The network for 'renal system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal system development

The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.

NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 21.000
Fgfr2fibroblast growth factor receptor 21.000
Foxc1forkhead box C11.000
Pitx2paired-like homeodomain transcription factor 21.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Sox2SRY-box containing gene 20.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Bmp4bone morphogenetic protein 40.999
Lhx1LIM homeobox protein 10.999
Pax8paired box gene 80.999
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Hoxa1homeobox A10.999
Wt1Wilms tumor 1 homolog0.998
Tbx1T-box 10.996
Smad6MAD homolog 6 (Drosophila)0.995
Ctnnb1catenin (cadherin associated protein), beta 10.995
Foxg1forkhead box G10.995
Hoxa11homeobox A110.994
Hoxd11homeobox D110.994
Fgf8fibroblast growth factor 80.994
Emx2empty spiracles homolog 2 (Drosophila)0.993
Tbx2T-box 20.993
Efnb2ephrin B20.992
Vangl2vang-like 2 (van gogh, Drosophila)0.992
Ptenphosphatase and tensin homolog0.992
Tbx3T-box 30.990
Otx2orthodenticle homolog 2 (Drosophila)0.990
Jag1jagged 10.989
Trp63transformation related protein 630.988
Nos3nitric oxide synthase 3, endothelial cell0.986
Gdnfglial cell line derived neurotrophic factor0.985
Sox9SRY-box containing gene 90.985
Mks1Meckel syndrome, type 10.983
Eya1eyes absent 1 homolog (Drosophila)0.982
Bcl2B-cell leukemia/lymphoma 20.981
Rarbretinoic acid receptor, beta0.981
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.979
Rargretinoic acid receptor, gamma0.978
Dlx5distal-less homeobox 50.978
Ptgs2prostaglandin-endoperoxide synthase 20.977
Hand1heart and neural crest derivatives expressed transcript 10.977
Hand2heart and neural crest derivatives expressed transcript 20.976
Pax3paired box gene 30.973
Msx2homeobox, msh-like 20.973
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.972
Rararetinoic acid receptor, alpha0.972
Acvr1activin A receptor, type 10.971
Ror2receptor tyrosine kinase-like orphan receptor 20.971
Hoxa13homeobox A130.971
Wnt3awingless-related MMTV integration site 3A0.970
Prrx1paired related homeobox 10.969
Tcf21transcription factor 210.969
Chd7chromodomain helicase DNA binding protein 70.967
Retret proto-oncogene0.966
Notch1Notch gene homolog 1 (Drosophila)0.965
Pbx1pre B-cell leukemia transcription factor 10.965
Emx1empty spiracles homolog 1 (Drosophila)0.965
Lmx1aLIM homeobox transcription factor 1 alpha0.964
Pax6paired box gene 60.961
Bmp7bone morphogenetic protein 70.961
Gli2GLI-Kruppel family member GLI20.960
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.955
Bicc1bicaudal C homolog 1 (Drosophila)0.954
Apcadenomatosis polyposis coli0.953
Wnt1wingless-related MMTV integration site 10.948
Arandrogen receptor0.947
Adam17a disintegrin and metallopeptidase domain 170.945
Slc12a1solute carrier family 12, member 10.945
Vegfavascular endothelial growth factor A0.945
Msx1homeobox, msh-like 10.945
Fgfr1fibroblast growth factor receptor 10.944
Gata4GATA binding protein 40.943
Gpc3glypican 30.942
Ednraendothelin receptor type A0.942
Lef1lymphoid enhancer binding factor 10.942
Wnt5awingless-related MMTV integration site 5A0.942
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.941
Dkk1dickkopf homolog 1 (Xenopus laevis)0.940
Tgfb2transforming growth factor, beta 20.938
Hoxb6homeobox B60.936
Gata6GATA binding protein 60.930
Fgfr3fibroblast growth factor receptor 30.929
Kif3akinesin family member 3A0.929
Ascl1achaete-scute complex homolog 1 (Drosophila)0.928
Notch3Notch gene homolog 3 (Drosophila)0.928
Hoxa10homeobox A100.924
Bdnfbrain derived neurotrophic factor0.916
Cdh5cadherin 50.908
Sox7SRY-box containing gene 70.906
Shesrc homology 2 domain-containing transforming protein E0.904
Tgfbr2transforming growth factor, beta receptor II0.904
Snai1snail homolog 1 (Drosophila)0.901
Rdh10retinol dehydrogenase 10 (all-trans)0.901
Gbx2gastrulation brain homeobox 20.897
Gas1growth arrest specific 10.897
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.895
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pax2apaired box gene 2a0.997
osr2odd-skipped related 2 (Drosophila)0.971
ift88intraflagellar transport 88 homolog0.958
tbx1T-box 10.948
shhasonic hedgehog a0.935
wt1bwilms tumor 1b0.920
jag2jagged 20.907
hand2heart and neural crest derivatives expressed transcript 20.887
hnf1baHNF1 homeobox Ba0.882
rfx2regulatory factor X, 2 (influences HLA class II expression)0.864
flhfloating head0.857
dusp6dual specificity phosphatase 60.838
bmp2abone morphogenetic protein 2a0.830
kdrlkinase insert domain receptor like0.805
bmp4bone morphogenetic protein 40.768
lef1lymphocyte enhancer binding factor 10.717
jag1bjagged 1b0.697
gdnfglial cell derived neurotrophic factor0.696
hoxc6ahomeo box C6a0.691
cdh6cadherin 60.678
myhz2myosin, heavy polypeptide 2, fast muscle specific0.678
osr1odd-skipped related 1 (Drosophila)0.661
myod1myogenic differentiation 10.652
nkx2.3NK2 transcription factor related 30.635
ndr2nodal-related 20.633
aplnrbapelin receptor b0.584
hoxb2ahomeo box B2a0.577
pitx3paired-like homeodomain transcription factor 30.562
ntlano tail a0.562
aldh1a2aldehyde dehydrogenase 1 family, member A20.536
eya1eyes absent homolog 10.523
rx3retinal homeobox gene 30.519
fgf10afibroblast growth factor 10a0.518
hey1hairy/enhancer-of-split related with YRPW motif 10.518
gata3GATA-binding protein 30.515
wnt2bbwingless-type MMTV integration site family, member 2Bb0.512
fn1fibronectin 10.512
epha4aeph receptor A4a0.509
sall4sal-like 4 (Drosophila)0.495
emx3empty spiracles homeobox 30.486
lrp2low density lipoprotein-related protein 20.486
oepone-eyed pinhead0.481
myf5myogenic factor 50.461
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.454
raraaretinoic acid receptor, alpha a0.448
ext1aexostoses (multiple) 1a0.445
rasl11bRAS-like, family 11, member B0.442
smosmoothened homolog (Drosophila)0.442
wt1awilms tumor 1a0.432
meis2.2myeloid ecotropic viral integration site 2.20.427
irx4biroquois homeobox protein 4b0.419
fgfr4fibroblast growth factor receptor 40.419
foxi1forkhead box I10.416
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.411
lrrc6leucine rich repeat containing 60.401
lhx2bLIM homeobox 2b0.401
fgf3fibroblast growth factor 30.400
wnt3awingless-type MMTV integration site family, member 3A0.390
tbx16T-box gene 160.380
kirrel3lkin of IRRE like 3 like0.377
sulf1sulfatase 10.370
bocbrother of CDO0.364
ascl1aachaete-scute complex-like 1a (Drosophila)0.360
cdx4caudal type homeo box transcription factor 40.354
gdf6agrowth differentiation factor 6a0.352
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.350
dhrs3adehydrogenase/reductase (SDR family) member 3a0.347
lrrc50leucine rich repeat containing 500.345
fzd7afrizzled homolog 7a0.339
bmp2bbone morphogenetic protein 2b0.334
gbx2gastrulation brain homeo box 20.330
hhexhematopoietically expressed homeobox0.322
hoxc8ahomeo box C8a0.319
hoxa13ahomeo box A13a0.313
