The network for 'protein folding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

NameDescriptionProbabilityFunc Analog Organism
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.917
Hspa8heat shock protein 80.903
Hsph1heat shock 105kDa/110kDa protein 10.895
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.859
Hsp90b1heat shock protein 90, beta (Grp94), member 10.834
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.826
Rpgrip1lRpgrip1-like0.737
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.611
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.543
Hspa5heat shock protein 50.541
Hspd1heat shock protein 1 (chaperonin)0.426
H2-DMahistocompatibility 2, class II, locus DMa0.411
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.411
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.374
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.374
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.361
Cct2chaperonin containing Tcp1, subunit 2 (beta)0.326
H2-Ab1histocompatibility 2, class II antigen A, beta 10.309
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.297
Stip1stress-induced phosphoprotein 10.242
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.231
Hbb-b2hemoglobin, beta adult minor chain0.212
H2-Aahistocompatibility 2, class II antigen A, alpha0.209
Cacybpcalcyclin binding protein0.206
Tcp1t-complex protein 10.190
Prnpprion protein0.185
IkbipIKBKB interacting protein0.184
Hspa9heat shock protein 90.178
H2-Eb1histocompatibility 2, class II antigen E beta0.172
Ptges3prostaglandin E synthase 3 (cytosolic)0.171
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.154
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.135
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.125
Garsglycyl-tRNA synthetase0.105
Narsasparaginyl-tRNA synthetase0.094
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.081
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.075
Copz2coatomer protein complex, subunit zeta 20.071
Ahi1Abelson helper integration site 10.070
Lrrk2leucine-rich repeat kinase 20.066
Kdelr2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.063
Tm9sf3transmembrane 9 superfamily member 30.062
Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked0.062
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.061
H2-K1histocompatibility 2, K1, K region0.055
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.053
Vcpvalosin containing protein0.049
Ahsa1AHA1, activator of heat shock protein ATPase homolog 1 (yeast)0.049
Mta1metastasis associated 10.048
Eprsglutamyl-prolyl-tRNA synthetase0.048
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.048
Pcbp1poly(rC) binding protein 10.048
Hspa1bheat shock protein 1B0.047
Eedembryonic ectoderm development0.047
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.046
Ppicpeptidylprolyl isomerase C0.043
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.043
H2-DMb2histocompatibility 2, class II, locus Mb20.042
P4hbprolyl 4-hydroxylase, beta polypeptide0.042
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.038
Cops2COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)0.038
Rpn2ribophorin II0.037
Dnajb2DnaJ (Hsp40) homolog, subfamily B, member 20.037
Spcs2signal peptidase complex subunit 2 homolog (S. cerevisiae)0.037
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.036
Calucalumenin0.035
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.035
Hbb-b1hemoglobin, beta adult major chain0.033
St13suppression of tumorigenicity 130.032
Creld2cysteine-rich with EGF-like domains 20.032
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.030
Txndc5thioredoxin domain containing 50.030
Fstl1follistatin-like 10.030
Pdia3protein disulfide isomerase associated 30.028
Plrg1pleiotropic regulator 1, PRL1 homolog (Arabidopsis)0.028
Hspa4lheat shock protein 4 like0.027
Lman1lectin, mannose-binding, 10.027
Pdia6protein disulfide isomerase associated 60.027
Stt3aSTT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)0.027
Dnajb4DnaJ (Hsp40) homolog, subfamily B, member 40.027
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.026
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.026
Hspa1aheat shock protein 1A0.026
Cct8chaperonin containing Tcp1, subunit 8 (theta)0.026
SetSET nuclear oncogene0.026
Magt1magnesium transporter 10.025
Tram1translocating chain-associating membrane protein 10.025
Sarsseryl-aminoacyl-tRNA synthetase0.025
Ghitmgrowth hormone inducible transmembrane protein0.024
Fam136afamily with sequence similarity 136, member A0.024
Pdia5protein disulfide isomerase associated 50.023
Rpn1ribophorin I0.023
Tmem33transmembrane protein 330.023
Iqcb1IQ calmodulin-binding motif containing 10.022
Skp1aS-phase kinase-associated protein 1A0.022
Hspa4heat shock protein 40.022
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.021
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.021
Fbn1fibrillin 10.021
Leprel4leprecan-like 40.020
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hsp-1Protein HSP-10.829
cct-2Protein CCT-20.309
hsp-4Protein HSP-40.220
dnj-19Protein DNJ-190.196
C30C11.4Protein C30C11.40.134
hsp-3Protein HSP-30.132
tag-320Protein TAG-3200.124
ZC395.10Protein ZC395.100.121
cct-6Protein CCT-60.111
CELE_C01G10.8Protein C01G10.80.103
pdi-1Protein PDI-10.076
fkb-6Protein FKB-60.074
daf-21Protein DAF-210.072
cct-1Protein CCT-10.064
dnj-12Protein DNJ-120.057
tbb-2Protein TBB-20.047
cct-5Protein CCT-50.043
dnj-13Protein DNJ-130.037
ahcy-1Protein AHCY-10.029
pdi-3Protein PDI-30.026
gars-1Protein GARS-10.025
ttll-12Protein TTLL-120.024
gdi-1Protein GDI-10.021
CELE_T05E11.3Protein T05E11.30.019
cct-4Protein CCT-40.018
hel-1Protein HEL-10.018
sti-1Protein STI-10.015
dars-1Protein DARS-10.015
cars-1Protein CARS-10.015
R107.5Protein R107.50.014
hke-4.2Protein HKE-4.20.014
par-5Protein PAR-50.014
stt-3Protein STT-30.013
T16G1.9Protein T16G1.90.013
eif-3.JProtein EIF-3.J0.013
sgt-1Protein SGT-10.011
D2085.3Protein D2085.30.011
nra-2Protein NRA-20.011
ubc-9Protein UBC-90.011
hip-1Protein HIP-10.010
pfn-1Protein PFN-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 11.000
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 11.000
HSPA8heat shock 70kDa protein 81.000
FKBP4FK506 binding protein 4, 59kDa1.000
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)1.000
TCP1t-complex 11.000
PDIA4protein disulfide isomerase family A, member 40.999
STIP1stress-induced-phosphoprotein 10.999
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.997
HSPH1heat shock 105kDa/110kDa protein 10.997
P4HBprolyl 4-hydroxylase, beta polypeptide0.997
PPIDpeptidylprolyl isomerase D0.994
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.993
HSPA4heat shock 70kDa protein 40.990
PDIA6protein disulfide isomerase family A, member 60.985
PTGES3prostaglandin E synthase 3 (cytosolic)0.984
EPRSglutamyl-prolyl-tRNA synthetase0.982
HSPA1Bheat shock 70kDa protein 1B0.979
CCT3chaperonin containing TCP1, subunit 3 (gamma)0.978
HSPD1heat shock 60kDa protein 1 (chaperonin)0.978
PDIA3protein disulfide isomerase family A, member 30.940
CCT5chaperonin containing TCP1, subunit 5 (epsilon)0.937
CACYBPcalcyclin binding protein0.926
CCT6Achaperonin containing TCP1, subunit 6A (zeta 1)0.898
CCT4chaperonin containing TCP1, subunit 4 (delta)0.878
PPP5Cprotein phosphatase 5, catalytic subunit0.875
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.857
HSPA9heat shock 70kDa protein 9 (mortalin)0.815
BAG3BCL2-associated athanogene 30.799
CDC37cell division cycle 37 homolog (S. cerevisiae)0.750
IARSisoleucyl-tRNA synthetase0.747
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.740
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.706
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.656
HSPA1Aheat shock 70kDa protein 1A0.635
CCT2chaperonin containing TCP1, subunit 2 (beta)0.634
HSPB8heat shock 22kDa protein 80.621
ARL2ADP-ribosylation factor-like 20.612
NUB1negative regulator of ubiquitin-like proteins 10.590
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.587
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.497
BAG1BCL2-associated athanogene0.426
CCT7chaperonin containing TCP1, subunit 7 (eta)0.425
ERO1LERO1-like (S. cerevisiae)0.421
HSPE1heat shock 10kDa protein 1 (chaperonin 10)0.420
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.420
BAG2BCL2-associated athanogene 20.420
CALRcalreticulin0.410
SUGT1SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)0.406
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.389
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.339
CCT8chaperonin containing TCP1, subunit 8 (theta)0.323
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.307
NUDCnuclear distribution gene C homolog (A. nidulans)0.273
SOD1superoxide dismutase 1, soluble0.267
HLA-DMBmajor histocompatibility complex, class II, DM beta0.235
MAP3K7mitogen-activated protein kinase kinase kinase 70.231
MARSmethionyl-tRNA synthetase0.217
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.199
UBQLN1ubiquilin 10.161
TBCDtubulin folding cofactor D0.155
GARSglycyl-tRNA synthetase0.141
TOR1Atorsin family 1, member A (torsin A)0.133
CCDC117coiled-coil domain containing 1170.122
KARSlysyl-tRNA synthetase0.122
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.120
CANXcalnexin0.114
PLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.112
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.111
BCL2L1BCL2-like 10.111
SARSseryl-tRNA synthetase0.110
TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)0.110
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.108
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.101
SMAD9SMAD family member 90.101
TBK1TANK-binding kinase 10.100
ASNSasparagine synthetase (glutamine-hydrolyzing)0.099
PSEN1presenilin 10.098
CRYAAcrystallin, alpha A0.095
NARSasparaginyl-tRNA synthetase0.094
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)0.092
DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 20.087
CHUKconserved helix-loop-helix ubiquitous kinase0.082
TOR1AIP2torsin A interacting protein 20.080
PDE6Dphosphodiesterase 6D, cGMP-specific, rod, delta0.079
TMED5transmembrane emp24 protein transport domain containing 50.076
CRYBB2crystallin, beta B20.075
LDHAlactate dehydrogenase A0.074
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.072
HSPA13heat shock protein 70kDa family, member 130.072
TTC4tetratricopeptide repeat domain 40.066
MAP3K1mitogen-activated protein kinase kinase kinase 10.063
TOR1Btorsin family 1, member B (torsin B)0.062
TAPBPTAP binding protein (tapasin)0.055
CSNK1A1casein kinase 1, alpha 10.054
SDF2L1stromal cell-derived factor 2-like 10.054
CRYGCcrystallin, gamma C0.053
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.053
HSPB2heat shock 27kDa protein 20.053
MRPL18mitochondrial ribosomal protein L180.053
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 10.991
Hsp90b1heat shock protein 90, beta, member 10.942
Hspd1heat shock protein 1 (chaperonin)0.927
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.793
Cct2chaperonin containing TCP1, subunit 2 (beta)0.678
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.632
Hspa8heat shock protein 80.605
Stip1stress-induced phosphoprotein 10.559
Hspa5heat shock protein 50.556
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.397
Pdia6protein disulfide isomerase family A, member 60.276
RT1-DaRT1 class II, locus Da0.268
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.221
Pdia3protein disulfide isomerase family A, member 30.184
Canxcalnexin0.162
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.158
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.133
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.069
Hspa1aheat shock 70kD protein 1A0.051
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.049
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.048
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.033
Xpo1exportin 1, CRM1 homolog (yeast)0.033
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.030
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.028
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.024
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.023
Ppidpeptidylprolyl isomerase D (cyclophilin D)0.022
Tcp1t-complex 10.022
Manfmesencephalic astrocyte-derived neurotrophic factor0.020
Pdia4protein disulfide isomerase family A, member 40.019
Caprin1cell cycle associated protein 10.017
Hyou1hypoxia up-regulated 10.017
Snd1staphylococcal nuclease and tudor domain containing 10.015
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.015
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.015
Lman2lectin, mannose-binding 20.013
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.013
Nsun2NOL1/NOP2/Sun domain family, member 20.012
RT1-BbRT1 class II, locus Bb0.012
Lrrc59leucine rich repeat containing 590.011
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.011
Rpn2ribophorin II0.010
Ttc9ctetratricopeptide repeat domain 9C0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CPR6Cpr6p0.997
STI1Sti1p0.989
SIS1Sis1p0.988
HSP82Hsp82p0.968
KAR2Kar2p0.960
BTN2Btn2p0.955
CCT2Cct2p0.942
CCT4Cct4p0.936
SSC1Ssc1p0.924
SSA4Ssa4p0.917
HSP60Hsp60p0.913
CIN1Cin1p0.909
SCJ1Scj1p0.908
MDJ1Mdj1p0.905
SSE1Sse1p0.900
SGT2Sgt2p0.898
YDJ1Ydj1p0.895
CCT6Cct6p0.892
AHA1Aha1p0.876
CCT8Cct8p0.872
HSP104Hsp104p0.871
TCP1Tcp1p0.784
CCT3Cct3p0.731
SSA3Ssa3p0.728
SBA1Sba1p0.726
HSC82Hsc82p0.722
SSA1Ssa1p0.700
CUR1Cur1p0.682
PHB2Phb2p0.669
SSA2Ssa2p0.641
SIL1Sil1p0.576
CCT7Cct7p0.565
PDI1Pdi1p0.565
STE24Ste24p0.529
HSP10Hsp10p0.515
FES1Fes1p0.503
GIM4Gim4p0.503
PLP2Plp2p0.503
APJ1Apj1p0.481
FPR2Fpr2p0.471
PIH1Pih1p0.439
ERV41Erv41p0.427
HSP78Hsp78p0.373
KEG1Keg1p0.343
PAC2Pac2p0.337
ERV46Erv46p0.318
CPR7Cpr7p0.309
CUE1Cue1p0.309
VMA11Vma11p0.306
YGR130Chypothetical protein0.299
UBC4Ubc4p0.286
TIM44Tim44p0.281
GET1Get1p0.274
AHP1Ahp1p0.261
PMT3Pmt3p0.227
SSE2Sse2p0.217
SLP1Slp1p0.198
ERV29Erv29p0.198
LHS1Lhs1p0.196
HSP42Hsp42p0.195
ADR1Adr1p0.191
TAH1Tah1p0.191
TSA1Tsa1p0.190
SEC28Sec28p0.188
ACP1Acp1p0.188
TRX1Trx1p0.187
MTG1Mtg1p0.184
TIM17Tim17p0.179
JEM1Jem1p0.179
YMR130Whypothetical protein0.178
SOD1Sod1p0.177
DOG2Dog2p0.174
LTP1Ltp1p0.173
NTA1Nta1p0.173
VPH2Vph2p0.168
EXG2Exg2p0.160
CAF130Caf130p0.159
HCH1Hch1p0.158
CDC37Cdc37p0.148
YBL029C-Ahypothetical protein0.147
TIM23Tim23p0.143
CUE4Cue4p0.141
DDI1Ddi1p0.139
SRP54Srp54p0.135
YRB2Yrb2p0.134
LPP1Lpp1p0.133
PPX1Ppx1p0.130
PHO86Pho86p0.128
NAT5Nat5p0.125
CCT5Cct5p0.124
YER163Chypothetical protein0.121
MIM1Mim1p0.111
YER140Whypothetical protein0.111
YHB1Yhb1p0.111
CRH1Crh1p0.108
AIM29Aim29p0.107
MGR2Mgr2p0.106
EGD2Egd2p0.106
YDL121Chypothetical protein0.106
HNT1Hnt1p0.105