The network for 'respiratory system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

respiratory system development

The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.

NameDescriptionProbabilityFunc Analog Organism
Bmp4bone morphogenetic protein 41.000
Pitx2paired-like homeodomain transcription factor 21.000
Shhsonic hedgehog1.000
Ptenphosphatase and tensin homolog1.000
Fgfr2fibroblast growth factor receptor 20.999
Foxc1forkhead box C10.999
Fgf8fibroblast growth factor 80.998
Otx2orthodenticle homolog 2 (Drosophila)0.997
Foxa2forkhead box A20.997
Vegfavascular endothelial growth factor A0.997
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.997
Vangl2vang-like 2 (van gogh, Drosophila)0.997
Pax3paired box gene 30.996
Eya1eyes absent 1 homolog (Drosophila)0.996
Hand2heart and neural crest derivatives expressed transcript 20.994
Tcf21transcription factor 210.994
Foxc2forkhead box C20.992
Tgfbr2transforming growth factor, beta receptor II0.989
Nos3nitric oxide synthase 3, endothelial cell0.986
Pbx1pre B-cell leukemia transcription factor 10.986
Tbx3T-box 30.986
Pax2paired box gene 20.984
Hand1heart and neural crest derivatives expressed transcript 10.984
Sox2SRY-box containing gene 20.982
Tcfap2atranscription factor AP-2, alpha0.981
Gata4GATA binding protein 40.976
Prrx1paired related homeobox 10.975
Nkx2-1NK2 homeobox 10.975
Gli2GLI-Kruppel family member GLI20.974
Hes1hairy and enhancer of split 1 (Drosophila)0.971
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.970
Gli3GLI-Kruppel family member GLI30.969
Jag1jagged 10.967
Gata6GATA binding protein 60.963
Ctnnb1catenin (cadherin associated protein), beta 10.961
Smosmoothened homolog (Drosophila)0.960
Hoxa13homeobox A130.958
Ror2receptor tyrosine kinase-like orphan receptor 20.954
Meox2mesenchyme homeobox 20.953
Notch2Notch gene homolog 2 (Drosophila)0.944
Smad4MAD homolog 4 (Drosophila)0.942
Rarbretinoic acid receptor, beta0.942
Msx1homeobox, msh-like 10.941
Sox9SRY-box containing gene 90.941
Hoxd3homeobox D30.940
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.936
Tgfb2transforming growth factor, beta 20.934
Epas1endothelial PAS domain protein 10.930
Nfibnuclear factor I/B0.923
Bmp7bone morphogenetic protein 70.923
Fgfr1fibroblast growth factor receptor 10.922
Smad6MAD homolog 6 (Drosophila)0.921
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.920
Hoxa5homeobox A50.904
Hoxa2homeobox A20.901
Hoxa1homeobox A10.899
Fgfr3fibroblast growth factor receptor 30.899
Emx1empty spiracles homolog 1 (Drosophila)0.897
Gscgoosecoid homeobox0.891
Fgf10fibroblast growth factor 100.885
Apoeapolipoprotein E0.883
Lhx1LIM homeobox protein 10.883
Fbn1fibrillin 10.882
Twist2twist homolog 2 (Drosophila)0.878
Tbx1T-box 10.878
Prrx2paired related homeobox 20.876
Pkd1polycystic kidney disease 1 homolog0.876
Isl1ISL1 transcription factor, LIM/homeodomain0.876
Rargretinoic acid receptor, gamma0.870
Lhx3LIM homeobox protein 30.870
Pax6paired box gene 60.869
Ednraendothelin receptor type A0.865
Tbx2T-box 20.862
Lama5laminin, alpha 50.861
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.858
Acvr1activin A receptor, type 10.845
Foxh1forkhead box H10.841
Ece1endothelin converting enzyme 10.830
Hspg2perlecan (heparan sulfate proteoglycan 2)0.826
Psen1presenilin 10.824
Pou5f1POU domain, class 5, transcription factor 10.821
Sox3SRY-box containing gene 30.816
Gdnfglial cell line derived neurotrophic factor0.807
Gbx2gastrulation brain homeobox 20.806
Hoxb6homeobox B60.804
Ptpn11protein tyrosine phosphatase, non-receptor type 110.792