lhx1aLIM homeobox 1a0.309
foxa2forkhead box A20.304
slc4a4asolute carrier family 4, member 4a0.303
ncs1aneuronal calcium sensor 1a0.302
tp53tumor protein p530.302
ccdc40coiled-coil domain containing 400.302
wtipWilms tumor 1 interacting protein0.302
crb2acrumbs homolog 2a0.299
mef2cbmyocyte enhancer factor 2cb0.297
wnt11wingless-type MMTV integration site family, member 110.296
vegfabvascular endothelial growth factor Ab0.295
gata4GATA-binding protein 40.294
notch1anotch homolog 1a0.294
six4bsine oculis homeobox homolog 4b0.291
bmp3bone morphogenetic protein 30.290
elk4ELK4, ETS-domain protein0.290
pou3f1POU class 3 homeobox 10.282
emx1empty spiracles homeobox 10.280
ptgs1prostaglandin-endoperoxide synthase 10.277
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor1.000
cicubitus interruptus0.999
E(spl)Enhancer of split0.982
emcextra macrochaetae0.977
eyaeyes absent0.952
slp1sloppy paired 10.926
stumpsCG31317 gene product from transcript CG31317-RC0.903
MadMothers against dpp0.885
HLHmgammaE(spl) region transcript mgamma0.853
fkhfork head0.760
HLHm7E(spl) region transcript m70.744
LanALaminin A0.733
mbcmyoblast city0.724
aopanterior open0.664
Mkp3Mitogen-activated protein kinase phosphatase 30.657
argosCG4531 gene product from transcript CG4531-RA0.561
DadDaughters against dpp0.554
HLHmbetaE(spl) region transcript mbeta0.527
LanB1CG7123 gene product from transcript CG7123-RA0.510
eveeven skipped0.507
HLHmdeltaE(spl) region transcript mdelta0.502
numbCG3779 gene product from transcript CG3779-RB0.474
opaodd paired0.461
HLHm5E(spl) region transcript m50.433
Stat92ESignal-transducer and activator of transcription protein at 92E0.413
l(2)gllethal (2) giant larvae0.389
sogshort gastrulation0.381
bab2CG9102 gene product from transcript CG9102-RA0.380
rheaCG6831 gene product from transcript CG6831-RA0.350
snssticks and stones0.345
gcmglial cells missing0.331
abd-Aabdominal A0.330
rolsrolling pebbles0.321
Ras85DRas oncogene at 85D0.293
howheld out wings0.292
rapretina aberrant in pattern0.290
fasfaint sausage0.284
grhgrainy head0.277
fz2frizzled 20.264
stanstarry night0.262
Six4CG3871 gene product from transcript CG3871-RA0.230
vvlventral veins lacking0.219
Mef2Myocyte enhancer factor 20.217
LanB2Laminin B20.215
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.997
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.991
NOTCH1notch 10.982
SMAD3SMAD family member 30.982
FHL2four and a half LIM domains 20.978
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.972
FGFR2fibroblast growth factor receptor 20.967
VEGFAvascular endothelial growth factor A0.963
ACTBactin, beta0.949
SMAD7SMAD family member 70.907
FLNAfilamin A, alpha0.892
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.890
RXRAretinoid X receptor, alpha0.890
BCL9B-cell CLL/lymphoma 90.889
PTPN1protein tyrosine phosphatase, non-receptor type 10.866
SKILSKI-like oncogene0.839
TAL1T-cell acute lymphocytic leukemia 10.837
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.818
FGF1fibroblast growth factor 1 (acidic)0.760
COL4A1collagen, type IV, alpha 10.736
PLCG1phospholipase C, gamma 10.734
RB1retinoblastoma 10.734
MDM2Mdm2 p53 binding protein homolog (mouse)0.696
TSC2tuberous sclerosis 20.682
JAG1jagged 10.674
POU3F2POU class 3 homeobox 20.661
IL4Rinterleukin 4 receptor0.660
THBS1thrombospondin 10.646
TIMP3TIMP metallopeptidase inhibitor 30.627
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.600
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.589
NR4A1nuclear receptor subfamily 4, group A, member 10.561
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.540
SMURF2SMAD specific E3 ubiquitin protein ligase 20.511
BCL2B-cell CLL/lymphoma 20.508
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.494
HNF4Ahepatocyte nuclear factor 4, alpha0.490
AKT1v-akt murine thymoma viral oncogene homolog 10.482
IGFBP5insulin-like growth factor binding protein 50.464
LAMC1laminin, gamma 1 (formerly LAMB2)0.455
SMAD2SMAD family member 20.449
CASP3caspase 3, apoptosis-related cysteine peptidase0.437
SORBS3sorbin and SH3 domain containing 30.436
CTGFconnective tissue growth factor0.397
BMP4bone morphogenetic protein 40.386
SMOsmoothened homolog (Drosophila)0.381
MEIS1Meis homeobox 10.368
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.367
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.360
UHRF2ubiquitin-like with PHD and ring finger domains 20.360
COL2A1collagen, type II, alpha 10.348
METmet proto-oncogene (hepatocyte growth factor receptor)0.347
XIAPX-linked inhibitor of apoptosis0.340
PAX3paired box 30.329
KLHL3kelch-like 3 (Drosophila)0.323
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.319
ARandrogen receptor0.316
FAF1Fas (TNFRSF6) associated factor 10.312
FGF10fibroblast growth factor 100.311
FGFR1fibroblast growth factor receptor 10.310
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.304
TGFB2transforming growth factor, beta 20.297
CD63CD63 molecule0.293
BMP2bone morphogenetic protein 20.288
TP53tumor protein p530.287
GSK3Bglycogen synthase kinase 3 beta0.284
CREBBPCREB binding protein0.279
FOXF1forkhead box F10.278
ITGB4integrin, beta 40.273
PAX8paired box 80.273
WNT1wingless-type MMTV integration site family, member 10.271
TBX2T-box 20.269
SMAD4SMAD family member 40.267
PTCH1patched 10.263
SSR1signal sequence receptor, alpha0.259
WNK4WNK lysine deficient protein kinase 40.258
CUL3cullin 30.255
COL4A4collagen, type IV, alpha 40.254
MYOD1myogenic differentiation 10.253
GHRgrowth hormone receptor0.251
ADRB1adrenergic, beta-1-, receptor0.250
APAF1apoptotic peptidase activating factor 10.249
FGF18fibroblast growth factor 180.247
PDIA3protein disulfide isomerase family A, member 30.247
BMPR1Abone morphogenetic protein receptor, type IA0.244
NCOR2nuclear receptor corepressor 20.236
COL4A5collagen, type IV, alpha 50.234
COL4A2collagen, type IV, alpha 20.232
NRP1neuropilin 10.232
FBXL12F-box and leucine-rich repeat protein 120.230
JAK1Janus kinase 10.228
COL4A6collagen, type IV, alpha 60.226
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.224
CFL1cofilin 1 (non-muscle)0.219
ADAM17ADAM metallopeptidase domain 170.217
NR4A3nuclear receptor subfamily 4, group A, member 30.213
DVL3dishevelled, dsh homolog 3 (Drosophila)0.211
NCOA6nuclear receptor coactivator 60.210
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pax8paired box 80.469
Plauplasminogen activator, urokinase0.447
Smad7SMAD family member 70.439
Gja5gap junction protein, alpha 50.424
Aebp1AE binding protein 10.369
Igfbp5insulin-like growth factor binding protein 50.359
DbpD site of albumin promoter (albumin D-box) binding protein0.329
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.314
Col1a1collagen, type I, alpha 10.311
Rararetinoic acid receptor, alpha0.308
Adrb1adrenergic, beta-1-, receptor0.296
Col1a2collagen, type I, alpha 20.295
Gstm1glutathione S-transferase mu 10.265
FosFBJ osteosarcoma oncogene0.243
Flt1FMS-related tyrosine kinase 10.239
Col3a1collagen, type III, alpha 10.199
Cpxm1carboxypeptidase X (M14 family), member 10.199
Hoxc4homeo box C40.199
Efnb1ephrin B10.199
Nek9NIMA (never in mitosis gene a)- related kinase 90.190
Itpr2inositol 1,4,5-triphosphate receptor, type 20.184
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.182
Bcl2B-cell CLL/lymphoma 20.173
Col14a1collagen, type XIV, alpha 10.161
Stat6signal transducer and activator of transcription 60.157
Postnperiostin, osteoblast specific factor0.156
FcgrtFc fragment of IgG, receptor, transporter, alpha0.149
Col12a1collagen, type XII, alpha 10.146
Aif1lallograft inflammatory factor 1-like0.143
Cd4Cd4 molecule0.139
Slc29a2solute carrier family 29 (nucleoside transporters), member 20.137
Figfc-fos induced growth factor0.135
Col8a1collagen, type VIII, alpha 10.135
Oxtoxytocin, prepropeptide0.135
Trhr2thyrotropin releasing hormone receptor 20.134
Tgfbr2transforming growth factor, beta receptor II0.133
Ccdc80coiled-coil domain containing 800.130
C1scomplement component 1, s subcomponent0.127
Syt9synaptotagmin IX0.126
Nos3nitric oxide synthase 3, endothelial cell0.126
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.125
Ghrgrowth hormone receptor0.125
S1pr2sphingosine-1-phosphate receptor 20.124
Mrc1mannose receptor, C type 10.122
MosMoloney sarcoma oncogene0.121
Prelpproline/arginine-rich end leucine-rich repeat protein0.120
Lgals5lectin, galactose binding, soluble 50.120
Gpr182G protein-coupled receptor 1820.119
Fbln1fibulin 10.117
Ephx1epoxide hydrolase 1, microsomal0.116
Hoxa2homeo box A20.116
Ptger4prostaglandin E receptor 4 (subtype EP4)0.115
Angptl2angiopoietin-like 20.115
Wt1Wilms tumor 10.114
Sc4molsterol-C4-methyl oxidase-like0.114
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.113
Slc15a1solute carrier family 15 (oligopeptide transporter), member 10.112
Lamc1laminin, gamma 10.112
Rnase4ribonuclease, RNase A family 40.112
Lst1leukocyte specific transcript 10.111
Pvrl4poliovirus receptor-related 40.109
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.108
Timp3TIMP metallopeptidase inhibitor 30.108
Phexphosphate regulating endopeptidase homolog, X-linked0.107
Cbscystathionine beta synthase0.104
Cpzcarboxypeptidase Z0.104
Tcf4transcription factor 40.103
Krt5keratin 50.102
Pacs1phosphofurin acidic cluster sorting protein 10.100
Lim2lens intrinsic membrane protein 20.099
Psbpc1prostatic steroid binding protein C10.098
Bmp7bone morphogenetic protein 70.098
Fgf16fibroblast growth factor 160.098
Sod3superoxide dismutase 3, extracellular0.097
Fgfr2fibroblast growth factor receptor 20.096
Neurog3neurogenin 30.096
Neu3sialidase 3 (membrane sialidase)0.094
RGD1564327similar to integrin alpha 80.094
Znf532zinc finger protein 5320.093
Il13ra1interleukin 13 receptor, alpha 10.092
Slc34a1solute carrier family 34 (sodium phosphate), member 10.092
Nfianuclear factor I/A0.091
Acacbacetyl-Coenzyme A carboxylase beta0.089
Ctskcathepsin K0.088
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.088
Htra3HtrA serine peptidase 30.087
Ahraryl hydrocarbon receptor0.087
Ghrhgrowth hormone releasing hormone0.086
Cyth3cytohesin 30.086
Wnt5awingless-type MMTV integration site family, member 5A0.085
Il6stinterleukin 6 signal transducer0.085
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.084
Tgfbr3transforming growth factor, beta receptor III0.084
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.083
Ttll3tubulin tyrosine ligase-like family, member 30.082
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism