-like apoptosis regulator0.051
Mapk7mitogen-activated protein kinase 70.051
Zfp598zinc finger protein 5980.051
Egln2EGL nine homolog 2 (C. elegans)0.051
Gtf3c1general transcription factor III C 10.051
Tesk1testis specific protein kinase 10.050
Per2period homolog 2 (Drosophila)0.049
Ube2aubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae)0.048
Cpsf1cleavage and polyadenylation specific factor 10.047
Fuca1fucosidase, alpha-L- 1, tissue0.046
1110067D22RikRIKEN cDNA 1110067D22 gene0.046
Usp8ubiquitin specific peptidase 80.046
Map3k2mitogen-activated protein kinase kinase kinase 20.045
Wbp2WW domain binding protein 20.044
Rab2aRAB2A, member RAS oncogene family0.044
Rab10RAB10, member RAS oncogene family0.044
Prdx6peroxiredoxin 60.044
Arpc1aactin related protein 2/3 complex, subunit 1A0.043
Scamp3secretory carrier membrane protein 30.043
RragcRas-related GTP binding C0.043
Stx8syntaxin 80.042
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Vps25Vacuolar protein sorting 250.995
lsnlarsen0.987
vps2CG14542 gene product from transcript CG14542-RA0.729
Syx7Syntaxin 70.674
Pp1-87BProtein phosphatase 1 at 87B0.411
Vps36Vacuolar protein sorting 360.276
Rab7Rab-protein 70.242
cpacapping protein alpha0.189
CG10103CG10103 gene product from transcript CG10103-RA0.174
shrbshrub0.165
vps24Charged multivesicular body protein 30.164
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.061
CHMP2BCharged multivesicular body protein 2b0.061
Sop2Suppressor of profilin 20.058
SybSynaptobrevin0.058
TSG101tumor suppressor protein 1010.052
Chmp1CG4108 gene product from transcript CG4108-RA0.048
captcapulet0.045
Rab5Rab-protein 50.043
Vps20Vacuolar protein sorting 200.041
sqhspaghetti squash0.033
CG6259CG6259 gene product from transcript CG6259-RA0.033
RhebCG1081 gene product from transcript CG1081-RA0.025
Rbsn-5Rabenosyn-50.023
sds22CG5851 gene product from transcript CG5851-RA0.021
lqfliquid facets0.016
CG12007CG12007 gene product from transcript CG12007-RA0.015
StamSignal transducing adaptor molecule0.013
Atg6Autophagy-specific gene 60.012
CG4699CG4699 gene product from transcript CG4699-RJ0.012
Pi3K59FPhosphotidylinositol 3 kinase 59F0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)1.000
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.982
TSG101tumor susceptibility gene 1010.902
SMURF2SMAD specific E3 ubiquitin protein ligase 20.789
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.726
PDCD6IPprogrammed cell death 6 interacting protein0.711
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.706
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.564
NEDD4neural precursor cell expressed, developmentally down-regulated 40.438
UBE2Wubiquitin-conjugating enzyme E2W (putative)0.357
ROCK1Rho-associated, coiled-coil containing protein kinase 10.240
TUBA1Atubulin, alpha 1a0.174
WWP1WW domain containing E3 ubiquitin protein ligase 10.148
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.109
CHMP4Bchromatin modifying protein 4B0.104
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)0.102
UBE2E1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)0.096
ZFYVE9zinc finger, FYVE domain containing 90.090
PDCD6programmed cell death 60.088
OTUB1OTU domain, ubiquitin aldehyde binding 10.068
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.063
SMAD4SMAD family member 40.062
ANKRD13Aankyrin repeat domain 13A0.057
LRSAM1leucine rich repeat and sterile alpha motif containing 10.055
C11orf2chromosome 11 open reading frame 20.050
TRIM39tripartite motif containing 390.049
EPS15epidermal growth factor receptor pathway substrate 150.047
UBQLN2ubiquilin 20.044
CHMP1Achromatin modifying protein 1A0.040
SMURF1SMAD specific E3 ubiquitin protein ligase 10.038
FBXL15F-box and leucine-rich repeat protein 150.038
ADRBK1adrenergic, beta, receptor kinase 10.036
SMAD5SMAD family member 50.034
RNF38ring finger protein 380.034
USP54ubiquitin specific peptidase 540.029
PTPN23protein tyrosine phosphatase, non-receptor type 230.028
NBR1neighbor of BRCA1 gene 10.026
CXXC5CXXC finger protein 50.025
RNF11ring finger protein 110.025
VPS25vacuolar protein sorting 25 homolog (S. cerevisiae)0.023
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.022
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.022
CHMP6chromatin modifying protein 60.022
STAMBPSTAM binding protein0.022
DTX2deltex homolog 2 (Drosophila)0.021
SMAD1SMAD family member 10.019
TRIM43tripartite motif containing 430.018
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.017
DYNC2H1dynein, cytoplasmic 2, heavy chain 10.017
SGTAsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.016
TRIM11tripartite motif containing 110.016
KRT15keratin 150.015
IDH3Gisocitrate dehydrogenase 3 (NAD+) gamma0.015
DHPSdeoxyhypusine synthase0.014
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.014
MTMR6myotubularin related protein 60.013
APIPAPAF1 interacting protein0.012
ELLelongation factor RNA polymerase II0.012
BFARbifunctional apoptosis regulator0.012
MUL1mitochondrial E3 ubiquitin protein ligase 10.012
SHARPINSHANK-associated RH domain interactor0.012
LARP1La ribonucleoprotein domain family, member 10.011
TOM1L1target of myb1 (chicken)-like 10.011
NEDD9neural precursor cell expressed, developmentally down-regulated 90.011
BAG6BCL2-associated athanogene 60.011
MARK2MAP/microtubule affinity-regulating kinase 20.011
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.011
ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 60.010
PPFIBP2PTPRF interacting protein, binding protein 2 (liprin beta 2)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
VPS36Vps36p0.031
BRO1Bro1p0.021
SNF7Snf7p0.020
YPR091Chypothetical protein0.016
DID2Did2p0.015
RAV2Rav2p0.015
BPT1Bpt1p0.012
VPS4Vps4p0.011
YLR001Chypothetical protein0.011
VPS60Vps60p0.011
ADP1Adp1p0.011
FPK1Fpk1p0.010
IST1Ist1p0.010