Sall4sal-like 4 (Drosophila)0.791
Notch1Notch gene homolog 1 (Drosophila)0.783
Loxlysyl oxidase0.779
Tlx2T-cell leukemia, homeobox 20.778
Ascl1achaete-scute complex homolog 1 (Drosophila)0.778
Foxd2forkhead box D20.776
Smad7MAD homolog 7 (Drosophila)0.754
Hoxd13homeobox D130.750
Fgf3fibroblast growth factor 30.749
Id1inhibitor of DNA binding 10.749
Zeb1zinc finger E-box binding homeobox 10.738
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.616
notch1anotch homolog 1a0.529
foxa3forkhead box A30.273
mibmind bomb0.243
eya1eyes absent homolog 10.236
pitx3paired-like homeodomain transcription factor 30.233
tfe3btranscription factor binding to IGHM enhancer 3b0.231
pax2apaired box gene 2a0.156
jag1bjagged 1b0.132
notch3notch homolog 30.132
foxi1forkhead box I10.131
fgfr2fibroblast growth factor receptor 20.121
wlswntless homolog (Drosophila)0.115
satb2SATB homeobox 20.097
fgf10afibroblast growth factor 10a0.094
wt1bwilms tumor 1b0.076
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.076
sulf1sulfatase 10.071
bmp4bone morphogenetic protein 40.067
six4bsine oculis homeobox homolog 4b0.064
hey1hairy/enhancer-of-split related with YRPW motif 10.063
fgf3fibroblast growth factor 30.063
lmx1b.1LIM homeobox transcription factor 1, beta 10.063
gata6GATA-binding protein 60.058
wnt2bbwingless-type MMTV integration site family, member 2Bb0.057
sox9bSRY-box containing gene 9b0.056
ptgs2aprostaglandin-endoperoxide synthase 2a0.054
tp53tumor protein p530.049
foxj1bforkhead box J1b0.047
kif17kinesin family member 170.046
acvr2aactivin receptor IIa0.046
robo1roundabout homolog 10.046
sox19aSRY-box containing gene 19a0.046
acvr2bactivin receptor IIb0.044
wtipWilms tumor 1 interacting protein0.042
fzd8afrizzled homolog 8a0.042
foxa2forkhead box A20.041
sox1aSRY-box containing gene 1a0.040
bmperBMP binding endothelial regulator0.038
sept7bseptin 7b0.038
rx3retinal homeobox gene 30.038
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.036
cldnhclaudin h0.036
wif1wnt inhibitory factor 10.035
irf6interferon regulatory factor 60.034
pea3ETS-domain transcription factor pea30.034
tfap2atranscription factor AP-2 alpha0.033
ptpraprotein tyrosine phosphatase, receptor type, A0.033
emx1empty spiracles homeobox 10.033
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.032
znf503zinc finger protein 5030.032
rfx2regulatory factor X, 2 (influences HLA class II expression)0.031
tbx1T-box 10.030
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.030
hnf1baHNF1 homeobox Ba0.029
cdh2cadherin 2, neuronal0.029
agr2anterior gradient homolog 2 (Xenopus laevis)0.029
pdgfaaplatelet-derived growth factor alpha a0.029
dlx5adistal-less homeobox gene 5a0.029
tfebtranscription factor EB0.028
arl13bADP-ribosylation factor-like 13b0.027
aldh1a3aldehyde dehydrogenase 1 family, member A30.026
six2asine oculis-related homeobox 2a0.026
ptgs1prostaglandin-endoperoxide synthase 10.026
nkx2.3NK2 transcription factor related 30.025
fstafollistatin a0.025
hmx4H6 family homeobox 40.025
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.025
sox21bSRY-box containing gene 21 b0.025
raraaretinoic acid receptor, alpha a0.025
foxa1forkhead box A10.024
foxc1aforkhead box C1a0.024
ndr2nodal-related 20.024
wnt3wingless-type MMTV integration site family, member 30.023
rarabretinoic acid receptor, alpha b0.022
hhexhematopoietically expressed homeobox0.021
ctsl1acathepsin L, 1 a0.021
bmp7bbone morphogenetic protein 7b0.021
igfbp3insulin-like growth factor binding protein 30.021
tp63tumor protein p630.020
trpv6transient receptor potential cation channel, subfamily V, member 60.020
her9hairy-related 90.020
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.020
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.019
jag2jagged 20.019
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.019
nr2f5nuclear receptor subfamily 2, group F, member 50.019
pdlim4PDZ and LIM domain 40.019
dlx2adistal-less homeobox gene 2a0.019
gpr126G protein-coupled receptor 1260.018
dhrs3adehydrogenase/reductase (SDR family) member 3a0.018
hoxb5bhomeo box B5b0.018
vax1ventral anterior homeobox 10.018
ctsbacathepsin B, a0.018
wnt11wingless-type MMTV integration site family, member 110.017
chd7chromodomain helicase DNA binding protein 70.017
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor1.000
cicubitus interruptus0.999
salmspalt major0.998
stanstarry night0.997
eyaeyes absent0.997
AtpalphaNa pump alpha subunit0.995
McrMacroglobulin complement-related0.992
CycACyclin A0.990
nrv2nervana 20.985
LanB2Laminin B20.978
GckIIIGerminal centre kinase III0.976
Rho1CG8416 gene product from transcript CG8416-RB0.974
Tsf2Transferrin 20.971
jingCG9397 gene product from transcript CG9397-RI0.964
Src42ASrc oncogene at 42A0.962
kkvkrotzkopf verkehrt0.960
HLHmdeltaE(spl) region transcript mdelta0.950
Nrx-IVNeurexin IV0.946
aopanterior open0.942
EcREcdysone receptor0.942
Vhlvon Hippel-Lindau0.937
Gyc76CGuanylyl cyclase at 76C0.936
Tsc1CG6147 gene product from transcript CG6147-RA0.936
nocno ocelli0.930
emcextra macrochaetae0.922
CG1298CG1298 gene product from transcript CG1298-RA0.917
phlpole hole0.914
Cdc42CG12530 gene product from transcript CG12530-RA0.911
S6kRPS6-p70-protein kinase0.903
TSG101tumor suppressor protein 1010.896
vvlventral veins lacking0.881
MrtfMyocardin-related transcription factor0.881
Rac1CG2248 gene product from transcript CG2248-RA0.879
Hs6stHeparan sulfate 6-O-sulfotransferase0.869
JraJun-related antigen0.851
Fas2Fasciclin 20.849
mbcmyoblast city0.839
MadMothers against dpp0.839
Nsf2NEM-sensitive fusion protein 20.836
form3formin 30.836
E(spl)Enhancer of split0.829
PvrPDGF- and VEGF-receptor related0.827
CatsupCatecholamines up0.824
AbiAbelson interacting protein0.801
rheaCG6831 gene product from transcript CG6831-RA0.801
cdicenter divider0.798
dallydivision abnormally delayed0.774
Spn77BaSerpin 77Ba0.757
LanALaminin A0.739
grhgrainy head0.737
slp1sloppy paired 10.729
ChcClathrin heavy chain0.722
CG2813CG2813 gene product from transcript CG2813-RA0.718
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FHL2four and a half LIM domains 20.948
FGFR2fibroblast growth factor receptor 20.924
FGF1fibroblast growth factor 1 (acidic)0.869
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.599
SMAD3SMAD family member 30.565
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.537
SP1Sp1 transcription factor0.484
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.444
TBX5T-box 50.348
BMP2bone morphogenetic protein 20.342
FLNAfilamin A, alpha0.293
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.292
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.290
NOTCH1notch 10.272
NCOA1nuclear receptor coactivator 10.268
NRP1neuropilin 10.244
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.241
JAG1jagged 10.218
VEGFAvascular endothelial growth factor A0.215
BMPR1Abone morphogenetic protein receptor, type IA0.183
ZFYVE9zinc finger, FYVE domain containing 90.178
SMAD7SMAD family member 70.175
PPARAperoxisome proliferator-activated receptor alpha0.170
SRSF4serine/arginine-rich splicing factor 40.165
FGFR1fibroblast growth factor receptor 10.155
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.148
STRN4striatin, calmodulin binding protein 40.144
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.138
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.125
GH1growth hormone 10.114
COL1A1collagen, type I, alpha 10.100
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.098
PKD2polycystic kidney disease 2 (autosomal dominant)0.093
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.087
NCOA6nuclear receptor coactivator 60.087
BMP4bone morphogenetic protein 40.086
RUNX1runt-related transcription factor 10.081
DVL3dishevelled, dsh homolog 3 (Drosophila)0.078
NCOA2nuclear receptor coactivator 20.078
COL2A1collagen, type II, alpha 10.069
CTGFconnective tissue growth factor0.068
FN1fibronectin 10.068
EIF2C2eukaryotic translation initiation factor 2C, 20.063
CSNK1Ecasein kinase 1, epsilon0.063
CHD7chromodomain helicase DNA binding protein 70.059
FOXD3forkhead box D30.057
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.057
FGF10fibroblast growth factor 100.057
STRN3striatin, calmodulin binding protein 30.052
PDCD6IPprogrammed cell death 6 interacting protein0.052
JUBjub, ajuba homolog (Xenopus laevis)0.051
ACVR1activin A receptor, type I0.049
WNT1wingless-type MMTV integration site family, member 10.048
ARandrogen receptor0.044
ESR1estrogen receptor 10.043
CCNE1cyclin E10.043
KRT8keratin 80.043
RXRAretinoid X receptor, alpha0.042
MAXMYC associated factor X0.041
HCFC1host cell factor C1 (VP16-accessory protein)0.041
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.040
NCOR2nuclear receptor corepressor 20.040
ITGB4integrin, beta 40.040
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.040
SRFserum response factor (c-fos serum response element-binding transcription factor)0.039
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.038
SORBS3sorbin and SH3 domain containing 30.037
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.036
TSC2tuberous sclerosis 20.036
PAX8paired box 80.035
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.035
FGF18fibroblast growth factor 180.035
TWIST2twist homolog 2 (Drosophila)0.035
PDGFAplatelet-derived growth factor alpha polypeptide0.034
CSH2chorionic somatomammotropin hormone 20.033
FBXW7F-box and WD repeat domain containing 70.033
GH2growth hormone 20.032
BMP7bone morphogenetic protein 70.032
CSHL1chorionic somatomammotropin hormone-like 10.031
CYR61cysteine-rich, angiogenic inducer, 610.031
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.031
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.031
U2AF1U2 small nuclear RNA auxiliary factor 10.030
PTPRCprotein tyrosine phosphatase, receptor type, C0.030
SMAD2SMAD family member 20.030
PDZD11PDZ domain containing 110.030
NOTCH3notch 30.030
WNT3Awingless-type MMTV integration site family, member 3A0.030
HMGA1high mobility group AT-hook 10.029
TGFB1transforming growth factor, beta 10.029
CHD8chromodomain helicase DNA binding protein 80.029
PLCG1phospholipase C, gamma 10.029
AKT1v-akt murine thymoma viral oncogene homolog 10.029
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loxl1lysyl oxidase-like 10.305
Otx1orthodenticle homeobox 10.175
Aebp1AE binding protein 10.131
Ifi30interferon gamma inducible protein 300.109
Pipprolactin induced protein0.108
DbpD site of albumin promoter (albumin D-box) binding protein0.101
Sox17SRY (sex determining region Y)-box 170.098
Col8a1collagen, type VIII, alpha 10.096
C1scomplement component 1, s subcomponent0.092
Tcn2transcobalamin 20.091
Ednraendothelin receptor type A0.083
Foxs1forkhead box S10.082
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.076
Leprleptin receptor0.073
Prl6a1prolactin family 6, subfamily a, member 10.070
Rab13RAB13, member RAS oncogene family0.068
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.067
Sox4SRY (sex determining region Y)-box 40.065
Prelpproline/arginine-rich end leucine-rich repeat protein0.064
Fgl2fibrinogen-like 20.061
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.059
Fuca1fucosidase, alpha-L- 1, tissue0.058
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.057
Prkchprotein kinase C, eta0.057
Igfbp7insulin-like growth factor binding protein 70.056
KitlgKIT ligand0.056
Loxlysyl oxidase0.056
Pmepa1prostate transmembrane protein, androgen induced 10.055
Ctsccathepsin C0.054
Mapk9mitogen-activated protein kinase 90.054
Vcsa2variable coding sequence A20.054
Il11interleukin 110.050
Cd40lgCD40 ligand0.050
Sp1Sp1 transcription factor0.049
Mapk3mitogen activated protein kinase 30.048
Tgfb2transforming growth factor, beta 20.047
Olfml2bolfactomedin-like 2B0.047
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.047
Vom2r40vomeronasal 2 receptor, 400.047
Hist1h1dhistone cluster 1, H1d0.047
S100a3S100 calcium binding protein A30.046
Pmp22peripheral myelin protein 220.045
Ebf1early B-cell factor 10.045
Lgals7lectin, galactoside-binding, soluble, 70.045
Adarb2adenosine deaminase, RNA-specific, B20.045
Spon1spondin 1, extracellular matrix protein0.043
Shox2short stature homeobox 20.043
Cald1caldesmon 10.043
Man2b1mannosidase, alpha, class 2B, member 10.043
Smcpsperm mitochondria-associated cysteine-rich protein0.043
B2mbeta-2 microglobulin0.042
Vegfcvascular endothelial growth factor C0.042
Agtr1aangiotensin II receptor, type 1a0.041
C1rcomplement component 1, r subcomponent0.041
Tmem176btransmembrane protein 176B0.041
Zfxzinc finger protein X-linked0.041
Wnt5awingless-type MMTV integration site family, member 5A0.041
Fgf10fibroblast growth factor 100.041
Irx4iroquois homeobox 40.040
RGD1565927similar to 4631422O05Rik protein0.040
C3complement component 30.039
Col12a1collagen, type XII, alpha 10.038
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.038
Sod3superoxide dismutase 3, extracellular0.038
Pou1f1POU class 1 homeobox 10.037
Tfpi2tissue factor pathway inhibitor 20.037
Cdk2cyclin dependent kinase 20.036
Prl3d4prolactin family 3, subfamily d, member 40.036
Slc7a12solute carrier family 7 (cationic amino acid transporter, y+ system), member 120.036
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.036
Crxcone-rod homeobox0.036
Msx2msh homeobox 20.035
Bmp4bone morphogenetic protein 40.035
Fbln5fibulin 50.035
Timp2TIMP metallopeptidase inhibitor 20.034
Cgaglycoprotein hormones, alpha polypeptide0.034
Casp3caspase 30.034
Pla1aphospholipase A1 member A0.033
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.033
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.033
Cpxm2carboxypeptidase X (M14 family), member 20.033
Scn9asodium channel, voltage-gated, type IX, alpha0.033
SnrkSNF related kinase0.032
Gja5gap junction protein, alpha 50.032
Calhm2calcium homeostasis modulator 20.032
Krt24keratin 240.032
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.031
Nutf2nuclear transport factor 20.031
Stx2syntaxin 20.031
Cyp51cytochrome P450, family 510.031
Tff2trefoil factor 20.031
Tbr1T-box, brain, 10.031
PawrPRKC, apoptosis, WT1, regulator0.031
Cdh13cadherin 130.030
Klks3kallikrein, submaxillary gland S30.030
Ednrbendothelin receptor type B0.030
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism