The network for 'regulation of heart induction by regulation of canonical wnt signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of heart induction by regulation of canonical wnt signaling pathway

Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes.

NameDescriptionProbabilityFunc Analog Organism
Sall4sal-like 4 (Drosophila)0.996
Fgf8fibroblast growth factor 80.962
Pitx2paired-like homeodomain transcription factor 20.952
Shhsonic hedgehog0.948
Foxc2forkhead box C20.905
NanogNanog homeobox0.902
Bmp4bone morphogenetic protein 40.817
Pax3paired box gene 30.804
Hand2heart and neural crest derivatives expressed transcript 20.799
Tcfap2atranscription factor AP-2, alpha0.777
Foxc1forkhead box C10.764
Tbx1T-box 10.760
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.699
Hand1heart and neural crest derivatives expressed transcript 10.581
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.530
Otx2orthodenticle homolog 2 (Drosophila)0.527
Gli3GLI-Kruppel family member GLI30.514
Tcfcp2l1transcription factor CP2-like 10.474
Fgfr2fibroblast growth factor receptor 20.394
Tgfb2transforming growth factor, beta 20.352
Eya1eyes absent 1 homolog (Drosophila)0.339
Sox9SRY-box containing gene 90.311
Hoxa3homeobox A30.307
Hoxa1homeobox A10.299
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.286
Ednraendothelin receptor type A0.278
Smosmoothened homolog (Drosophila)0.271
Gscgoosecoid homeobox0.265
Sall1sal-like 1 (Drosophila)0.262
Isl1ISL1 transcription factor, LIM/homeodomain0.261
Msx1homeobox, msh-like 10.254
Prrx1paired related homeobox 10.246
Rargretinoic acid receptor, gamma0.212
Gata4GATA binding protein 40.207
Sall3sal-like 3 (Drosophila)0.195
Msx2homeobox, msh-like 20.189
Rarbretinoic acid receptor, beta0.170
Sox2SRY-box containing gene 20.169
Nodalnodal0.167
Nr0b1nuclear receptor subfamily 0, group B, member 10.159
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.121
Wnt3awingless-related MMTV integration site 3A0.117
Rararetinoic acid receptor, alpha0.112
Hoxa2homeobox A20.110
Vegfavascular endothelial growth factor A0.109
Chd7chromodomain helicase DNA binding protein 70.104
Gli2GLI-Kruppel family member GLI20.097
Dlx5distal-less homeobox 50.094
Meox2mesenchyme homeobox 20.085
Gbx2gastrulation brain homeobox 20.085
Mta3metastasis associated 30.078
Pitx1paired-like homeodomain transcription factor 10.073
Prrx2paired related homeobox 20.073
Ror2receptor tyrosine kinase-like orphan receptor 20.066
Bmp7bone morphogenetic protein 70.060
Lmx1bLIM homeobox transcription factor 1 beta0.059
Chrdchordin0.056
Rxraretinoid X receptor alpha0.056
Alx4aristaless-like homeobox 40.054
Jag1jagged 10.053
Gata6GATA binding protein 60.050
Fgfr1fibroblast growth factor receptor 10.045
Pax8paired box gene 80.045
Hoxd3homeobox D30.045
Hoxb3homeobox B30.044
Pax6paired box gene 60.044
Ntf3neurotrophin 30.042
Pax2paired box gene 20.039
Tbrachyury0.038
En1engrailed 10.036
Vangl2vang-like 2 (van gogh, Drosophila)0.036
Nkx3-2NK3 homeobox 20.035
Nkx2-6NK2 transcription factor related, locus 6 (Drosophila)0.033
Esrrbestrogen related receptor, beta0.033
Fgf15fibroblast growth factor 150.032
Hesx1homeobox gene expressed in ES cells0.031
Foxg1forkhead box G10.030
Hoxd11homeobox D110.030
Nognoggin0.029
Foxe3forkhead box E30.029
Wnt6wingless-related MMTV integration site 60.029
Crabp1cellular retinoic acid binding protein I0.028
Pax1paired box gene 10.028
Ribc2RIB43A domain with coiled-coils 20.028
Ece1endothelin converting enzyme 10.028
Fgf3fibroblast growth factor 30.027
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.027
Ptpn11protein tyrosine phosphatase, non-receptor type 110.027
Acvr1activin A receptor, type 10.026
Fgf10fibroblast growth factor 100.026
Ctnnb1catenin (cadherin associated protein), beta 10.026
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.026
Cldn6claudin 60.026
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.025
Pax9paired box gene 90.024
Rhox6reproductive homeobox 60.023
Sox11SRY-box containing gene 110.022
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.022
Tcf15transcription factor 150.022
Alx3aristaless-like homeobox 30.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FOXD3forkhead box D31.000
PAX3paired box 31.000
SOX10SRY (sex determining region Y)-box 101.000
WWP2WW domain containing E3 ubiquitin protein ligase 21.000
SOX2SRY (sex determining region Y)-box 21.000
HCFC1host cell factor C1 (VP16-accessory protein)0.999
LRP6low density lipoprotein receptor-related protein 60.986
MEOX2mesenchyme homeobox 20.788
PDX1pancreatic and duodenal homeobox 10.717
SOX1SRY (sex determining region Y)-box 10.688
HMGA1high mobility group AT-hook 10.631
NOVA2neuro-oncological ventral antigen 20.532
SOX11SRY (sex determining region Y)-box 110.520
SMAD7SMAD family member 70.517
OTPorthopedia homeobox0.497
TLX2T-cell leukemia homeobox 20.470
NR0B1nuclear receptor subfamily 0, group B, member 10.450
POU3F2POU class 3 homeobox 20.412
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.410
FOXE1forkhead box E1 (thyroid transcription factor 2)0.331
TP73tumor protein p730.329
NEUROG3neurogenin 30.325
POU4F1POU class 4 homeobox 10.304
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.296
LHX1LIM homeobox 10.292
HRKharakiri, BCL2 interacting protein (contains only BH3 domain)0.280
POU3F3POU class 3 homeobox 30.208
HOXD12homeobox D120.195
POU3F4POU class 3 homeobox 40.185
NKX2-8NK2 homeobox 80.177
HES2hairy and enhancer of split 2 (Drosophila)0.176
NKX2-1NK2 homeobox 10.174
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.172
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.149
ZNF281zinc finger protein 2810.144
NKX6-1NK6 homeobox 10.142
BHLHE23basic helix-loop-helix family, member e230.141
FGF8fibroblast growth factor 8 (androgen-induced)0.141
SFRP5secreted frizzled-related protein 50.136
LHX5LIM homeobox 50.129
OLIG2oligodendrocyte lineage transcription factor 20.122
HTThuntingtin0.115
SIX6SIX homeobox 60.113
ASCL1achaete-scute complex homolog 1 (Drosophila)0.110
NFYAnuclear transcription factor Y, alpha0.103
BCL6B-cell CLL/lymphoma 60.096
SIX2SIX homeobox 20.090
LBX1ladybird homeobox 10.088
NPAS1neuronal PAS domain protein 10.087
ALX3ALX homeobox 30.086
ADARB1adenosine deaminase, RNA-specific, B10.084
ZBTB17zinc finger and BTB domain containing 170.082
TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)0.081
FOXB1forkhead box B10.080
PYYpeptide YY0.079
PAX6paired box 60.077
GATA5GATA binding protein 50.075
VAX2ventral anterior homeobox 20.074
FGF3fibroblast growth factor 30.073
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.072
DMRT1doublesex and mab-3 related transcription factor 10.071
ZNF157zinc finger protein 1570.063
PAX2paired box 20.061
PAX7paired box 70.061
GSC2goosecoid homeobox 20.061
FOXA2forkhead box A20.059
NHLH2nescient helix loop helix 20.057
TLX1T-cell leukemia homeobox 10.056
MDFIMyoD family inhibitor0.055
CDX2caudal type homeobox 20.054
POU4F2POU class 4 homeobox 20.054
RAXretina and anterior neural fold homeobox0.051
NELL1NEL-like 1 (chicken)0.051
HOXB7homeobox B70.049
EVX1even-skipped homeobox 10.048
CALCAcalcitonin-related polypeptide alpha0.048
DLX4distal-less homeobox 40.046
PRDM13PR domain containing 130.046
FOXL1forkhead box L10.045
POU4F3POU class 4 homeobox 30.042
DRD4dopamine receptor D40.041
PITX2paired-like homeodomain 20.041
VSX1visual system homeobox 10.040
HOXD9homeobox D90.040
POU3F1POU class 3 homeobox 10.038
BARX1BARX homeobox 10.038
HOXC8homeobox C80.038
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.038
HOXB9homeobox B90.037
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.037
HOXB13homeobox B130.036
HOXD11homeobox D110.036
DLX2distal-less homeobox 20.036
GJD2gap junction protein, delta 2, 36kDa0.034
SIM2single-minded homolog 2 (Drosophila)0.033
HMX2H6 family homeobox 20.033
GBX2gastrulation brain homeobox 20.033
PAX5paired box 50.032
RNF11ring finger protein 110.032
MNX1motor neuron and pancreas homeobox 10.032
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism