The network for 'regulation of transcription involved in cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transcription involved in cell fate commitment

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate.

NameDescriptionProbabilityFunc Analog Organism
Pax3paired box gene 30.982
Fgfr2fibroblast growth factor receptor 20.978
Pax6paired box gene 60.973
Eya1eyes absent 1 homolog (Drosophila)0.973
Shhsonic hedgehog0.969
Isl1ISL1 transcription factor, LIM/homeodomain0.965
Rxraretinoid X receptor alpha0.922
Tcfap2atranscription factor AP-2, alpha0.911
Leprleptin receptor0.905
Gli3GLI-Kruppel family member GLI30.888
Otx2orthodenticle homolog 2 (Drosophila)0.884
Sox9SRY-box containing gene 90.879
Hand2heart and neural crest derivatives expressed transcript 20.879
Gata4GATA binding protein 40.848
Msx1homeobox, msh-like 10.812
Fgf8fibroblast growth factor 80.807
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.785
Alx4aristaless-like homeobox 40.784
Hand1heart and neural crest derivatives expressed transcript 10.763
Dlx5distal-less homeobox 50.742
Trp53transformation related protein 530.717
Sall3sal-like 3 (Drosophila)0.631
Gscgoosecoid homeobox0.630
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.536
Ptf1apancreas specific transcription factor, 1a0.529
Pax2paired box gene 20.510
Foxc1forkhead box C10.448
Bmp7bone morphogenetic protein 70.430
Sox2SRY-box containing gene 20.420
Cdkn1bcyclin-dependent kinase inhibitor 1B0.419
Ptenphosphatase and tensin homolog0.408
Rararetinoic acid receptor, alpha0.398
Ppargperoxisome proliferator activated receptor gamma0.390
Tbx1T-box 10.380
Edarectodysplasin-A receptor0.355
Meox2mesenchyme homeobox 20.338
Bmp4bone morphogenetic protein 40.328
Onecut1one cut domain, family member 10.325
Pax9paired box gene 90.311
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.300
Sall4sal-like 4 (Drosophila)0.286
Nf1neurofibromatosis 10.284
Hoxd3homeobox D30.272
Hoxd13homeobox D130.271
Tgfb2transforming growth factor, beta 20.246
Fgf10fibroblast growth factor 100.240
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.235
Ctnnb1catenin (cadherin associated protein), beta 10.228
Hes1hairy and enhancer of split 1 (Drosophila)0.227
Hoxa13homeobox A130.219
Rargretinoic acid receptor, gamma0.213
Pitx2paired-like homeodomain transcription factor 20.212
Sox11SRY-box containing gene 110.198
Hoxa2homeobox A20.196
Ednraendothelin receptor type A0.190
Dlx2distal-less homeobox 20.187
Rarbretinoic acid receptor, beta0.187
Phox2bpaired-like homeobox 2b0.185
Gata6GATA binding protein 60.174
Pou3f3POU domain, class 3, transcription factor 30.173
Vegfavascular endothelial growth factor A0.171
Nos3nitric oxide synthase 3, endothelial cell0.168
Trp63transformation related protein 630.168
Ntf3neurotrophin 30.166
Foxd2forkhead box D20.164
Lepleptin0.163
Zeb1zinc finger E-box binding homeobox 10.162
Prrx1paired related homeobox 10.159
Wnt3awingless-related MMTV integration site 3A0.148
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.148
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.144
Pdx1pancreatic and duodenal homeobox 10.143
Apoeapolipoprotein E0.135
Atoh7atonal homolog 7 (Drosophila)0.133
Neurod1neurogenic differentiation 10.131
Ascl1achaete-scute complex homolog 1 (Drosophila)0.130
Sox3SRY-box containing gene 30.127
Lef1lymphoid enhancer binding factor 10.121
Sox10SRY-box containing gene 100.121
Tgfb1transforming growth factor, beta 10.120
Rspo2R-spondin 2 homolog (Xenopus laevis)0.119
Alx1ALX homeobox 10.117
Cav1caveolin 1, caveolae protein0.116
Foxc2forkhead box C20.116
Dlx6distal-less homeobox 60.115
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.114
Insm1insulinoma-associated 10.113
Ghrgrowth hormone receptor0.112
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.111
Dlx1distal-less homeobox 10.110
Wnt1wingless-related MMTV integration site 10.109
Insrinsulin receptor0.107
Barx1BarH-like homeobox 10.107
Hoxd1homeobox D10.106
Lhx3LIM homeobox protein 30.105
Itgb1integrin beta 1 (fibronectin receptor beta)0.105
Foxo1forkhead box O10.097
Hoxa10homeobox A100.097
Gli2GLI-Kruppel family member GLI20.095
Ptpn11protein tyrosine phosphatase, non-receptor type 110.093
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlx5adistal-less homeobox gene 5a0.981
bmp2bbone morphogenetic protein 2b0.978
bmp4bone morphogenetic protein 40.964
chdchordin0.956
col2a1acollagen type II, alpha-1a0.878
dlx2adistal-less homeobox gene 2a0.877
msxcmuscle segment homeobox C0.865
fgf24fibroblast growth factor 240.854
nkx2.2aNK2 transcription factor related 2a0.690
osr1odd-skipped related 1 (Drosophila)0.675
sox9bSRY-box containing gene 9b0.661
dlx4adistal-less homeobox gene 4a0.612
tcf7transcription factor 7 (T-cell specific, HMG-box)0.586
eve1even-skipped-like10.410
otx2orthodenticle homolog 20.404
msxdmuscle segment homeobox D0.398
dlx3bdistal-less homeobox gene 3b0.394
nkx6.1NK6 transcription factor related, locus 1 (Drosophila)0.362
nkx2.5NK2 transcription factor related 50.252
sp7Sp7 transcription factor0.251
tpbgltrophoblast glycoprotein-like0.242
bglapbone gamma-carboxyglutamate (gla) protein0.225
ascl1aachaete-scute complex-like 1a (Drosophila)0.222
dlx1adistal-less homeobox gene 1a0.212
fgf3fibroblast growth factor 30.210
fezf2FEZ family zinc finger 20.205
mab21l2mab-21-like 20.188
foxa2forkhead box A20.172
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.156
dlx4bdistal-less homeobox gene 4b0.152
tgfb3transforming growth factor, beta 30.151
bmp2abone morphogenetic protein 2a0.149
bonbonnie and clyde0.149
dccdeleted in colorectal carcinoma0.140
hoxd11ahomeo box D11a0.140
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.132
msxemuscle segment homeobox E0.122
hoxd10ahomeo box D10a0.116
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.116
sox9aSRY-box containing gene 9a0.114
gata3GATA-binding protein 30.114
hoxa11bhomeo box A11b0.112
hoxa13bhomeo box A13b0.105
hoxa9bhomeo box A9b0.096
irf6interferon regulatory factor 60.096
gata6GATA-binding protein 60.092
prdm1aPR domain containing 1a, with ZNF domain0.091
otx1aorthodenticle homolog 1a0.088
dlx6adistal-less homeobox gene 6a0.084
ventventral expressed homeobox0.083
hoxa10bhomeo box A10b0.081
mtpmicrosomal triglyceride transfer protein0.077
pax6bpaired box gene 6b0.077
zic1zic family member 1 (odd-paired homolog, Drosophila)0.077
prox1prospero-related homeobox gene 10.076
acvr1bactivin A receptor, type IB0.075
prickle1aprickle-like 1 (Drosophila) a0.071
dlx2bdistal-less homeobox gene 2b0.071
hoxd13ahomeo box D13a0.069
unc5bunc-5 homolog B (C. elegans)0.068
msxamuscle segment homeobox A0.068
foxa3forkhead box A30.066
gata5GATA-binding protein 50.064
ihhaIndian hedgehog homolog a0.061
nkx6.2NK6 transcription factor related, locus 20.060
otpborthopedia homolog b0.057
hoxc1ahomeo box C1a0.057
lrrn1leucine rich repeat neuronal 10.056
pbx1apre-B-cell leukemia transcription factor 1a0.056
olig4oligodendrocyte transcription factor 40.056
fgf20afibroblast growth factor 20a0.053
gata2aGATA-binding protein 2a0.052
sall4sal-like 4 (Drosophila)0.048
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.047
lft1lefty10.046
pou3f3aPOU class 3 homeobox 3a0.045
hoxd9ahomeo box D9a0.044
foxp2forkhead box P20.044
msxbmuscle segment homeobox B0.044
epha4beph receptor A4b0.043
sox17SRY-box containing gene 170.043
voxventral homeobox0.042
twist3twist30.042
vsx2visual system homeobox 20.041
gdf6agrowth differentiation factor 6a0.041
mgpmatrix Gla protein0.041
zgc:171553zgc:1715530.040
cx43connexin 430.040
admpanti-dorsalizing morphogenic protein0.040
metmet proto-oncogene (hepatocyte growth factor receptor)0.039
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.038
pitx3paired-like homeodomain transcription factor 30.036
apoebapolipoprotein Eb0.036
emx3empty spiracles homeobox 30.035
cdx4caudal type homeo box transcription factor 40.035
six3bsine oculis homeobox homolog 3b0.035
junbjun B proto-oncogene0.034
dkk1bdickkopf 1b0.034
pax7apaired box gene 7a0.034
lhx1aLIM homeobox 1a0.034
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha0.999
SP1Sp1 transcription factor0.981
NCOA1nuclear receptor coactivator 10.917
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.898
MED25mediator complex subunit 250.842
HNF4Ahepatocyte nuclear factor 4, alpha0.745
HTThuntingtin0.724
ESR1estrogen receptor 10.528
NR0B1nuclear receptor subfamily 0, group B, member 10.408
FOXD3forkhead box D30.208
NCOR2nuclear receptor corepressor 20.177
BMPR1Abone morphogenetic protein receptor, type IA0.168
HMGA1high mobility group AT-hook 10.128
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.090
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.085
CREBBPCREB binding protein0.069
SOX2SRY (sex determining region Y)-box 20.068
ARID1AAT rich interactive domain 1A (SWI-like)0.067
MTA1metastasis associated 10.067
MTA2metastasis associated 1 family, member 20.063
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.051
NCOA3nuclear receptor coactivator 30.046
PROX1prospero homeobox 10.041
PAX3paired box 30.041
RXRAretinoid X receptor, alpha0.038
MBD3methyl-CpG binding domain protein 30.037
SOX10SRY (sex determining region Y)-box 100.037
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.036
NCOR1nuclear receptor corepressor 10.034
WWP2WW domain containing E3 ubiquitin protein ligase 20.031
SREBF2sterol regulatory element binding transcription factor 20.031
CARM1coactivator-associated arginine methyltransferase 10.029
PDX1pancreatic and duodenal homeobox 10.029
NR0B2nuclear receptor subfamily 0, group B, member 20.027
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.027
ESRRGestrogen-related receptor gamma0.027
SPOPspeckle-type POZ protein0.025
EP300E1A binding protein p3000.024
MTA3metastasis associated 1 family, member 30.021
FSTL1follistatin-like 10.021
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.020
HDAC1histone deacetylase 10.019
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.018
SMAD3SMAD family member 30.017
HNF1AHNF1 homeobox A0.016
TP53tumor protein p530.013
ARID1BAT rich interactive domain 1B (SWI1-like)0.012
ZFYVE9zinc finger, FYVE domain containing 90.011
RNF8ring finger protein 80.011
SGSM2small G protein signaling modulator 20.011
PPARGperoxisome proliferator-activated receptor gamma0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism