The network for 'cellular hyperosmotic salinity response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular hyperosmotic salinity response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

NameDescriptionProbabilityFunc Analog Organism
Aifm1apoptosis-inducing factor, mitochondrion-associated 11.000
Gpx1glutathione peroxidase 11.000
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.991
Mlh1mutL homolog 1 (E. coli)0.415
Ptcd3pentatricopeptide repeat domain 30.368
Exosc7exosome component 70.356
Rars2arginyl-tRNA synthetase 2, mitochondrial0.277
Cpsf3cleavage and polyadenylation specificity factor 30.271
Elp3elongation protein 3 homolog (S. cerevisiae)0.238
Ints3integrator complex subunit 30.124
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.115
Parp1poly (ADP-ribose) polymerase family, member 10.111
Msh2mutS homolog 2 (E. coli)0.101
Rpap1RNA polymerase II associated protein 10.095
Pmpcbpeptidase (mitochondrial processing) beta0.081
Axin1axin 10.078
Elp2elongation protein 2 homolog (S. cerevisiae)0.074
Psmg2proteasome (prosome, macropain) assembly chaperone 20.074
Ift172intraflagellar transport 172 homolog (Chlamydomonas)0.062
Dhx30DEAH (Asp-Glu-Ala-His) box polypeptide 300.054
TcrdT-cell receptor delta chain0.054
TcrbT-cell receptor beta chain0.049
Mrpl21mitochondrial ribosomal protein L210.049
Gpr52G protein-coupled receptor 520.047
Rpa3replication protein A30.046
Mettl3methyltransferase like 30.043
Exosc10exosome component 100.040
Gartphosphoribosylglycinamide formyltransferase0.039
Tars2threonyl-tRNA synthetase 2, mitochondrial (putative)0.038
Adsladenylosuccinate lyase0.037
Ints4integrator complex subunit 40.029
Gnpatglyceronephosphate O-acyltransferase0.029
Mcm3apminichromosome maintenance deficient 3 (S. cerevisiae) associated protein0.028
Rpa1replication protein A10.026
Parnpoly(A)-specific ribonuclease (deadenylation nuclease)0.024
Zmym6zinc finger, MYM-type 60.024
Larsleucyl-tRNA synthetase0.023
Dmddystrophin, muscular dystrophy0.022
Aasdhaminoadipate-semialdehyde dehydrogenase0.022
Gon4lgon-4-like (C.elegans)0.021
A830093I24RikRIKEN cDNA A830093I24 gene0.021
Gm13570predicted gene 135700.021
Clk2CDC-like kinase 20.020
Trp53bp1transformation related protein 53 binding protein 10.020
Fsd1lfibronectin type III and SPRY domain containing 1-like0.019
3010085J16RikRIKEN cDNA 3010085J16 gene0.019
Numa1nuclear mitotic apparatus protein 10.019
Gm16498predicted gene 164980.018
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.018
E130304F04RikRIKEN cDNA E130304F04 gene0.018
Tti1Tel2 interacting protein 1 homolog (S. pombe)0.017
Prpf8pre-mRNA processing factor 80.016
Cobra1cofactor of BRCA10.016
Anapc2anaphase promoting complex subunit 20.016
Gm10484predicted gene 104840.016
Dcaf8DDB1 and CUL4 associated factor 80.014
Btbd2BTB (POZ) domain containing 20.014
D130046C19RikRIKEN cDNA D130046C19 gene0.014
Gm10048predicted gene 100480.014
Cd59bCD59b antigen0.014
Gpr21G protein-coupled receptor 210.013
Fan1FANCD2/FANCI-associated nuclease 10.013
Mrps31mitochondrial ribosomal protein S310.013
Zfp167zinc finger protein 1670.013
Anapc1anaphase promoting complex subunit 10.013
Gm13476predicted gene 134760.013
D130050E23RikRIKEN cDNA D130050E23 gene0.012
F830001A07RikRIKEN cDNA F830001A07 gene0.012
Cul7cullin 70.012
Nup85nucleoporin 850.012
Olfr1033olfactory receptor 10330.012
6530402D11RikRIKEN cDNA 6530402D11 gene0.012
AF357341snoRNA AF3573410.012
Gpn3GPN-loop GTPase 30.012
Dio3deiodinase, iodothyronine type III0.012
Gm4724predicted gene 47240.011
B430203G13RikRIKEN cDNA B430203G13 gene0.011
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.011
Mc4rmelanocortin 4 receptor0.011
Gm17449predicted gene, 174490.011
6030499A19RikRIKEN cDNA 6030499A19 gene0.011
Zfp174zinc finger protein 1740.011
F830212C03RikRIKEN cDNA F830212C03 gene0.011
Gm16497predicted gene 164970.011
Zfp459zinc finger protein 4590.010
Gm5136predicted gene 51360.010
Tmem22transmembrane protein 220.010
Zfp607zinc finger proten 6070.010
Zc3h12bzinc finger CCCH-type containing 12B0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
C48E7.1Protein C48E7.10.301
egl-18Protein EGL-180.267
cnd-1Protein CND-10.250
hlh-2Protein HLH-20.100
flt-1Protein FLT-10.071
pha-4Protein PHA-40.059
pes-1Protein PES-10.057
nhr-2Protein NHR-20.047
nhr-34Protein NHR-340.044
ten-1Protein TEN-10.039
elt-6Protein ELT-60.034
vang-1Protein VANG-10.032
ceh-43Protein CEH-430.032
unc-130Protein UNC-1300.031
ceh-16Protein CEH-160.027
mls-2Protein MLS-20.025
hnd-1Protein HND-10.025
tbx-8Protein TBX-80.024
cam-1Protein CAM-10.023
zip-7Protein ZIP-70.018
amx-3Protein AMX-30.018
ref-1Protein REF-10.016
sdz-36Protein SDZ-360.016
H06I04.1Protein H06I04.10.015
flh-2Protein FLH-20.015
hlh-1Protein HLH-10.015
ceh-13Protein CEH-130.014
psf-1Protein PSF-10.014
lin-15AProtein LIN-15A0.014
nhr-67Protein NHR-670.014
sdz-33Protein SDZ-330.014
hlh-14Protein HLH-140.014
pop-1Protein POP-10.013
dcar-1Protein DCAR-10.013
inx-3Protein INX-30.013
egl-46Protein EGL-460.013
K02D7.1Protein K02D7.10.013
nhr-25Protein NHR-250.013
CELE_R04B5.5Protein R04B5.50.013
fmi-1Protein FMI-10.013
T23F11.4Protein T23F11.40.012
mrp-1Protein MRP-10.012
ref-2Protein REF-20.012
ceh-20Protein CEH-200.012
Y5H2B.3Protein Y5H2B.30.011
ceh-21Protein CEH-210.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Gcn2CG1609 gene product from transcript CG1609-RA0.016
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YKR015Chypothetical protein0.108
MIG2Mig2p0.074
CAB3Cab3p0.041
GAT2Gat2p0.040
HXT3Hxt3p0.039
YKR075Chypothetical protein0.038
MIG1Mig1p0.026
SMP1Smp1p0.022
VHS1Vhs1p0.022
VID24Vid24p0.022
MIG3Mig3p0.020
ZAP1Zap1p0.020
ROX1Rox1p0.020
MHP1Mhp1p0.020
FMP48Fmp48p0.018
YPL014Whypothetical protein0.017
TPO2Tpo2p0.016
RGS2Rgs2p0.016
TOS8Tos8p0.015
MKS1Mks1p0.015
MSN4Msn4p0.014
SSK2Ssk2p0.014
SKS1Sks1p0.014
RDS2Rds2p0.013
SAK1Sak1p0.013
HAL5Hal5p0.013
YNL234Whypothetical protein0.013
STB5Stb5p0.013
YPR157Whypothetical protein0.013
LYS5Lys5p0.012
VAC7Vac7p0.012
GIP2Gip2p0.012
DOT6Dot6p0.012
VPS27Vps27p0.012
ICY1Icy1p0.012
NUP157Nup157p0.012
PSR2Psr2p0.012
NRG1Nrg1p0.011
YKL187Chypothetical protein0.011
YPL150Whypothetical protein0.011
TOS3Tos3p0.011
SRD1Srd1p0.011
FAA2Faa2p0.010
YPR013Chypothetical protein0.010